Research Topics
| VOJO P DERETICSummaryAffiliation: University of New Mexico Country: USA Publications
Research Grants
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Detail Information
Publications
Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIVVojo Deretic
Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
Cell Microbiol 6:999-1009. 2004..We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases--AIDS and tuberculosis...- Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanismVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
Cell Microbiol 8:719-27. 2006..tuberculosis survival. This review summarizes the findings centred around the PI3P-nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect... - Autophagy as an immune defense mechanismVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Curr Opin Immunol 18:375-82. 2006..We propose the term immunophagy for these defense processes... - Autophagy in immune defense against Mycobacterium tuberculosisIsabelle Vergne
Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
Autophagy 2:175-8. 2006..Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated... 
Autophagy and pattern recognition receptors in innate immunityMonica Delgado
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Immunol Rev 227:189-202. 2009....- Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammationVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
Trends Cell Biol 22:397-406. 2012.... - Autophagy: an emerging immunological paradigmVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Immunol 189:15-20. 2012..Collectively, the unique features of autophagy as an immunological process and its contributions to other arms of the immune system represent a new immunological paradigm... - Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptorsVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
Curr Opin Immunol 24:21-31. 2012.... 
Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's diseaseVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, The University of New Mexico, Northeast Albuquerque, NM 87131, USA
Dev Cell 15:641-2. 2008..Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta...- Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass itVojo Deretic
University of New Mexico Health Sciences Center, Department of Molecular Genetics and Microbiology, Albuquerque, NM 87131 001, USA
Future Microbiol 3:517-24. 2008..This is a new, rapidly growing field replete with possibilities for novel, previously untried immunologic and pharmacologic interventions applicable not only to TB but to other stubborn bacterial, parasitic and viral diseases... - Strange bedfellows expose ancient secrets of autophagy in immunityVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 001, USA
Immunity 30:479-81. 2009..In this issue of Immunity, Shelly et al. (2009) use VSV infection in Drosophila to show the role of autophagy genes in controlling viruses... - Multiple regulatory and effector roles of autophagy in immunityVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
Curr Opin Immunol 21:53-62. 2009..A properly functioning autophagy helps prevent autoimmunity and assists in clearing pathogens. When aberrant, it contributes to human inflammatory disorders such as Crohn's disease... - Links between autophagy, innate immunity, inflammation and Crohn's diseaseVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 001, USA
Dig Dis 27:246-51. 2009.... - Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagyVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Curr Top Microbiol Immunol 335:169-88. 2009..This work and related studies by others have led us to propose a model of how autophagy, an ancient innate immunity defense, became integrated over the course of evolution with other immune mechanisms of ever-increasing complexity... - Autophagy in immunity and cell-autonomous defense against intracellular microbesVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Immunol Rev 240:92-104. 2011.... - Autophagy, immunity, and microbial adaptationsVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
Cell Host Microbe 5:527-49. 2009..Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters... - A master conductor for aggregate clearance by autophagyVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Dev Cell 18:694-6. 2010..provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein, Alfy, interacts with p62, Atg5, and PI3P to coordinate target recognition with site-specific activation of autophagic components... - Autophagy in infectionVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Curr Opin Cell Biol 22:252-62. 2010.... - Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivoGraham S Timmins
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
J Bacteriol 186:5427-31. 2004..We also provide in vivo evidence that INH-derived NO* can inhibit key mycobacterial respiratory enzymes, which may contribute to the overall antimycobacterial action of INH... - Mycobacterium tuberculosis prevents inflammasome activationSharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation... - Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascadeIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
J Exp Med 198:653-9. 2003..tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages... - Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane traffickingIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA
Traffic 4:600-6. 2003..M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes... - T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosisJames Harris
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Immunity 27:505-17. 2007..These findings establish a mechanism through which Th1-Th2 polarization differentially affects the immune control of intracellular pathogens... - Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosisIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Proc Natl Acad Sci U S A 102:4033-8. 2005..tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation... - Control of autophagy initiation by phosphoinositide 3-phosphatase JumpyIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
EMBO J 28:2244-58. 2009.... - The role of PI3P phosphatases in the regulation of autophagyIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
FEBS Lett 584:1313-8. 2010..This review sums up our knowledge on PI3P phosphatases and discusses the recent progress on their role in autophagy... - Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomesAlexander S Davis
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
PLoS Pathog 3:e186. 2007..Our findings are consistent with a model for the block in iNOS association with mycobacterial phagosomes as a mechanism dependent primarily on reduced EBP50 recruitment... - Human IRGM induces autophagy to eliminate intracellular mycobacteriaSudha B Singh
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Science 313:1438-41. 2006..We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load... - Cell biology of mycobacterium tuberculosis phagosomeIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 001, USA
Annu Rev Cell Dev Biol 20:367-94. 2004..Here we review the fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation... - Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrestGeorge B Kyei
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
EMBO J 25:5250-9. 2006..Rab14 enables mycobacterial phagosomes to maintain early endosomal characteristics and avoid late endosomal/lysosomal degradative components... - Microarray analysis reveals induction of lipoprotein genes in mucoid Pseudomonas aeruginosa: implications for inflammation in cystic fibrosisAaron M Firoved
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Infect Immun 72:5012-8. 2004..Blocking the signaling cascade responding to bacterial lipotoxins may provide therapeutic benefits for CF patients... - Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosisGraham S Timmins
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Antimicrob Agents Chemother 48:3006-9. 2004..In conclusion, INH-derived NO* has biological activity, which directly contributes to the antimycobacterial action of INH... - Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cellsElizabeth A Perkett
Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
Pediatr Pulmonol 41:771-8. 2006..S9; pCEP-R vs. pCEP, CuFi-4 vs. NuLi-1). Levels of TGF-beta were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF-beta levels... - Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organellesJennifer Chua
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 8713, USA
J Biol Chem 279:36982-92. 2004.... - Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusionIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
Mol Biol Cell 15:751-60. 2004..tuberculosis has evolved a two-prong strategy to modify its intracellular niche: its products block acquisition of late endosomal/lysosomal constituents, while facilitating fusion with early endosomal compartments... - Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosisJens F Poschet
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Am J Physiol Lung Cell Mol Physiol 293:L712-9. 2007..Our study suggests that phosphodiesterase 5 inhibition provides an opportunity for simultaneous and concerted correction of seemingly disparate complications in CF... - Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranesRutilio A Fratti
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
J Biol Chem 278:46961-7. 2003..These findings show that p38 MAPK activity contributes to the arrest of M. tuberculosis phagosome maturation and demonstrate a negative regulatory role of p38 in phagolysosome biogenesis... - Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicityWojciech Ornatowski
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
J Clin Invest 117:3489-97. 2007..These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF... - Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial propertiesMarisa Ponpuak
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Immunity 32:329-41. 2010..tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles... - Higher order Rab programming in phagolysosome biogenesisEsteban A Roberts
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
J Cell Biol 174:923-9. 2006..M. tuberculosis parasitizes this process by actively recruiting and maintaining Rab22a on its phagosome, thus, preventing Rab7 acquisition and blocking phagolysosomal biogenesis... - Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosaSimon R Wood
College of Pharmacy, Toxicology Program, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
Free Radic Res 41:208-15. 2007..Our data suggest that the lowered levels of innate-immune nitrosative mediators (such as GSNO) in the CF lung exacerbate the effects of mucoid P. aeruginosa, by failing to suppress alginate biosynthesis... - The Mycobacterium tuberculosis phagosomeEsteban A Roberts
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Methods Mol Biol 445:439-49. 2008.... - Monitoring autophagy during Mycobacterium tuberculosis infectionMarisa Ponpuak
Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, USA
Methods Enzymol 452:345-61. 2009..The described assays can be used to investigate and identify factors important for autophagic elimination of mycobacteria that could potentially provide new therapeutic targets to defeat this disease... - A tale of two lipids: Mycobacterium tuberculosis phagosome maturation arrestJennifer Chua
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131-001, USA
Curr Opin Microbiol 7:71-7. 2004..Understanding these processes could provide new targets for pharmacological intervention in tuberculosis... - In vitro phagosome-endosome fusionIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Methods Mol Biol 445:301-9. 2008..Fusion is quantified using a fluorescence-based detection method that measures the peroxidase activity associated with the beads... - Mechanisms of action of isoniazidGraham S Timmins
College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Mol Microbiol 62:1220-7. 2006.... - Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatmentJens Poschet
Dept of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Trends Mol Med 8:512-9. 2002..The increased acidity of the intracellular organelles and of the lung lining in CF could be linked, and both represent potential therapeutic targets... - Toll-like receptors control autophagyMonica A Delgado
Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
EMBO J 27:1110-21. 2008.... - Ay, there's the Rab: organelle maturation by Rab conversionVojo Deretic
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Dev Cell 9:446-8. 2005.... - Autophagosome and phagosomeVojo Deretic
Health Sciences Center, Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Methods Mol Biol 445:1-10. 2008..Autophagy and phagocytosis cooperate in the latter two processes. In this chapter, we briefly review the regulatory and execution stages of both autophagy and phagocytosis... - Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosaAaron M Firoved
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Bacteriol 186:4046-50. 2004..NO* consumption however, showed that both strains mount functional, protein synthesis-dependent NO*-consumptive responses... - Autophagy in innate and adaptive immunityVojo Deretic
Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Trends Immunol 26:523-8. 2005..A protective role has recently been demonstrated in infectious diseases, which represents a previously unrecognized immune mechanism acting against intracellular microbes. This review reviews autophagy as an immune mechanism... - Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophagesGeorge B Kyei
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
J Cell Biol 186:255-68. 2009..The role of Nef in the latter process enhances yields of infectious HIV and may be of significance for progression to clinical AIDS... - Nonclassical pathway of Pseudomonas aeruginosa DNA-induced interleukin-8 secretion in cystic fibrosis airway epithelial cellsMonica A Delgado
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Infect Immun 74:2975-84. 2006..Our findings also show that treatments with drugs diminishing organellar acidification may reduce the inflammatory response in cystic fibrosis... - Autophagic proteolysis of long-lived proteins in nonliver cellsEsteban A Roberts
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Methods Mol Biol 445:111-7. 2008..Here we describe a protocol to quantify autophagic degradation of longlived proteins in macrophages. This chapter details the method of analyzing autophagic proteolysis in RAW264.7 mouse macrophages...
Research Grants
- Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSVOJO P DERETIC; Fiscal Year: 2010..Our project will lead to novel treatments of difficult cases such as drug resistant MTB in AIDS patients. ..
- Pseudomonas in Cystic Fibrosis-Regulation of MucoidyVojo Deretic; Fiscal Year: 2006..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..abstract_text> ..
- M. tuberculosis defenses against host oxidant systems.Vojo Deretic; Fiscal Year: 2006..The phenomena addressed in this proposal will provide a foundation for development of new therapies that will improve present treatments of tuberculosis. ..
- Autophagy in TuberculosisVojo Deretic; Fiscal Year: 2007..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
- M. tuberculosis defenses against host oxidant systems.Vojo Deretic; Fiscal Year: 2007..The phenomena addressed in this proposal will provide a foundation for development of new therapies that will improve present treatments of tuberculosis. ..
- Mechanism of M. tuberculosis Phagosome Maturation ArrestVojo Deretic; Fiscal Year: 2007..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
- LOSS OF OXYR IN M TUBERCULOSISVojo Deretic; Fiscal Year: 2002..The proposed studies are expected to improve understanding of the elusive virulence attributes of M. tuberculosis, and may help explain, at least in part, its high sensitivity to the front-line antituberculosis agent INH. ..
- PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDYVojo Deretic; Fiscal Year: 2001..aeruginosa virulence and pathogenesis in CF with implications for pharmacological or immunological intervention. ..
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..