RIK M DERYNCK
Affiliation: University of California
Budi E, Mamaï O, Hoffman S, Akhurst R, Derynck R. Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. iScience. 2019;11:474-491 pubmed publisher
..We conclude that enhanced autocrine TGF-β signaling is integral to endothelial cell and angiogenic responses to insulin. ..
Katsuno Y, Qin J, Oses Prieto J, Wang H, Jackson Weaver O, Zhang T, et al
. Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018;293:13059-13072 pubmed publisher
..This critical mechanism positions PRMT1 as an essential mediator of TGF-β signaling that controls the EMT and epithelial cell stemness through SMAD7 methylation. ..
Derynck R, Muthusamy B, SAETEURN K. Signaling pathway cooperation in TGF-Î²-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014;31:56-66 pubmed publisher
Budi E, Muthusamy B, Derynck R. The insulin response integrates increased TGF-Î² signaling through Akt-induced enhancement of cell surface delivery of TGF-Î² receptors. Sci Signal. 2015;8:ra96 pubmed publisher
..The enhancement of TGF-Î² responsiveness in response to Akt activation may help to explain the biological effects of insulin, the progression of cancers in which Akt is activated, and the increased incidence of fibroses in diabetes. ..
Budi E, Xu J, Derynck R. Regulation of TGF-Î² Receptors. Methods Mol Biol. 2016;1344:1-33 pubmed publisher
..e., the type I (TÎ²RI) and type II (TÎ²RII) TGF-Î² receptors, and describe basic methods to identify and quantify TGF-Î² cell surface receptors. ..
Xu P, Bailey Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, et al
. Innate antiviral host defense attenuates TGF-Î² function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014;56:723-37 pubmed publisher
..WeÂ present a mechanism of regulation of TGF-Î² signaling by the antiviral defense, with evidence for its role in immune tolerance and cancer cell behavior. ..
Budi E, Duan D, Derynck R. Transforming Growth Factor-Î² Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017;27:658-672 pubmed publisher