Charlene S Dezzutti

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    Lisa C Rohan
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9310. 2010
  2. doi request reprint Use of human mucosal tissue to study HIV-1 pathogenesis and evaluate HIV-1 prevention modalities
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, 204 Craft Avenue, Rm 503B, Pittsburgh, PA 15213, USA
    Curr HIV/AIDS Rep 10:12-20. 2013
  3. pmc Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity
    Charlene S Dezzutti
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e48328. 2012
  4. pmc Mucosal Escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, Pennsylvania 15213, USA
    J Infect Dis 206:1931-5. 2012
  5. pmc Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Antiviral Res 96:221-5. 2012
  6. pmc Reformulated tenofovir gel for use as a dual compartment microbicide
    Charlene S Dezzutti
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Antimicrob Chemother 67:2139-42. 2012
  7. pmc Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e23136. 2011
  8. pmc Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model
    Marilyn Cost
    Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:3058-66. 2012
  9. pmc Antiviral Activity of Genital Tract Secretions After Oral or Topical Tenofovir Pre-exposure Prophylaxis for HIV-1
    Betsy C Herold
    Departments of Pediatrics and Microbiology Immunology, Albert Einstein College of Medicine, Yeshiva University, New York, NY University of Pittsburgh, Pittsburgh, PA Magee Womens Research Institute, Pittsburgh, PA University of Washington, Seattle, WA Fred Hutchinson Cancer Research Center, Seattle, WA and Johns Hopkins University, Baltimore, MD
    J Acquir Immune Defic Syndr 66:65-73. 2014
  10. pmc Effect of topical microbicides on infectious human immunodeficiency virus type 1 binding to epithelial cells
    Susan Roth
    University of Pittsburgh, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:1972-8. 2007

Detail Information

Publications14

  1. pmc In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    Lisa C Rohan
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9310. 2010
    ..To validate our findings with on-going clinical trial results, we evaluated topical tenofovir gel for safety and efficacy. We also modeled systemic application of tenofovir for efficacy...
  2. doi request reprint Use of human mucosal tissue to study HIV-1 pathogenesis and evaluate HIV-1 prevention modalities
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, 204 Craft Avenue, Rm 503B, Pittsburgh, PA 15213, USA
    Curr HIV/AIDS Rep 10:12-20. 2013
    ..This review will discuss the use of mucosal tissue to better understand HIV-1 pathogenesis and prevention modalities...
  3. pmc Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity
    Charlene S Dezzutti
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e48328. 2012
    ..The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm...
  4. pmc Mucosal Escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, Pennsylvania 15213, USA
    J Infect Dis 206:1931-5. 2012
    ..22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition...
  5. pmc Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Antiviral Res 96:221-5. 2012
    ..The safety and efficacy profiles of the gels were similar for ectocervical and colorectal tissues suggesting these gels have the potential for dual compartment use...
  6. pmc Reformulated tenofovir gel for use as a dual compartment microbicide
    Charlene S Dezzutti
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Antimicrob Chemother 67:2139-42. 2012
    ..This study evaluated the pre-clinical safety and efficacy of a reformulated (reduced osmolality) tenofovir gel product...
  7. pmc Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e23136. 2011
    ..However, optimal methods for sample collection do not exist. This study compared collection methods...
  8. pmc Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model
    Marilyn Cost
    Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:3058-66. 2012
    ..This study successfully demonstrates the feasibility of using this novel combination of antiretroviral agents in an aqueous gel as an HIV infection preventative...
  9. pmc Antiviral Activity of Genital Tract Secretions After Oral or Topical Tenofovir Pre-exposure Prophylaxis for HIV-1
    Betsy C Herold
    Departments of Pediatrics and Microbiology Immunology, Albert Einstein College of Medicine, Yeshiva University, New York, NY University of Pittsburgh, Pittsburgh, PA Magee Womens Research Institute, Pittsburgh, PA University of Washington, Seattle, WA Fred Hutchinson Cancer Research Center, Seattle, WA and Johns Hopkins University, Baltimore, MD
    J Acquir Immune Defic Syndr 66:65-73. 2014
    ..We measured CVL antiviral activity in women using oral or vaginal tenofovir-based pre-exposure prophylaxis and correlated activity with drug and immune mediator levels...
  10. pmc Effect of topical microbicides on infectious human immunodeficiency virus type 1 binding to epithelial cells
    Susan Roth
    University of Pittsburgh, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:1972-8. 2007
    ..Therefore, functional virological assays in addition to measuring viral RNA should be included when clinically evaluating topical microbicide use by infected persons...
  11. ncbi request reprint Preventing the sexual transmission of HIV-1 with topical microbicides: another piece of the equation
    Lisa C Rohan
    Department of Pharmaceutical Science, School of Pharmacy, University of Pittsburgh, PA, USA
    J Infect Dis 196:1285-7. 2007
  12. ncbi request reprint Development of HIV-1 Rectal-Specific Microbicides and Colonic Tissue Evaluation
    Charlene S Dezzutti
    Magee Womens Research Institute, Pittsburgh, Pennsylvania, United States of America Department Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e102585. 2014
    ..Our in vitro and ex vivo results show successful formulation of unique RMs. Moreover, the results of flex sig and surgically resected tissues were comparable suggesting the incorporation of both in pre-clinical testing algorithms. ..
  13. doi request reprint Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles
    Anthony S Ham
    Magee Womens Research Institute, 204 Craft Avenue, B509, Pittsburgh, Pennsylvania, 15213, USA
    Pharm Res 26:502-11. 2009
    ..Nanoparticles formulated from the biodegradable co-polymer poly(lactic-co-glycolic acid) (PLGA), were investigated as a drug delivery system to enhance tissue uptake, permeation, and targeting for PSC-RANTES anti-HIV-1 activity...
  14. pmc HIV-1 infection of female genital tract tissue for use in prevention studies
    Charlene S Dezzutti
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA Alpha StatConsult, LLC, Damascus, MD and University of Pittsburgh Medical Center, Pittsburgh, PA
    J Acquir Immune Defic Syndr 63:548-54. 2013
    ..Ex vivo HIV-1 challenge has been proposed as a bioindicator of microbicide product effectiveness. The objective of this study was to establish optimal parameters for use of female genital tract tissue in this model...