Paula Desplats

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    Paula Desplats
    Department of Neuroscience, University of California San Diego, 9500 Gilman Dr, MTF 344, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 7:49. 2012
  2. pmc α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:31691-702. 2012
  3. pmc Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:9031-7. 2011
  4. pmc Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    Paula Desplats
    Department of Neurosciences and Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:13010-5. 2009
  5. pmc Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice
    Leslie Crews
    Departments of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 28:4250-60. 2008
  6. pmc Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
    Igor F Tsigelny
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 3:e3135. 2008
  7. pmc Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
    Leslie Crews
    Department of Pathology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e9313. 2010
  8. pmc In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy
    Lidia Reznichenko
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:9992-8. 2012
  9. pmc Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine
    Christina Patrick
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Am J Pathol 178:1646-61. 2011
  10. pmc Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity
    Diana L Price
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14020. 2010

Collaborators

Detail Information

Publications13

  1. pmc Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    Paula Desplats
    Department of Neuroscience, University of California San Diego, 9500 Gilman Dr, MTF 344, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 7:49. 2012
    ..While PD is characterized by neuronal loss in the substantia nigra, we previously showed that accumulation of α-synuclein in the limbic system contributes to neurodegeneration by interfering with adult neurogenesis...
  2. pmc α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:31691-702. 2012
    ..This study provides a molecular basis for α-synuclein-mediated disruption of adult neurogenesis in Parkinson disease...
  3. pmc Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:9031-7. 2011
    ..Our results underscore a novel mechanism for epigenetic dysregulation in Lewy body diseases, which might underlie the decrease in DNA methylation reported for PD and DLB...
  4. pmc Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    Paula Desplats
    Department of Neurosciences and Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:13010-5. 2009
    ..These findings demonstrate the cell-to-cell transmission of alpha-synuclein aggregates and provide critical insights into the mechanism of pathological progression in PD and other proteinopathies...
  5. pmc Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice
    Leslie Crews
    Departments of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 28:4250-60. 2008
    ..Together, these results suggest that accumulation of alpha-syn might impair survival of NPCs by interfering with the Notch signaling pathway. Similar mechanisms could be at play in PD and Lewy body disease...
  6. pmc Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
    Igor F Tsigelny
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 3:e3135. 2008
    ..However the molecular characteristics and consequences of these interactions are not completely clear...
  7. pmc Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
    Leslie Crews
    Department of Pathology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e9313. 2010
    ..For this reason, we sought to examine the expression levels of members of the autophagy pathway in brains of patients with DLB and Alzheimer's Disease (AD) and in alpha-synuclein transgenic mice...
  8. pmc In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy
    Lidia Reznichenko
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:9992-8. 2012
    ....
  9. pmc Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine
    Christina Patrick
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Am J Pathol 178:1646-61. 2011
    ..These findings indicate that abnormal CDK5 activation contributes to the neurodegenerative process in HIVE via abnormal tau phosphorylation; thus, reducing CDK5 might ameliorate the cognitive impairments associated with HIVE...
  10. pmc Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity
    Diana L Price
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14020. 2010
    ..These results highlight the therapeutic importance of mGluR5 antagonists in alpha-synucleinopathies...
  11. pmc Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission
    Eun Jin Bae
    Department of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    J Neurosci 32:13454-69. 2012
    ..These findings provide an underlying mechanistic basis for immunotherapy for PD/DLB and suggest extracellular forms of α-synuclein as potential therapeutic targets...
  12. pmc TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease
    Andreas Bender
    Department of Neurology with Friedrich Baur Institute, University of Munich, Munich, Germany
    PLoS ONE 8:e62277. 2013
    ..Our results suggest that alterations in the mitochondrial protein transport machinery might contribute to mitochondrial impairment in α-Synucleinopathies...
  13. pmc Molecular and pathologic insights from latent HIV-1 infection in the human brain
    Paula Desplats
    Department of Neurosciences, University of California San Diego, La Jolla, USA
    Neurology 80:1415-23. 2013
    ..We aimed to investigate whether HIV latency in the CNS might have adverse molecular, pathologic, and clinical consequences...