Umesh S Deshmukh

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 168:5326-32. 2002
  2. pmc HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Autoimmun 37:254-62. 2011
  3. ncbi request reprint Epitope spreading within lupus-associated ribonucleoprotein antigens
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 117:112-20. 2005
  4. ncbi request reprint A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:2565-71. 2007
  5. pmc Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function
    Umesh S Deshmukh
    Division of Rheumatology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Oral Pathol Med 38:42-7. 2009
  6. ncbi request reprint Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Autoimmun Rev 5:414-8. 2006
  7. pmc Genetic complementation results in augmented autoantibody responses to lupus-associated antigens
    Davis L Sim
    Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 183:3505-11. 2009
  8. ncbi request reprint Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses
    Rahul Pal
    The Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 175:7669-77. 2005
  9. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
  10. pmc T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria
    Agnieszka Szymula
    Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Clin Immunol 152:1-9. 2014

Research Grants

  1. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2007
  2. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
  3. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Umesh Deshmukh; Fiscal Year: 2009
  4. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Shu Man Fu; Fiscal Year: 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 168:5326-32. 2002
    ..These data have significant implications for the mechanisms of autoantibody diversification in systemic lupus erythematosus...
  2. pmc HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Autoimmun 37:254-62. 2011
    ..In addition, the novel findings reported herein may have significant implications in the pathogenesis of SLE...
  3. ncbi request reprint Epitope spreading within lupus-associated ribonucleoprotein antigens
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 117:112-20. 2005
    ..This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis...
  4. ncbi request reprint A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:2565-71. 2007
    ..Thus caution must be taken in the identification of Ags responsible for initiating autoimmune responses based solely on serological analysis of patients and animals with systemic autoimmune disorders...
  5. pmc Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function
    Umesh S Deshmukh
    Division of Rheumatology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Oral Pathol Med 38:42-7. 2009
    ..As viral infections are considered to be a trigger for SS, in this study we investigated whether in vivo engagement of TLR3 affects salivary gland function...
  6. ncbi request reprint Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Autoimmun Rev 5:414-8. 2006
    ..Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis...
  7. pmc Genetic complementation results in augmented autoantibody responses to lupus-associated antigens
    Davis L Sim
    Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 183:3505-11. 2009
    ..In NZM/NOD F(1) mouse, genetic complementation between NZM and NOD genes leads to expression of phenotypes similar to those seen in certain lupus patients...
  8. ncbi request reprint Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses
    Rahul Pal
    The Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 175:7669-77. 2005
    ..The presence of multiple cross-reactive epitopes on Ro60 might be important for the generation of anti-Ro60 Ab in SLE patients and in normal individuals displaying no evidence of clinical disease...
  9. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..In addition, our findings provide insights into the origin of the anti-dsDNA Abs often detected in patients with systemic lupus erythematosus...
  10. pmc T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria
    Agnieszka Szymula
    Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Clin Immunol 152:1-9. 2014
    ..Thus, immune responses to commensal microbiota and opportunistic pathogens should be explored as potential triggers for initiating autoimmunity in SLE and Sjögren's syndrome...
  11. pmc Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice
    Lingjie Zheng
    Department of Microbiology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Int Immunol 20:517-23. 2008
    ..Collectively, the data demonstrate that Treg deficiency allows polyclonal expansion of T cells in a stochastic manner, resulting in widespread changes in the TCR repertoire...
  12. ncbi request reprint HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules
    Tawatchai Paisansinsup
    Division of Rheumatology, Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 168:5876-84. 2002
    ..The results of the present study demonstrate the importance of HLA class II in controlling the immune responses to the Ro-ribonucleoprotein...
  13. pmc X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms
    Rahul Sharma
    Center for Inflammation, Immunity, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Immunol 183:3212-8. 2009
    ..Our study demonstrates that Sf mutation affects SMG development through adaptive immunity against accessory reproductive organs, and the manifestation of SMG inflammation in Sf mice is critically controlled through innate immunity...
  14. ncbi request reprint Mechanisms of autoantibody diversification to SLE-related autoantigens
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann N Y Acad Sci 987:91-8. 2003
    ..The Ag-dependent unique patterns of Ab diversification will facilitate analyses of patients' sera. These results have implications regarding the nature of the Ag-driven autoimmune process...
  15. pmc Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    Samuel T Waters
    The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Exp Med 199:255-64. 2004
    ..These results reaffirm that anti-dsDNA and related Ab production and chronic glomerulonephritis are under independent genetic control. These findings have significant implications in the pathogenesis of systemic lupus erythematosus...
  16. pmc Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate
    Rahul Sharma
    Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Autoimmun 37:113-21. 2011
    ..Our study has significant implications to the stability, plasticity and fate of Treg. The usefulness and limitation of iTreg-hyb as a novel tool to study Foxp3 regulation and the fate of specific Treg subsets are discussed...
  17. ncbi request reprint Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes
    Harini Bagavant
    Department of Internal Medicine, Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:8258-65. 2006
    ..This T cell activation and infiltration are influenced by gender-dependent end-organ factors and may determine the progression of acute GN to chronic GN and renal failure...
  18. pmc Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 mice
    Umesh S Deshmukh
    University of Virginia, Charlottesville, VA 22908, USA
    Arthritis Rheum 58:1318-23. 2008
    ..This study was undertaken to determine whether induction of systemic inflammation accelerates the development of Sjögren's syndrome (SS) in genetically susceptible mice...
  19. pmc Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling
    Seshagiri Rao Nandula
    Division of Nephrology, Center for Immunity Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Oral Pathol Med 42:66-72. 2013
    ..As a major consequence of poly(I:C) treatment is type I interferon (IFN) production, this study was undertaken to investigate their role in salivary gland dysfunction...
  20. pmc Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR
    Shu Man Fu
    Division of Clinical Rheumatology, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Autoimmun 37:104-12. 2011
    ..This hypothesis accounts for most of the features unique to SLE and has clinical implications as to how patients should be treated...
  21. ncbi request reprint Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice
    Dan Grinnan
    Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, VA 22901, USA
    J Allergy Clin Immunol 118:1234-41. 2006
    ..Chemokines for these cells include the CCR7 agonists secondary lymphoid chemokine/CCL21 and EBV-induced lymphoid chemokine/CCL19, but their role in allergic asthma is poorly understood...
  22. ncbi request reprint A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis
    Rahul Sharma
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:1251-5. 2007
    ..Our study demonstrates the critical control of CD8(+) T(M) cell homeostasis by a Treg cell-dependent novel function of CD25 and resolves its mechanism of action...
  23. pmc Pathogenesis of kidney disease in systemic lupus erythematosus
    Harini Bagavant
    Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Curr Opin Rheumatol 21:489-94. 2009
    ..A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis...
  24. ncbi request reprint Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung
    C Edward Rose
    Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Microcirculation 10:273-88. 2003
    ....
  25. pmc Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice
    Rahul Sharma
    Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Biomed Sci 16:20. 2009
    ..Sf mice are also useful to determine the important inflammation process at the checkpoint after Treg regulation using genetic analysis through breeding...
  26. pmc IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation
    Rahul Sharma
    Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 186:1268-78. 2011
    ..Thus, IL-2 is potentially a master regulator for multiorgan inflammation and an underlying etiological factor for various diseases associated with skin and lung inflammation...
  27. pmc Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysis
    Rahul Sharma
    Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 181:6934-41. 2008
    ..Our study has implications with respect to the roles of Ag and dual TCR in the selection and regulation of Treg and Treg-controlled Ag-dependent T cell expansion in TCR Tg and TCR Tg Sf mice, respectively...
  28. ncbi request reprint A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  29. pmc IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation
    Rahul Sharma
    Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 183:1065-73. 2009
    ..IL-2 also has additional roles because the protection of skin and lung inflammation in Sf.Il2(-/-), but not Sf.CD103(-/-) mice is lifelong and Sf.Il2(-/-) mice have longer lifespan than Sf.CD103(-/-) mice...
  30. pmc Inhibitor of differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease
    Dominika Nackiewicz
    Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA, USA
    Nephron Exp Nephrol 126:141-7. 2014
    ..The present study was carried out to further investigate the contribution of ID3 in hyperlipidemia-associated kidney disease...
  31. pmc Mesangial pathology in glomerular disease: targets for therapeutic intervention
    Yogesh M Scindia
    Department of Medicine, University of Virginia, Charlottesville, 22908, USA
    Adv Drug Deliv Rev 62:1337-43. 2010
    ..The currently available modalities demonstrating the feasibility of mesangial cell targeting are discussed...
  32. ncbi request reprint New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells
    Harini Bagavant
    Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, 22908, USA
    Curr Opin Rheumatol 17:523-8. 2005
    ..Recent findings conflicting with the current paradigm that loss of tolerance to chromatin is the critical step for end-organ injury are discussed...
  33. ncbi request reprint Novel negative regulator of expression in Fas ligand (CD178) cytoplasmic tail: evidence for translational regulation and against Fas ligand retention in secretory lysosomes
    Sheng Xiao
    Department of Internal Medicine, Division of Rheumatology and Immunology, University of Virginia, Charlottesville 22908, USA
    J Immunol 173:5095-102. 2004
    ..Our study demonstrated a novel negative regulator of FasL expression in the FasLCyt region and its mechanism of action...
  34. pmc Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice
    Rahul Sharma
    Department of Medicine, Division of Rheumatology and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Autoimmun 29:10-9. 2007
    ..Various conditions that control the expression of autoimmune T cells are discussed...
  35. pmc Murine lung eosinophil activation and chemokine production in allergic airway inflammation
    C Edward Rose
    Division of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Cell Mol Immunol 7:361-74. 2010
    ....
  36. ncbi request reprint Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjögren's syndrome
    Yukiko Ohyama
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:7391-7. 2006
    ..Thus, chronic inflammation induced by MCMV with decreased secretory function in NZM2328 mice resembles the disease manifestations of human Sjögren's syndrome...
  37. ncbi request reprint Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death
    Sheng Xiao
    Division of Rheumatology and Immunology, Department of Internal Medicine, and Special Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:52730-8. 2003
    ....
  38. pmc Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis
    Weici Zhang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 49:545-52. 2009
    ....
  39. pmc A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms
    Lingjie Zheng
    Department of Microbiology and Center of Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville 22908, USA
    J Immunol 179:8035-41. 2007
    ..Our study demonstrated a novel role of IL-2 in regulating multiorgan autoimmune inflammation beyond the Treg checkpoint and indicated that both Il2-/- and Faslpr/lpr genes prolong the lifespan of Sf mice but by different mechanisms...

Research Grants4

  1. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2007
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  2. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  3. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Umesh Deshmukh; Fiscal Year: 2009
    ..This will identify infectious microorganisms that can be predisposing factors for the development of an autoimmune disorder such as lupus. ..
  4. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Shu Man Fu; Fiscal Year: 2010
    ..This will identify infectious microorganisms that can be predisposing factors for the development of an autoimmune disorder such as lupus. ..