Research Topics
Genomes and GenesSpecies | John DetreSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Shape-based alignment of hippocampal subfields: evaluation in postmortem MRIPaul A Yushkevich
Department of Radiology, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 11:510-7. 2008....- Applications of arterial spin labeled MRI in the brainJohn A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 35:1026-37. 2012..This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care... 
Correlation of diffusion MRI and heat shock protein in a rat embolic stroke modelJ A Detre
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
J Neurol Sci 148:163-9. 1997..These findings suggest that intermediate ADC values occur in penumbral regions. Heterogeneity of ischemic cellular injury is suggested as the basis for the intermediate ADC values observed in these regions...
Arterial spin-labeled perfusion MRI in basic and clinical neuroscienceJohn A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Opin Neurol 22:348-55. 2009....- Technical aspects and utility of fMRI using BOLD and ASLJohn A Detre
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
Clin Neurophysiol 113:621-34. 2002.... - fMRI: applications in epilepsyJohn A Detre
Center for Functional Neuroimaging, Departments of Neurology and Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:26-31. 2004.... - Clinical applicability of functional MRIJohn A Detre
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 23:808-15. 2006.... - Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer diseaseY Chen
Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
Neurology 77:1977-85. 2011..We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls... - Functional MRI and its applications to the clinical neurosciencesJ A Detre
Departments of Neurology, Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Neuroscientist 7:64-79. 2001..Because the technology for fMRI is widely available, its impact could be substantial... - Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosisJ A Detre
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
J Magn Reson Imaging 10:870-5. 1999..J. Magn. Reson. Imaging 1999;10:870-875... - Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous systemJ A Detre
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
Eur J Radiol 30:115-24. 1999..These techniques have a broad range of potential applications in clinical and basic research of brain physiology, as well as in other organs... - Signal averaged laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortexJ A Detre
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
Brain Res 796:91-8. 1998..This finding was also observed during hypercapnia. Characterization of AFC in the model provides a background for future studies of the effects of pharmacological manipulation or pathophysiological states... - Large-scale neural network for sentence processingAyanna Cooke
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Brain Lang 96:14-36. 2006.... - Neural representation of verb meaning: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
Hum Brain Mapp 15:124-34. 2002..We suggest that left posterolateral temporal activation supports aspects of lexical semantic processing concerned with the neural representation of propositional knowledge contributing to COGNITION verbs... - Neural basis for verb processing in Alzheimer's disease: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychology 17:658-74. 2003..These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing... - Neural basis for sentence comprehension deficits in frontotemporal dementiaAyanna Cooke
Department of Neurology-2 Gibson, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Brain Lang 85:211-21. 2003..We conclude that FTD subgroups have distinct patterns of sentence comprehension difficulty in part because of selective interruptions of a large-scale neural network for sentence processing... - The neural basis for category-specific knowledge: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Neuroimage 15:936-48. 2002.... - Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 TMaria A Fernandez-Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 54:1241-7. 2005..The method was further improved using parallel imaging techniques to provide increased spatial resolution and better separation of the gray-white matter cerebral blood flow maps... - Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasksJunghoon Kim
Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 1200 W Tabor Road, Philadelphia, PA 19141, USA
Neuroimage 31:376-85. 2006..Increased applications of the method to the investigation of cognitively impaired populations are expected to follow... - Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Brain 126:292-311. 2003..Components of the large-scale neural network underlying semantic memory may modify themselves to maintain performance in the face of a neurodegenerative disease... - Sentence processing strategies in healthy seniors with poor comprehension: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Brain Lang 80:296-313. 2002..Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension... - Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomyBeau M Ances
Department of Neurology, Department of Neurosurgery, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Neuroimaging 14:133-8. 2004..78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization... - Experimental design for functional MRI of scene memory encodingVeena M Narayan
Department of Neurology and Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA
Epilepsy Behav 6:242-9. 2005..Our results suggest that although improved design augments the sensitivity of event-related designs, these benefits are not sufficient to overcome the sensitivity advantages of traditional blocked designs... - Neural basis for sentence comprehension: grammatical and short-term memory componentsAyanna Cooke
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
Hum Brain Mapp 15:80-94. 2002.... - Arterial spin labeling perfusion MRI in pediatric arterial ischemic stroke: initial experiencesJuan Chen
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 29:282-90. 2009..To investigate the feasibility and utility of arterial spin labeling (ASL) perfusion MRI for characterizing alterations of cerebral blood flow (CBF) in pediatric patients with arterial ischemic stroke (AIS)... - Boost up the detection sensitivity of ASL perfusion fMRI through support vector machineZe Wang
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Conf Proc IEEE Eng Med Biol Soc 1:1006-9. 2006..Evaluations were performed using 7 subjects' fingertapping ASL perfusion fMRI data, yielding similar activation patterns with enhanced sensitivity compared to the standard GLM based group analysis... - Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 TeslaJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
Magn Reson Med 48:242-54. 2002..5T functional data, with reduced fractional perfusion signal change and increased intersubject variability. Possible reasons for these experimental results, including susceptibility effects and physiological noise, are discussed... - Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenosesAnne C Roc
Center for Functional Neuroimaging, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Stroke 37:382-7. 2006..A simple visuomotor BOLD activation paradigm can reflect alterations in the hemodynamic response in patients with hemodynamically significant stenoses... - Physiological modulations in arterial spin labeling perfusion magnetic resonance imagingWen Chau Wu
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 28:703-9. 2009..CASL with a labeling duration at a multiple of an R-R interval can be used to minimize signal fluctuation originating from cardiac pulsation... - Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry studyJunghoon Kim
Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
Neuroimage 39:1014-26. 2008.... - Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRIWen Chau Wu
Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 28:445-52. 2008..To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements... - Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3TZe Wang
Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Med 54:732-7. 2005..Such results highlight the potential utility of array coils and parallel imaging in ASL perfusion MRI... - Hippocampus-specific fMRI group activation analysis with continuous M-RepsPaul A Yushkevich
Penn Image Computing and Science Laboratory, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 9:284-91. 2006..When applied to real fMRI data, the method detects more significant hippocampal activation than the established whole-brain method... - Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in ratsDonald G Buerk
Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Neuroimage 18:1-9. 2003..M. Ances et al., 2001, Neurosci. Lett. 306, 106-110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation... - Neural substrates of knowledge of hand postures for object grasping and functional object use: evidence from fMRILaurel J Buxbaum
Moss Rehabilitation Research Institute, Korman 213, 1200 W. Tabor Road, Philadelphia, PA 19141, USA
Brain Res 1117:175-85. 2006..These data confirm the importance of the left IPL in storing knowledge of hand postures for functional object use, and have implications for understanding the interaction of dorsal and ventral visual processing systems... - Imaging mesial temporal lobe activation during scene encoding: comparison of fMRI using BOLD and arterial spin labelingMaria A Fernandez Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Brain Mapp 28:1391-400. 2007..Future improvements in ASL spatial and temporal resolution would allow the benefits of both approaches to be combined to further enhance the sensitivity for detecting mTL activation during memory encoding... - Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypassThomas F Floyd
Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Cardiothorac Vasc Anesth 21:212-7. 2007..In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested... - Neural substrates of abstinence-induced cigarette cravings in chronic smokersZe Wang
Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:14035-40. 2007..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse... - Gender difference in neural response to psychological stressJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Soc Cogn Affect Neurosci 2:227-39. 2007..Our study may represent an initial step in uncovering the neurobiological basis underlying the contrasting health consequences of psychosocial stress in men and women... - A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labelingWen Chau Wu
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 58:1020-7. 2007..These improvements provide a better balance between tagging efficiency and SNR... - Hippocampus-specific fMRI group activation analysis using the continuous medial representationPaul A Yushkevich
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, 3600 Market St, Ste 370, Philadelphia, PA 19104, USA
Neuroimage 35:1516-30. 2007..Human Brain Mapping, 2(4): 189-210) at low levels of smoothing, suggesting that greater specificity can be achieved by the new method without a severe tradeoff in sensitivity... - Functional magnetic resonance imaging and working memory in adolescents with gestational cocaine exposureHallam Hurt
Department of Neonatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Pediatr 152:371-7. 2008..To assess the effect of gestational cocaine exposure on the prefrontal cortex (PFC) with functional magnetic resonance imaging (fMRI)... - Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRIWen Chau Wu
Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Physiol Heart Circ Physiol 294:H2129-36. 2008..These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance... - Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defectsTurgut Durduran
ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
J Biomed Opt 15:037004. 2010..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population... - Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohortTeresa R Franklin
Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Addict Biol 16:308-22. 2011..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs... - Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling responseBeau M Ances
Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
Brain Res 1309:19-28. 2010..Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response... - Serotonin transporter genotype modulates amygdala activity during mood regulationSeth J Gillihan
Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Soc Cogn Affect Neurosci 5:1-10. 2010.... - Hippocampal volumetry and functional MRI of memory in temporal lobe epilepsyDawn Mechanic-Hamilton
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA
Epilepsy Behav 16:128-38. 2009..These findings support continued investigation of the utility of MRI and fMRI in the presurgical evaluation of TLE... - Structure specific analysis of the hippocampus in temporal lobe epilepsySandhitsu R Das
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Hippocampus 19:517-25. 2009..Summary measurements generated by integrating quantities of interest over the entire hippocampus can also be used, as is done in conventional ROI analysis... - Appearance and incomplete label matching for diffeomorphic template based hippocampus segmentationJohn Pluta
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hippocampus 19:565-71. 2009..Thus, this approach does not require expert neuroanatomical training and is viable for high-throughput studies of both the normal and the highly atrophic hippocampus... - Function lateralization via measuring coherence lateralityZe Wang
Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
Neuroimage 47:281-8. 2009.... - Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patientsTurgut Durduran
Departments of Radiology, University of Pennsylvania, PA, USA
Opt Express 17:3884-902. 2009..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere... - A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 TPaul A Yushkevich
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 44:385-98. 2009..An example application examining subfield-level hippocampal atrophy in temporal lobe epilepsy demonstrates the application of the atlas to in vivo studies... - DAT genotype modulates brain and behavioral responses elicited by cigarette cuesTeresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
Neuropsychopharmacology 34:717-28. 2009..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues... - Neural correlates of voluntary and involuntary risk taking in the human brain: an fMRI Study of the Balloon Analog Risk Task (BART)Hengyi Rao
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 42:902-10. 2008..The present paradigm may be extended to pathological populations to determine the specific neural components of their impaired risk behavior... - Nicotine abstinence-induced cerebral blood flow changes by genotypeZe Wang
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
Neurosci Lett 438:275-80. 2008..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers... - Effects of varenicline on smoking cue–triggered neural and craving responsesTeresa Franklin
Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 68:516-26. 2011.... - Why perfusion in neonates with congenital heart defects is negative--technical issues related to pulsed arterial spin labelingJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 24:249-54. 2006.... - Functional magnetic resonance imaging in the treatment of epilepsyJoseph E Sullivan
Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
Curr Neurol Neurosci Rep 5:299-306. 2005.... - Using perfusion fMRI to measure continuous changes in neural activity with learningIngrid R Olson
Centers for Cognitive Neuroscience, CCN, and Functional Neuroimaging, CfN, University of Pennsylvania, 3400 Spruce Street, Philadelphia, 19104, USA
Brain Cogn 60:262-71. 2006..More generally, our results show that perfusion fMRI may be applied to the study of mental operations that produce gradual changes in neural activity... - Pediatric perfusion imaging using pulsed arterial spin labelingJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
J Magn Reson Imaging 18:404-13. 2003..To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T... - Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and agingThomas F Floyd
Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 76:2037-42. 2003..To better understand changes in perioperative CBF physiology we have measured changes in CBF and the influence of anemia and aging on these changes... - Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 TeslaJiongjiong Wang
Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Magn Reson Imaging 22:1-7. 2004..ASL images, either with or without subtraction of the control, provide a robust alternative to blood oxygenation level dependant (BOLD) methods for activation imaging in regions of high static field inhomogeneity... - Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetryTurgut Durduran
Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cereb Blood Flow Metab 24:518-25. 2004.... - Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 TeslaRonald L Wolf
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 22:475-82. 2005..To differentiate glioma grade based on blood flow measured using continuous arterial spin labeled (CASL) perfusion MRI, implemented at 3 Tesla for improved signal-to-noise ratio (SNR) and spin labeling effect... - Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanningAndrew B Newberg
Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Neuroimage 28:500-6. 2005..Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology... - Empirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 TJiongjiong Wang
Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neuroimage 19:1449-62. 2003.... - Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)Jiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 50:599-607. 2003..Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities... - Recurrence of stroke after cardiac surgery: insight into pathogenesis via diffusion-weighted and continuous arterial spin labeling perfusion magnetic resonance imagingThomas F Floyd
Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
J Cardiothorac Vasc Anesth 21:106-9. 2007 - Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular diseaseRonald L Wolf
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Neuroimaging 13:17-27. 2003.... - Arterial spin labeling perfusion fMRI with very low task frequencyJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Magn Reson Med 49:796-802. 2003..The improved sensitivity of the ASL contrast for low task frequency and longitudinal studies, along with its superior power in group analysis, is expected to extend the range of experimental designs that can be studied using fMRI... - Imaging brain activity during natural vision using CASL perfusion fMRIHengyi Rao
Department of Neurology, Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hum Brain Mapp 28:593-601. 2007.... - Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activationTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 29:1766-8. 2004..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored... - To smooth or not to smooth? ROC analysis of perfusion fMRI dataJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 23:75-81. 2005..In contrast to the BOLD fMRI, temporal smoothing or filtering reduces the power of perfusion fMRI data analyses whereas spatial smoothing is beneficial to the efficacy of analyses... - Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATAThomas F Floyd
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Appl Physiol 95:2453-61. 2003..Regression analysis confirmed the independent cerebral vasoconstrictive effect of increased arterial Po2. The present results also demonstrate that the magnitude of this effect at 1.0 ATA is greater than previously measured... - Strategies for reducing large fMRI data sets for independent component analysisZe Wang
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 19104, USA
Magn Reson Imaging 24:591-6. 2006..Real fMRI data were used to evaluate the PC extraction precision, computational expense, and memory usage of the presented methods... - Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility studyJiongjiong Wang
Department of Radiology, and Center for Functional Neuroimaging, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Radiology 235:218-28. 2005..Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach... - Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRIZe Wang
Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
Neuroimage 39:973-8. 2008..These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function... - Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adultsMeeri N Kim
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
Neurocrit Care 12:173-80. 2010.... - Remifentanil-induced cerebral blood flow effects in normal humans: dose and ApoE genotypeW Andrew Kofke
Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Anesth Analg 105:167-75. 2007..We tested the hypothesis that, in the absence of surgery, small doses of remifentanil produce limbic system activation in humans which varies with dose and ApoE genotype... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - Migraine and circle of Willis anomaliesBrett Cucchiara
Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, United States
Med Hypotheses 70:860-5. 2008.... - Neuroimaging, genetics and the treatment of nicotine addictionRiju Ray
Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Behav Brain Res 193:159-69. 2008..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment... - Prelude to passion: limbic activation by "unseen" drug and sexual cuesAnna Rose Childress
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e1506. 2008..recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?.. - The optimal template effect in hippocampus studies of diseased populationsBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 49:2457-66. 2010..Furthermore, explicit geometric optimization of the shape component of the unbiased template positively impacts the study of diseased hippocampi... - Age-related changes in working memory during sentence comprehension: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA
Neuroimage 15:302-17. 2002..Seniors with good comprehension appear to up-regulate portions of the neural substrate for WM during sentence processing to achieve comprehension accuracy that equals young subjects... - Support vector machine learning-based fMRI data group analysisZe Wang
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Neuroimage 36:1139-51. 2007..Providing inferences on the probability of being activated or deactivated at each voxel, these individual-level PMU-based group analysis methods can be used to threshold the analysis results of GLM RFX, SDM RFX or SDM PMU... - Genetic variation in serotonin transporter alters resting brain function in healthy individualsHengyi Rao
Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Biol Psychiatry 62:600-6. 2007..Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals... - Physiology of functional activationJohn A Detre
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:365-8. 2003 - Clinical neuroimaging using arterial spin-labeled perfusion magnetic resonance imagingRonald L Wolf
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Neurotherapeutics 4:346-59. 2007..Recent technical advances have improved the sensitivity of ASL perfusion MRI, and increasing use is expected in the coming years. The present review focuses on ASL perfusion MRI and applications in clinical neuroimaging... - Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbxZe Wang
Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 26:261-9. 2008..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets... - MR susceptometry for measuring global brain oxygen extractionMaria A Fernandez-Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 55:967-73. 2006..Unlike alternative methods, the susceptometric technique does not require calibration... - A multilayered approach to studying cortical malformations: EEG-fMRIJohn A Detre
Neurology 64:1108-10. 2005 - Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI studyTeresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Neuropsychopharmacology 32:2301-9. 2007.... - Distinctions between manipulation and function knowledge of objects: evidence from functional magnetic resonance imagingConsuelo B Boronat
Moss Rehabilitation Research Institute, Korman 213, 1200 W. Tabor Rd, Philadelphia, PA 19141, USA
Brain Res Cogn Brain Res 23:361-73. 2005..No brain regions were significantly more activated in the F than M condition. These data suggest that brain regions specialized for sensory-motor function are a critical component of distributed representations of manipulable objects... - Activation-flow coupling during graded cerebral ischemiaMark G Burnett
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, 415 Stemmler Hall, 3450 Hamilton Walk, University of Pennsylvania, Philadelphia, PA 19104-6063, USA
Brain Res 1047:112-8. 2005..However, the AFC response is also preserved when flow is reduced below ischemic thresholds... - Acute functional recovery of cerebral blood flow after forebrain ischemia in ratChao Zhou
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Cereb Blood Flow Metab 28:1275-84. 2008..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)... - Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defectsDaniel J Licht
Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Wood Building 6th Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 128:841-9. 2004..The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurologic conditions... - Functional MRI predicts post-surgical memory following temporal lobectomyMarcie L Rabin
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Brain 127:2286-98. 2004.... - Perfusion functional MRI reveals cerebral blood flow pattern under psychological stressJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:17804-9. 2005..Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response... - Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territoriesThomas F Floyd
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 18:649-55. 2003..To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals...
Research Grants
- Neuroscience neuroimaging training programJohn Detre; Fiscal Year: 2007....
- Neuroscience Neuroimaging CenterJohn Detre; Fiscal Year: 2007....
- Perfusion MRI for multisite studies of brain functionJohn Detre; Fiscal Year: 2007..The resulting technology will be made available to the biomedical community as a research product. ..
- Mentoring and research in translational neuroimagingJohn Detre; Fiscal Year: 2007....
- Perfusion fMRI in Cocaine AddictionJohn Detre; Fiscal Year: 2004..abstract_text> ..
- PHYSIOLOGY & PATHOPHYSIOLOGY OF ACTIVATION FLOW COUPLINGJohn Detre; Fiscal Year: 2002..These studies will provide further insight into the parameters affecting the AFC response, and will suggest approaches for optimizing and interpreting functional imaging data. ..
- MRI OF STRUCTURE/FUNCTION IN TEMPORAL LOBE EPILEPSYJohn Detre; Fiscal Year: 2003..Validation of an fMRI protocol for assessing memory function will improve the safety and quality of the preoperative assessment for temporal lobectomy, and may have important implications for neurosurgical planning and prognosis. ..
- Perfusion MRI for multisite studies of brain functionJohn A Detre; Fiscal Year: 2010..The resulting technology will be made available to the biomedical community as a research product. ..