Emily A Desmet

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
  2. pmc PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells
    Kendra A Bussey
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    J Virol 85:7020-8. 2011
  3. pmc Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies
    Leslie A MacDonald
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 426:51-9. 2012
  4. pmc Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Virol 87:3108-18. 2013
  5. pmc PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
    Kendra A Bussey
    Department of Microbiology and Immunology, University of Rochester School of Medicine, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    J Virol 84:4395-406. 2010
  6. pmc Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure
    Oksana Polesskaya
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Hear Res 270:21-7. 2010
  7. pmc Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro
    Kristy M Bialas
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e50595. 2012

Collaborators

Detail Information

Publications7

  1. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
    ..These findings support a role for MLK3 in viral production during influenza infection...
  2. pmc PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells
    Kendra A Bussey
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    J Virol 85:7020-8. 2011
    ..Our results suggest that multiple mutations in PA, which were rarely present in previous influenza isolates, are involved in mammalian adaptation and pathogenicity of the 2009 pH1N1...
  3. pmc Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies
    Leslie A MacDonald
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 426:51-9. 2012
    ..These results suggest that PA-PB1 interactions induce a conformational change in PA, which could be required for its nuclear translocation...
  4. pmc Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Virol 87:3108-18. 2013
    ..Our data indicate strain variations in PA gene products, which play a major role in suppression of host protein synthesis...
  5. pmc PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
    Kendra A Bussey
    Department of Microbiology and Immunology, University of Rochester School of Medicine, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    J Virol 84:4395-406. 2010
    ..Our results clearly indicate the contribution of PB2 amino acid 271 to enhanced polymerase activity and viral growth in mammalian hosts...
  6. pmc Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure
    Oksana Polesskaya
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Hear Res 270:21-7. 2010
    ..Rather, other MLK family members such as MLK1, which is also expressed in cochlea, may have a previously unappreciated role in noise- and aminoglycoside-induced ototoxicity...
  7. pmc Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro
    Kristy M Bialas
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e50595. 2012
    ..These data suggest a direct role for pH1N1 specific M1 residues in the production and release of spherical progeny, which may contribute to the rapid spread of the pandemic virus...