Affiliation: University of North Carolina
Geden M, Romero S, Deshmukh M. Apoptosis versus Axon Pruning: Molecular Intersection of Two Distinct Pathways for Axon Degeneration. Neurosci Res. 2018;: pubmed publisher
..We outline what is known about the molecular mechanisms of apoptosis and axon pruning and focus on highlighting the similarities and differences of these two pathways. ..
Cliffe A, Arbuckle J, Vogel J, Geden M, Rothbart S, Cusack C, et al
. Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cell Host Microbe. 2015;18:649-58 pubmed publisher
..JNK is present on viral promoters during reactivation, thereby linking a neuronal-specific stress pathway and HSV reactivation from latency. ..
Gama V, Deshmukh M. Life after MOMP. Mol Cell. 2015;58:199-201 pubmed publisher
Swahari V, Nakamura A, Baran Gale J, Garcia I, Crowther A, Sons R, et al
. Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum. Cell Rep. 2016;14:216-24 pubmed publisher
..Together, these results identify an essential function of Dicer in resolving the spontaneous DNA damage that occurs during the rapid proliferation of developmental progenitors and malignant cells. ..
Geden M, Deshmukh M. Axon degeneration: context defines distinct pathways. Curr Opin Neurobiol. 2016;39:108-15 pubmed publisher
..However, the specific mechanisms by which caspases are activated during apoptosis versus pruning appear distinct, with apoptosis requiring Apaf-1 but not caspase-6 while pruning requires caspase-6 but not Apaf-1. ..
Hollville E, Deshmukh M. Physiological functions of non-apoptotic caspase activity in the nervous system. Semin Cell Dev Biol. 2018;82:127-136 pubmed publisher
Gama V, Swahari V, Schafer J, Kole A, Evans A, Huang Y, et al
. The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. Sci Signal. 2014;7:ra67 pubmed publisher
..These findings suggest that PARC-mediated ubiquitination and degradation of Cyt c is a strategy engaged by both neurons and cancer cells to prevent apoptosis during conditions of mitochondrial stress. ..
Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, SMITH S, et al
. Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. J Neurosci. 2016;36:5448-61 pubmed publisher