Vikas R Dharnidharka

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Associations between EBV serostatus and organ transplant type in PTLD risk: an analysis of the SRTR National Registry Data in the United States
    V R Dharnidharka
    College of Medicine, University of Florida, Gainesville, FL, USA
    Am J Transplant 12:976-83. 2012
  2. ncbi request reprint Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes
    Vikas R Dharnidharka
    Departments of Pediatrics and Pathology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Ann N Y Acad Sci 958:160-2. 2002
  3. ncbi request reprint Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients--an analysis of USRDS data
    V R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Transplant 7:653-61. 2007
  4. ncbi request reprint Effects of urinary tract infection on outcomes after renal transplantation in children
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida Health Science Center, Gainesville, FL 32610 0296, USA
    Clin J Am Soc Nephrol 2:100-6. 2007
  5. ncbi request reprint Infection frequency and profile in different age groups of kidney transplant recipients
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville FL 32610 0296, USA
    Transplantation 81:1662-7. 2006
  6. ncbi request reprint Cat scratch disease and acute rejection after pediatric renal transplantation
    Vikas R Dharnidharka
    The Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Pediatr Transplant 6:327-31. 2002
  7. ncbi request reprint Extracorporeal removal of toxic valproic acid levels in children
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, P O Box 100296, 1600 SW Archer Road, Gainesville FL 32610 0296, USA
    Pediatr Nephrol 17:312-5. 2002
  8. doi request reprint Intermediate dose cidofovir does not cause additive nephrotoxicity in BK virus allograft nephropathy
    Carlos E Araya
    Divisions of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Transplant 12:790-5. 2008
  9. doi request reprint An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Transplantation 87:1019-26. 2009
  10. doi request reprint Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 14:145-50. 2010

Research Grants

  1. Pediatric Transplant Infections and Outcomes
    Vikas Dharnidharka; Fiscal Year: 2006

Detail Information

Publications45

  1. doi request reprint Associations between EBV serostatus and organ transplant type in PTLD risk: an analysis of the SRTR National Registry Data in the United States
    V R Dharnidharka
    College of Medicine, University of Florida, Gainesville, FL, USA
    Am J Transplant 12:976-83. 2012
    ..053, p < 0.0001).Recipient EBV seronegativity is still significantly associated with risk for PTLD in LTX, though less so because of higher baseline risk in the EBV seropositive LTX group...
  2. ncbi request reprint Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes
    Vikas R Dharnidharka
    Departments of Pediatrics and Pathology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Ann N Y Acad Sci 958:160-2. 2002
    ..Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes...
  3. ncbi request reprint Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients--an analysis of USRDS data
    V R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Transplant 7:653-61. 2007
    ..53, 2.12); (iv) female gender AHR 1.63, 95% CI = 1.41, 1.88). Lower AHR for HVI was seen in CMV-positive recipients and for HBI with more recent year of transplant. Other covariates did not impact significantly in either HVI or HBI...
  4. ncbi request reprint Effects of urinary tract infection on outcomes after renal transplantation in children
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida Health Science Center, Gainesville, FL 32610 0296, USA
    Clin J Am Soc Nephrol 2:100-6. 2007
    ..In girls, only those in the youngest age category (0 to 1) had higher risk for UTI. Children are at greater risk for graft loss after early but not necessarily late UTI. UTI was not an independent predictor of death in this population...
  5. ncbi request reprint Infection frequency and profile in different age groups of kidney transplant recipients
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville FL 32610 0296, USA
    Transplantation 81:1662-7. 2006
    ....
  6. ncbi request reprint Cat scratch disease and acute rejection after pediatric renal transplantation
    Vikas R Dharnidharka
    The Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Pediatr Transplant 6:327-31. 2002
    ..Acute rejection following CSD has not been previously reported. CSD should be included in the differential diagnosis of fever in the post-transplant setting, especially where PTLD is suspected...
  7. ncbi request reprint Extracorporeal removal of toxic valproic acid levels in children
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, P O Box 100296, 1600 SW Archer Road, Gainesville FL 32610 0296, USA
    Pediatr Nephrol 17:312-5. 2002
    ..9 h after dialysis. Both conventional hemodialysis and high-flux hemodiafiltration are effective treatment modalities that should be offered to all pediatric patients with valproic acid ingestion and neurological compromise...
  8. doi request reprint Intermediate dose cidofovir does not cause additive nephrotoxicity in BK virus allograft nephropathy
    Carlos E Araya
    Divisions of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Transplant 12:790-5. 2008
    ..In this larger series with extended follow up, intermediate dose cidofovir without probenecid for the treatment of BKVAN continues to show stabilization of renal function without progression to renal failure...
  9. doi request reprint An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Transplantation 87:1019-26. 2009
    ..This study determined the rates of TBKV within 24 months posttransplant time and elucidated the risk factors for TBKV from this multicenter database...
  10. doi request reprint Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 14:145-50. 2010
    ..All patients tolerated leflunomide without side effects. Leflunomide use in a select group of patients is well tolerated and may provide an alternative for treatment of BKVAN in pediatric patients...
  11. doi request reprint The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine and Shands Children s Hospital, 1600 SW Archer Road, PO Box 100296 HD 214, Gainesville, FL 32610 0296, USA
    Pediatr Nephrol 26:1763-74. 2011
    ..Similarities and differences between cytomegalovirus, Epstein-Barr virus, and BV virus, the three major viral infections in kidney transplantation, are highlighted...
  12. doi request reprint Missed viral surveillance testing visits associate with full blown viral diseases in children receiving kidney transplants
    Eihab Al Khasawneh
    Division of Pediatric Nephrology, University of Florida College of Medicine and Shands Children s Hospital, Gainesville, FL, USA
    Pediatr Transplant 17:129-32. 2013
    ..Prospective randomized trials to confirm the benefit of regular viral testing are recommended...
  13. ncbi request reprint Post-transplant lymphoproliferative disease
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, PO Box 100296, 1600 SW Archer Road, Gainesville, FL 32610 0296, USA
    Pediatr Nephrol 24:731-6. 2009
    ..PTLD remains a risk factor for graft loss, though re-transplants have not, to date, been associated with repeat PTLD...
  14. ncbi request reprint Post-transplant lymphoproliferative disorder in the United States: young Caucasian males are at highest risk
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Transplant 2:993-8. 2002
    ..The PTLD incidence per year and incidence density have increased in recent years. Young Caucasian males are at highest risk for PTLD development among solid-organ-transplant recipients. The incidence of PTLD is increasing...
  15. pmc Immune biomarker panel monitoring utilizing IDO enzyme activity and CD4 ATP levels: prediction of acute rejection vs. viral replication events
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 15:321-8. 2011
    ..01) and blood CD4-ATP levels showed a decrease (p = 0.007) prior to a major infection event. These pilot results suggest that a panel of biomarkers together can predict over- or under-immunosuppression, but need independent validation...
  16. doi request reprint Assessing the value of ureteral stent placement in pediatric kidney transplant recipients
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Transplantation 85:986-91. 2008
    ..However, stent placement may also increase risk for early urinary tract infection (early UTI; <3 months after transplant) and BK virus allograft nephropathy (BKVAN). In children, the usefulness of stent placement is not well defined...
  17. doi request reprint Recombinant growth hormone use pretransplant and risk for post-transplant lymphoproliferative disease--a report of the NAPRTCS
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 12:689-95. 2008
    ..88, 95% CI = 1.00-3.55, p = 0.05). In contrast, use of rhGH during dialysis or post-transplant only was not associated with a higher risk for PTLD. Continued monitoring is recommended...
  18. ncbi request reprint En-bloc kidney transplantation in the United states: an analysis of united network of organ sharing (UNOS) data from 1987 to 2003
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, USA
    Am J Transplant 5:1513-7. 2005
    ..9% versus 23.4%, p < 0.001). National registry data suggest that EBK transplants present a viable option for transplantation of very young donor kidneys...
  19. ncbi request reprint Pediatric kidney transplantation literature review 2006
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Transplant 11:354-65. 2007
    ..This review is meant to be comprehensive but not exhaustive...
  20. ncbi request reprint Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 10:32-7. 2006
    ..In our experience, intermediate-dose cidofovir without probenecid, used judiciously, is not associated with additional nephrotoxicity and may provide an additional alternative for treatment...
  21. ncbi request reprint Post-transplant infections now exceed acute rejection as cause for hospitalization: a report of the NAPRTCS
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Transplant 4:384-9. 2004
    ..001 for trend by transplant year). We conclude that the causes of hospitalization at all times up to 24 months post-transplant, including the critical early 6 months, have shifted away from AR to PTI...
  22. doi request reprint Native kidney post-transplant lymphoproliferative disorder in a non-renal transplant patient
    Carlos E Araya
    University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Transplant 13:495-8. 2009
    ..To our knowledge, this is the first such child to be reported and highlights the importance of remaining vigilant for renal PTLD even in non-kidney organ recipients...
  23. doi request reprint Comparison of generic tacrolimus and Prograf drug levels in a pediatric kidney transplant program: brief communication
    Husam A Abdulnour
    Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Transplant 14:1007-11. 2010
    ..Mean creatinine rose from 1.15 ± 0.05 to 2.168 ± 0.07 after switch (p < 0.001). Given our mixed picture with the early data, we suggest careful monitoring of pediatric patients who get switched to generic tacrolimus...
  24. ncbi request reprint Hemodialysis catheter-related bacteremia in children: increasing antibiotic resistance and changing bacteriological profile
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 50:119-23. 2007
    ..We determined whether the rate of positive blood culture results per tunneled catheter-days, the spectrum of bacterial isolates, and their antibiotic susceptibility changed over time in our pediatric dialysis unit...
  25. ncbi request reprint Post-transplant lymphoproliferative disease: association with induction therapy?
    Vikas R Dharnidharka
    University of Florida College of Medicine, Gainesville, Florida 32610 0296, USA
    Drugs 66:429-38. 2006
    ..While some studies suggest an increased risk of PTLD after induction antibody use, other studies do not; the available data are not conclusive either way at this time...
  26. ncbi request reprint Nephrogenic fibrosing dermopathy in pediatric patients
    Sima M Jain
    Division of Dermatology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Pediatr Nephrol 19:467-70. 2004
    ..Since both our patients also had previously experienced large vessel thrombosis, hypercoagulable states may also be implicated...
  27. ncbi request reprint Risk for post-transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida Coillege of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 9:622-6. 2005
    ..There is a higher aRR for PTLD after kidney transplantation with E-ATG, but not R-ATG. This may only partially be explained by shorter follow up time and may represent differential hazard for PTLD among the agents...
  28. ncbi request reprint Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
  29. ncbi request reprint Renal transplantation: the present and the future
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL, USA
    Indian J Pediatr 72:785-8. 2005
    ..Newer technologies such as stem cell transplantation, tissue engineering and xenotransplantation promise even more changes in the future...
  30. ncbi request reprint Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida Health Science Center, Gainesville, FL 32610 0296, USA
    Clin J Am Soc Nephrol 1:1161-6. 2006
    ..STS seems well tolerated in children and young adults with CUA and has mild adverse effects. For determination of its efficacy, optimum dosage, duration of therapy, and dialysis modality, controlled trials are needed...
  31. ncbi request reprint Hodgkin's lymphoma after post-transplant lymphoproliferative disease in a renal transplant recipient
    Vikas R Dharnidharka
    Department of Pediatrics, Division of Pediatric Nephrology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0296, USA
    Pediatr Transplant 8:87-90. 2004
    ..True HL following PTLD has been reported in only three previous cases, with good response to standard chemotherapy in each...
  32. doi request reprint Post-transplant lymphoproliferative disorder in children: recent outcomes and response to dual rituximab/low-dose chemotherapy combination
    Sushil Gupta
    Department of Pediatrics, University of Florida College of Medicine and Shands Children s Hospital, Gainesville, FL, USA
    Pediatr Transplant 14:896-902. 2010
    ..Other chemotherapy (n = 7, including all 4 T-cell PTLDs) had 57% CR, 0% recurrence and 14% mortality. Direct dual R/C combination therapy after failed RI is effective and offers another treatment option for B-cell PTLD...
  33. ncbi request reprint Prolonged neuromuscular block due to cholinesterase depletion by plasmapheresis
    Bhiken Naik
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Anesth 14:381-4. 2002
    ..Anesthesiologists should be aware of plasmapheresis as a mechanism for plasma cholinesterase depletion when using neuromuscular blocking drugs that are metabolized by this enzyme...
  34. ncbi request reprint Mycophenolate, tacrolimus and post-transplant lymphoproliferative disorder: a report of the North American Pediatric Renal Transplant Cooperative Study
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, Florida, USA
    Pediatr Transplant 6:396-9. 2002
    ..28, p = 0.692). There have been no cases of PTLD in 197 patients who received both FK506 and MMF at day 30. We conclude that FK506 and MMF use are not currently associated with increased risk of PTLD in pediatric kidney transplants...
  35. doi request reprint Xanthogranulomatous pyelonephritis in pediatric patients: case report and review of literature
    Sushil Gupta
    Division of Pediatric Nephrology, University of Florida College of Medicine, 1600 SW Archer Road, PO Box 100296 HD 214, Gainesville, FL 32610 0296, USA
    J Pediatr Urol 6:355-8. 2010
    ..The patient eventually failed conservative management. Our review of the literature suggests that medical management has worked in some focal XPN cases, but has not been sufficiently tested in diffuse XPN...
  36. ncbi request reprint Acute-onset hearing loss with renal failure: differential diagnosis
    Carlos E Araya
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Kidney Dis 47:553-8. 2006
  37. pmc The factors that may predict response to rituximab therapy in recurrent focal segmental glomerulosclerosis: a systematic review
    Carlos E Araya
    Division of Pediatric Nephrology, University of Florida College of Medicine, 1600 SW Archer Road, Room HD 214, Gainesville, FL 32610 0296, USA
    J Transplant 2011:374213. 2011
    ..Rituximab for recurrence of FSGS may be beneficial for only some patients. A younger age at transplant and normal serum albumin level at recurrence diagnosis may predict response...
  38. ncbi request reprint Isolated idiopathic hypomagnesemia presenting as aphasia and seizures
    Vikas R Dharnidharka
    Division of Pediatric Nephrology, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Pediatr Neurol 33:61-5. 2005
    ..In the present case, neuronal depolarization may have been localized to language areas in the temporal lobes...
  39. ncbi request reprint Transient proximal tubular renal injury following Ecstasy ingestion
    Charles Kwon
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Nephrol 18:820-2. 2003
    ..To our knowledge, this is the first example of an acute and transient proximal tubular injury with Ecstasy ingestion. This complication may become more apparent with increasing use of this drug...
  40. ncbi request reprint Utility of renal imaging in the diagnostic evaluation of obese childhood primary hypertension
    Sanjeev Y Tuli
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32610 0296, USA
    Clin Pediatr (Phila) 44:589-92. 2005
    ..Larger studies may confirm that the evaluation of CP-HTN in older obese children could be similar to guidelines for evaluation of adult-HTN...
  41. ncbi request reprint Costimulation blockade with belatacept in renal transplantation
    Vikas R Dharnidharka
    N Engl J Med 353:2085-6; author reply 2085-6. 2005
  42. ncbi request reprint Sirolimus in pediatric solid organ transplantation
    Vikas R Dharnidharka
    Pediatr Transplant 9:427-9. 2005
  43. ncbi request reprint Hodgkin's-like PTLD versus true Hodgkin's disease
    Vikas R Dharnidharka
    Pediatr Transplant 8:581-2. 2004
  44. ncbi request reprint TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy
    Mark D Denton
    Division of Nephrology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Transplantation 78:1218-21. 2004
    ..08+/-0.11). Therefore, TNP-470 interrupts the progression of CAV when given late but does not prevent its development when given immediately posttransplantation...
  45. ncbi request reprint BK virus nephropathy in pediatric renal transplant recipients: an analysis of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) registry
    Jodi M Smith
    Division of Nephrology, Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, M1 5, Seattle, WA 98105, USA
    Clin J Am Soc Nephrol 2:1037-42. 2007
    ..The objective of this study was to evaluate cases of BK virus nephropathy in the North American Pediatric Renal Trials and Collaborative Studies database...

Research Grants1

  1. Pediatric Transplant Infections and Outcomes
    Vikas Dharnidharka; Fiscal Year: 2006
    ..abstract_text> ..