John Detre

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Shape-based alignment of hippocampal subfields: evaluation in postmortem MRI
    Paul A Yushkevich
    Department of Radiology, University of Pennsylvania, USA
    Med Image Comput Comput Assist Interv 11:510-7. 2008
  2. ncbi request reprint Functional MRI and its applications to the clinical neurosciences
    J A Detre
    Departments of Neurology, Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuroscientist 7:64-79. 2001
  3. pmc Applications of arterial spin labeled MRI in the brain
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 35:1026-37. 2012
  4. ncbi request reprint Correlation of diffusion MRI and heat shock protein in a rat embolic stroke model
    J A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    J Neurol Sci 148:163-9. 1997
  5. doi request reprint Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
  6. ncbi request reprint Technical aspects and utility of fMRI using BOLD and ASL
    John A Detre
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Clin Neurophysiol 113:621-34. 2002
  7. ncbi request reprint fMRI: applications in epilepsy
    John A Detre
    Center for Functional Neuroimaging, Departments of Neurology and Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:26-31. 2004
  8. ncbi request reprint Clinical applicability of functional MRI
    John A Detre
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 23:808-15. 2006
  9. pmc Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease
    Y Chen
    Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neurology 77:1977-85. 2011
  10. ncbi request reprint Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis
    J A Detre
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Magn Reson Imaging 10:870-5. 1999

Detail Information

Publications103 found, 100 shown here

  1. pmc Shape-based alignment of hippocampal subfields: evaluation in postmortem MRI
    Paul A Yushkevich
    Department of Radiology, University of Pennsylvania, USA
    Med Image Comput Comput Assist Interv 11:510-7. 2008
    ....
  2. ncbi request reprint Functional MRI and its applications to the clinical neurosciences
    J A Detre
    Departments of Neurology, Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuroscientist 7:64-79. 2001
    ..Because the technology for fMRI is widely available, its impact could be substantial...
  3. pmc Applications of arterial spin labeled MRI in the brain
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 35:1026-37. 2012
    ..This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care...
  4. ncbi request reprint Correlation of diffusion MRI and heat shock protein in a rat embolic stroke model
    J A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    J Neurol Sci 148:163-9. 1997
    ..These findings suggest that intermediate ADC values occur in penumbral regions. Heterogeneity of ischemic cellular injury is suggested as the basis for the intermediate ADC values observed in these regions...
  5. doi request reprint Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
    ....
  6. ncbi request reprint Technical aspects and utility of fMRI using BOLD and ASL
    John A Detre
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Clin Neurophysiol 113:621-34. 2002
    ....
  7. ncbi request reprint fMRI: applications in epilepsy
    John A Detre
    Center for Functional Neuroimaging, Departments of Neurology and Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:26-31. 2004
    ....
  8. ncbi request reprint Clinical applicability of functional MRI
    John A Detre
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 23:808-15. 2006
    ....
  9. pmc Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease
    Y Chen
    Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neurology 77:1977-85. 2011
    ..We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls...
  10. ncbi request reprint Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis
    J A Detre
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Magn Reson Imaging 10:870-5. 1999
    ..J. Magn. Reson. Imaging 1999;10:870-875...
  11. ncbi request reprint Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system
    J A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Radiol 30:115-24. 1999
    ..These techniques have a broad range of potential applications in clinical and basic research of brain physiology, as well as in other organs...
  12. ncbi request reprint Signal averaged laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortex
    J A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Brain Res 796:91-8. 1998
    ..This finding was also observed during hypercapnia. Characterization of AFC in the model provides a background for future studies of the effects of pharmacological manipulation or pathophysiological states...
  13. ncbi request reprint Large-scale neural network for sentence processing
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Lang 96:14-36. 2006
    ....
  14. ncbi request reprint Neural representation of verb meaning: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Hum Brain Mapp 15:124-34. 2002
    ..We suggest that left posterolateral temporal activation supports aspects of lexical semantic processing concerned with the neural representation of propositional knowledge contributing to COGNITION verbs...
  15. ncbi request reprint Neural basis for verb processing in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neuropsychology 17:658-74. 2003
    ..These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing...
  16. ncbi request reprint Neural basis for sentence comprehension deficits in frontotemporal dementia
    Ayanna Cooke
    Department of Neurology 2 Gibson, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Brain Lang 85:211-21. 2003
    ..We conclude that FTD subgroups have distinct patterns of sentence comprehension difficulty in part because of selective interruptions of a large-scale neural network for sentence processing...
  17. ncbi request reprint The neural basis for category-specific knowledge: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neuroimage 15:936-48. 2002
    ....
  18. ncbi request reprint Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 T
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 54:1241-7. 2005
    ..The method was further improved using parallel imaging techniques to provide increased spatial resolution and better separation of the gray-white matter cerebral blood flow maps...
  19. pmc Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasks
    Junghoon Kim
    Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 1200 W Tabor Road, Philadelphia, PA 19141, USA
    Neuroimage 31:376-85. 2006
    ..Increased applications of the method to the investigation of cognitively impaired populations are expected to follow...
  20. ncbi request reprint Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Brain 126:292-311. 2003
    ..Components of the large-scale neural network underlying semantic memory may modify themselves to maintain performance in the face of a neurodegenerative disease...
  21. ncbi request reprint Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Brain Lang 80:296-313. 2002
    ..Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension...
  22. ncbi request reprint Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy
    Beau M Ances
    Department of Neurology, Department of Neurosurgery, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuroimaging 14:133-8. 2004
    ..78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization...
  23. ncbi request reprint Experimental design for functional MRI of scene memory encoding
    Veena M Narayan
    Department of Neurology and Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA
    Epilepsy Behav 6:242-9. 2005
    ..Our results suggest that although improved design augments the sensitivity of event-related designs, these benefits are not sufficient to overcome the sensitivity advantages of traditional blocked designs...
  24. ncbi request reprint Neural basis for sentence comprehension: grammatical and short-term memory components
    Ayanna Cooke
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Hum Brain Mapp 15:80-94. 2002
    ....
  25. pmc Arterial spin labeling perfusion MRI in pediatric arterial ischemic stroke: initial experiences
    Juan Chen
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 29:282-90. 2009
    ..To investigate the feasibility and utility of arterial spin labeling (ASL) perfusion MRI for characterizing alterations of cerebral blood flow (CBF) in pediatric patients with arterial ischemic stroke (AIS)...
  26. ncbi request reprint Boost up the detection sensitivity of ASL perfusion fMRI through support vector machine
    Ze Wang
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1006-9. 2006
    ..Evaluations were performed using 7 subjects' fingertapping ASL perfusion fMRI data, yielding similar activation patterns with enhanced sensitivity compared to the standard GLM based group analysis...
  27. ncbi request reprint Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Magn Reson Med 48:242-54. 2002
    ..5T functional data, with reduced fractional perfusion signal change and increased intersubject variability. Possible reasons for these experimental results, including susceptibility effects and physiological noise, are discussed...
  28. ncbi request reprint Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses
    Anne C Roc
    Center for Functional Neuroimaging, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Stroke 37:382-7. 2006
    ..Because cerebrovascular disease may result in altered CBF, we assessed the temporal dynamics and magnitude of the BOLD response in patients with major arterial stenoses...
  29. doi request reprint Physiological modulations in arterial spin labeling perfusion magnetic resonance imaging
    Wen Chau Wu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 28:703-9. 2009
    ..CASL with a labeling duration at a multiple of an R-R interval can be used to minimize signal fluctuation originating from cardiac pulsation...
  30. pmc Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study
    Junghoon Kim
    Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Neuroimage 39:1014-26. 2008
    ....
  31. pmc Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI
    Wen Chau Wu
    Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 28:445-52. 2008
    ..To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements...
  32. ncbi request reprint Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3T
    Ze Wang
    Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Med 54:732-7. 2005
    ..Such results highlight the potential utility of array coils and parallel imaging in ASL perfusion MRI...
  33. ncbi request reprint Hippocampus-specific fMRI group activation analysis with continuous M-Reps
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory, University of Pennsylvania, USA
    Med Image Comput Comput Assist Interv 9:284-91. 2006
    ..When applied to real fMRI data, the method detects more significant hippocampal activation than the established whole-brain method...
  34. ncbi request reprint Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats
    Donald G Buerk
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Neuroimage 18:1-9. 2003
    ..M. Ances et al., 2001, Neurosci. Lett. 306, 106-110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation...
  35. ncbi request reprint Neural substrates of knowledge of hand postures for object grasping and functional object use: evidence from fMRI
    Laurel J Buxbaum
    Moss Rehabilitation Research Institute, Korman 213, 1200 W Tabor Road, Philadelphia, PA 19141, USA
    Brain Res 1117:175-85. 2006
    ..These data confirm the importance of the left IPL in storing knowledge of hand postures for functional object use, and have implications for understanding the interaction of dorsal and ventral visual processing systems...
  36. ncbi request reprint Imaging mesial temporal lobe activation during scene encoding: comparison of fMRI using BOLD and arterial spin labeling
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:1391-400. 2007
    ..Future improvements in ASL spatial and temporal resolution would allow the benefits of both approaches to be combined to further enhance the sensitivity for detecting mTL activation during memory encoding...
  37. ncbi request reprint Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypass
    Thomas F Floyd
    Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 21:212-7. 2007
    ..In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested...
  38. pmc Neural substrates of abstinence-induced cigarette cravings in chronic smokers
    Ze Wang
    Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14035-40. 2007
    ..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse...
  39. pmc Gender difference in neural response to psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 2:227-39. 2007
    ..Our study may represent an initial step in uncovering the neurobiological basis underlying the contrasting health consequences of psychosocial stress in men and women...
  40. ncbi request reprint A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling
    Wen Chau Wu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 58:1020-7. 2007
    ..These improvements provide a better balance between tagging efficiency and SNR...
  41. pmc Hippocampus-specific fMRI group activation analysis using the continuous medial representation
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, 3600 Market St, Ste 370, Philadelphia, PA 19104, USA
    Neuroimage 35:1516-30. 2007
    ..Human Brain Mapping, 2(4): 189-210) at low levels of smoothing, suggesting that greater specificity can be achieved by the new method without a severe tradeoff in sensitivity...
  42. doi request reprint Functional magnetic resonance imaging and working memory in adolescents with gestational cocaine exposure
    Hallam Hurt
    Department of Neonatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Pediatr 152:371-7. 2008
    ..To assess the effect of gestational cocaine exposure on the prefrontal cortex (PFC) with functional magnetic resonance imaging (fMRI)...
  43. pmc Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI
    Wen Chau Wu
    Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 294:H2129-36. 2008
    ..These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance...
  44. pmc Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
    Turgut Durduran
    ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
    J Biomed Opt 15:037004. 2010
    ..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population...
  45. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
    ..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
  46. pmc Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response
    Beau M Ances
    Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Brain Res 1309:19-28. 2010
    ..Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response...
  47. pmc Serotonin transporter genotype modulates amygdala activity during mood regulation
    Seth J Gillihan
    Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 5:1-10. 2010
    ....
  48. pmc Hippocampal volumetry and functional MRI of memory in temporal lobe epilepsy
    Dawn Mechanic-Hamilton
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA
    Epilepsy Behav 16:128-38. 2009
    ..These findings support continued investigation of the utility of MRI and fMRI in the presurgical evaluation of TLE...
  49. pmc Structure specific analysis of the hippocampus in temporal lobe epilepsy
    Sandhitsu R Das
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 19:517-25. 2009
    ..Summary measurements generated by integrating quantities of interest over the entire hippocampus can also be used, as is done in conventional ROI analysis...
  50. doi request reprint Appearance and incomplete label matching for diffeomorphic template based hippocampus segmentation
    John Pluta
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hippocampus 19:565-71. 2009
    ..Thus, this approach does not require expert neuroanatomical training and is viable for high-throughput studies of both the normal and the highly atrophic hippocampus...
  51. pmc Function lateralization via measuring coherence laterality
    Ze Wang
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 47:281-8. 2009
    ....
  52. pmc Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients
    Turgut Durduran
    Departments of Radiology, University of Pennsylvania, PA, USA
    Opt Express 17:3884-902. 2009
    ..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere...
  53. pmc A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 T
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 44:385-98. 2009
    ..An example application examining subfield-level hippocampal atrophy in temporal lobe epilepsy demonstrates the application of the atlas to in vivo studies...
  54. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  55. doi request reprint Neural correlates of voluntary and involuntary risk taking in the human brain: an fMRI Study of the Balloon Analog Risk Task (BART)
    Hengyi Rao
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 42:902-10. 2008
    ..The present paradigm may be extended to pathological populations to determine the specific neural components of their impaired risk behavior...
  56. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
    ..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers...
  57. pmc Effects of varenicline on smoking cue–triggered neural and craving responses
    Teresa Franklin
    Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 68:516-26. 2011
    ....
  58. ncbi request reprint Why perfusion in neonates with congenital heart defects is negative--technical issues related to pulsed arterial spin labeling
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 24:249-54. 2006
    ....
  59. ncbi request reprint Functional magnetic resonance imaging in the treatment of epilepsy
    Joseph E Sullivan
    Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Neurol Neurosci Rep 5:299-306. 2005
    ....
  60. ncbi request reprint Using perfusion fMRI to measure continuous changes in neural activity with learning
    Ingrid R Olson
    Centers for Cognitive Neuroscience, CCN, and Functional Neuroimaging, CfN, University of Pennsylvania, 3400 Spruce Street, Philadelphia, 19104, USA
    Brain Cogn 60:262-71. 2006
    ..More generally, our results show that perfusion fMRI may be applied to the study of mental operations that produce gradual changes in neural activity...
  61. ncbi request reprint Pediatric perfusion imaging using pulsed arterial spin labeling
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    J Magn Reson Imaging 18:404-13. 2003
    ..To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T...
  62. ncbi request reprint Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and aging
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 76:2037-42. 2003
    ..To better understand changes in perioperative CBF physiology we have measured changes in CBF and the influence of anemia and aging on these changes...
  63. ncbi request reprint Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 Tesla
    Jiongjiong Wang
    Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    Magn Reson Imaging 22:1-7. 2004
    ..ASL images, either with or without subtraction of the control, provide a robust alternative to blood oxygenation level dependant (BOLD) methods for activation imaging in regions of high static field inhomogeneity...
  64. ncbi request reprint Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry
    Turgut Durduran
    Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 24:518-25. 2004
    ....
  65. ncbi request reprint Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 22:475-82. 2005
    ..To differentiate glioma grade based on blood flow measured using continuous arterial spin labeled (CASL) perfusion MRI, implemented at 3 Tesla for improved signal-to-noise ratio (SNR) and spin labeling effect...
  66. ncbi request reprint Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Neuroimage 28:500-6. 2005
    ..Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology...
  67. ncbi request reprint Empirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 T
    Jiongjiong Wang
    Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neuroimage 19:1449-62. 2003
    ....
  68. ncbi request reprint Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 50:599-607. 2003
    ..Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities...
  69. ncbi request reprint Recurrence of stroke after cardiac surgery: insight into pathogenesis via diffusion-weighted and continuous arterial spin labeling perfusion magnetic resonance imaging
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cardiothorac Vasc Anesth 21:106-9. 2007
  70. ncbi request reprint Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuroimaging 13:17-27. 2003
    ....
  71. ncbi request reprint Arterial spin labeling perfusion fMRI with very low task frequency
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 49:796-802. 2003
    ..The improved sensitivity of the ASL contrast for low task frequency and longitudinal studies, along with its superior power in group analysis, is expected to extend the range of experimental designs that can be studied using fMRI...
  72. ncbi request reprint Imaging brain activity during natural vision using CASL perfusion fMRI
    Hengyi Rao
    Department of Neurology, Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 28:593-601. 2007
    ....
  73. ncbi request reprint Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 29:1766-8. 2004
    ..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored...
  74. ncbi request reprint To smooth or not to smooth? ROC analysis of perfusion fMRI data
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 23:75-81. 2005
    ..In contrast to the BOLD fMRI, temporal smoothing or filtering reduces the power of perfusion fMRI data analyses whereas spatial smoothing is beneficial to the efficacy of analyses...
  75. ncbi request reprint Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 95:2453-61. 2003
    ..Regression analysis confirmed the independent cerebral vasoconstrictive effect of increased arterial Po2. The present results also demonstrate that the magnitude of this effect at 1.0 ATA is greater than previously measured...
  76. ncbi request reprint Strategies for reducing large fMRI data sets for independent component analysis
    Ze Wang
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 19104, USA
    Magn Reson Imaging 24:591-6. 2006
    ..Real fMRI data were used to evaluate the PC extraction precision, computational expense, and memory usage of the presented methods...
  77. ncbi request reprint Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study
    Jiongjiong Wang
    Department of Radiology, and Center for Functional Neuroimaging, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Radiology 235:218-28. 2005
    ..Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach...
  78. pmc Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
    Ze Wang
    Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
    Neuroimage 39:973-8. 2008
    ..These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function...
  79. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
    ....
  80. ncbi request reprint Remifentanil-induced cerebral blood flow effects in normal humans: dose and ApoE genotype
    W Andrew Kofke
    Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Anesth Analg 105:167-75. 2007
    ..We tested the hypothesis that, in the absence of surgery, small doses of remifentanil produce limbic system activation in humans which varies with dose and ApoE genotype...
  81. pmc Design of comprehensive Alzheimer's disease centers to address unmet national needs
    John Q Trojanowski
    Institute on Aging, Philadelphia, PA, USA
    Alzheimers Dement 6:150-5. 2010
    ..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders...
  82. doi request reprint Migraine and circle of Willis anomalies
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, United States
    Med Hypotheses 70:860-5. 2008
    ....
  83. pmc Neuroimaging, genetics and the treatment of nicotine addiction
    Riju Ray
    Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 193:159-69. 2008
    ..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
  84. pmc Prelude to passion: limbic activation by "unseen" drug and sexual cues
    Anna Rose Childress
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1506. 2008
    ..recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?..
  85. pmc The optimal template effect in hippocampus studies of diseased populations
    Brian B Avants
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 49:2457-66. 2010
    ..Furthermore, explicit geometric optimization of the shape component of the unbiased template positively impacts the study of diseased hippocampi...
  86. ncbi request reprint Age-related changes in working memory during sentence comprehension: an fMRI study
    Murray Grossman
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Neuroimage 15:302-17. 2002
    ..Seniors with good comprehension appear to up-regulate portions of the neural substrate for WM during sentence processing to achieve comprehension accuracy that equals young subjects...
  87. pmc Support vector machine learning-based fMRI data group analysis
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 36:1139-51. 2007
    ..Providing inferences on the probability of being activated or deactivated at each voxel, these individual-level PMU-based group analysis methods can be used to threshold the analysis results of GLM RFX, SDM RFX or SDM PMU...
  88. ncbi request reprint Genetic variation in serotonin transporter alters resting brain function in healthy individuals
    Hengyi Rao
    Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Biol Psychiatry 62:600-6. 2007
    ..Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals...
  89. ncbi request reprint Physiology of functional activation
    John A Detre
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:365-8. 2003
  90. pmc Clinical neuroimaging using arterial spin-labeled perfusion magnetic resonance imaging
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Neurotherapeutics 4:346-59. 2007
    ..Recent technical advances have improved the sensitivity of ASL perfusion MRI, and increasing use is expected in the coming years. The present review focuses on ASL perfusion MRI and applications in clinical neuroimaging...
  91. pmc Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx
    Ze Wang
    Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 26:261-9. 2008
    ..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets...
  92. ncbi request reprint MR susceptometry for measuring global brain oxygen extraction
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 55:967-73. 2006
    ..Unlike alternative methods, the susceptometric technique does not require calibration...
  93. ncbi request reprint A multilayered approach to studying cortical malformations: EEG-fMRI
    John A Detre
    Neurology 64:1108-10. 2005
  94. ncbi request reprint Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  95. ncbi request reprint Distinctions between manipulation and function knowledge of objects: evidence from functional magnetic resonance imaging
    Consuelo B Boronat
    Moss Rehabilitation Research Institute, Korman 213, 1200 W Tabor Rd, Philadelphia, PA 19141, USA
    Brain Res Cogn Brain Res 23:361-73. 2005
    ..No brain regions were significantly more activated in the F than M condition. These data suggest that brain regions specialized for sensory-motor function are a critical component of distributed representations of manipulable objects...
  96. ncbi request reprint Activation-flow coupling during graded cerebral ischemia
    Mark G Burnett
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, 415 Stemmler Hall, 3450 Hamilton Walk, University of Pennsylvania, Philadelphia, PA 19104 6063, USA
    Brain Res 1047:112-8. 2005
    ..However, the AFC response is also preserved when flow is reduced below ischemic thresholds...
  97. pmc Acute functional recovery of cerebral blood flow after forebrain ischemia in rat
    Chao Zhou
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 28:1275-84. 2008
    ..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)...
  98. ncbi request reprint Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects
    Daniel J Licht
    Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Wood Building 6th Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 128:841-9. 2004
    ..The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurologic conditions...
  99. ncbi request reprint Functional MRI predicts post-surgical memory following temporal lobectomy
    Marcie L Rabin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Brain 127:2286-98. 2004
    ....
  100. pmc Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:17804-9. 2005
    ..Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response...
  101. ncbi request reprint Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories
    Thomas F Floyd
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 18:649-55. 2003
    ..To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals...

Research Grants20

  1. Neuroscience neuroimaging training program
    John Detre; Fiscal Year: 2007
    ....
  2. Neuroscience Neuroimaging Center
    John Detre; Fiscal Year: 2007
    ....
  3. Perfusion MRI for multisite studies of brain function
    John Detre; Fiscal Year: 2007
    ..The resulting technology will be made available to the biomedical community as a research product. ..
  4. Mentoring and research in translational neuroimaging
    John Detre; Fiscal Year: 2007
    ....
  5. Perfusion fMRI in Cocaine Addiction
    John Detre; Fiscal Year: 2004
    ..abstract_text> ..
  6. PHYSIOLOGY & PATHOPHYSIOLOGY OF ACTIVATION FLOW COUPLING
    John Detre; Fiscal Year: 2002
    ..These studies will provide further insight into the parameters affecting the AFC response, and will suggest approaches for optimizing and interpreting functional imaging data. ..
  7. MRI OF STRUCTURE/FUNCTION IN TEMPORAL LOBE EPILEPSY
    John Detre; Fiscal Year: 2003
    ..Validation of an fMRI protocol for assessing memory function will improve the safety and quality of the preoperative assessment for temporal lobectomy, and may have important implications for neurosurgical planning and prognosis. ..
  8. Perfusion MRI for multisite studies of brain function
    John A Detre; Fiscal Year: 2010
    ..The resulting technology will be made available to the biomedical community as a research product. ..