John DeVincenzo

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. doi request reprint RNA interference strategies as therapy for respiratory viral infections
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S118-22. 2008
  2. doi request reprint Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
    John DeVincenzo
    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Memphis, TN 38103, USA
    Antiviral Res 77:225-31. 2008
  3. doi request reprint 2007 International Congress on Respiratory Viruses. Introduction
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S53. 2008
  4. doi request reprint Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials
    John P DeVincenzo
    University of Tennessee School of Medicine, Department of Pediatrics, LeBonheur Children s Medical Center, Room 433, 50N Dunlap Street, Memphis, TN 38103, USA
    Early Hum Dev 85:S31-5. 2009
  5. ncbi request reprint Factors predicting childhood respiratory syncytial virus severity: what they indicate about pathogenesis
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN, USA
    Pediatr Infect Dis J 24:S177-83, discussion S182. 2005
  6. ncbi request reprint Respiratory syncytial virus load predicts disease severity in previously healthy infants
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, Tennessee, USA
    J Infect Dis 191:1861-8. 2005
  7. ncbi request reprint Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Res 56:914-7. 2004
  8. ncbi request reprint Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004
  9. ncbi request reprint Opportunities for early therapy of respiratory syncytial virus (RSV) infection: what happens before hospitalization
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee and the Children s Foundation Research Center, 4th floor CFRC, LBCMC, 50 North Dunlap St, Memphis, TN 38103, USA
    Antiviral Res 62:47-51. 2004
  10. ncbi request reprint Respiratory syncytial virus (RSV) loads in premature infants with and without prophylactic RSV fusion protein monoclonal antibody
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, and the Children s Foundation Research Center, Memphis, Tennessee 38103, USA
    J Pediatr 143:123-6. 2003

Research Grants

Collaborators

Detail Information

Publications21

  1. doi request reprint RNA interference strategies as therapy for respiratory viral infections
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S118-22. 2008
    ..RNAi may offer new strategies for the treatment of respiratory syncytial virus and other respiratory viruses...
  2. doi request reprint Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
    John DeVincenzo
    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Memphis, TN 38103, USA
    Antiviral Res 77:225-31. 2008
    ..Systemic bioavailability of ALN-RSV01 was minimal. ALN-RSV01 appears safe and well tolerated when delivered intranasally and is a promising therapeutic candidate for further clinical development...
  3. doi request reprint 2007 International Congress on Respiratory Viruses. Introduction
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S53. 2008
  4. doi request reprint Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials
    John P DeVincenzo
    University of Tennessee School of Medicine, Department of Pediatrics, LeBonheur Children s Medical Center, Room 433, 50N Dunlap Street, Memphis, TN 38103, USA
    Early Hum Dev 85:S31-5. 2009
    ..RNAi may offer new strategies for the treatment of a variety of orphan diseases including neonatal diseases, RSV infections, and other respiratory viruses...
  5. ncbi request reprint Factors predicting childhood respiratory syncytial virus severity: what they indicate about pathogenesis
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN, USA
    Pediatr Infect Dis J 24:S177-83, discussion S182. 2005
    ..Reviewing and interpreting the clinical risk factors to gain an insight into RSV pathogenesis is important, especially considering the relative lack of parallel between many animal models of RSV infection and observed human disease...
  6. ncbi request reprint Respiratory syncytial virus load predicts disease severity in previously healthy infants
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, Tennessee, USA
    J Infect Dis 191:1861-8. 2005
    ..Elucidating the relationship between viral load and respiratory syncytial virus (RSV) disease severity is critical to understanding pathogenesis and predicting the utility of antivirals...
  7. ncbi request reprint Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Res 56:914-7. 2004
    ..Disease severity risk factors were similar between subgroups. RSV loads were similar between A and B subgroups (4.77 versus 4.68 log PFU/mL). Measures of disease severity were also similar between subgroups...
  8. ncbi request reprint Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004
    ..Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab...
  9. ncbi request reprint Opportunities for early therapy of respiratory syncytial virus (RSV) infection: what happens before hospitalization
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee and the Children s Foundation Research Center, 4th floor CFRC, LBCMC, 50 North Dunlap St, Memphis, TN 38103, USA
    Antiviral Res 62:47-51. 2004
    ..6 +/- 1.8 days. RSV-hospitalized infants routinely have contact with health care professionals at significantly early time points in their illness. These contacts are potential opportunities for initiation of early anti-RSV therapy...
  10. ncbi request reprint Respiratory syncytial virus (RSV) loads in premature infants with and without prophylactic RSV fusion protein monoclonal antibody
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, and the Children s Foundation Research Center, Memphis, Tennessee 38103, USA
    J Pediatr 143:123-6. 2003
    ..Mean (SEM) RSV loads in the MAb and non-MAb groups were 3.36 (0.59) versus 4.89 (0.27) logPFU/ml (P=.01). Prophylactic palivizumab reduces nasal RSV in premature hospitalized infants...
  11. pmc A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
    John DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38103, USA
    Proc Natl Acad Sci U S A 107:8800-5. 2010
    ....
  12. doi request reprint Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population
    Chadi M El Saleeby
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital for Children, Boston, MA 02114, USA
    J Pediatr 156:409-14. 2010
    ..To examine whether genetic variations within the surfactant protein A2 (SP-A2) gene are associated with respiratory syncytial virus (RSV) disease severity in infected children...
  13. ncbi request reprint A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: effects on RSV quantity and clinical outcome
    Steven C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    J Infect Dis 185:1222-8. 2002
    ....
  14. pmc Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, USA
    Am J Respir Crit Care Med 182:1305-14. 2010
    ..Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immune-mediated rather than being driven by viral load...
  15. pmc Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus
    Stephanie M Perkins
    Unversity of Tennessee School of Medicine, Memphis, TN, USA
    J Clin Microbiol 43:2356-62. 2005
    ..The utility of the RTrtPCR quantification technique for clinical studies would be solidified after its correlation with RSV disease severity is established...
  16. ncbi request reprint Passive antibody prophylaxis for RSV
    John DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    Pediatr Infect Dis J 27:69-70. 2008
  17. doi request reprint Risk factors for severe respiratory syncytial virus disease in children with cancer: the importance of lymphopenia and young age
    Chadi M El Saleeby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Pediatrics 121:235-43. 2008
    ..We sought to determine the epidemiologic features of respiratory syncytial virus infection in immunocompromised pediatric patients and to identify the risk factors for severe disease...
  18. pmc Human genetic factors and respiratory syncytial virus disease severity
    Isao Miyairi
    Department of Pediatrics, University of Tennessee, Memphis, Tennessee 38103, USA
    Clin Microbiol Rev 21:686-703. 2008
    ..Such problems highlight the limitation of the candidate gene approach and the need for an unbiased large-scale genome-wide association study to evaluate this important disease...
  19. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..These studies highlight the distinct responses of different cell types to viral infection and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens...
  20. ncbi request reprint Relationship between respiratory syncytial virus load and illness severity in children
    John P DeVincenzo
    J Infect Dis 186:1376-7; author reply 1377. 2002
  21. ncbi request reprint A new direction in understanding the pathogenesis of respiratory syncytial virus bronchiolitis: how real infants suffer
    John P DeVincenzo
    J Infect Dis 195:1084-6. 2007

Research Grants5

  1. IMMUNOGENETICS AND THE PATHOGENESIS OF RSV INFECTION
    John DeVincenzo; Fiscal Year: 2004
    ..With the help of this award, this goal can be achieved. ..