Sridevi Devaraj

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Pathol Lab Med 132:1432-5. 2008
  2. ncbi Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 38:1212-20. 2005
  3. ncbi Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 44:1203-8. 2008
  4. ncbi Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research and General Clinical Research Center, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Clin Nutr 84:756-61. 2006
  5. ncbi Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Metabolism 60:256-9. 2011
  6. ncbi Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome
    Uma Singh
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California, USA
    Am J Cardiol 102:321-5. 2008
  7. ncbi Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 92:3136-40. 2007
  8. ncbi CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 II Ave, Res 1 Bldg, Rm 3000, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 291:H1170-6. 2006
  9. ncbi A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, CA 95817, USA
    J Am Coll Nutr 27:267-73. 2008
  10. ncbi Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome
    Ishwarlal Jialal
    Department of Pathology and Laboratory Medicine, University of California at Davis, Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 97:E1844-50. 2012

Research Grants

  1. Cellular pathways of inflammation in type 1 diabetes
    Sridevi Devaraj; Fiscal Year: 2007

Detail Information

Publications97

  1. ncbi Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Pathol Lab Med 132:1432-5. 2008
    ..However, there is a paucity of data comparing circulating monocytes to cholesterol-laden macrophages (foam cells), with regard to their atherogenic properties, especially in subjects with established risk factors such as hyperlipidemia...
  2. ncbi Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 38:1212-20. 2005
    ..Furthermore, AT and the 5-LO inhibitor decreased NFkappab-binding activity. Thus, in activated human monocytes, AT appears to inhibit TNF mRNA and protein by inhibition of 5-LO...
  3. ncbi Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 44:1203-8. 2008
    ....
  4. ncbi Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research and General Clinical Research Center, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Clin Nutr 84:756-61. 2006
    ..High-sensitivity C-reactive protein (hs-CRP), the prototypic marker of inflammation, is a cardiovascular disease risk marker; however, there is a paucity of data on the effect of plant sterols on CRP concentrations...
  5. ncbi Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Metabolism 60:256-9. 2011
    ..005). Thus, we make the novel observation that TLR2 and TLR4 expression and signaling are increased in T1DM-MV compared with T1DM and may contribute to the accentuated proinflammatory state and complications of T1DM...
  6. ncbi Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome
    Uma Singh
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California, USA
    Am J Cardiol 102:321-5. 2008
    ..In conclusion, this randomized trial of subjects with MS showed the superiority of atorvastatin 80 mg compared with its 10-mg dose in decreasing oxidized LDL, hs-CRP, matrix metalloproteinase-9, and NF-kB activity...
  7. ncbi Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 92:3136-40. 2007
    ..TIDM is a proinflammatory state. Whereas there is consensus on lipid management in type 2 diabetes, there is a lack of data in type 1 diabetes. In addition to benefits on the lipid profile, statin therapy is antiinflammatory...
  8. ncbi CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 II Ave, Res 1 Bldg, Rm 3000, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 291:H1170-6. 2006
    ..Thus, in HAEC, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64...
  9. ncbi A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, CA 95817, USA
    J Am Coll Nutr 27:267-73. 2008
    ..Thus, we tested the effects of different doses of purified lycopene supplementation on biomarkers of oxidative stress in healthy volunteers...
  10. ncbi Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome
    Ishwarlal Jialal
    Department of Pathology and Laboratory Medicine, University of California at Davis, Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 97:E1844-50. 2012
    ..Oxidative stress (OS) could contribute to this excess risk. However, there are few data examining both cellular and circulating biomarkers of OS in MetS uncomplicated by diabetes and CVD...
  11. ncbi A randomized placebo-controlled crossover trial of aloe vera on bioavailability of vitamins C and B(12), blood glucose, and lipid profile in healthy human subjects
    Jung Mi Yun
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, California 95817, USA
    J Diet Suppl 7:145-53. 2010
    ..01). Thus, AG and AL preparations are safe, well tolerated, and enhance the bioavailability of vitamins C and B(12) and antioxidant potential...
  12. ncbi Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome
    Long Wang
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
    Metab Syndr Relat Disord 6:149-52. 2008
    ..Their levels are increased in the MS. The current study was to investigate the effects of simvastatin on PAI-1, sP-selectin, and sCD40 ligand...
  13. ncbi High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes 57:3090-8. 2008
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions...
  14. ncbi Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center and Veterans Affairs Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 91:4489-96. 2006
    ..CONCLUSIONS: Thus, we show a direct antiinflammatory effect of simvastatin therapy in MS. These findings could partly explain the benefit of statin therapy in these patients...
  15. ncbi The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    J Lipid Res 48:509-12. 2007
    ..This is the first study to positively authenticate the significance of earlier in vitro reports on CRP biological effects...
  16. ncbi Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications
    Sridevi Devaraj
    Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA
    Diabetes 56:2790-6. 2007
    ....
  17. ncbi Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes Care 33:861-8. 2010
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression, their ligands, and signaling in monocytes of recently diagnosed type 2 diabetic patients...
  18. ncbi Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers
    Jung Mi Yun
    Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
    Br J Nutr 103:1771-7. 2010
    ..05) in both groups. Thus, in part, EGCG enhances the functionality of Tregs, i.e. IL-10 production and number by suppressing the NF-kappaB signalling pathway via inducing epigenetic changes...
  19. ncbi C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 26:2469-75. 2006
    ..CONCLUSIONS: This study provides novel evidence that CRP, by decreasing IL-10 alters the antiinflammatory/proinflammatory balance, accentuating inflammation, which is pivotal in atherothrombosis...
  20. ncbi Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway
    Sridevi Devaraj
    Department of Medical Pathology and Laboratory Medicine, Laboratory for Atherosclerosis and Metabolic Research, Robert E Stowell Endowed Chair in Experimental Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Cytokine 47:6-10. 2009
    ..Thus, we demonstrate increased circulating and monocytic IP-10 in T1DM. Down-regulation of TLR2 and TLR4 abrogates HG-induced IP-10 release via NF-kappaB inhibition...
  21. ncbi Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Endocrinology 150:3457-64. 2009
    ..Data suggest that Pam- and LPS-induced TLR2 and TLR4 expression are inhibited by PIO in human monocytes and db/db mice. Thus, we define a novel pathway by which PIO could induce antiinflammatory effects...
  22. ncbi Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Clin Nutr 30:668-71. 2011
    ....
  23. ncbi CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1
    R Michael Gower
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Arterioscler Thromb Vasc Biol 31:160-6. 2011
    ..Involvement of β(2)-integrin CD11c/CD18 in atherogenesis was recently shown in dyslipidemic mice, which motivates our study of its inflammatory function during hypertriglyceridemia in humans...
  24. ncbi C-reactive protein induces M-CSF release and macrophage proliferation
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA
    J Leukoc Biol 85:262-7. 2009
    ..These effects appear to be mediated via activation of NF-kappaB via CD32 and CD64. These studies provide further evidence for a proatherogenic role for CRP...
  25. ncbi Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
    ..TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state...
  26. ncbi Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
    Joy X Jiang
    Department of Internal Medicine, UC Davis, Sacramento, CA, USA
    Free Radic Biol Med 53:289-96. 2012
    ..In conclusion, NOX4 plays a key role in liver fibrosis. GKT137831 is a potent inhibitor of fibrosis and hepatocyte apoptosis; therefore, it is a promising therapeutic agent for future translational studies...
  27. ncbi S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial
    Valentina Medici
    Department of Internal Medicine, University of California Davis, Sacramento, California 95817, USA
    Alcohol Clin Exp Res 35:1960-5. 2011
    ..The primary endpoints were changes in serum aminotransferase levels and liver histopathology scores, and the secondary endpoints were changes in serum levels of methionine metabolites...
  28. ncbi C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo
    Sridevi Devaraj
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 203:67-74. 2009
    ..CRP-induced ROS appears to precede tissue factor release. These effects are abrogated by blocking Fc gamma receptors, CD32 and CD64. This in vivo demonstration provides further evidence for a role for CRP in atherothrombosis...
  29. ncbi Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/autocrine effects
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California Medical Center, Sacramento, CA 95817, USA
    Am J Pathol 166:1265-71. 2005
    ....
  30. ncbi Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): a real-time intravital microscopy study
    Anthony T W Cheung
    Department of Pathology and Laboratory Medicine, University of California Davis, School of Medicine, Sacramento, CA 95817, USA
    Clin Hemorheol Microcirc 42:285-95. 2009
    ....
  31. ncbi Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
    Jung Mi Yun
    Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    J Nutr Biochem 23:699-705. 2012
    ..Thus, resveratrol decreases HG-induced superoxide production via up-regulation of SIRT1, induction of FOXO3a and inhibition of p47phox in monocytes...
  32. ncbi Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease
    Sonia Vega-Lopez
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    J Investig Med 52:24-32. 2004
    ..Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality...
  33. ncbi Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo
    Joy X Jiang
    UC Davis Medical Center, PSSB, Sacramento, CA 95817, USA
    Am J Physiol Gastrointest Liver Physiol 302:G439-46. 2012
    ..In summary, extracellular galectin-3 plays a key role in liver fibrosis by mediating HSC phagocytosis, activation, and subsequent autocrine and paracrine signaling by a feedforward mechanism...
  34. ncbi High glucose induces IL-1beta expression in human monocytes: mechanistic insights
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Ave, Research Bldg 1, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 293:E337-46. 2007
    ..Targeting signaling pathways mediating IL-1beta release could result in the amelioration of inflammation and possibly diabetic vasculopathies...
  35. ncbi C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, University of California Davis, 4635 2nd Avenue, Sacramento, CA 95817, USA
    J Mol Cell Cardiol 43:780-91. 2007
    ..CRP appears to mediate these effects through the Fcgamma receptors, CD32 and CD64. To conclude, CRP uncouples eNOS resulting in increased superoxide production, decreased NO production and altered eNOS phosphorylation...
  36. ncbi The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology, UC Davis Medical Center, Sacramento, California 95817, USA
    Nutr Rev 64:348-54. 2006
    ..Present evidence is accumulating to promote their use for lowering LDL cholesterol levels, as a first line of therapy (as well as adjunctive therapy) in patients on statin therapy...
  37. ncbi Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein
    Sridevi Devaraj
    Department of Pathology, UCDavis Medical Center, Sacramento, CA 95817, USA
    Atherosclerosis 184:48-52. 2006
    ..001). Thus, native pentameric CRP compared to modified CRP exerts more potent atherogenic effects in human aortic endothelial cells...
  38. ncbi Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease
    Valentina Medici
    Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Hepatol 53:551-7. 2010
    ..The aim of this clinical study was to determine the relationship between serum levels of methionine metabolites in chronic alcoholics and the risk and pathological severity of ALD...
  39. ncbi Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers
    Sonia Vega-Lopez
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA, USA
    Metabolism 53:236-40. 2004
    ..In conclusion, supplementation with n3PUFA and all-rac AT at these doses is not anti-inflammatory...
  40. ncbi C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunction
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Cardiovasc Res 84:479-84. 2009
    ..The glycocalyx decorates the luminal surface and affords critical protection of the endothelium. Thus, the aim of the study was to examine the effect of C-reactive protein on the endothelial glycocalyx...
  41. ncbi Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 Second Avenue, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 28:1368-74. 2008
    ..We tested the hypothesis that adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose)...
  42. ncbi Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, The University of California Davis Medical Center, 4635, II Ave, Res 1 Bldg, Rm 3000, Sacramento, CA 95817, USA
    Diabetes 54:85-91. 2005
    ..Thus, inhibition of PKC-alpha and -beta can ameliorate the proinflammatory state of diabetes...
  43. ncbi C-reactive protein induces release of both endothelial microparticles and circulating endothelial cells in vitro and in vivo: further evidence of endothelial dysfunction
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    Clin Chem 57:1757-61. 2011
    ..However, there is a paucity of data examining the effect of CRP on CEC and EMP production in vitro and in vivo...
  44. ncbi C-reactive protein stimulates myeloperoxidase release from polymorphonuclear cells and monocytes: implications for acute coronary syndromes
    Uma Singh
    Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Clin Chem 55:361-4. 2009
    ..Because MPO and CRP concentrations are increased in acute coronary syndrome (ACS) patients and predict poor outcomes, we tested the effect of CRP on MPO release from PMNs and monocytes...
  45. ncbi Adipose tissue dysregulation in patients with metabolic syndrome
    Andrew A Bremer
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 96:E1782-8. 2011
    ..Numerous groups have shown increased circulating biomarkers of inflammation in MetS. However, there are scanty data on the cellular sources contributing to this low-grade inflammation...
  46. ncbi Postprandial metabolic responses to dietary glycemic index in hypercholesterolemic postmenopausal women
    Radhika N Bukkapatnam
    Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Prev Cardiol 13:29-35. 2010
    ..The results suggest a postprandial impact of glycemic index on cardiovascular metabolic biomarkers in postmenopausal women and may have implications for dietary glycemic modification of cardiovascular risk in women...
  47. ncbi Human C-reactive protein and the metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, and VA Medical Center, Mather, USA
    Curr Opin Lipidol 20:182-9. 2009
    ..The purpose of this review is to outline the role of inflammation and high sensitivity CRP in the MetS...
  48. ncbi CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Am J Clin Pathol 129:815-22. 2008
    ..5; 95% CI, 1.3-4.5), its oligomers, or the adiponectin/ hsCRP ratio (OR, 2.6; 95% CI, 1.5, 4.8). Thus, measurements of CRP, adiponectin, or its oligomers provide robust biomarkers for predicting MetS...
  49. ncbi Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin
    Jung Mi Yun
    Department of Pathology and Laboratory Medicine, University of California, Davis, CA, USA
    J Nutr Biochem 22:450-8. 2011
    ..In conclusion, curcumin supplementation by reducing vascular inflammation may prevent diabetic complications...
  50. ncbi Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
    ..These results have a major implication on our understanding of the role of inflammation in vasculopathies in type 1 diabetes...
  51. ncbi Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Arterioscler Thromb Vasc Biol 25:1359-63. 2005
    ..Several investigators have reported that CRP binds to Fcgamma receptors on leukocytes. The aim of the study is to determine the processing of CRP by human aortic endothelial cells (HAECs)...
  52. ncbi C-reactive protein decreases tissue plasminogen activator activity in human aortic endothelial cells: evidence that C-reactive protein is a procoagulant
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 25:2216-21. 2005
    ..Plasminogen activator-1, a marker of fibrinolysis, is the primary inhibitor of tissue plasminogen activator (tPA). Thus, we tested the effect of CRP on tPA in human aortic endothelial cells...
  53. ncbi Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, USA
    Nutr Rev 63:290-3. 2005
    ..Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention...
  54. ncbi Dietary factors that promote or retard inflammation
    Arpita Basu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 26:995-1001. 2006
    ..Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss...
  55. ncbi Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, California 95817, USA
    Diabetes 51:3049-54. 2002
    ....
  56. ncbi Defining the proinflammatory phenotype using high sensitive C-reactive protein levels as the biomarker
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 90:4549-54. 2005
    ..This systemic inflammatory phenotype may contribute to vascular inflammation or may reflect inflammation in vessels or at other sites...
  57. ncbi High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy
    Uma Singh
    University of California Davis Medical Center, Sacramento, California 95817, USA
    Clin Chem 53:525-8. 2007
    ..Few data are available on the effect of AT therapy alone on HDL subfractions, which we addressed in this study...
  58. ncbi Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, 95817, USA
    Clin Chem 51:2252-6. 2005
    ..CONCLUSIONS: The release of TNF-alpha after stimulation of THP-1 cells with LPS is a valid model system to test novel compounds for potential antiinflammatory effects...
  59. ncbi The evolving role of C-reactive protein in atherothrombosis
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    Clin Chem 55:229-38. 2009
    ..In addition to being a risk marker, there is much evidence indicating that CRP may indeed participate in atherogenesis...
  60. ncbi High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Metabolism 57:867-70. 2008
    ..03). Thus, in subjects with MetS, consumption of an energy-dense, fatty meal (FFS breakfast) results in increased postprandial oxidative stress compared to a heart-healthy meal (AHA)...
  61. ncbi C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 31:1397-402. 2011
    ..Several studies point to a proinflammatory role for C-reactive protein (CRP). Because there is a paucity of data on the effects of CRP on macrophage phenotype, we tested effects of CRP on macrophage polarization...
  62. ncbi Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome
    Sridevi Devaraj
    University of California Davis Medical Center, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 12:110-8. 2010
    ..This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes...
  63. ncbi C-reactive protein adversely alters the protein-protein interaction of the endothelial isoform of nitric oxide synthase
    Simona Valleggi
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Clin Chem 56:1345-8. 2010
    ..In this study, we examined the effect of CRP treatment of human aortic endothelial cells (HAECs) on eNOS interaction with caveolin-1, Hsp90, and porin...
  64. ncbi Effects of colesevelam hydrochloride (WelChol) on biomarkers of inflammation in patients with mild hypercholesterolemia
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California, USA
    Am J Cardiol 98:641-3. 2006
    ..No correlation was found between LDL cholesterol lowering and hs-CRP lowering (r = 0.3). In conclusion, our results show that colesevelam HCl monotherapy significantly lowered hs-CRP levels in a double-blind, placebo-controlled study...
  65. ncbi The effect of weight loss and dietary fatty acids on inflammation
    Sridevi Devaraj
    VA Northern California Health System, Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 8:477-86. 2006
    ..Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss...
  66. ncbi C-reactive protein decreases prostacyclin release from human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, Sacramento, Calif, USA
    Circulation 108:1676-8. 2003
    ..CONCLUSIONS: Thus, CRP decreases PGI2 release from HAECs by inactivating PGIS via nitration, additionally contributing to its atherogenicity...
  67. ncbi Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Opin Nephrol Hypertens 14:33-7. 2005
    ..Recent evidence from different cell types suggests that CRP is not only a risk marker but may also be a participant in atherogenesis. This review will focus on the effects of CRP on different cells involved in atherosclerosis...
  68. ncbi C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
    ..In conclusion, CRP is a risk marker for cardiovascular disease and, based on future studies, could emerge as a mediator in atherogenesis...
  69. ncbi RRR-alpha-tocopherol decreases the expression of the major scavenger receptor, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2)
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, 4635, 2nd Avenue, Room #3000, Research Building 1, Sacramento, CA 95817, USA
    Atherosclerosis 175:213-20. 2004
    ..In conclusion, this study demonstrates an additional direct cellular effect of AT, i.e. inhibition of CD36 expression via inhibition of tyrosine kinase (Tyk2)...
  70. ncbi Effect of C-reactive protein on chemokine expression in human aortic endothelial cells
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California, Davis Medical Center, 4635 Second Avenue, Research 1 Building, Rm 3000, Sacramento, CA 95817, USA
    J Mol Cell Cardiol 36:405-10. 2004
    ..01). In conclusion, this study makes the novel observation that CRP induces IL-8 synthesis and secretion in HAEC via upregulation of NF-kappa B activity...
  71. ncbi Role of C-reactive protein in the assessment of cardiovascular risk
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    Am J Cardiol 91:200-2. 2003
  72. ncbi Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, 4635 Second Avenue, Res 1 Building, Room 3000, Sacramento CA 95817, USA
    Arterioscler Thromb Vasc Biol 24:e25-8. 2004
    ..CONCLUSIONS: Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen...
  73. ncbi Circulating levels of endothelial progenitor cell mobilizing factors in the metabolic syndrome
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center and the VA Medical Center, Sacramento, California, USA
    Am J Cardiol 106:1606-8. 2010
    ....
  74. ncbi Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Lipids 37:931-4. 2002
    ..Hence, following oral supplementation in humans, PYC significantly increases antioxidant capacity of plasma, as determined by ORAC, and exerts favorable effects on the lipid profile...
  75. ncbi C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 107:398-404. 2003
    ..CONCLUSIONS: This study makes the novel observation that CRP induces PAI-1 expression and activity in HAECs and thus has implications for both the metabolic syndrome and atherothrombosis...
  76. ncbi Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 106:1439-41. 2002
    ..C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis...
  77. ncbi S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet
    Jesus A Villanueva
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1934-43. 2007
    ....
  78. ncbi Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Davis, CA, USA
    Am J Cardiol 100:1397-9. 2007
    ..In conclusion, although simvastatin is anti-inflammatory, it failed to affect adiponectin levels or improve insulin sensitivity in subjects with the MS...
  79. ncbi Coenzyme Q10 supplementation and heart failure
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    Nutr Rev 65:286-93. 2007
    ..However, much further research is required, especially in the use of state-of-the-art techniques to assess functional outcomes in patients with congestive heart failure...
  80. ncbi Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners
    Angela Mastaloudis
    Departments of Exercise and Sport Science, Oregon State University, Corvallis, OR 97731, USA
    Free Radic Biol Med 36:1329-41. 2004
    ..03). Markers of inflammation were increased dramatically in response to the run regardless of treatment group. Thus, AO supplementation prevented endurance exercise-induced lipid peroxidation but had no effect on inflammatory markers...
  81. ncbi Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults
    Sridevi Devaraj
    Center for Human Nutrition and the Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Clin Nutr 76:1367-74. 2002
    ..CGJ flavonoids are potent antioxidants that may protect against oxidative stress and reduce the risk of free radical damage and chronic diseases...
  82. ncbi Oxidative stress, alpha-tocopherol therapy, and atherosclerosis
    Andrea Harris
    University of Texas Southwestern Medical Center, Dallas, 75390 09073, USA
    Curr Atheroscler Rep 4:373-80. 2002
    ..Clearly, more clinical trials are required in individuals with increased oxidative stress before a definitive recommendation can be made with respect to AT supplementation in atherosclerosis...
  83. ncbi alpha-Tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients
    Sridevi Devaraj
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9073, USA
    Diabetes Care 25:524-9. 2002
    ..005). CONCLUSIONS: Thus, AT therapy decreases markers of thrombosis in diabetic patients and control subjects and could be an adjunctive therapy in the prevention of atherosclerosis...
  84. ncbi Modulation of monocyte-macrophage function with alpha-tocopherol: implications for atherosclerosis
    Sridevi Devaraj
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9073, USA
    Nutr Rev 60:8-14. 2002
    ..Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease...
  85. ncbi Autoantibodies to oxidized low-density lipoprotein in patients with type 2 diabetes mellitus
    Rebecca M Hsu
    Department of Pathology, Division of Clinical Biochemistry and Human Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9073, USA
    Clin Chim Acta 317:145-50. 2002
    ..01). CONCLUSION: This assay may serve as a future test for the assessment of cardiovascular risk especially in patients with increased oxidative stress...
  86. ncbi Statins and biomarkers of inflammation
    Sridevi Devaraj
    Curr Atheroscler Rep 9:33-41. 2007
    ....
  87. ncbi Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans
    Surekha Mathur
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390-9073, USA
    J Nutr 132:3663-7. 2002
    ..In conclusion, cocoa products supplementation in humans affects LDL oxidizability, but not urinary F(2) isoprostanes or markers of inflammation...
  88. ncbi Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients
    Kylie Sherée Smith
    Department of Nutrition and Food Management, Oregon State University, Corvallis, Oregon 97331, USA
    Lipids 38:813-9. 2003
    ..Importantly, serum vitamin E metabolite concentrations that increased 10-fold within 30 d of supplementation did not increase further, suggesting routes other than urine for removal of metabolites...
  89. ncbi Gamma-tocopherol, the new vitamin E?
    Sridevi Devaraj
    Am J Clin Nutr 77:530-1. 2003
  90. ncbi Remnant lipoproteins: measurement and clinical significance
    Ishwarlal Jialal
    Clin Chem 48:217-9. 2002
  91. ncbi Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circulation 113:2135-50; discussion 2150. 2006
  92. ncbi Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease
    Sridevi Devaraj
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Clin Nutr 86:1392-8. 2007
    ..Oxidative stress and inflammation are crucial in atherogenesis. alpha-Tocopherol is both an antioxidant and an antiinflammatory agent...
  93. ncbi Increased lipoprotein remnant cholesterol levels in HIV-positive patients during antiretroviral therapy
    Erdembileg Anuurad
    Department of Medicine, University of California, Davis, CA 95817, USA
    Atherosclerosis 198:192-7. 2008
    ..024, ANOVA). In conclusion, during HIV conditions, HAART resulted in a pro-atherogenic pattern with accumulation of remnant lipoproteins...
  94. ncbi Accelerated atherosclerosis, dyslipidemia, and oxidative stress in end-stage renal disease
    Surekha Mathur
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
    Curr Opin Nephrol Hypertens 11:141-7. 2002
    ..Clinical trials with statins and other drugs that improve dyslipidemia also need to be undertaken. These therapies could clearly lead to a reduction in cardiovascular morbidity and mortality in these patients...
  95. ncbi Metabolic syndrome: an appraisal of the pro-inflammatory and procoagulant status
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4365 Second Avenue, Room 3000, Sacramento CA 95817, USA
    Endocrinol Metab Clin North Am 33:431-53, table of contents. 2004
    ..Elevated von Willebrand's factor and factor VIII levels aggregate with indicators of endothelial injury,whereas vitamin K-dependent coagulation proteins correlate with triglyceride levels...
  96. ncbi Statin therapy in acute cardiovascular syndromes
    Ishwarlal Jialal
    Curr Opin Lipidol 18:610-2. 2007
  97. ncbi Therapy and clinical trials
    Ishwarlal Jialal
    Curr Opin Lipidol 18:479-81. 2007

Research Grants2

  1. Cellular pathways of inflammation in type 1 diabetes
    Sridevi Devaraj; Fiscal Year: 2007
    ..abstract_text> ..