Rajiv Dhir

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays
    Kulkarni Prakash
    Gene Logic Inc, 708 Quince Orchard Road, Gaithersburg, MD 20878, USA
    Proc Natl Acad Sci U S A 99:7598-603. 2002
  2. ncbi request reprint Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy
    Sheldon Bastacky
    Department of Pathology, University of Pittsburgh School of Medicine, PA, USA
    Hum Pathol 35:281-9. 2004
  3. ncbi request reprint Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells
    Sourabh Kharait
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 343:848-56. 2006
  4. ncbi request reprint Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck
    Carmen Visus
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Res 67:10538-45. 2007
  5. doi request reprint p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ
    Ming Yin
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Hum Pathol 39:527-35. 2008
  6. doi request reprint Prostate cancer biobanking
    Rajiv Dhir
    Health Sciences Tissue Bank, University of Pittsburgh UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
    Curr Opin Urol 18:309-14. 2008
  7. pmc A multidisciplinary approach to honest broker services for tissue banks and clinical data: a pragmatic and practical model
    Rajiv Dhir
    Department of Pathology, University of Pittsburgh, UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
    Cancer 113:1705-15. 2008
  8. ncbi request reprint Prostate cancer screening parameters in a high-risk African-Caribbean population
    Clareann H Bunker
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Urology 63:737-41. 2004
  9. pmc National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research
    Waqas Amin
    Department of Biomedical Informatics, University of Pittsburgh, PA, USA
    BMC Cancer 8:236. 2008
  10. pmc An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource
    Ashokkumar A Patel
    Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Cancer 6:120. 2006

Detail Information

Publications76

  1. pmc Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays
    Kulkarni Prakash
    Gene Logic Inc, 708 Quince Orchard Road, Gaithersburg, MD 20878, USA
    Proc Natl Acad Sci U S A 99:7598-603. 2002
    ..This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH...
  2. ncbi request reprint Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy
    Sheldon Bastacky
    Department of Pathology, University of Pittsburgh School of Medicine, PA, USA
    Hum Pathol 35:281-9. 2004
    ....
  3. ncbi request reprint Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells
    Sourabh Kharait
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 343:848-56. 2006
    ..Thus, we conclude that PKCdelta inhibition can limit migration and invasion of prostate cancer cells...
  4. ncbi request reprint Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck
    Carmen Visus
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Res 67:10538-45. 2007
    ..A smaller cohort of subjects with SCCHN, whose tumors express little to no ALDH1A1, and thus are deficient in conversion of retinal to retinoic acid, could benefit from chemoprevention therapy...
  5. doi request reprint p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ
    Ming Yin
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Hum Pathol 39:527-35. 2008
    ..Alterations of 9p21/chromosome 9 detected by fluorescence in situ hybridization can also be used for diagnostic confirmation and prognostic prediction...
  6. doi request reprint Prostate cancer biobanking
    Rajiv Dhir
    Health Sciences Tissue Bank, University of Pittsburgh UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
    Curr Opin Urol 18:309-14. 2008
    ..It addresses issues related to collection and appropriate annotation of prostate samples, ethics and administrative aspects of biorepository functioning...
  7. pmc A multidisciplinary approach to honest broker services for tissue banks and clinical data: a pragmatic and practical model
    Rajiv Dhir
    Department of Pathology, University of Pittsburgh, UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
    Cancer 113:1705-15. 2008
    ..This complex process needs resolution of a variety of issues regarding the precise role of the HB and their interaction with data. There also is an obvious need for software solutions to make the task of deidentification easier...
  8. ncbi request reprint Prostate cancer screening parameters in a high-risk African-Caribbean population
    Clareann H Bunker
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Urology 63:737-41. 2004
    ..To estimate the prostate cancer screening parameters in a population-based study of African-Caribbean men from the Island of Tobago...
  9. pmc National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research
    Waqas Amin
    Department of Biomedical Informatics, University of Pittsburgh, PA, USA
    BMC Cancer 8:236. 2008
    ..The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need...
  10. pmc An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource
    Ashokkumar A Patel
    Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Cancer 6:120. 2006
    ..Here we describe the CPCTR information management system architecture, common data element (CDE) development, query interfaces, data curation, and quality control...
  11. ncbi request reprint Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 12:6836-43. 2006
    ..The present study was undertaken to determine the effect of garlic constituent diallyl trisulfide (DATS) on growth of PC-3 human prostate cancer xenograft in vivo...
  12. ncbi request reprint Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma
    Uzma S Shah
    Department of Urology, University of Pittsburgh, PA 15232, USA
    Hum Pathol 37:401-9. 2006
    ..These findings suggest that FASN gene copy number increases may be involved in the resultant increase in FASN protein expression observed in prostatic disease...
  13. doi request reprint Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors
    Federico A Monzon
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Mod Pathol 21:599-608. 2008
    ....
  14. doi request reprint Optimization of the Affymetrix GeneChip Mapping 10K 2.0 Assay for routine clinical use on formalin-fixed paraffin-embedded tissues
    Maureen Lyons-Weiler
    Clinical Genomics Facility, University of Pittsburgh, Pittsburgh, PA, USA
    Diagn Mol Pathol 17:3-13. 2008
    ..0 SNP array. This optimized protocol opens up the potential for the GeneChip Mapping assay to be used in the development of clinical test assays...
  15. pmc Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome
    Laura P Stabile
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:154-64. 2011
    ..Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome...
  16. pmc Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
    Uma R Chandran
    Departmental of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    BMC Cancer 7:64. 2007
    ..Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets...
  17. ncbi request reprint Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 4:1747-54. 2005
    ..In conclusion, the present study indicates that caspase-dependent apoptosis by guggulsterone is mediated in part by Bax and Bak...
  18. ncbi request reprint Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    Yan Ping Yu
    University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Oncol 22:2790-9. 2004
    ..Identification of the genes and patterns of gene expression will provide a more cohesive picture of prostate cancer biology...
  19. pmc Renal cell neoplasms contain shared tumor type-specific copy number variations
    John M Krill-Burger
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Am J Pathol 180:2427-39. 2012
    ..The genomic amplifications/deletions identified herein represent potential diagnostic and/or prognostic biomarkers...
  20. pmc Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion
    Qian Wu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Cancer 11:3. 2012
    ..While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively with cancer progression though the molecular basis remains unclear...
  21. pmc Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up
    Marie Dvorakova
    Department of Pathology, UPMC Shadyside, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
    Diagn Pathol 5:32. 2010
    ..FISH results, even those showing significant chromosomal abnormalities, should not alter the primarily morphology-based diagnosis of RO...
  22. pmc Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma
    Simion Chiosea
    Department of Pathology, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, C920 1, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Pathol 169:1812-20. 2006
    ..The presence of up-regulated microRNA machinery may predict the susceptibility of prostate adenocarcinoma to RNA interference-based therapy...
  23. doi request reprint Initial experience with a novel pre-sign-out quality assurance tool for review of random surgical pathology diagnoses in a subspecialty-based university practice
    Scott R Owens
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 34:1319-23. 2010
    ..The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors...
  24. doi request reprint Amylase α-1A (AMY1A): a novel immunohistochemical marker to differentiate chromophobe renal cell carcinoma from benign oncocytoma
    Sarika Jain
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA Department of Pathology, East Carolina University, Greenville, NC
    Am J Surg Pathol 37:1824-30. 2013
    ..95-1.00) and 90.74% (95% confidence interval, 0.80-0.97), respectively. These data show that the novel marker AMY1A can be of great diagnostic utility when trying to differentiate ChRCC (classic and eosinophilic variant) and oncocytoma. ..
  25. pmc Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomas
    Carmen Visus
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Immunol Immunother 60:919-29. 2011
    ..Our findings provide the basis for future studies aimed at developing cancer vaccines for targeting HSD17B12, which apparently can be functional in critical metabolic pathways involved in inflammation and cancer...
  26. pmc Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography
    William A LaFramboise
    University of Pittsburgh, Department of Pathology, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
    BMC Med 10:157. 2012
    ....
  27. doi request reprint Prevalence of incidental prostate cancer in the general population: a study of healthy organ donors
    Ming Yin
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Urol 179:892-5; discussion 895. 2008
    ..We analyzed our data set of incidental prostate cancer, derived from a project accruing prostate tissues for research from normal organ donors, who are a predominantly white population...
  28. ncbi request reprint Prostate cancer risk is three-fold higher among men, aged 50-64, of African descent compared with men of Asian-Indian descent in Trinidad and Tobago
    Clareann H Bunker
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Ethn Dis 12:S3-30-3. 2002
    ..To test the hypothesis that the screening-detected prevalence of prostate cancer is higher among men of African descent than among men of Asian-Indian descent living in Trinidad & Tobago...
  29. ncbi request reprint Contribution of the prostate limits the usefulness of survivin for the detection of bladder cancer
    Benjamin Davies
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    J Urol 174:1767-70. 2005
    ..We determined if urinary survivin is influenced by the prostate and analyzed survivin levels in a healthy control population...
  30. pmc Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy
    Uddhav P Kelavkar
    Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 8:112-24. 2006
    ..These observations also provide clues as to its mechanisms of action...
  31. pmc Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate
    Jeffrey J Tomaszewski
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Prostate 71:1287-93. 2011
    ....
  32. pmc Suppressive roles of calreticulin in prostate cancer growth and metastasis
    Mahesh Alur
    Department of Urology, University of Pittsburgh, 5200 Centre Ave, Shadyside Medical Center, Suite G40, Pittsburgh, PA 15232, USA
    Am J Pathol 175:882-90. 2009
    ..Overall, our data support the hypothesis that calreticulin inhibits growth and/or metastasis of prostate cancer cells and that this suppression requires the P-domain...
  33. ncbi request reprint Perineural invasion in prostate cancer biopsies is not associated with higher rates of positive surgical margins
    Glenn M Cannon
    Department of Urology, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213 3232, USA
    Prostate 63:336-40. 2005
    ..The contemporary rates of extracapsular tumor extension (ECE) and margin status associated with biopsy PNI were investigated...
  34. pmc Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium
    Michael Schlicht
    Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
    BMC Genomics 5:58. 2004
    ..This method is made possible through the use of highly controlled spotted cDNA slide production and the use of comparative bioinformatics databases without the use of cross-species slide hybridizations...
  35. ncbi request reprint Gene expression analysis of prostate cancers
    Jian Hua Luo
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pensylvania 15261, USA
    Mol Carcinog 33:25-35. 2002
    ..Cluster analysis using the 84-gene list showed that the highly aggressive prostate cancers contained gene-expression patterns that were distinct from organ-confined prostate cancers...
  36. doi request reprint Frozen section diagnosis: is there discordance between what pathologists say and what surgeons hear?
    Somak Roy
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Clin Pathol 140:363-9. 2013
    ..The frozen section (FS) diagnosis in patient care is dependent on successful communication between pathologists and surgeons. However, very few studies looking at FS errors analyzed postanalytic communication issues...
  37. pmc Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model
    Shivendra V Singh
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Natl Cancer Inst 104:1228-39. 2012
    ..Phenethyl isothiocyanate (PEITC) is a natural plant compound with chemopreventative potential against some cancers and the ability to induce apoptosis in breast cancer cells...
  38. pmc Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors
    Uma R Chandran
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
    BMC Cancer 5:45. 2005
    ..However, normal appearing prostate tissue from tumor free organ donors represents an alterative source of baseline tissue for differential expression studies...
  39. pmc The development of common data elements for a multi-institute prostate cancer tissue bank: the Cooperative Prostate Cancer Tissue Resource (CPCTR) experience
    Ashokkumar A Patel
    Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Cancer 5:108. 2005
    ..To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data...
  40. ncbi request reprint Detection of prostate cancer with a blood-based assay for early prostate cancer antigen
    Barbara Paul
    Department of Urology, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 65:4097-100. 2005
    ..EPCA, when coupled with prostate-specific antigen, may help reduce the number of both unnecessary biopsies and undetected prostate tumors...
  41. pmc Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
    Milton W Datta
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Cancer 5:9. 2006
    ..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...
  42. ncbi request reprint Characterization of the nuclear matrix proteins in a transgenic mouse model for prostate cancer
    Eddy S Leman
    Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pennsylvania 15232, USA
    J Cell Biochem 86:203-12. 2002
    ..Identification of these NMPs permits the development of novel markers that can characterize various stages of prostate cancer development as well as potentially therapeutic targets...
  43. pmc Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors
    Ji Young Song
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cancer Epidemiol 37:518-22. 2013
    ..To investigate the association between inherited variation in the estrogen receptor beta (ERβ) gene (ESR2) and ERβ lung tumor expression, a phenotype that possibly affects survival differently in men and women...
  44. pmc The development and deployment of Common Data Elements for tissue banks for translational research in cancer - an emerging standard based approach for the Mesothelioma Virtual Tissue Bank
    Sambit K Mohanty
    Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    BMC Cancer 8:91. 2008
    ....
  45. ncbi request reprint Androgen regulation of JM-27 is associated with the diseased prostate
    Uzma S Shah
    Department of Urology, University of Pittsburgh, Pennsylvania, USA
    J Androl 25:618-24. 2004
    ..Further studies are underway to evaluate such a function for JM-27 in prostatic diseases...
  46. pmc Expression of myopodin induces suppression of tumor growth and metastasis
    Ling Jing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 164:1799-806. 2004
    ..All these results support the hypothesis that myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells...
  47. pmc Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis
    Kazuhisa Konishi
    Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 180:167-75. 2009
    ..The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF...
  48. ncbi request reprint The cooperative prostate cancer tissue resource: a specimen and data resource for cancer researchers
    Jonathan Melamed
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 10:4614-21. 2004
    ..This communication describes the CPCTR to investigators interested in obtaining prostate cancer tissue samples...
  49. pmc Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion
    Gunjan Malik
    Departments of Urology and Pathology, University of Pittsburgh School of Medicine, Shadyside Medical Center, Prostate Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Cancer Res 70:4327-34. 2010
    ....
  50. ncbi request reprint Increased apoptosis of periprostatic adipose tissue in VDR null mice
    Meral Guzey
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Cell Biochem 93:133-41. 2004
    ..This may be particularly attractive for VDR targets for the inhibition of cancer progression using VD(3) and its analogs as potential chemo-preventive agents...
  51. pmc Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer
    Guimin Chang
    Department of Urology, University of Pittsburgh, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
    Clin Cancer Res 16:5390-401. 2010
    ..CADM-1, CADM-3, and CADM-4 have been shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, CADM-2 expression has not been determined in prostate cancer...
  52. pmc Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice
    Shivendra V Singh
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA
    Cancer Res 68:9503-11. 2008
    ..In conclusion, the results of the present study show, for the first time, that DATS administration prevents progression to invasive carcinoma and lung metastasis in TRAMP mice...
  53. pmc Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases
    Yvonne Chao
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA, 15213, USA
    Cancer Microenviron 5:19-28. 2012
    ..Our results suggest that cancer cells continue to display phenotypic plasticity beyond the EMT that initiates metastasis...
  54. pmc Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: a Gynecologic Oncology Group study
    Jennifer M Rubatt
    Division of Gynecologic Oncology, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Gynecol Oncol 125:421-6. 2012
    ..This study sought to assess the prognostic value of ERCC1 expression, measured by immunohistochemistry (IHC) using a highly specific antibody, in advanced epithelial ovarian cancer (EOC) patients treated with platinum-based chemotherapy...
  55. doi request reprint Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues
    Stergios J Moschos
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Pathol 41:1286-98. 2010
    ....
  56. doi request reprint The development and testing of a laboratory information system-driven tool for pre-sign-out quality assurance of random surgical pathology reports
    Scott R Owens
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Clin Pathol 133:836-41. 2010
    ..There has been no significant delay in case turnaround time since implementation. Further assessment of the tool's function after full departmental application is underway...
  57. ncbi request reprint Age-associated changes in alpha-methyl CoA racemase (AMACR) expression in nonneoplastic prostatic tissues
    Adrian Gologan
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Surg Pathol 29:1435-41. 2005
    ..4) Ki-67 staining was very variable and showed no correlation with age and AMACR expression levels. AMACR expression had no correlation with proliferative index...
  58. ncbi request reprint Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
    Diane L Carlisle
    Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Pulm Pharmacol Ther 20:629-41. 2007
    ..In addition, exposure of NSCLC patients to nicotine through use of nicotine replacement products or use of tobacco products may alter the efficacy of therapy with EGFR inhibitors...
  59. doi request reprint Tissue microarrays: an overview
    Rajiv Dhir
    Department of Pathology, UPMC Shadyside Presbyterian Hospital, Pittsburgh, PA, USA
    Methods Mol Biol 441:91-103. 2008
    ..The presence of OCT can sporadically interfere with certain assays. However, it does provide a novel mechanism for high-throughput evaluation of frozen tissue, with corresponding visualization of tissue morphology...
  60. ncbi request reprint Early identification of individuals with prostate cancer in negative biopsies
    Rajiv Dhir
    Department of Urology, University of Pittsburgh and Prostate and Urologic Cancer Program of the University of Pittsburgh Cancer Institute, Pennsylvania 15232, USA
    J Urol 171:1419-23. 2004
    ..The novel prostate cancer marker, EPCA, is expressed throughout the prostate of individuals with prostate cancer but not in those without the disease...
  61. ncbi request reprint Stat3 activation in prostatic carcinomas
    Rajiv Dhir
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Prostate 51:241-6. 2002
    ..The aim of this study is to examine quantitative Stat3 activity in benign and malignant human prostate tissues and analyze the association between Stat3 activity levels and the clinical and pathologic parameters...
  62. doi request reprint Polyunsaturated fatty acid metabolizing 15-Lipoxygenase-1 (15-LO-1) expression in normal and tumorigenic human bladder tissues
    Brian J Philips
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
    Appl Immunohistochem Mol Morphol 16:159-64. 2008
    ..Our finding of variable 15-LO-1 expression and enzyme activity in bladder tissues suggests a role for 15-LO-1 in bladder carcinogenesis...
  63. doi request reprint Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid
    Pang Ning Teng
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Proteome Res 10:1333-42. 2011
    ....
  64. ncbi request reprint Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer
    Patricia Cano
    Department of Urologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14213, and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 67:511-9. 2007
    ..Thus, the ability of epithelial cells to modulate coregulator recruitment to the AR transcriptional complex on androgen-responsive genes seems altered in the stromal microenvironment of prostate cancer...
  65. ncbi request reprint High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer Survey
    Clareann H Bunker
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Cancer Epidemiol Biomarkers Prev 11:726-9. 2002
    ..These data support the hypothesis that populations of African descent share genetic and/or lifestyle factors that contribute to their elevated risk for prostate cancer...
  66. ncbi request reprint Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
    Ajita V Singh
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Carcinogenesis 25:83-90. 2004
    ..To the best of our knowledge, the present study is the first published report to document in vivo anticancer activity of SFN in a tumor xenograft model...
  67. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  68. ncbi request reprint Vitamin D and androgen regulation of prostatic growth
    Eddy S Leman
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
    J Cell Biochem 90:138-47. 2003
    ..These studies may reveal important information about the potential efficacy of 1,25 D as well as hormonal status in understanding the development of prostate diseases...
  69. ncbi request reprint Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma
    Zuyao Ni
    Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Urol 167:1859-62. 2002
    ..Constitutive activation of STATs has been found in a wide variety of human tumors. In this study we examined the activity of STATs in primary human prostate tissues...
  70. ncbi request reprint Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    Carcinogenesis 27:2223-34. 2006
    ..In conclusion, the present study indicates that the PEITC-induced apoptosis in PC-3 cells is mediated by ROS-dependent disruption of the mitochondrial membrane potential and regulated by Bax and Bid...
  71. pmc The tissue microarray data exchange specification: implementation by the Cooperative Prostate Cancer Tissue Resource
    Jules J Berman
    Cancer Diagnosis Program, National Cancer Institute, National Institutes of Health, Bethesda, USA
    BMC Bioinformatics 5:19. 2004
    ..The purpose of this paper is to demonstrate how the TMA Data Exchange Specification is implemented in a prostate cancer TMA...
  72. ncbi request reprint Down-regulation of macrophage inhibitory cytokine-1/prostate derived factor in benign prostatic hyperplasia
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    Prostate 59:351-6. 2004
    ..Macrophage inhibitory cytokine-1 (MIC-1) is a member of transforming growth factor-beta/bone morphogenetic protein (BMP) superfamily. Despite its potential role in prostatic regulation, little is known about its biological activity...
  73. ncbi request reprint Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions
    Malabika Sen
    Department of Urology, University of Pittsburgh and Cancer Institute, PA 15232, USA
    Prostaglandins Other Lipid Mediat 81:1-13. 2006
    ..Thus, our findings demonstrate the effectiveness of this viral system for 15-LO-1 expression studies in tissues...
  74. ncbi request reprint Prostate cancer in patients with screening serum prostate specific antigen values less than 4.0 ng/dl: results from the cooperative prostate cancer tissue resource
    Milton W Datta
    Departments of Pathology, New York University School of Medicine, New York, New York, USA
    J Urol 173:1546-51. 2005
    ..0 ng/ml). It is currently unclear whether these tumors are different from prostate cancer in patients with high PSA levels (greater than 4.0 ng/ml)...
  75. ncbi request reprint Prostate cancer with low PSA levels
    Milton W Datta
    N Engl J Med 351:1802-3. 2004
  76. doi request reprint Polymeric immunoglobulin receptor-negative tumors represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junction
    Adrian Gologan
    Department of Pathology, McGill University, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Arch Pathol Lab Med 132:1295-301. 2008
    ....