Affiliation: University of California
- Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signalPeifang Tian
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 107:15246-51. 2010....
- The challenge of connecting the dots in the B.R.A.I.NAnna Devor
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Electronic address
Neuron 80:270-4. 2013..Here, we outline our collective vision for what we can achieve within a decade with properly targeted efforts and discuss likely technological deliverables and neuroscience progress. ..
- Frontiers in optical imaging of cerebral blood flow and metabolismAnna Devor
Department of Neurosciences, UCSD, La Jolla, CA, USA
J Cereb Blood Flow Metab 32:1259-76. 2012....
- "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vesselsAnna Devor
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
J Neurosci 31:13676-81. 2011....
- Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signalAnna Devor
Department of Neurosciences, University of California, San Diego, California 92093, USA
J Neurosci 27:4452-9. 2007....
- Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortexAnna Devor
Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
Neuron 39:353-9. 2003....
- Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortexAnna Devor
Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
J Neurosci 28:14347-57. 2008..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus...
- Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic responseEdward Baraghis
Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
J Biomed Opt 16:106003. 2011..The general approach of the correction algorithm can be extended to other TPLSM measurements, where changes in the optical properties of the tissue confound physiological measurements, such as the detection of calcium dynamics...
- A vascular anatomical network model of the spatio-temporal response to brain activationDavid A Boas
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Neuroimage 40:1116-29. 2008....
- Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortexAndrew K Dunn
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 27:279-90. 2005..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes...
- Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissueSava Sakadzic
Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
Nat Methods 7:755-9. 2010..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
- Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activityAnna Devor
Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:3822-7. 2005..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data...
- Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulationElizabeth M C Hillman
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuroimage 35:89-104. 2007....
- In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increaseKrystal Nizar
Neurosciences Graduate Program, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 33:8411-22. 2013..Moreover, an increase in astrocytic intracellular calcium was not required for normal vasodilation in the IP3R2-KO animals...
- Oxygen advection and diffusion in a three- dimensional vascular anatomical networkQianqian Fang
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Opt Express 16:17530-41. 2008..We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments...
- Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brainPeifang Tian
University of California, San Diego, Department of Neurosciences, La Jolla, California 92093, USA
J Biomed Opt 16:016006. 2011..Our results provide valuable guidance for the optimization of optical imaging systems and data interpretation...
- Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imagingShuai Yuan
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
Appl Opt 44:1823-30. 2005..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents...
- Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activationAndrew K Dunn
Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
Opt Lett 28:28-30. 2003..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
- In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathyLidia Reznichenko
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 32:9992-8. 2012....
- On the estimation of population-specific synaptic currents from laminar multielectrode recordingsSergey L Gratiy
Department of Radiology, University of California San Diego La Jolla, CA, USA
Front Neuroinform 5:32. 2011....
- Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron levelChris I De Zeeuw
Department of Neuroscience, Medical Faculty, Erasmus MC, 3000DR Rotterdam, The Netherlands
J Neurosci 23:4700-11. 2003....
- The great gate: control of sensory information flow to the cerebellumAnna Devor
Department of Neurobiology, Institute of Life Sciences Hebrew University of Jerusalem, Jerusalem 91904, Israel
Cerebellum 1:27-34. 2002..The sensory filtering role of the inferior olivary nucleus invites comparison between the cerebellum and cerebellar-like structures. This comparison sheds important light on the function of the cerebellum...
- Is there a common origin to surround-inhibition as seen through electrical activity versus hemodynamic changes? Focus on "Duration-dependent response in SI to vibrotactile stimulation in squirrel monkey"Anna Devor
J Neurophysiol 97:1880-2. 2007
- Laminar population analysis: estimating firing rates and evoked synaptic activity from multielectrode recordings in rat barrel cortexGaute T Einevoll
Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, PO Box 5003, N 1432 As, Norway
J Neurophysiol 97:2174-90. 2007..Furthermore, the time dependence of the stimulus-evoked population firing activity is predicted, and the temporal ordering of response onset is found to be compatible with earlier findings...
- Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuitiesKlas H Pettersen
Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As
J Neurosci Methods 154:116-33. 2006..To illustrate the application to real data, iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method...
- In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasingTrygve B Leergaard
Neural Systems and Graphics Computing Laboratory, Centre for Molecular Biology and Neuroscience and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
Neuroimage 20:1591-600. 2003..The method allows a higher data throughput for 3-D studies of large-scale brain connectivity than conventional methods based on tissue sectioning...
- Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordingsAnna Devor
Department of Neurobiology, Institute of Life Sciences and the Interdisciplinary Center for Neuronal Computation, Hebrew University, Jerusalem 91904, Israel
J Neurophysiol 87:3048-58. 2002..Since somatic recordings may not reveal coupling through remote dendrites, we conclude that each neuron is directly connected to > or =50 neurons forming two distinct networks of curly and straight cells...
- Neurovascular Coupling in Cerebrum and CerebellumAnna Devor; Fiscal Year: 2006..Ultimately, accurate interpretation of imaging data in terms of neuronal activity will play an important role in the early detection, diagnosis and treatment of human disease. ..
- Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopyAnna Devor; Fiscal Year: 2010..The proposed project will provide a mechanistic framework for understanding of fMRI signals and ultimately will guide the development of novel therapeutic, preventative, and diagnostic approaches. ..