Research Topics
| ROBERT DERUBEISSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Cognitive therapy vs medications in the treatment of moderate to severe depressionRobert J Derubeis
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 62:409-16. 2005..There is substantial evidence that antidepressant medications treat moderate to severe depression effectively, but there is less data on cognitive therapy's effects in this population...
Cognitive therapy versus medication for depression: treatment outcomes and neural mechanismsRobert J Derubeis
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Neurosci 9:788-96. 2008..A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes...- Empirically supported individual and group psychological treatments for adult mental disordersR J DeRubeis
Department of Psychology, University of Pennsylvania, Philadelphia 19104 1696, USA
J Consult Clin Psychol 66:37-52. 1998..Continued research is recommended on Aptitude x Treatment interactions, cost-benefit ratios, and generalization of treatments to a variety of patient populations, therapists, and treatment settings... - Medications versus cognitive behavior therapy for severely depressed outpatients: mega-analysis of four randomized comparisonsR J DeRubeis
Department of Psychology, University of Pennsylvania, Philadelphia 19104 6196, USA
Am J Psychiatry 156:1007-13. 1999.... - Determining the pertinence of psychotherapy outcome research findings for clinical practice: comment on Westen and Morrison (2001)R J DeRubeis
Department of Psychology, University of Pennsylvania, Philadelphia 19104 1696, USA
J Consult Clin Psychol 69:908-9. 2001..Continued dialogue between proponents and opponents of contemporary trends in psychotherapy outcome research is encouraged... - High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levelsE P Zorrilla
Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA
Psychoneuroendocrinology 20:591-601. 1995..The present findings suggest that individual differences in basal HPA-function are associated with individual differences in psychological functioning following stress... - Change in compensatory skills in cognitive therapy for depressionJ P Barber
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
J Psychother Pract Res 10:8-13. 2001..The WOR appears to be a sensitive measure of change during CT that covaries with change in depression. It remains to be tested whether change on the WOR is specific to CT... - Reliability and validity of a daily diary for premenstrual syndromeE W Freeman
Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Psychiatry Res 65:97-106. 1996..The moderate correlations of the DSR with other standard symptom measures add to the evidence that PMS overlaps with other mood disorders at the premenstrual time but is not simply a brief depression or a truncated anxiety disorder... - Sudden gains and critical sessions in cognitive-behavioral therapy for depressionT Z Tang
Department of Psychology, University of Pennsylvania, Philadelphia 19104 1696, USA
J Consult Clin Psychol 67:894-904. 1999.... - The factor structure of the working alliance inventory in cognitive-behavioral therapyT P Andrusyna
Department of Psychiatry, Center for Psychotherapy Research, University of Pennsylvania School of Medicine, 3535 Market St, Philadelphia, PA 19104, USA
J Psychother Pract Res 10:173-8. 2001.... 
Can pharmacotherapists be too supportive? A process study of active medication and placebo in the treatment of depressionD R Strunk
Department of Psychology, Ohio State University, Columbus, OH 43210, USA
Psychol Med 40:1379-87. 2010..This study examined therapist-patient interactions during clinical management with antidepressant medication and pill-placebo...- Patients' competence in and performance of cognitive therapy skills: relation to the reduction of relapse risk following treatment for depressionDaniel R Strunk
Department of Psychology, Ohio State University, Columbus, OH 43210, USA
J Consult Clin Psychol 75:523-30. 2007..Thus, CT coping skills and independent use of CT principles, but not overall satisfaction with oneself, appear to play an important role in relapse prevention... - Antidepressant medications v. cognitive therapy in people with depression with or without personality disorderJay C Fournier
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104 6196, USA
Br J Psychiatry 192:124-9. 2008..There is conflicting evidence about comorbid personality pathology in depression treatments... - The relation of patients' treatment preferences to outcome in a randomized clinical trialYan Leykin
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Behav Ther 38:209-17. 2007..These results do not provide support for the claim that the external validity of randomized controlled trials suffers from this aspect of the randomization procedure... - Anxiety symptom focus in sessions of cognitive therapy for depressionCarly J Gibbons
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6196, USA
Behav Ther 39:117-25. 2008..Irrespective of intake anxiety level, more time and effort spent addressing anxiety in session was found to predict less improvement in both depression and anxiety symptoms over the course of treatment... - Are samples in randomized controlled trials of psychotherapy representative of community outpatients? A new methodology and initial findingsShannon Wiltsey Stirman
Department of Psychology, University of Pennsylvania, Philadelphia 19104 6193, USA
J Consult Clin Psychol 71:963-72. 2003..The most common reasons that patients in their sample did not match with published RCTs for psychotherapy are listed, and the implications of these findings for research and practice are discussed... - Progressive resistance to a selective serotonin reuptake inhibitor but not to cognitive therapy in the treatment of major depressionYan Leykin
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104 6196, USA
J Consult Clin Psychol 75:267-76. 2007..If these findings are replicated in methodologically rigorous studies of paroxetine and other antidepressants, CT should be recommended, in preference to AD, for patients with multiple prior AD exposures... - Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressantsMohit P Chopra
Department of Psychiatry, 3535 Market Street, Room 3023, Philadelphia, PA 19104, USA
Biol Psychiatry 55:957-9. 2004..CONCLUSIONS: The CT group was resistant to the effects of tryptophan depletion, but the SSRI group was not... - Reducing exposure of clinical research subjects to placebo treatmentsRonald E S Noble
University of Pennsylvania, Philadelphia, PA 19104-6196, USA
J Clin Psychol 61:881-92. 2005..Group sequential methods involve successive looks at accumulating data, with rules for terminating a trial (or an arm of a trial) early if results are strong enough... - Prevention of relapse following cognitive therapy vs medications in moderate to severe depressionSteven D Hollon
Department of Psychology, Vanderbilt University, 306 Wilson Hall Nashville, TN 37203, USA
Arch Gen Psychiatry 62:417-22. 2005..Antidepressant medication prevents the return of depressive symptoms, but only as long as treatment is continued... - Can the randomized controlled trial literature generalize to nonrandomized patients?Shannon Wiltsey Stirman
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104 6196, USA
J Consult Clin Psychol 73:127-35. 2005..The implications of these findings for future research and clinical practice are discussed... - Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapySunil S Bhar
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Affect Disord 110:161-6. 2008..The authors examined the patterns of improvement in cognitive and vegetative symptoms of major depression in individuals treated with cognitive therapy (CT) or pharmacotherapy (PT)... - Cognitive changes, critical sessions, and sudden gains in cognitive-behavioral therapy for depressionTony Z Tang
Department of Psychology, Northwestern University, Evanston, IL 60208, USA
J Consult Clin Psychol 73:168-72. 2005..75 and found that these CBT sudden gains were also preceded by substantial cognitive changes in the pregain sessions... - Sudden gains in cognitive therapy of depression and depression relapse/recurrenceTony Z Tang
Department of Psychology, Northwestern University, Chicago, IL 60208, USA
J Consult Clin Psychol 75:404-8. 2007..The current authors' findings suggest that CT sudden gains are not measurement artifacts, and that sudden gains and their causes and consequences might be important in preventing relapses... - Depressive symptoms are associated with unrealistic negative predictions of future life eventsDaniel R Strunk
Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104 6196, USA
Behav Res Ther 44:861-82. 2006..General imprecision in predictions for undesirable events was associated with depressive symptoms. These findings suggest that depression is associated with pessimistic bias rather than accuracy in judgment...
Research Grants
- Prevention of Recurrence in Depression with Drugs and CTRobert J Derubeis; Fiscal Year: 2010....
- Prevention of Recurrence in Depression with Drugs and CTROBERT DERUBEIS; Fiscal Year: 2009....
- Prevention of Recurrence in Depression with Drugs and CTROBERT DERUBEIS; Fiscal Year: 2007....
- Prevention of Recurrence in Depression with Drugs and CTROBERT DERUBEIS; Fiscal Year: 2006..Analyses will be employed to estimate the relative cost-effectiveness of adding CT to ADM for acute response and recurrence prevention. ..
- Prevention of Recurrence in Depression with Drugs and CTRobert J Derubeis; Fiscal Year: 2010..In addition, mechanisms and processes that influence outcome will be studied, which will have the potential to lead to new treatment approaches and further improved outcomes. ..