R Derynck

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1
    S Lawler
    Department of Growth and Development, University of California, San Francisco 94143 0640
    Development 120:165-75. 1994
  2. pmc TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    D Liu
    Department of Growth and Development, University of California at San Francisco, 94143, USA
    Genes Dev 15:2950-66. 2001
  3. pmc Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation
    L Choy
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, California 94143 0640, USA
    J Cell Biol 149:667-82. 2000
  4. pmc Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
    Jeremy Skillington
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 159:135-46. 2002
  5. ncbi TGF-beta receptor signaling
    R Derynck
    Department of Growth and Development, University of California at San Francisco, 94143 0640, USA
    Biochim Biophys Acta 1333:F105-50. 1997
  6. ncbi TGF-beta signaling in tumor suppression and cancer progression
    R Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 29:117-29. 2001
  7. ncbi Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    Rik Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Nature 425:577-84. 2003
  8. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
  9. ncbi The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response
    L Choy
    Departments of Growth and Development, and Anatomy, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, California 94143 0640, USA
    J Biol Chem 273:31455-62. 1998
  10. ncbi The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues
    S Lawler
    Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 272:14850-9. 1997

Collaborators

Detail Information

Publications53

  1. ncbi The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1
    S Lawler
    Department of Growth and Development, University of California, San Francisco 94143 0640
    Development 120:165-75. 1994
    ....
  2. pmc TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    D Liu
    Department of Growth and Development, University of California at San Francisco, 94143, USA
    Genes Dev 15:2950-66. 2001
    ..Together, these results reveal a model for how TGF-beta, through Smad3-mediated transcriptional repression, inhibits myogenic differentiation...
  3. pmc Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation
    L Choy
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, California 94143 0640, USA
    J Cell Biol 149:667-82. 2000
    ..Smad6 and Smad7 act as negative regulators of adipogenesis and, even though known to inhibit TGF-beta responses, enhance the effects of TGF-beta on these cells...
  4. pmc Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
    Jeremy Skillington
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 159:135-46. 2002
    ..Finally, BMP-RIA and BMP-RIB induced osteoblast differentiation and repressed adipocytic differentiation to a similar extent...
  5. ncbi TGF-beta receptor signaling
    R Derynck
    Department of Growth and Development, University of California at San Francisco, 94143 0640, USA
    Biochim Biophys Acta 1333:F105-50. 1997
  6. ncbi TGF-beta signaling in tumor suppression and cancer progression
    R Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 29:117-29. 2001
    ..Here we evaluate the role of TGF-beta in tumor development and attempt to reconcile the positive and negative effects of TGF-beta in carcinogenesis...
  7. ncbi Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    Rik Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Nature 425:577-84. 2003
    ..Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses...
  8. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
    ..This mechanism of transcriptional activation by TGF-beta, through functional and physical interactions between Smad3-Smad4 and c-Jun-c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites...
  9. ncbi The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response
    L Choy
    Departments of Growth and Development, and Anatomy, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, California 94143 0640, USA
    J Biol Chem 273:31455-62. 1998
    ..Expression of other segments of TRIP-1 increased the TGF-beta-induced gene expression response and therefore may exert a dominant negative phenotype. We conclude that TRIP-1 acts as a modulator of the TGF-beta response...
  10. ncbi The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues
    S Lawler
    Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 272:14850-9. 1997
    ..These results demonstrate that the type II TGF-beta receptor can function as a dual specificity kinase and suggest a role for tyrosine autophosphorylation in TGF-beta receptor signaling...
  11. pmc TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    T Alliston
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, San Francisco, CA 94143-0640, USA
    EMBO J 20:2254-72. 2001
    ..Altering Smad3 signaling influenced osteoblast differentiation in the presence or absence of TGF-beta, implicating Smad3/TGF-beta-mediated repression in autocrine regulation of osteoblast differentiation...
  12. pmc Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A
    I Griswold-Prenner
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Mol Cell Biol 18:6595-604. 1998
    ..Because Balpha has been characterized as a regulator of phosphatase 2A activity, our observations suggest possible functional interactions between the TGF-beta receptor complex and the regulation of protein phosphatase 2A...
  13. ncbi Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass
    E Filvaroff
    Department of Growth, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 126:4267-79. 1999
    ..Our results demonstrate that endogenous TGF-beta acts directly on osteoblasts to regulate bone remodeling, structure and biomechanical properties...
  14. pmc Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0640, USA
    EMBO J 19:5178-93. 2000
    ..These findings explain the tumor suppressor roles of Smad2 and Smad4 in growth arrest signaling by TGF-beta...
  15. pmc Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
    R Y Wu
    Department of Growth and Development, University of California at San Francisco, 94143 0640, USA
    Mol Cell Biol 17:2521-8. 1997
    ..These results correlate the ability of individual Smads to homomerize with transcriptional activation and additionally with their biological activity in mammalian cells...
  16. ncbi Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor
    R Ebner
    Department of Growth and Development, University of California, San Francisco 94143 0640
    Science 260:1344-8. 1993
    ..Combinatorial interactions and stoichiometric ratios between the type I and II receptors may therefore determine the extent of TGF-beta binding and the resulting biological activities...
  17. pmc Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55
    A Kuo
    Departments of Growth and Development, and Anatomy, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0640, USA
    EMBO J 19:6427-39. 2000
    ..Our observations suggest a role for membrane tethering of p59/GRASP55 to select transmembrane proteins, including TGF-alpha, in maturation and transport to the cell surface...
  18. ncbi Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
    Y Zhang
    Department of Growth and Development, University of California at San Francisco, 94143 0640, USA
    Nature 383:168-72. 1996
    ..These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor...
  19. ncbi Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine 90095, USA
    Eur J Neurosci 11:3236-46. 1999
    ..These findings indicate that HB-EGF may be an important trophic factor in the developing CNS and is a useful candidate molecule for brain repair strategies...
  20. ncbi Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities
    R H Chen
    Department of Growth and Development, University of California, San Francisco 94143
    Science 260:1335-8. 1993
    ..Selective inactivation of the type II receptors alters the TGF-beta response in a similar manner to the functional inactivation of pRB, suggesting a role for pRB in the type II, but not the type I, receptor pathway...
  21. ncbi Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells
    D Gazit
    Department of Growth and Development, University of California, San Francisco 94143 0640
    Mol Endocrinol 7:189-98. 1993
    ..These data also establish the C26 and 10T1/2 cell lines as convenient in vitro model systems for exploring the autoregulation of osteogenic differentiation by members of the TGF beta superfamily...
  22. ncbi Intracellular signalling: the mad way to do it
    R Derynck
    Department of Growth and Development, University of California at San Francisco 94143 0640, USA
    Curr Biol 6:1226-9. 1996
    ..Like the prototype Drosophila protein Mad, many members of the family play key roles in developmental signalling...
  23. pmc The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143 0640 USA
    Genes Dev 12:2153-63. 1998
    ..The coactivator functions and physical interactions of Smad4 and CBP/p300 with Smad3 allow a model for the induction of gene expression in response to TGF-beta...
  24. ncbi The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
    Y Zhang
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Curr Biol 7:270-6. 1997
    ....
  25. ncbi Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine, 90095, USA
    J Neurosci Res 53:697-717. 1998
    ..These data demonstrate that EGF-R expression is critical for the maintenance of large portions of the postnatal mouse forebrain as well as the normal development of astrocytes...
  26. pmc Osteoblastic responses to TGF-beta during bone remodeling
    A Erlebacher
    Departments of Growth and Development, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Biol Cell 9:1903-18. 1998
    ..These results suggest that TGF-beta is a physiological regulator of osteoblast differentiation and acts as a central component of the coupling of bone formation to resorption during bone remodeling...
  27. ncbi Impaired lung branching morphogenesis in the absence of functional EGF receptor
    P J Miettinen
    Department of Growth and Development, University of California at San Francisco, 94143, USA
    Dev Biol 186:224-36. 1997
    ..Taken together, our data indicate that signal transduction through the EGF receptor plays a major role in lung development and that its inactivation leads to a respiratory distress-like syndrome...
  28. ncbi Regulation of Smad signalling by protein associations and signalling crosstalk
    Y Zhang
    Depts of Growth and Development, and Anatomy, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0640, USA
    Trends Cell Biol 9:274-9. 1999
    ..This signalling crosstalk might explain the complexity of the responses to TGF-beta and related factors...
  29. ncbi Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
    P J Miettinen
    Department of Growth and Development, University of California, San Francisco 94143 0452, USA
    Nat Genet 22:69-73. 1999
    ....
  30. ncbi Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors
    X H Feng
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143, USA
    J Biol Chem 271:13123-9. 1996
    ..Our results indicate that the cytoplasmic domains of the type I and type II TGF-beta receptors physically and functionally interact with each other in the heteromeric complex...
  31. ncbi TGF-beta signaling in cancer--a double-edged sword
    R J Akhurst
    Mt Zion Cancer Research Institute, University of California at San Francisco, San Francisco, CA 94143 0875, USA
    Trends Cell Biol 11:S44-51. 2001
    ..Therapeutic approaches should aim to inhibit the TGF-beta-induced invasive phenotype, but also to retain its growth-inhibitory and apoptosis-inducing effects...
  32. pmc Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation
    M H Verlhac
    Department of Growth and Development, University of California at San Francisco, San Francisco, CA 94143 0640, USA
    EMBO J 16:6812-22. 1997
    ..Our results provide support for both physical and functional interactions between three subunits, TIF34, PRT1 and p33, in the eIF3 complex...
  33. ncbi A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor
    R H Chen
    Department of Growth and Development, University of California at San Francisco 94143 0640, USA
    Nature 377:548-52. 1995
    ..This is supported by coexpression of TRIP-1 and type II receptor during development. The existence of TRIP-1 homologues in plant and yeast suggests a conserved function in all eukaryotes...
  34. ncbi Structure and sequence of the mouse Bmp6 gene
    S E Gitelman
    Department of Pediatrics, Box 0136, MU East Rm 405, 500 Parnassus Avenue, University of California at San Francisco, San Francisco, California 94143, USA
    Mamm Genome 8:212-4. 1997
  35. ncbi Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association
    L Shum
    Department of Growth and Development, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 271:28502-8. 1996
    ..The palmitoylation of these cysteines suggests a possibly dynamic role of fatty acid modification in the integrity and function of the transmembrane TGF-alpha complex...
  36. ncbi Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    P J Miettinen
    Department of Growth and Development, University of California, San Francisco 94143 0640, USA
    Nature 376:337-41. 1995
    ..We find that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract...
  37. ncbi Nomenclature: vertebrate mediators of TGFbeta family signals
    R Derynck
    Cell 87:173. 1996
  38. pmc Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    R Serra
    Department of Cell Biology and the Vanderbilt Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Cell Biol 139:541-52. 1997
    ..Loss of responsiveness to TGF-beta promotes chondrocyte terminal differentiation and results in development of degenerative joint disease resembling osteoarthritis in humans...
  39. pmc Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition
    X J Wang
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:2386-91. 1997
    ..These data document the role of the type II TGF-beta receptor in mediating TGF-beta-induced growth inhibition of the epidermis in vivo and in maintenance of epidermal homeostasis...
  40. pmc Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region
    B A Arrick
    Department of Developmental Biology, Genentech Inc, South San Francisco, California 94080
    Mol Cell Biol 11:4306-13. 1991
    ..Thus, TGF-beta 3 mRNA is a recent example of an expanding group of growth-related mRNAs in which the 5' untranslated region contains upstream open reading frames and other sequences which inhibit translation...
  41. ncbi Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues
    D A Miller
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Endocrinol 3:1926-34. 1989
    ..5-17.5 days postcoitum, with higher levels observed in the latter stages. The differential expression of these TGF beta genes suggests that the various TGF beta species may have distinct physiological roles in vivo...
  42. pmc Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily
    K Lyons
    Department of Developmental Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 86:4554-8. 1989
    ..The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development...
  43. ncbi Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos
    D A Miller
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Endocrinol 3:1108-14. 1989
    ..The patterns of expression suggest a physiological role for TGF-beta 2 both in embryonic development and in the maintenance of adult tissues...
  44. ncbi The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins
    P Oquendo
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    J Biol Chem 264:4133-7. 1989
    ..By extension, the KC protein is the murine counterpart of the protein encoded by the gro gene. The gro protein corresponds to a factor described as "melanoma growth-stimulating activity."..
  45. ncbi Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells
    R Derynck
    Nature 316:701-5. 1985
    ..TGF-beta messenger RNA is synthesized in various normal and transformed cells...
  46. pmc Sequence of the porcine transforming growth factor-beta precursor
    R Derynck
    Nucleic Acids Res 15:3187. 1987
  47. ncbi Human transforming growth factor-alpha: precursor structure and expression in E. coli
    R Derynck
    Cell 38:287-97. 1984
    ..The 50 amino acid mature TGF-alpha produced by expression of the appropriate coding sequence in E. coli binds to the epidermal growth factor receptor and induces the anchorage independence of normal mammalian cells in culture...
  48. ncbi Expression of human immune interferon cDNA in E. coli and monkey cells
    P W Gray
    Nature 295:503-8. 1982
  49. ncbi Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
    D Pennica
    Nature 312:724-9. 1984
    ..Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice...
  50. ncbi Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor
    E H Filvaroff
    Department of Growth and Development, University of California at San Francisco 94143 0640
    Development 120:1085-95. 1994
    ..We propose that TGF-beta signaling through the type II receptor is required for several distinct aspects of myogenic differentiation and that TGF-beta acts as a competence factor in this multistep process...
  51. ncbi Determination of type I receptor specificity by the type II receptors for TGF-beta or activin
    R Ebner
    Departments of Growth and Development, and Anatomy, University of California at San Francisco 94143 0640
    Science 262:900-2. 1993
    ..Tsk 7L can therefore act as type I receptor for both activin and TGF-beta, and possibly other ligands...
  52. pmc Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
    Y Zhang
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:974-9. 2001
    ....