Anna Devor

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal
    Peifang Tian
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:15246-51. 2010
  2. pmc The challenge of connecting the dots in the B.R.A.I.N
    Anna Devor
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Electronic address
    Neuron 80:270-4. 2013
  3. pmc Frontiers in optical imaging of cerebral blood flow and metabolism
    Anna Devor
    Department of Neurosciences, UCSD, La Jolla, CA, USA
    J Cereb Blood Flow Metab 32:1259-76. 2012
  4. pmc "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    Anna Devor
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
    J Neurosci 31:13676-81. 2011
  5. pmc Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal
    Anna Devor
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    J Neurosci 27:4452-9. 2007
  6. ncbi request reprint Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Anna Devor
    Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 39:353-9. 2003
  7. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
  8. pmc Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response
    Edward Baraghis
    Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 16:106003. 2011
  9. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
  10. ncbi request reprint Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005

Collaborators

Detail Information

Publications28

  1. pmc Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal
    Peifang Tian
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:15246-51. 2010
    ....
  2. pmc The challenge of connecting the dots in the B.R.A.I.N
    Anna Devor
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Electronic address
    Neuron 80:270-4. 2013
    ..Here, we outline our collective vision for what we can achieve within a decade with properly targeted efforts and discuss likely technological deliverables and neuroscience progress. ..
  3. pmc Frontiers in optical imaging of cerebral blood flow and metabolism
    Anna Devor
    Department of Neurosciences, UCSD, La Jolla, CA, USA
    J Cereb Blood Flow Metab 32:1259-76. 2012
    ....
  4. pmc "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    Anna Devor
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
    J Neurosci 31:13676-81. 2011
    ....
  5. pmc Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal
    Anna Devor
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    J Neurosci 27:4452-9. 2007
    ....
  6. ncbi request reprint Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Anna Devor
    Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 39:353-9. 2003
    ....
  7. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
    ..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus...
  8. pmc Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response
    Edward Baraghis
    Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 16:106003. 2011
    ..The general approach of the correction algorithm can be extended to other TPLSM measurements, where changes in the optical properties of the tissue confound physiological measurements, such as the detection of calcium dynamics...
  9. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
    ....
  10. ncbi request reprint Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005
    ..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes...
  11. pmc Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation
    Elizabeth M C Hillman
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 35:89-104. 2007
    ....
  12. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    ..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
  13. pmc Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity
    Anna Devor
    Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:3822-7. 2005
    ..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data...
  14. pmc In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase
    Krystal Nizar
    Neurosciences Graduate Program, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 33:8411-22. 2013
    ..Moreover, an increase in astrocytic intracellular calcium was not required for normal vasodilation in the IP3R2-KO animals...
  15. pmc Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain
    Peifang Tian
    University of California, San Diego, Department of Neurosciences, La Jolla, California 92093, USA
    J Biomed Opt 16:016006. 2011
    ..Our results provide valuable guidance for the optimization of optical imaging systems and data interpretation...
  16. pmc Oxygen advection and diffusion in a three- dimensional vascular anatomical network
    Qianqian Fang
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Express 16:17530-41. 2008
    ..We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments...
  17. ncbi request reprint Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
    Shuai Yuan
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1823-30. 2005
    ..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents...
  18. ncbi request reprint Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
    ..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
  19. pmc In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy
    Lidia Reznichenko
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:9992-8. 2012
    ....
  20. pmc On the estimation of population-specific synaptic currents from laminar multielectrode recordings
    Sergey L Gratiy
    Department of Radiology, University of California San Diego La Jolla, CA, USA
    Front Neuroinform 5:32. 2011
    ....
  21. ncbi request reprint Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level
    Chris I De Zeeuw
    Department of Neuroscience, Medical Faculty, Erasmus MC, 3000DR Rotterdam, The Netherlands
    J Neurosci 23:4700-11. 2003
    ....
  22. ncbi request reprint The great gate: control of sensory information flow to the cerebellum
    Anna Devor
    Department of Neurobiology, Institute of Life Sciences Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Cerebellum 1:27-34. 2002
    ..The sensory filtering role of the inferior olivary nucleus invites comparison between the cerebellum and cerebellar-like structures. This comparison sheds important light on the function of the cerebellum...
  23. ncbi request reprint In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing
    Trygve B Leergaard
    Neural Systems and Graphics Computing Laboratory, Centre for Molecular Biology and Neuroscience and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    Neuroimage 20:1591-600. 2003
    ..The method allows a higher data throughput for 3-D studies of large-scale brain connectivity than conventional methods based on tissue sectioning...
  24. ncbi request reprint Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities
    Klas H Pettersen
    Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As
    J Neurosci Methods 154:116-33. 2006
    ..To illustrate the application to real data, iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method...
  25. ncbi request reprint Is there a common origin to surround-inhibition as seen through electrical activity versus hemodynamic changes? Focus on "Duration-dependent response in SI to vibrotactile stimulation in squirrel monkey"
    Anna Devor
    J Neurophysiol 97:1880-2. 2007
  26. ncbi request reprint Laminar population analysis: estimating firing rates and evoked synaptic activity from multielectrode recordings in rat barrel cortex
    Gaute T Einevoll
    Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, PO Box 5003, N 1432 As, Norway
    J Neurophysiol 97:2174-90. 2007
    ..Furthermore, the time dependence of the stimulus-evoked population firing activity is predicted, and the temporal ordering of response onset is found to be compatible with earlier findings...
  27. ncbi request reprint Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings
    Anna Devor
    Department of Neurobiology, Institute of Life Sciences and the Interdisciplinary Center for Neuronal Computation, Hebrew University, Jerusalem 91904, Israel
    J Neurophysiol 87:3048-58. 2002
    ..Since somatic recordings may not reveal coupling through remote dendrites, we conclude that each neuron is directly connected to > or =50 neurons forming two distinct networks of curly and straight cells...

Research Grants4

  1. Neurovascular Coupling in Cerebrum and Cerebellum
    Anna Devor; Fiscal Year: 2005
    ..Ultimately, accurate interpretation of imaging data in terms of neuronal activity will play an important role in the early detection, diagnosis and treatment of human disease. ..
  2. Neurovascular Coupling in Cerebrum and Cerebellum
    Anna Devor; Fiscal Year: 2006
    ..Ultimately, accurate interpretation of imaging data in terms of neuronal activity will play an important role in the early detection, diagnosis and treatment of human disease. ..
  3. Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopy
    Anna Devor; Fiscal Year: 2009
    ..The proposed project will provide a mechanistic framework for understanding of fMRI signals and ultimately will guide the development of novel therapeutic, preventative, and diagnostic approaches. ..
  4. Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopy
    Anna Devor; Fiscal Year: 2010
    ..The proposed project will provide a mechanistic framework for understanding of fMRI signals and ultimately will guide the development of novel therapeutic, preventative, and diagnostic approaches. ..