Bernie Devlin

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The heritability of IQ
    B Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nature 388:468-71. 1997
  2. ncbi request reprint Analysis of multilocus models of association
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Genet Epidemiol 25:36-47. 2003
  3. ncbi request reprint Linkage analysis of anorexia nervosa incorporating behavioral covariates
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Hum Mol Genet 11:689-96. 2002
  4. ncbi request reprint Genomic control, a new approach to genetic-based association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Theor Popul Biol 60:155-66. 2001
  5. ncbi request reprint Mixture models for linkage analysis of affected sibling pairs and covariates
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Genet Epidemiol 22:52-65. 2002
  6. ncbi request reprint Genome-wide distribution of linkage disequilibrium in the population of Palau and its implications for gene flow in Remote Oceania
    B Devlin
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Hum Genet 108:521-8. 2001
  7. ncbi request reprint Genomic control for association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Biometrics 55:997-1004. 1999
  8. ncbi request reprint Unbiased methods for population-based association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 21:273-84. 2001
  9. ncbi request reprint Alcohol use disorder comorbidity in eating disorders: a multicenter study
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7160, USA
    J Clin Psychiatry 65:1000-6. 2004
  10. pmc Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure
    Mikhil Bamne
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Schizophr Bull 38:1149-54. 2012

Detail Information

Publications85

  1. ncbi request reprint The heritability of IQ
    B Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nature 388:468-71. 1997
    ..Our analysis suggests that it will be important to understand the basis for these maternal effects if ways in which IQ might be increased are to be identified...
  2. ncbi request reprint Analysis of multilocus models of association
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Genet Epidemiol 25:36-47. 2003
    ..Naturally, as for any method seeking to explore complex genetic models, the power of the methods is limited by sample size and model complexity...
  3. ncbi request reprint Linkage analysis of anorexia nervosa incorporating behavioral covariates
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Hum Mol Genet 11:689-96. 2002
    ..50, P = 0.00035). By comparing our results to those implemented using more standard linkage methods, we find the covariates convey substantial information for the linkage analysis...
  4. ncbi request reprint Genomic control, a new approach to genetic-based association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Theor Popul Biol 60:155-66. 2001
    ..For each study design our goal is to achieve control similar to that obtained for a family-based study, but with the convenience found in a population-based design...
  5. ncbi request reprint Mixture models for linkage analysis of affected sibling pairs and covariates
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Genet Epidemiol 22:52-65. 2002
    ....
  6. ncbi request reprint Genome-wide distribution of linkage disequilibrium in the population of Palau and its implications for gene flow in Remote Oceania
    B Devlin
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Hum Genet 108:521-8. 2001
    ..1% less). Palauan Y haplotypes also fall into distinct clusters, again unlike that of Europe. We argue these data are consistent with waves of male-biased gene flow...
  7. ncbi request reprint Genomic control for association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Biometrics 55:997-1004. 1999
    ..The performance of our genomic control method is quite good for plausible effects of liability genes, which bodes well for future genetic analyses of complex disorders...
  8. ncbi request reprint Unbiased methods for population-based association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 21:273-84. 2001
    ..It, too, is widely applicable. Both also have weaknesses, as elaborated in our review...
  9. ncbi request reprint Alcohol use disorder comorbidity in eating disorders: a multicenter study
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7160, USA
    J Clin Psychiatry 65:1000-6. 2004
    ..Our aim was to explore the nature of the co-morbid relation between AUDs and eating disorders in a large and phenotypically well-characterized group of individuals...
  10. pmc Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure
    Mikhil Bamne
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Schizophr Bull 38:1149-54. 2012
    ..3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on SZ risk with and without exposure...
  11. pmc Selection of eating-disorder phenotypes for linkage analysis
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Med Genet B Neuropsychiatr Genet 139:81-7. 2005
    ..Linkage results appear in a subsequent report. Our report lays out a systematic roadmap for utilizing a rich set of phenotypes for genetic analyses, including the selection of linkage methods paired to those phenotypes...
  12. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  13. pmc Consanguinity and increased risk for schizophrenia in Egypt
    Hader Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 120:108-12. 2010
    ..Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population...
  14. ncbi request reprint Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Hum Genet 121:675-84. 2007
    ..Regions in which at least two adjacent markers produced substantial association statistics include 2p12-11.2, 2q24.1-32.1, 6q12-14.1, 10q23.2-24.21, 12q23.2-24.21 and 17q23.2-23.3...
  15. pmc A network of dopaminergic gene variations implicated as risk factors for schizophrenia
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Mol Genet 17:747-58. 2008
    ..Our data suggest that a network of dopaminergic polymorphisms increase risk for SZ...
  16. ncbi request reprint Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:570-7. 2006
    ..Because most studies have evaluated only rs6280, the inconsistencies might reflect associations with other variants...
  17. ncbi request reprint The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
    ....
  18. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
    ..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
  19. ncbi request reprint Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 126:46-50. 2004
    ..Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism...
  20. pmc Screen and clean: a tool for identifying interactions in genome-wide association studies
    Jing Wu
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 34:275-85. 2010
    ..When the method is applied to data obtained from the Wellcome Trust Case Control Consortium study of Type 1 Diabetes it uncovers evidence supporting interaction within the HLA class II region as well as within Chromosome 12q24...
  21. ncbi request reprint Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk
    Brian H Shirts
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    Schizophr Res 94:342-53. 2007
    ..There are a number of explanations for the associations, including chance variation, as well as gene-virus interactions. Further replicate studies are warranted, as are functional studies of these polymorphisms...
  22. pmc Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates
    Silviu Alin Bacanu
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Am J Med Genet B Neuropsychiatr Genet 139:61-8. 2005
    ..3); for covariate-based linkage analysis, five suggestive signals (for BMI at 4q13.1, for CM at 11p11.2 and 17q25.1, and for OBF at 17q25.1 and 15q26.2). Overlap between the two cohorts was minimal for substantial linkage signals...
  23. pmc The genetics of anorexia nervosa collaborative study: methods and sample description
    Walter H Kaye
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
    Int J Eat Disord 41:289-300. 2008
    ..Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN)...
  24. doi request reprint Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:459-72. 2010
    ....
  25. pmc Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:560-9. 2009
    ..047, OR = 1.46). Our analyses suggest several associations at PAH, with consistent evidence for rs1522305. Further analyses, including additional variations and environmental influences such as phenylalanine exposure are warranted...
  26. ncbi request reprint Association studies for quantitative traits in structured populations
    Silviu Alin Bacanu
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Genet Epidemiol 22:78-93. 2002
    ..The latter suggests greater power can be achieved by specifying more complex genetic models, but this observation only follows when such models are largely correct and specified a priori...
  27. pmc TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease
    Su Hee Chu
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
    Neurobiol Aging 32:2328.e1-9. 2011
    ..Our findings do not support the association of poly-T repeat length with age of onset in LOAD. The clinical implications of this repeat length polymorphism remain to be elucidated...
  28. pmc Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees
    Nadine Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 70:1115-21. 2011
    ....
  29. doi request reprint Discovering genetic ancestry using spectral graph theory
    Ann B Lee
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 34:51-9. 2010
    ..Often the results from Spectral-GEM are straightforward to interpret and therefore useful in association analysis. We illustrate the new algorithm with an analysis of the POPRES data [Nelson et al., 2008]...
  30. pmc Integration of association statistics over genomic regions using Bayesian adaptive regression splines
    Xiaohua Zhang
    Department of Statistics, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Hum Genomics 1:20-9. 2003
    ....
  31. ncbi request reprint Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?
    Jung Jin Kim
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Ann Med 39:145-53. 2007
    ..Published data support genetic variants, as well as certain infectious agents, as potential risk factors for schizophrenia. Less is known about interactions between the risk factors...
  32. doi request reprint Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies
    Andrew Crossett
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Stat Med 29:2932-45. 2010
    ..Once samples are well-matched, mCLR yields comparable power to competing methods while ensuring excellent control over Type I error...
  33. ncbi request reprint Genetic analysis of bulimia nervosa: methods and sample description
    Walter H Kaye
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Int J Eat Disord 35:556-70. 2004
    ..The current study presents the clinical characteristics of this sample as well as a description of the study methodology...
  34. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    ..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles...
  35. pmc No association of psychosis in Alzheimer disease with neurodegenerative pathway genes
    Mary Ann A DeMichele-Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Aging 32:555.e9-11. 2011
    ..Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms (SNPs), and gene-based tests were used to enhance power. We found no association of these genes with AD + P...
  36. pmc On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants
    Diana Luca
    Department of Statistics, Carnegie Mellon University Pittsburgh, PA 15213, USA
    Am J Hum Genet 82:453-63. 2008
    ..We perform a GWA by matching Americans with type 1 diabetes (T1D) to controls from Germany. Despite the complex study design, these analyses identify numerous loci known to confer risk for T1D...
  37. pmc Principal components of heritability from neurocognitive domains differ between families with schizophrenia and control subjects
    Howard Wiener
    Department of Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Schizophr Bull 39:464-71. 2013
    ..We use eigenvector transformations that maximize heritability of multiple neurocognitive measures, namely principal components of heritability (PCH), and evaluate how they distribute in SZ families and controls...
  38. ncbi request reprint Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia
    Lambertus Klei
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Hum Genet 117:349-56. 2005
    ..g., 3q28) appear to be novel results for schizophrenia linkage analyses...
  39. doi request reprint Consanguinity associated with increased risk for bipolar I disorder in Egypt
    Hader Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:879-85. 2009
    ..Self-reported estimates of consanguinity are bolstered by DNA-based estimates, and both show significant case-control differences for BP1...
  40. ncbi request reprint Circadian phase variation in bipolar I disorder
    Hader A Mansour
    Department of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Chronobiol Int 22:571-84. 2005
    ..Thus, distinct patterns of M/E were noted among BD1 patients and among BD1 subgroups. The impact of medication, mood state, and chronicity on CS scores needs to be considered...
  41. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  42. ncbi request reprint Pleiotropy and principal components of heritability combine to increase power for association analysis
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 32:9-19. 2008
    ..This cross-validation approach maintains the type I error control and yet utilizes the data efficiently, resulting in a powerful test for association...
  43. ncbi request reprint Characterization of multilocus linkage disequilibrium
    Alessandro Rinaldo
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 28:193-206. 2005
    ..We also propose a new, efficient method to select SNPs for association analysis, namely tag SNPs. These methods compare favorably to similar blocking and tagging methods using simulations...
  44. ncbi request reprint Analysis of single-locus tests to detect gene/disease associations
    Kathryn Roeder
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 28:207-19. 2005
    ..Finally, when a SNP selection procedure that targets a minimal number of SNPs per gene is applied, the average performances of T(P) and T(R) are indistinguishable...
  45. pmc Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes
    H Seltman
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
    Am J Hum Genet 68:1250-63. 2001
    ..More importantly, our results show that, when multiple polymorphisms are found within the gene, the ET-TDT can be useful for determining which polymorphisms affect liability...
  46. pmc Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study
    David Brent
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Rm 315 Bellefield Towers, Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:190-7. 2010
    ..The authors sought to assess the relationship between candidate genes and two clinical outcomes, namely, symptomatic improvement and the occurrence of suicidal events, in a sample of treatment-resistant depressed adolescents...
  47. ncbi request reprint No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet 114:667-72. 2002
    ..Therefore, although we cannot exclude the possibility that the samples in the two studies are intrinsically different, our data from our sample argue against a major role for HOXA1 (His)73(Arg) in liability to autism...
  48. pmc De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    Stephan J Sanders
    Program on Neurogenetics, Child Study Center, Department of Psychiatry, Yale University School of Medicine, 230 South Frontage Road, New Haven, Connecticut 06520, USA
    Nature 485:237-41. 2012
    ....
  49. ncbi request reprint Repositioning the hereditary paraganglioma critical region on chromosome band 11q23
    B E Baysal
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213 2593, USA
    Hum Genet 104:219-25. 1999
    ..Thus, we confined PGL1 to an approximately 1.5 Mb region between D11S1986 and D11S1347, and showed identity-by-descent sharing for a group of American PGL families...
  50. ncbi request reprint A Bayesian hierarchical model for allele frequencies
    J R Lockwood
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 20:17-33. 2001
    ..By analysis of simulated data, we highlight how the hierarchical model, as implemented in the publicly available program AllDist, combines prior information with the observed data to refine allele frequency estimates...
  51. pmc The power of genomic control
    S A Bacanu
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Hum Genet 66:1933-44. 2000
    ..Therefore, GC methods should prove a useful complement to family-based methods for the genetic analysis of complex traits...
  52. ncbi request reprint Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
    B E Baysal
    Department of Psychiatry, The University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    Science 287:848-51. 2000
    ..These findings indicate that mitochondria play an important role in the pathogenesis of certain tumors and that cybS plays a role in normal CB physiology...
  53. ncbi request reprint A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region
    B E Baysal
    Department of Psychiatry, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Eur J Hum Genet 9:121-9. 2001
    ..This map will help assess this gene-rich region in PGL and in other common tumours...
  54. ncbi request reprint Increased familial risk of the psychotic phenotype of Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 58:907-11. 2002
    ..Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors...
  55. ncbi request reprint Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:1026-36. 2005
    ..Examination of variation at ERE6 in subjects with schizophrenia, and further examination of the independent and additive effects of variations in COMT on gene expression, is warranted...
  56. ncbi request reprint Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23
    B E Baysal
    Department of Psychiatry, The University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Gene 217:107-16. 1998
    ..In conclusion, we precisely mapped and characterized the structure of PPP2R1B and evaluated it as a candidate gene for PGL1...
  57. ncbi request reprint Autism and the serotonin transporter: the long and short of it
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 10:1110-6. 2005
    ..Determining the factors influencing the relationship between autism phenotypes and HTTLPR variation, as well as other loci in SLC6A4, could be an important advance in our understanding of this complex disorder...
  58. ncbi request reprint Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
    H A Mansour
    Departments of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Genes Brain Behav 5:150-7. 2006
    ..Thus far, evidence for association between specific SNPs at the circadian gene loci and BD1 is tentative. Additional studies using larger samples are required to evaluate the associations reported here...
  59. ncbi request reprint Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
    Mol Psychiatry 8:383-92. 2003
    ..We discuss possible genetic models of psychotic symptoms in AD, and suggest strategies for further investigation. Identification of such genetic factors may facilitate gene-mapping studies for both AD and idiopathic psychoses...
  60. pmc Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nat Genet 44:1349-54. 2012
    ..These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07)...
  61. pmc Common genetic variants, acting additively, are a major source of risk for autism
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Autism 3:9. 2012
    ..abstract:..
  62. ncbi request reprint Haplotypes of the monoamine oxidase genes and the risk for substance use disorders
    Michael M Vanyukov
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 125:120-5. 2004
    ..Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems...
  63. pmc Do common variants play a role in risk for autism? Evidence and theoretical musings
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Res 1380:78-84. 2011
    ..We lay out this theory, calculate plausible distributions, and discuss the results in the context of results from GWA studies for schizophrenia...
  64. ncbi request reprint Heritability of psychosis in Alzheimer disease
    Silviu Alin Bacanu
    Dept of Psychiatry, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:624-7. 2005
    ..The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P...
  65. pmc On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit
    Jung Ying Tzeng
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Am J Hum Genet 72:891-902. 2003
    ..We show that both approaches can be powerful, but under quite different conditions. Moreover, we show that the power of both approaches can be enhanced by clustering rare haplotypes from the distributions before performing a test...
  66. doi request reprint The AVPR1A gene and substance use disorders: association, replication, and functional evidence
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Psychiatry 70:519-27. 2011
    ..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms...
  67. doi request reprint Genetic architecture in autism spectrum disorder
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Curr Opin Genet Dev 22:229-37. 2012
    ..Identification of ASD risk genes with high penetrance will broaden the targets amenable to genetic testing; while the biological pathways revealed by the deeper list of ASD genes should narrow the targets for therapeutic intervention...
  68. ncbi request reprint Sequence variation in the primate dopamine transporter gene and its relationship to social dominance
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, USA
    Mol Biol Evol 25:18-28. 2008
    ..This suggests that the DAT gene has followed different evolutionary trajectories during primate speciation...
  69. doi request reprint Neural correlates of symptom dimensions in pediatric obsessive-compulsive disorder: a functional magnetic resonance imaging study
    Andrew R Gilbert
    University of Pittsburgh School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 48:936-44. 2009
    ..Similar symptom dimensions are apparent in childhood and adolescence, but their functional neural correlates remain to be elucidated...
  70. ncbi request reprint Association and linkage analyses of RGS4 polymorphisms in schizophrenia
    Kodavali V Chowdari
    Department of Psychiatry, University of Pittsburgh, School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, PA 15213, USA
    Hum Mol Genet 11:1373-80. 2002
    ..Our results illustrate the potential power of combining gene expression profiling and genomic analyses to identify susceptibility genes for genetically complex disorders...
  71. pmc Incomplete response in late-life depression: getting to remission
    Eric J Lenze
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
    Dialogues Clin Neurosci 10:419-30. 2008
    ..Such studies may advance us toward the goal of personalized treatment in late-life depression...
  72. ncbi request reprint Linkage analysis of Alzheimer disease with psychosis
    S A Bacanu
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
    Neurology 59:118-20. 2002
    ..Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity...
  73. pmc Significant linkage on chromosome 10p in families with bulimia nervosa
    Cynthia M Bulik
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Hum Genet 72:200-7. 2003
    ..92 and 3.39, meet the widely accepted criterion for genomewide significance. Another region on 14q meets the criterion for genomewide suggestive linkage, with MLSs of 1.97 (full sample) and 1.75 (subset) at 62 centimorgans from p-ter...
  74. ncbi request reprint Evolutionary-based association analysis using haplotype data
    Howard Seltman
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 25:48-58. 2003
    ..The exploratory analyses, such as error checking, estimation of haplotype frequencies, and tools for building cladograms, should facilitate the implementation of cladistic-based association analysis with haplotypes...
  75. ncbi request reprint Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 7:689-94. 2002
    ..Similar to the results for other populations, our results suggest there are multiple genes conferring liability to schizophrenia even in the small population of Palau (roughly 21,000 individuals) in remote Oceania...
  76. pmc Shedding new light on genetic dark matter
    Nadine Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Genome Med 2:79. 2010
    ..By enhancing our understanding of molecular genetic etiology, such methods will help us to understand disease processes better and will advance the promise of personalized medicine...
  77. ncbi request reprint Improving power in genome-wide association studies: weights tip the scale
    Kathryn Roeder
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Genet Epidemiol 31:741-7. 2007
    ..If no groups show apparent signals, then the weights will be approximately equal. The only restriction on the procedure is that the number of groups be small, relative to the total number of tests performed...
  78. pmc Using linkage genome scans to improve power of association in genome scans
    Kathryn Roeder
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
    Am J Hum Genet 78:243-52. 2006
    ..This inquiry reveals that, among genetic models that are seemingly equal in genetic information, some are much more promising than others for this mode of analysis...
  79. ncbi request reprint Association of multiple DRD2 polymorphisms with anorexia nervosa
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Neuropsychopharmacology 30:1703-10. 2005
    ..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN...
  80. ncbi request reprint Personality characteristics of women before and after recovery from an eating disorder
    Kelly L Klump
    Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
    Psychol Med 34:1407-18. 2004
    ..This study compares personality characteristics among women who are ill with eating disorders, recovered from eating disorders, and those without eating or other Axis I disorder pathology...
  81. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
    ..These observations diminish the possibility that loci in the TOMM40 gene may have a major effect on the risk for LOAD in Caucasians...
  82. ncbi request reprint Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
    Rodney C P Go
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005
    ..Our results suggest that NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of LOAD families...
  83. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  84. ncbi request reprint ADLAPH: A molecular haplotyping method based on allele-discriminating long-range PCR
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 84:600-12. 2004
    ..We demonstrate the feasibility of this molecular haplotyping procedure by generating apolipoprotein E (APOE) haplotypes from 100 unrelated subjects...
  85. ncbi request reprint Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods
    Muktar H Aliyu
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 2041, and Duke University Medical Center John Umstead Hospital, Butner, NC, United States
    Schizophr Res 87:32-44. 2006
    ..This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia...