Research Topics
Genomes and Genes
| Rajiv DhirSummaryAffiliation: University of Pittsburgh Country: USA Publications
| Collaborators
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Detail Information
Publications
Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarraysKulkarni Prakash
Gene Logic Inc, 708 Quince Orchard Road, Gaithersburg, MD 20878, USA
Proc Natl Acad Sci U S A 99:7598-603. 2002..This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH...
Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsySheldon Bastacky
Department of Pathology, University of Pittsburgh School of Medicine, PA, USA
Hum Pathol 35:281-9. 2004....- Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cellsSourabh Kharait
Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh VAMC, Pittsburgh, PA 15261, USA
Biochem Biophys Res Commun 343:848-56. 2006..Thus, we conclude that PKCdelta inhibition can limit migration and invasion of prostate cancer cells... - Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neckCarmen Visus
Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Cancer Res 67:10538-45. 2007..A smaller cohort of subjects with SCCHN, whose tumors express little to no ALDH1A1, and thus are deficient in conversion of retinal to retinoic acid, could benefit from chemoprevention therapy... 
p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situMing Yin
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
Hum Pathol 39:527-35. 2008..Alterations of 9p21/chromosome 9 detected by fluorescence in situ hybridization can also be used for diagnostic confirmation and prognostic prediction...- Prostate cancer biobankingRajiv Dhir
Health Sciences Tissue Bank, University of Pittsburgh UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
Curr Opin Urol 18:309-14. 2008..It addresses issues related to collection and appropriate annotation of prostate samples, ethics and administrative aspects of biorepository functioning... - A multidisciplinary approach to honest broker services for tissue banks and clinical data: a pragmatic and practical modelRajiv Dhir
Department of Pathology, University of Pittsburgh, UPMC Shadyside Presbyterian Hospital, Pittsburgh, Pennsylvania 15232, USA
Cancer 113:1705-15. 2008..This complex process needs resolution of a variety of issues regarding the precise role of the HB and their interaction with data. There also is an obvious need for software solutions to make the task of deidentification easier... - Prostate cancer screening parameters in a high-risk African-Caribbean populationClareann H Bunker
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
Urology 63:737-41. 2004..The screening was highly efficacious, with a positive predictive value of 56% for an elevated PSA level and 40% for an elevated PSA level and/or abnormal DRE findings... - National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational researchWaqas Amin
Department of Biomedical Informatics, University of Pittsburgh, PA, USA
BMC Cancer 8:236. 2008..The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need... - An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue ResourceAshokkumar A Patel
Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
BMC Cancer 6:120. 2006..Here we describe the CPCTR information management system architecture, common data element (CDE) development, query interfaces, data curation, and quality control... - Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak inductionDong Xiao
Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 12:6836-43. 2006..CONCLUSIONS: The present study indicates that DATS administration inhibits growth of PC-3 xenografts in vivo in association with induction of Bax and Bak... - Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinomaUzma S Shah
Department of Urology, University of Pittsburgh, PA 15232, USA
Hum Pathol 37:401-9. 2006..These findings suggest that FASN gene copy number increases may be involved in the resultant increase in FASN protein expression observed in prostatic disease... - Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcomeLaura P Stabile
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 17:154-64. 2011..Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome... - Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumorsFederico A Monzon
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Mod Pathol 21:599-608. 2008.... - Optimization of the Affymetrix GeneChip Mapping 10K 2.0 Assay for routine clinical use on formalin-fixed paraffin-embedded tissuesMaureen Lyons-Weiler
Clinical Genomics Facility, University of Pittsburgh, Pittsburgh, PA, USA
Diagn Mol Pathol 17:3-13. 2008..0 SNP array. This optimized protocol opens up the potential for the GeneChip Mapping assay to be used in the development of clinical test assays... - Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and BakShivendra V Singh
Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA
Mol Cancer Ther 4:1747-54. 2005..In conclusion, the present study indicates that caspase-dependent apoptosis by guggulsterone is mediated in part by Bax and Bak... - Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic processUma R Chandran
Departmental of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15260, USA
BMC Cancer 7:64. 2007..Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets... - Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancyYan Ping Yu
University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Oncol 22:2790-9. 2004..CONCLUSION: We also found that gene expression patterns can be used to predict the aggressiveness of prostate cancer using a novel model... - Renal cell neoplasms contain shared tumor type-specific copy number variationsJohn M Krill-Burger
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
Am J Pathol 180:2427-39. 2012..The genomic amplifications/deletions identified herein represent potential diagnostic and/or prognostic biomarkers... - Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasionQian Wu
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Mol Cancer 11:3. 2012..While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively with cancer progression though the molecular basis remains unclear... - Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-upMarie Dvorakova
Department of Pathology, UPMC Shadyside, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
Diagn Pathol 5:32. 2010..FISH results, even those showing significant chromosomal abnormalities, should not alter the primarily morphology-based diagnosis of RO... - Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinomaSimion Chiosea
Department of Pathology, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, C920 1, 200 Lothrop St, Pittsburgh, PA 15213, USA
Am J Pathol 169:1812-20. 2006..The presence of up-regulated microRNA machinery may predict the susceptibility of prostate adenocarcinoma to RNA interference-based therapy... - Initial experience with a novel pre-sign-out quality assurance tool for review of random surgical pathology diagnoses in a subspecialty-based university practiceScott R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 34:1319-23. 2010..The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors... - Prostate cancer risk is three-fold higher among men, aged 50-64, of African descent compared with men of Asian-Indian descent in Trinidad and TobagoClareann H Bunker
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Ethn Dis 12:S3-30-3. 2002..To test the hypothesis that the screening-detected prevalence of prostate cancer is higher among men of African descent than among men of Asian-Indian descent living in Trinidad & Tobago... - Prevalence of incidental prostate cancer in the general population: a study of healthy organ donorsMing Yin
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Urol 179:892-5; discussion 895. 2008..We analyzed our data set of incidental prostate cancer, derived from a project accruing prostate tissues for research from normal organ donors, who are a predominantly white population... - Contribution of the prostate limits the usefulness of survivin for the detection of bladder cancerBenjamin Davies
Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
J Urol 174:1767-70. 2005..We determined if urinary survivin is influenced by the prostate and analyzed survivin levels in a healthy control population... - Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiographyWilliam A LaFramboise
University of Pittsburgh, Department of Pathology, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
BMC Med 10:157. 2012.... - The development of common data elements for a multi-institute prostate cancer tissue bank: the Cooperative Prostate Cancer Tissue Resource (CPCTR) experienceAshokkumar A Patel
Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
BMC Cancer 5:108. 2005..To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data... - Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomyUddhav P Kelavkar
Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
Neoplasia 8:112-24. 2006..These observations also provide clues as to its mechanisms of action... - Suppressive roles of calreticulin in prostate cancer growth and metastasisMahesh Alur
Department of Urology, University of Pittsburgh, 5200 Centre Ave, Shadyside Medical Center, Suite G40, Pittsburgh, PA 15232, USA
Am J Pathol 175:882-90. 2009..Overall, our data support the hypothesis that calreticulin inhibits growth and/or metastasis of prostate cancer cells and that this suppression requires the P-domain... - Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donorsUma R Chandran
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
BMC Cancer 5:45. 2005..However, normal appearing prostate tissue from tumor free organ donors represents an alterative source of baseline tissue for differential expression studies... - Perineural invasion in prostate cancer biopsies is not associated with higher rates of positive surgical marginsGlenn M Cannon
Department of Urology, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213 3232, USA
Prostate 63:336-40. 2005..The contemporary rates of extracapsular tumor extension (ECE) and margin status associated with biopsy PNI were investigated... - Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to seleniumMichael Schlicht
Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
BMC Genomics 5:58. 2004..This method is made possible through the use of highly controlled spotted cDNA slide production and the use of comparative bioinformatics databases without the use of cross-species slide hybridizations... - Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomasCarmen Visus
Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Cancer Immunol Immunother 60:919-29. 2011..Our findings provide the basis for future studies aimed at developing cancer vaccines for targeting HSD17B12, which apparently can be functional in critical metabolic pathways involved in inflammation and cancer... - Increased cancer cell proliferation in prostate cancer patients with high levels of serum folateJeffrey J Tomaszewski
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Prostate 71:1287-93. 2011.... - Gene expression analysis of prostate cancersJian-Hua Luo
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pensylvania 15261, USA
Mol Carcinog 33:25-35. 2002..Cluster analysis using the 84-gene list showed that the highly aggressive prostate cancers contained gene-expression patterns that were distinct from organ-confined prostate cancers... - Detection of prostate cancer with a blood-based assay for early prostate cancer antigenBarbara Paul
Department of Urology, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Cancer Res 65:4097-100. 2005..EPCA, when coupled with prostate-specific antigen, may help reduce the number of both unnecessary biopsies and undetected prostate tumors... - Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathwayMilton W Datta
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Mol Cancer 5:9. 2006..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer... - Characterization of the nuclear matrix proteins in a transgenic mouse model for prostate cancerEddy S Leman
Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pennsylvania 15232, USA
J Cell Biochem 86:203-12. 2002..Identification of these NMPs permits the development of novel markers that can characterize various stages of prostate cancer development as well as potentially therapeutic targets... - The development and deployment of Common Data Elements for tissue banks for translational research in cancer - an emerging standard based approach for the Mesothelioma Virtual Tissue BankSambit K Mohanty
Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
BMC Cancer 8:91. 2008.... - Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasionGunjan Malik
Departments of Urology and Pathology, University of Pittsburgh School of Medicine, Shadyside Medical Center, Prostate Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Cancer Res 70:4327-34. 2010.... - Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosisKazuhisa Konishi
Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Respir Crit Care Med 180:167-75. 2009..The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF... - Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancerGuimin Chang
Department of Urology, University of Pittsburgh, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
Clin Cancer Res 16:5390-401. 2010..CADM-1, CADM-3, and CADM-4 have been shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, CADM-2 expression has not been determined in prostate cancer... - Expression of myopodin induces suppression of tumor growth and metastasisLing Jing
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Pathol 164:1799-806. 2004..All these results support the hypothesis that myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells... - Androgen regulation of JM-27 is associated with the diseased prostateUzma S Shah
Department of Urology, University of Pittsburgh, Pennsylvania, USA
J Androl 25:618-24. 2004..Further studies are underway to evaluate such a function for JM-27 in prostatic diseases... - The cooperative prostate cancer tissue resource: a specimen and data resource for cancer researchersJonathan Melamed
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
Clin Cancer Res 10:4614-21. 2004..Interested investigators are encouraged to apply for use of this material (www.prostatetissues.org)... - Increased apoptosis of periprostatic adipose tissue in VDR null miceMeral Guzey
Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Cell Biochem 93:133-41. 2004..This may be particularly attractive for VDR targets for the inhibition of cancer progression using VD(3) and its analogs as potential chemo-preventive agents... - Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP miceShivendra V Singh
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA
Cancer Res 68:9503-11. 2008..In conclusion, the results of the present study show, for the first time, that DATS administration prevents progression to invasive carcinoma and lung metastasis in TRAMP mice... - Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse modelShivendra V Singh
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Natl Cancer Inst 104:1228-39. 2012..Phenethyl isothiocyanate (PEITC) is a natural plant compound with chemopreventative potential against some cancers and the ability to induce apoptosis in breast cancer cells... - Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastasesYvonne Chao
Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA, 15213, USA
Cancer Microenviron 5:19-28. 2012..Our results suggest that cancer cells continue to display phenotypic plasticity beyond the EMT that initiates metastasis... - Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: a Gynecologic Oncology Group studyJennifer M Rubatt
Division of Gynecologic Oncology, Magee Womens Hospital, Pittsburgh, PA 15213, USA
Gynecol Oncol 125:421-6. 2012..This study sought to assess the prognostic value of ERCC1 expression, measured by immunohistochemistry (IHC) using a highly specific antibody, in advanced epithelial ovarian cancer (EOC) patients treated with platinum-based chemotherapy... - Tissue microarrays: an overviewRajiv Dhir
Department of Pathology, UPMC Shadyside Presbyterian Hospital, Pittsburgh, PA, USA
Methods Mol Biol 441:91-103. 2008..The presence of OCT can sporadically interfere with certain assays. However, it does provide a novel mechanism for high-throughput evaluation of frozen tissue, with corresponding visualization of tissue morphology... - Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissuesStergios J Moschos
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Pathol 41:1286-98. 2010.... - Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cellsDiane L Carlisle
Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA
Pulm Pharmacol Ther 20:629-41. 2007..In addition, exposure of NSCLC patients to nicotine through use of nicotine replacement products or use of tobacco products may alter the efficacy of therapy with EGFR inhibitors... - The development and testing of a laboratory information system-driven tool for pre-sign-out quality assurance of random surgical pathology reportsScott R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Clin Pathol 133:836-41. 2010..There has been no significant delay in case turnaround time since implementation. Further assessment of the tool's function after full departmental application is underway... - Age-associated changes in alpha-methyl CoA racemase (AMACR) expression in nonneoplastic prostatic tissuesAdrian Gologan
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Am J Surg Pathol 29:1435-41. 2005..4) Ki-67 staining was very variable and showed no correlation with age and AMACR expression levels. AMACR expression had no correlation with proliferative index... - Early identification of individuals with prostate cancer in negative biopsiesRajiv Dhir
Department of Urology, University of Pittsburgh and Prostate and Urologic Cancer Program of the University of Pittsburgh Cancer Institute, Pennsylvania 15232, USA
J Urol 171:1419-23. 2004..In addition, this test might also help limit the numbers of biopsies performed as part of subsequent routine evaluation for increased PSA... - Stat3 activation in prostatic carcinomasRajiv Dhir
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Prostate 51:241-6. 2002..The aim of this study is to examine quantitative Stat3 activity in benign and malignant human prostate tissues and analyze the association between Stat3 activity levels and the clinical and pathologic parameters... - Differential proteomic analysis of renal cell carcinoma tissue interstitial fluidPang Ning Teng
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Proteome Res 10:1333-42. 2011.... - Polyunsaturated fatty acid metabolizing 15-Lipoxygenase-1 (15-LO-1) expression in normal and tumorigenic human bladder tissuesBrian J Philips
Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
Appl Immunohistochem Mol Morphol 16:159-64. 2008..Our finding of variable 15-LO-1 expression and enzyme activity in bladder tissues suggests a role for 15-LO-1 in bladder carcinogenesis... - Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancerPatricia Cano
Department of Urologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14213, and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cancer Res 67:511-9. 2007..Thus, the ability of epithelial cells to modulate coregulator recruitment to the AR transcriptional complex on androgen-responsive genes seems altered in the stromal microenvironment of prostate cancer... - Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivoAjita V Singh
Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Carcinogenesis 25:83-90. 2004..To the best of our knowledge, the present study is the first published report to document in vivo anticancer activity of SFN in a tumor xenograft model... - Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary diseaseZhi Hua Chen
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS ONE 3:e3316. 2008..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear... - High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer SurveyClareann H Bunker
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Cancer Epidemiol Biomarkers Prev 11:726-9. 2002..These data support the hypothesis that populations of African descent share genetic and/or lifestyle factors that contribute to their elevated risk for prostate cancer... - Vitamin D and androgen regulation of prostatic growthEddy S Leman
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
J Cell Biochem 90:138-47. 2003..These studies may reveal important information about the potential efficacy of 1,25 D as well as hormonal status in understanding the development of prostate diseases... - Selective activation of members of the signal transducers and activators of transcription family in prostate carcinomaZuyao Ni
Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Urol 167:1859-62. 2002..Constitutive activation of STATs has been found in a wide variety of human tumors. In this study we examined the activity of STATs in primary human prostate tissues... - Down-regulation of macrophage inhibitory cytokine-1/prostate derived factor in benign prostatic hyperplasiaYoshiyuki Kakehi
Department of Urology, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
Prostate 59:351-6. 2004..Macrophage inhibitory cytokine-1 (MIC-1) is a member of transforming growth factor-beta/bone morphogenetic protein (BMP) superfamily. Despite its potential role in prostatic regulation, little is known about its biological activity... - Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potentialDong Xiao
Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
Carcinogenesis 27:2223-34. 2006..In conclusion, the present study indicates that the PEITC-induced apoptosis in PC-3 cells is mediated by ROS-dependent disruption of the mitochondrial membrane potential and regulated by Bax and Bid... - The tissue microarray data exchange specification: implementation by the Cooperative Prostate Cancer Tissue ResourceJules J Berman
Cancer Diagnosis Program, National Cancer Institute, National Institutes of Health, Bethesda, USA
BMC Bioinformatics 5:19. 2004..The purpose of this paper is to demonstrate how the TMA Data Exchange Specification is implemented in a prostate cancer TMA... - Polymeric immunoglobulin receptor-negative tumors represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junctionAdrian Gologan
Department of Pathology, McGill University, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Arch Pathol Lab Med 132:1295-301. 2008.... - Prostate cancer with low PSA levelsMilton W Datta
N Engl J Med 351:1802-3. 2004 - Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesionsMalabika Sen
Department of Urology, University of Pittsburgh and Cancer Institute, PA 15232, USA
Prostaglandins Other Lipid Mediat 81:1-13. 2006..Thus, our findings demonstrate the effectiveness of this viral system for 15-LO-1 expression studies in tissues... - Prostate cancer in patients with screening serum prostate specific antigen values less than 4.0 ng/dl: results from the cooperative prostate cancer tissue resourceMilton W Datta
Departments of Pathology, New York University School of Medicine, New York, New York, USA
J Urol 173:1546-51. 2005..0 ng/ml had smaller, lower grade tumors and lower recurrence rates than patients with PSA 4.0 ng/ml or greater. This was not true for those older than 62 years and for black men...