RIK M DERYNCK

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    Samy Lamouille
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 178:437-51. 2007
  2. ncbi request reprint Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    Rik Derynck
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    Nat Cell Biol 9:1000-4. 2007
  3. ncbi request reprint Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    Rik Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Nature 425:577-84. 2003
  4. pmc TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation
    Dong Liu
    Departments of Growth and Development and Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA, USA
    EMBO J 23:1557-66. 2004
  5. ncbi request reprint Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    Lisa Choy
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 278:9609-19. 2003
  6. ncbi request reprint Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling
    Pierre S W Lee
    Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 278:27853-63. 2003
  7. pmc Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    Jong Seok Kang
    Department of Cell and Tissue Biology, Department of Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0512, USA
    EMBO J 24:2543-55. 2005
  8. pmc Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter
    Denise M Piscopo
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:31690-703. 2009
  9. ncbi request reprint Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
    Tamara Alliston
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    J Biol Chem 280:24227-37. 2005
  10. pmc Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter
    Jing Qing
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 24:1411-25. 2004

Collaborators

  • Rosemary Akhurst
  • Xia Lin
  • Chenbei Chang
  • Jong Seok Kang
  • Samy Lamouille
  • Cheng Liu
  • Tamara Alliston
  • Pinglong Xu
  • Jian Xu
  • Lisa Choy
  • Dong Liu
  • Denise M Piscopo
  • Liyu Wu
  • Isabella Imhof
  • Takatoshi Nakagawa
  • Guive Balooch
  • Jing Qing
  • Pierre S W Lee
  • Jeremy Skillington
  • Eric B Johansen
  • Warren J Gasper
  • Elise F Saunier
  • Grayson W Marshall
  • Tien C Ko
  • Xin Hua Feng
  • Michael Rizen
  • Hong zhong Zhang
  • Ravi K Nalla
  • Ellen H Filvaroff
  • Yao Yun Liang
  • Anne Bang
  • Diane Hu
  • Sally J Marshall
  • Annabel Guichard
  • Carolina Perez Castro
  • Ethan Bier
  • Rachel Delston
  • Jill Helms
  • Stephen Schilling
  • Mehdi Balooch
  • Robert O Ritchie
  • Yang Xiao
  • Yanna Cao
  • Rui Yun Wu
  • Joseph S Pagano

Detail Information

Publications21

  1. pmc Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    Samy Lamouille
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 178:437-51. 2007
    ..Activation of mTOR by TGF-beta, which leads to increased cell size and invasion, adds to the role of TGF-beta-induced EMT in cancer progression and may represent a therapeutic opportunity for rapamycin analogues in cancer...
  2. ncbi request reprint Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    Rik Derynck
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    Nat Cell Biol 9:1000-4. 2007
    ..Hence, various pathologies in adults may be considered diseases of abnormal development and differentiation...
  3. ncbi request reprint Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    Rik Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Nature 425:577-84. 2003
    ..Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses...
  4. pmc TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation
    Dong Liu
    Departments of Growth and Development and Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA, USA
    EMBO J 23:1557-66. 2004
    ..These findings indicate that the TGF-beta/Smad3 pathway targets two critical components of the myogenic transcription machinery to inhibit terminal differentiation...
  5. ncbi request reprint Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    Lisa Choy
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 278:9609-19. 2003
    ..Smad3/4 did not reduce the ability of C/EBP to bind to its cognate DNA sequence, but repressed transcription by inhibiting the transactivation function of C/EBP...
  6. ncbi request reprint Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling
    Pierre S W Lee
    Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 278:27853-63. 2003
    ..These observations suggest a role for Smad4 sumoylation in the regulation of TGF-beta signaling through Smads...
  7. pmc Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    Jong Seok Kang
    Department of Cell and Tissue Biology, Department of Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0512, USA
    EMBO J 24:2543-55. 2005
    ..Our results indicate that class IIa HDACs act as corepressors for TGF-beta/Smad3-mediated transcriptional repression of Runx2 function in differentiating osteoblasts and are cell-intrinsic regulators of osteoblast differentiation...
  8. pmc Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter
    Denise M Piscopo
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:31690-703. 2009
    ..The expression of TRPS1 modulates mineralized bone matrix formation in differentiating osteoblast cells. These data suggest a role for TRPS1 in osteoblast differentiation, in addition to its previously described role in chondrogenesis...
  9. ncbi request reprint Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
    Tamara Alliston
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    J Biol Chem 280:24227-37. 2005
    ..In this way, Evi-1 acts as a general Smad corepressor to inhibit TGF-beta-, activin-, and BMP-inducible transcription...
  10. pmc Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter
    Jing Qing
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 24:1411-25. 2004
    ..Our studies underscore a role of TGF-beta/Smad3 signaling in IRF-7-mediated induction of IFN-beta expression...
  11. pmc The type I TGF-beta receptor is covalently modified and regulated by sumoylation
    Jong Seok Kang
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, California 94143, USA
    Nat Cell Biol 10:654-64. 2008
    ..T beta RI sumoylation therefore controls responsiveness to TGF-beta, with implications for tumour progression. Sumoylation of cell-surface receptors may regulate other growth factor responses...
  12. pmc Essential role of TGF-beta signaling in glucose-induced cell hypertrophy
    Liyu Wu
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143, USA
    Dev Cell 17:35-48. 2009
    ..The consequent autocrine TGF-beta signaling in response to glucose led to Akt-TOR pathway activation. Accordingly, preventing MMP-2/MMP-9 or TGF-beta-induced TOR activation inhibited high glucose-induced cell hypertrophy...
  13. doi request reprint TGF-beta-induced epithelial to mesenchymal transition
    Jian Xu
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California San Francisco, San Francisco, CA, USA
    Cell Res 19:156-72. 2009
    ..In this review, we will discuss the induction of EMT in response to TGF-beta, and focus on the underlying signaling and transcription mechanisms...
  14. pmc Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
    Jeremy Skillington
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 159:135-46. 2002
    ..Finally, BMP-RIA and BMP-RIB induced osteoblast differentiation and repressed adipocytic differentiation to a similar extent...
  15. pmc TGF-beta regulates the mechanical properties and composition of bone matrix
    Guive Balooch
    Graduate Program in Oral and Craniofacial Sciences, Departments of Preventive and Restorative Dental Sciences and Cell and Tissue Biology, and Programs in Cell Biology and Development, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:18813-8. 2005
    ..Our results provide evidence that bone matrix properties are controlled by growth factor signaling...
  16. ncbi request reprint Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization
    Isabella Imhof
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Cell Sci 121:2265-74. 2008
    ..These results provide insight into the role of CD9 in the presentation of TGFalpha in epithelial and carcinoma cells, whose physiology is driven by ligand-induced EGFR activation...
  17. pmc TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling
    Cheng Liu
    Programs in Cell Biology and Developmental Biology, Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 35:26-36. 2009
    ..The decreased growth inhibition by TGF-beta, due to elevated TACE activity, complements the growth stimulation resulting from increased release of TGF-alpha family ligands...
  18. doi request reprint New regulatory mechanisms of TGF-beta receptor function
    Jong Seok Kang
    Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Cell Biol 19:385-94. 2009
    ..Here, we discuss recent insights into the effects of post-translational modifications, protein associations and mode of internalization on the functions of the TGF-beta receptors and their signaling responses...
  19. ncbi request reprint Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands
    Takatoshi Nakagawa
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    Dev Dyn 233:1315-31. 2005
    ..The characterization of this protein extends our understanding of the rhomboid family of regulatory proteins...
  20. pmc Oncogene and tumour suppressor: the two faces of SnoN
    Samy Lamouille
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA, USA
    EMBO J 28:3459-60. 2009
    ..The tumour suppressor role of SnoN results from its interaction with the promyelocytic leukaemia (PML) protein and the accumulation of SnoN in PML nuclear bodies, thus allowing SnoN to stabilize p53 and induce premature senescence...
  21. doi request reprint Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
    Pinglong Xu
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 37:551-66. 2010
    ..Autocrine EGF receptor activation through TACE-mediated ectodomain shedding intimately links inflammation and cancer progression and may play a role in stress and conditions that relate to p38 MAP kinase activation...

Research Grants36

  1. TGF-Beta and Smad-mediated regulation of gene expression
    Rik Derynck; Fiscal Year: 2009
    ..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
  2. TGF-beta-induced non-Smad signaling events and cancer cell behavior
    Rik Derynck; Fiscal Year: 2009
    ..This knowledge is likely to provide new and more selective avenues than hitherto possible to block the invasive and metastatic behavior of cancers. ..
  3. TGF-Beta and Smad-mediated regulation of gene expression
    Rik Derynck; Fiscal Year: 2004
    ..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
  4. MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALING
    Rik Derynck; Fiscal Year: 2000
    ..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
  5. FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 2001
    ..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..
  6. TGF-beta receptor sumoylation and cell behavior
    Rik Derynck; Fiscal Year: 2007
    ..The proposed studies should provide a basis for the characterization of the mechanism of the TGF- beta receptor sumoylation, its role in the cell's response to TGF-beta and in cancer cell behavior and cancer progression. ..
  7. MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALING
    Rik Derynck; Fiscal Year: 2003
    ..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
  8. TGF-Beta Superfamily: Signaling and Development
    Rik Derynck; Fiscal Year: 2003
    ..Throughout the sessions special emphasis will be placed on understanding the role of TGF-beta superfamily members in contributing to human disease by analysis of developmental and biochemical model systems. ..
  9. MOLECULAR PHYSIOLOGY OF TGF-A IN TUMOR AND NORMAL CELLS
    Rik Derynck; Fiscal Year: 1992
    ..g., in psoriasis, it is also our hope that this knowledge will provide a rational basis for the prevention, diagnosis and treatment of some epithelial disorders, including epithelial tumors...
  10. MOLECULAR CHARACTERIZATION OF TGFA ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 1999
    ....
  11. Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    RIK M DERYNCK; Fiscal Year: 2010
    ..e. adding methyl groups. This research program is aimed at understanding how methyl transferases regulate Smad functions. ..
  12. FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 2005
    ..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..
  13. TGF-Beta and Smad-mediated regulation of gene expression
    Rik Derynck; Fiscal Year: 2007
    ..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
  14. TGF-beta-induced non-Smad signaling events and cancer cell behavior
    RIK M DERYNCK; Fiscal Year: 2010
    ..This knowledge is likely to provide new and more selective avenues than hitherto possible to block the invasive and metastatic behavior of cancers. ..
  15. TGF-Beta and Smad-mediated regulation of gene expression
    Rik Derynck; Fiscal Year: 2006
    ..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
  16. TGF-Beta and Smad-mediated regulation of gene expression
    Rik Derynck; Fiscal Year: 2005
    ..Mutation analyses of IRF-3/7, based on the three-dimensional IRF-3, structure will assist in these investigations. ..
  17. MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALING
    Rik Derynck; Fiscal Year: 1999
    ..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
  18. MOLECULAR PHYSIOLOGY OF TGF-A IN TUMOR AND NORMAL CELLS
    Rik Derynck; Fiscal Year: 1993
    ..g., in psoriasis, it is also our hope that this knowledge will provide a rational basis for the prevention, diagnosis and treatment of some epithelial disorders, including epithelial tumors...
  19. MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALING
    Rik Derynck; Fiscal Year: 2001
    ..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
  20. FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 2002
    ..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..
  21. MECHANISMS OF TGF B RECEPTOR AND SMAD SIGNALING
    Rik Derynck; Fiscal Year: 2002
    ..Our findings should help us understand the role of TGF-beta receptor signaling in normal and tumor development, and in the regulation of cell growth and differentiation. ..
  22. FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 2003
    ..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..
  23. FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    Rik Derynck; Fiscal Year: 2004
    ..Aim 4 focuses on the functional characterization of p59, a PDZ containing protein implicated in TM TGF-a transport through the Golgi ..