RIK M DERYNCKSummaryAffiliation: University of California Country: USA Publications
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Publications
Differentiation plasticity regulated by TGF-beta family proteins in development and diseaseRik Derynck
Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, San Francisco, CA 94143 0512, USA
Nat Cell Biol 9:1000-4. 2007..Hence, various pathologies in adults may be considered diseases of abnormal development and differentiation...- Smad-dependent and Smad-independent pathways in TGF-beta family signallingRik Derynck
Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
Nature 425:577-84. 2003..Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses... 
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiationDong Liu
Departments of Growth and Development and Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA, USA
EMBO J 23:1557-66. 2004..These findings indicate that the TGF-beta/Smad3 pathway targets two critical components of the myogenic transcription machinery to inhibit terminal differentiation...- Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathwaySamy Lamouille
Department of Cell and Tissue Biology, Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 178:437-51. 2007..Activation of mTOR by TGF-beta, which leads to increased cell size and invasion, adds to the role of TGF-beta-induced EMT in cancer progression and may represent a therapeutic opportunity for rapamycin analogues in cancer... - Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation functionLisa Choy
Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143 0640, USA
J Biol Chem 278:9609-19. 2003..Smad3/4 did not reduce the ability of C/EBP to bind to its cognate DNA sequence, but repressed transcription by inhibiting the transactivation function of C/EBP... - Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signalingPierre S W Lee
Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
J Biol Chem 278:27853-63. 2003..These observations suggest a role for Smad4 sumoylation in the regulation of TGF-beta signaling through Smads... - Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3Jong Seok Kang
Department of Cell and Tissue Biology, Department of Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0512, USA
EMBO J 24:2543-55. 2005..Our results indicate that class IIa HDACs act as corepressors for TGF-beta/Smad3-mediated transcriptional repression of Runx2 function in differentiating osteoblasts and are cell-intrinsic regulators of osteoblast differentiation... - Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoterDenise M Piscopo
Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143, USA
J Biol Chem 284:31690-703. 2009..The expression of TRPS1 modulates mineralized bone matrix formation in differentiating osteoblast cells. These data suggest a role for TRPS1 in osteoblast differentiation, in addition to its previously described role in chondrogenesis... - Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1Tamara Alliston
Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
J Biol Chem 280:24227-37. 2005..In this way, Evi-1 acts as a general Smad corepressor to inhibit TGF-beta-, activin-, and BMP-inducible transcription... - Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoterJing Qing
Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143, USA
Mol Cell Biol 24:1411-25. 2004..Our studies underscore a role of TGF-beta/Smad3 signaling in IRF-7-mediated induction of IFN-beta expression... - The type I TGF-beta receptor is covalently modified and regulated by sumoylationJong Seok Kang
Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, California 94143, USA
Nat Cell Biol 10:654-64. 2008..T beta RI sumoylation therefore controls responsiveness to TGF-beta, with implications for tumour progression. Sumoylation of cell-surface receptors may regulate other growth factor responses... - Essential role of TGF-beta signaling in glucose-induced cell hypertrophyLiyu Wu
Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143, USA
Dev Cell 17:35-48. 2009..The consequent autocrine TGF-beta signaling in response to glucose led to Akt-TOR pathway activation. Accordingly, preventing MMP-2/MMP-9 or TGF-beta-induced TOR activation inhibited high glucose-induced cell hypertrophy... 
TGF-beta-induced epithelial to mesenchymal transitionJian Xu
Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California San Francisco, San Francisco, CA, USA
Cell Res 19:156-72. 2009..In this review, we will discuss the induction of EMT in response to TGF-beta, and focus on the underlying signaling and transcription mechanisms...- Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytesJeremy Skillington
Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 159:135-46. 2002..Finally, BMP-RIA and BMP-RIB induced osteoblast differentiation and repressed adipocytic differentiation to a similar extent... - TGF-beta regulates the mechanical properties and composition of bone matrixGuive Balooch
Graduate Program in Oral and Craniofacial Sciences, Departments of Preventive and Restorative Dental Sciences and Cell and Tissue Biology, and Programs in Cell Biology and Development, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:18813-8. 2005..Our results provide evidence that bone matrix properties are controlled by growth factor signaling... - Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organizationIsabella Imhof
Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
J Cell Sci 121:2265-74. 2008..These results provide insight into the role of CD9 in the presentation of TGFalpha in epithelial and carcinoma cells, whose physiology is driven by ligand-induced EGFR activation... - TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signalingCheng Liu
Programs in Cell Biology and Developmental Biology, Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA
Mol Cell 35:26-36. 2009..The decreased growth inhibition by TGF-beta, due to elevated TACE activity, complements the growth stimulation resulting from increased release of TGF-alpha family ligands... - New regulatory mechanisms of TGF-beta receptor functionJong Seok Kang
Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
Trends Cell Biol 19:385-94. 2009..Here, we discuss recent insights into the effects of post-translational modifications, protein associations and mode of internalization on the functions of the TGF-beta receptors and their signaling responses... - Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligandsTakatoshi Nakagawa
Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
Dev Dyn 233:1315-31. 2005..The characterization of this protein extends our understanding of the rhomboid family of regulatory proteins... - Oncogene and tumour suppressor: the two faces of SnoNSamy Lamouille
Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA, USA
EMBO J 28:3459-60. 2009..The tumour suppressor role of SnoN results from its interaction with the promyelocytic leukaemia (PML) protein and the accumulation of SnoN in PML nuclear bodies, thus allowing SnoN to stabilize p53 and induce premature senescence... - Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferationPinglong Xu
Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
Mol Cell 37:551-66. 2010..Autocrine EGF receptor activation through TACE-mediated ectodomain shedding intimately links inflammation and cancer progression and may play a role in stress and conditions that relate to p38 MAP kinase activation...
Research Grants
- TGF-Beta and Smad-mediated regulation of gene expressionRik Derynck; Fiscal Year: 2009..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
- MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALINGRik Derynck; Fiscal Year: 2003..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
- TGF-Beta Superfamily: Signaling and DevelopmentRik Derynck; Fiscal Year: 2003..Throughout the sessions special emphasis will be placed on understanding the role of TGF-beta superfamily members in contributing to human disease by analysis of developmental and biochemical model systems. ..
- FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINSRik Derynck; Fiscal Year: 2005..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..
- TGF-beta receptor sumoylation and cell behaviorRik Derynck; Fiscal Year: 2007..The proposed studies should provide a basis for the characterization of the mechanism of the TGF- beta receptor sumoylation, its role in the cell's response to TGF-beta and in cancer cell behavior and cancer progression. ..
- TGF-beta-induced non-Smad signaling events and cancer cell behaviorRIK M DERYNCK; Fiscal Year: 2010..This knowledge is likely to provide new and more selective avenues than hitherto possible to block the invasive and metastatic behavior of cancers. ..
- Functional crosstalk of TGF-beta/Smad signaling with methyl transferasesRIK M DERYNCK; Fiscal Year: 2010..e. adding methyl groups. This research program is aimed at understanding how methyl transferases regulate Smad functions. ..
- MOLECULAR CHARACTERIZATION OF TGFA ASSOCIATED PROTEINSRik Derynck; Fiscal Year: 1999....
- MOLECULAR PHYSIOLOGY OF TGF-A IN TUMOR AND NORMAL CELLSRik Derynck; Fiscal Year: 1993..g., in psoriasis, it is also our hope that this knowledge will provide a rational basis for the prevention, diagnosis and treatment of some epithelial disorders, including epithelial tumors...