Research Topics
Species | Umesh S DeshmukhSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteinsUmesh S Deshmukh
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Immunol 168:5326-32. 2002..These data have significant implications for the mechanisms of autoantibody diversification in systemic lupus erythematosus...
HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmDUmesh S Deshmukh
Division of Rheumatology and Immunology, Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
J Autoimmun 37:254-62. 2011..In addition, the novel findings reported herein may have significant implications in the pathogenesis of SLE...- Role of anti-DNA antibodies in the pathogenesis of lupus nephritisUmesh S Deshmukh
Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
Autoimmun Rev 5:414-8. 2006..Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis... - Epitope spreading within lupus-associated ribonucleoprotein antigensUmesh S Deshmukh
Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA
Clin Immunol 117:112-20. 2005..This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis... - A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreadingUmesh S Deshmukh
Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 178:2565-71. 2007..Thus caution must be taken in the identification of Ags responsible for initiating autoimmune responses based solely on serological analysis of patients and animals with systemic autoimmune disorders... - Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland functionUmesh S Deshmukh
Division of Rheumatology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Oral Pathol Med 38:42-7. 2009..As viral infections are considered to be a trigger for SS, in this study we investigated whether in vivo engagement of TLR3 affects salivary gland function... - Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responsesRahul Pal
The Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville 22908, USA
J Immunol 175:7669-77. 2005..The presence of multiple cross-reactive epitopes on Ro60 might be important for the generation of anti-Ro60 Ab in SLE patients and in normal individuals displaying no evidence of clinical disease... - Genetic complementation results in augmented autoantibody responses to lupus-associated antigensDavis L Sim
Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
J Immunol 183:3505-11. 2009..In NZM/NOD F(1) mouse, genetic complementation between NZM and NOD genes leads to expression of phenotypes similar to those seen in certain lupus patients... - Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigensChao Jiang
Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Immunol 184:1085-91. 2010..In addition, our findings provide insights into the origin of the anti-dsDNA Abs often detected in patients with systemic lupus erythematosus... - Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient miceLingjie Zheng
Department of Microbiology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
Int Immunol 20:517-23. 2008..Collectively, the data demonstrate that Treg deficiency allows polyclonal expansion of T cells in a stochastic manner, resulting in widespread changes in the TCR repertoire... - HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR moleculesTawatchai Paisansinsup
Division of Rheumatology, Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 168:5876-84. 2002..The results of the present study demonstrate the importance of HLA class II in controlling the immune responses to the Ro-ribonucleoprotein... - X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanismsRahul Sharma
Center for Inflammation, Immunity, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
J Immunol 183:3212-8. 2009..Our study demonstrates that Sf mutation affects SMG development through adaptive immunity against accessory reproductive organs, and the manifestation of SMG inflammation in Sf mice is critically controlled through innate immunity... - Mechanisms of autoantibody diversification to SLE-related autoantigensUmesh S Deshmukh
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
Ann N Y Acad Sci 987:91-8. 2003..The Ag-dependent unique patterns of Ab diversification will facilitate analyses of patients' sera. These results have implications regarding the nature of the Ag-driven autoimmune process... - Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritisSamuel T Waters
The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Exp Med 199:255-64. 2004..These results reaffirm that anti-dsDNA and related Ab production and chronic glomerulonephritis are under independent genetic control. These findings have significant implications in the pathogenesis of systemic lupus erythematosus... - Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fateRahul Sharma
Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
J Autoimmun 37:113-21. 2011..Our study has significant implications to the stability, plasticity and fate of Treg. The usefulness and limitation of iTreg-hyb as a novel tool to study Foxp3 regulation and the fate of specific Treg subsets are discussed... - Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodesHarini Bagavant
Department of Internal Medicine, Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 177:8258-65. 2006..This T cell activation and infiltration are influenced by gender-dependent end-organ factors and may determine the progression of acute GN to chronic GN and renal failure... - A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasisRahul Sharma
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 178:1251-5. 2007..Our study demonstrates the critical control of CD8(+) T(M) cell homeostasis by a Treg cell-dependent novel function of CD25 and resolves its mechanism of action... - Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 miceUmesh S Deshmukh
University of Virginia, Charlottesville, VA 22908, USA
Arthritis Rheum 58:1318-23. 2008..This study was undertaken to determine whether induction of systemic inflammation accelerates the development of Sjögren's syndrome (SS) in genetically susceptible mice... - Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DRShu Man Fu
Division of Clinical Rheumatology, University of Virginia, Charlottesville, VA 22908 0412, USA
J Autoimmun 37:104-12. 2011..This hypothesis accounts for most of the features unique to SLE and has clinical implications as to how patients should be treated... - Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant miceDan Grinnan
Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, VA 22901, USA
J Allergy Clin Immunol 118:1234-41. 2006..CLINICAL IMPLICATIONS: Disruption of chemokines responsible for trafficking of antigen-processing cells and lymphocytes to the draining lymph nodes might lead to enhanced allergic airway responses... - Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy miceRahul Sharma
Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Biomed Sci 16:20. 2009..Sf mice are also useful to determine the important inflammation process at the checkpoint after Treg regulation using genetic analysis through breeding... - Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lungC Edward Rose
Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Microcirculation 10:273-88. 2003.... - Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysisRahul Sharma
Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 181:6934-41. 2008..Our study has implications with respect to the roles of Ag and dual TCR in the selection and regulation of Treg and Treg-controlled Ag-dependent T cell expansion in TCR Tg and TCR Tg Sf mice, respectively... - IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammationRahul Sharma
Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 186:1268-78. 2011..Thus, IL-2 is potentially a master regulator for multiorgan inflammation and an underlying etiological factor for various diseases associated with skin and lung inflammation... - Pathogenesis of kidney disease in systemic lupus erythematosusHarini Bagavant
Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Curr Opin Rheumatol 21:489-94. 2009..A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis... - A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteinsSun Sang J Sung
Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
J Immunol 176:2161-72. 2006..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis... - IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammationRahul Sharma
Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 183:1065-73. 2009..IL-2 also has additional roles because the protection of skin and lung inflammation in Sf.Il2(-/-), but not Sf.CD103(-/-) mice is lifelong and Sf.Il2(-/-) mice have longer lifespan than Sf.CD103(-/-) mice... - Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signalingSeshagiri Rao Nandula
Division of Nephrology, Center for Immunity Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Oral Pathol Med 42:66-72. 2013..As a major consequence of poly(I:C) treatment is type I interferon (IFN) production, this study was undertaken to investigate their role in salivary gland dysfunction... - Mesangial pathology in glomerular disease: targets for therapeutic interventionYogesh M Scindia
Department of Medicine, University of Virginia, Charlottesville, 22908, USA
Adv Drug Deliv Rev 62:1337-43. 2010..The currently available modalities demonstrating the feasibility of mesangial cell targeting are discussed... - New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cellsHarini Bagavant
Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, 22908, USA
Curr Opin Rheumatol 17:523-8. 2005..Thus, murine models provide new insights into the pathogenesis of systemic lupus erythematosus... - Novel negative regulator of expression in Fas ligand (CD178) cytoplasmic tail: evidence for translational regulation and against Fas ligand retention in secretory lysosomesSheng Xiao
Department of Internal Medicine, Division of Rheumatology and Immunology, University of Virginia, Charlottesville 22908, USA
J Immunol 173:5095-102. 2004..Our study demonstrated a novel negative regulator of FasL expression in the FasLCyt region and its mechanism of action... - Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjögren's syndromeYukiko Ohyama
Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 177:7391-7. 2006..Thus, chronic inflammation induced by MCMV with decreased secretory function in NZM2328 mice resembles the disease manifestations of human Sjögren's syndrome... - Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy miceRahul Sharma
Department of Medicine, Division of Rheumatology and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Autoimmun 29:10-9. 2007..Various conditions that control the expression of autoimmune T cells are discussed... - Murine lung eosinophil activation and chemokine production in allergic airway inflammationC Edward Rose
Division of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Cell Mol Immunol 7:361-74. 2010.... - Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell deathSheng Xiao
Division of Rheumatology and Immunology, Department of Internal Medicine, and Special Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 278:52730-8. 2003.... - Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitisWeici Zhang
Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
Hepatology 49:545-52. 2009..These findings reflect on the importance of regulatory T cells in other murine models as well as in patients with primary biliary cirrhosis... - A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanismsLingjie Zheng
Department of Microbiology and Center of Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville 22908, USA
J Immunol 179:8035-41. 2007..Our study demonstrated a novel role of IL-2 in regulating multiorgan autoimmune inflammation beyond the Treg checkpoint and indicated that both Il2-/- and Faslpr/lpr genes prolong the lifespan of Sf mice but by different mechanisms...
Research Grants
- Genetics of Autontibody DiversificationUmesh Deshmukh; Fiscal Year: 2007..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
- T Cell Epitope Mimicry for Autoimmune Responses in SLEShu Man Fu; Fiscal Year: 2010..This will identify infectious microorganisms that can be predisposing factors for the development of an autoimmune disorder such as lupus. ..