VOJO P DERETIC

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. ncbi request reprint Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV
    Vojo Deretic
    Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 6:999-1009. 2004
  2. ncbi request reprint Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 8:719-27. 2006
  3. ncbi request reprint Autophagy as an immune defense mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Curr Opin Immunol 18:375-82. 2006
  4. ncbi request reprint Autophagy in immune defense against Mycobacterium tuberculosis
    Isabelle Vergne
    Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
    Autophagy 2:175-8. 2006
  5. pmc Autophagy and pattern recognition receptors in innate immunity
    Monica Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Immunol Rev 227:189-202. 2009
  6. pmc Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    J Exp Med 198:653-9. 2003
  7. pmc Higher order Rab programming in phagolysosome biogenesis
    Esteban A Roberts
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Cell Biol 174:923-9. 2006
  8. pmc Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
    Nat Cell Biol 12:1154-65. 2010
  9. pmc Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    Trends Cell Biol 22:397-406. 2012
  10. pmc Autophagy: an emerging immunological paradigm
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Immunol 189:15-20. 2012

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV
    Vojo Deretic
    Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 6:999-1009. 2004
    ..We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases--AIDS and tuberculosis...
  2. ncbi request reprint Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 8:719-27. 2006
    ..tuberculosis survival. This review summarizes the findings centred around the PI3P-nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect...
  3. ncbi request reprint Autophagy as an immune defense mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Curr Opin Immunol 18:375-82. 2006
    ..We propose the term immunophagy for these defense processes...
  4. ncbi request reprint Autophagy in immune defense against Mycobacterium tuberculosis
    Isabelle Vergne
    Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
    Autophagy 2:175-8. 2006
    ..Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated...
  5. pmc Autophagy and pattern recognition receptors in innate immunity
    Monica Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Immunol Rev 227:189-202. 2009
    ....
  6. pmc Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    J Exp Med 198:653-9. 2003
    ..tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages...
  7. pmc Higher order Rab programming in phagolysosome biogenesis
    Esteban A Roberts
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Cell Biol 174:923-9. 2006
    ..M. tuberculosis parasitizes this process by actively recruiting and maintaining Rab22a on its phagosome, thus, preventing Rab7 acquisition and blocking phagolysosomal biogenesis...
  8. pmc Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
    Nat Cell Biol 12:1154-65. 2010
    ..By acting on mitochondria, IRGM confers autophagic protection or cell death, explaining IRGM action both in defence against tuberculosis and in the damaging inflammation caused by Crohn's disease...
  9. pmc Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    Trends Cell Biol 22:397-406. 2012
    ....
  10. pmc Autophagy: an emerging immunological paradigm
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Immunol 189:15-20. 2012
    ..Collectively, the unique features of autophagy as an immunological process and its contributions to other arms of the immune system represent a new immunological paradigm...
  11. pmc Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    Curr Opin Immunol 24:21-31. 2012
    ....
  12. pmc A master conductor for aggregate clearance by autophagy
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Dev Cell 18:694-6. 2010
    ..provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein, Alfy, interacts with p62, Atg5, and PI3P to coordinate target recognition with site-specific activation of autophagic components...
  13. pmc Autophagy in infection
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Curr Opin Cell Biol 22:252-62. 2010
    ....
  14. pmc Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Curr Top Microbiol Immunol 335:169-88. 2009
    ..This work and related studies by others have led us to propose a model of how autophagy, an ancient innate immunity defense, became integrated over the course of evolution with other immune mechanisms of ever-increasing complexity...
  15. pmc Links between autophagy, innate immunity, inflammation and Crohn's disease
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131 001, USA
    Dig Dis 27:246-51. 2009
    ....
  16. pmc Strange bedfellows expose ancient secrets of autophagy in immunity
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 001, USA
    Immunity 30:479-81. 2009
    ..In this issue of Immunity, Shelly et al. (2009) use VSV infection in Drosophila to show the role of autophagy genes in controlling viruses...
  17. pmc Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it
    Vojo Deretic
    University of New Mexico Health Sciences Center, Department of Molecular Genetics and Microbiology, Albuquerque, NM 87131 001, USA
    Future Microbiol 3:517-24. 2008
    ..This is a new, rapidly growing field replete with possibilities for novel, previously untried immunologic and pharmacologic interventions applicable not only to TB but to other stubborn bacterial, parasitic and viral diseases...
  18. pmc Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's disease
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, The University of New Mexico, Northeast Albuquerque, NM 87131, USA
    Dev Cell 15:641-2. 2008
    ..Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta...
  19. pmc Multiple regulatory and effector roles of autophagy in immunity
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Curr Opin Immunol 21:53-62. 2009
    ..A properly functioning autophagy helps prevent autoimmunity and assists in clearing pathogens. When aberrant, it contributes to human inflammatory disorders such as Crohn's disease...
  20. pmc Autophagy, immunity, and microbial adaptations
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    Cell Host Microbe 5:527-49. 2009
    ..Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters...
  21. pmc Autophagy in immunity and cell-autonomous defense against intracellular microbes
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Immunol Rev 240:92-104. 2011
    ....
  22. pmc Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo
    Graham S Timmins
    College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    J Bacteriol 186:5427-31. 2004
    ..We also provide in vivo evidence that INH-derived NO* can inhibit key mycobacterial respiratory enzymes, which may contribute to the overall antimycobacterial action of INH...
  23. pmc Mycobacterium tuberculosis prevents inflammasome activation
    Sharon S Master
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cell Host Microbe 3:224-32. 2008
    ..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
  24. ncbi request reprint T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis
    James Harris
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Immunity 27:505-17. 2007
    ..These findings establish a mechanism through which Th1-Th2 polarization differentially affects the immune control of intracellular pathogens...
  25. pmc Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 102:4033-8. 2005
    ..tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation...
  26. ncbi request reprint Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA
    Traffic 4:600-6. 2003
    ..M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes...
  27. pmc Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis
    Graham S Timmins
    College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Antimicrob Agents Chemother 48:3006-9. 2004
    ..In conclusion, INH-derived NO* has biological activity, which directly contributes to the antimycobacterial action of INH...
  28. pmc Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Mol Biol Cell 15:751-60. 2004
    ..tuberculosis has evolved a two-prong strategy to modify its intracellular niche: its products block acquisition of late endosomal/lysosomal constituents, while facilitating fusion with early endosomal compartments...
  29. pmc Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    EMBO J 28:2244-58. 2009
    ....
  30. pmc Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes
    Alexander S Davis
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
    PLoS Pathog 3:e186. 2007
    ..Our findings are consistent with a model for the block in iNOS association with mycobacterial phagosomes as a mechanism dependent primarily on reduced EBP50 recruitment...
  31. ncbi request reprint Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells
    Elizabeth A Perkett
    Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Pediatr Pulmonol 41:771-8. 2006
    ..S9; pCEP-R vs. pCEP, CuFi-4 vs. NuLi-1). Levels of TGF-beta were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF-beta levels...
  32. ncbi request reprint Human IRGM induces autophagy to eliminate intracellular mycobacteria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Science 313:1438-41. 2006
    ..We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load...
  33. ncbi request reprint Cell biology of mycobacterium tuberculosis phagosome
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 001, USA
    Annu Rev Cell Dev Biol 20:367-94. 2004
    ..Here we review the fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation...
  34. pmc Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest
    George B Kyei
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    EMBO J 25:5250-9. 2006
    ..Rab14 enables mycobacterial phagosomes to maintain early endosomal characteristics and avoid late endosomal/lysosomal degradative components...
  35. pmc The role of PI3P phosphatases in the regulation of autophagy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    FEBS Lett 584:1313-8. 2010
    ..This review sums up our knowledge on PI3P phosphatases and discusses the recent progress on their role in autophagy...
  36. ncbi request reprint Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis
    Jens F Poschet
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Am J Physiol Lung Cell Mol Physiol 293:L712-9. 2007
    ..Our study suggests that phosphodiesterase 5 inhibition provides an opportunity for simultaneous and concerted correction of seemingly disparate complications in CF...
  37. pmc Microarray analysis reveals induction of lipoprotein genes in mucoid Pseudomonas aeruginosa: implications for inflammation in cystic fibrosis
    Aaron M Firoved
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Infect Immun 72:5012-8. 2004
    ..Blocking the signaling cascade responding to bacterial lipotoxins may provide therapeutic benefits for CF patients...
  38. ncbi request reprint Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles
    Jennifer Chua
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 8713, USA
    J Biol Chem 279:36982-92. 2004
    ....
  39. pmc Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
    Marisa Ponpuak
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Immunity 32:329-41. 2010
    ..tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles...
  40. ncbi request reprint Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes
    Rutilio A Fratti
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    J Biol Chem 278:46961-7. 2003
    ..These findings show that p38 MAPK activity contributes to the arrest of M. tuberculosis phagosome maturation and demonstrate a negative regulatory role of p38 in phagolysosome biogenesis...
  41. ncbi request reprint Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa
    Simon R Wood
    College of Pharmacy, Toxicology Program, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
    Free Radic Res 41:208-15. 2007
    ..Our data suggest that the lowered levels of innate-immune nitrosative mediators (such as GSNO) in the CF lung exacerbate the effects of mucoid P. aeruginosa, by failing to suppress alginate biosynthesis...
  42. pmc Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity
    Wojciech Ornatowski
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    J Clin Invest 117:3489-97. 2007
    ..These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF...
  43. doi request reprint The Mycobacterium tuberculosis phagosome
    Esteban A Roberts
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Methods Mol Biol 445:439-49. 2008
    ....
  44. pmc Monitoring autophagy during Mycobacterium tuberculosis infection
    Marisa Ponpuak
    Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, USA
    Methods Enzymol 452:345-61. 2009
    ..The described assays can be used to investigate and identify factors important for autophagic elimination of mycobacteria that could potentially provide new therapeutic targets to defeat this disease...
  45. ncbi request reprint A tale of two lipids: Mycobacterium tuberculosis phagosome maturation arrest
    Jennifer Chua
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Curr Opin Microbiol 7:71-7. 2004
    ..Understanding these processes could provide new targets for pharmacological intervention in tuberculosis...
  46. ncbi request reprint Mechanisms of action of isoniazid
    Graham S Timmins
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Mol Microbiol 62:1220-7. 2006
    ....
  47. doi request reprint In vitro phagosome-endosome fusion
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Methods Mol Biol 445:301-9. 2008
    ..Fusion is quantified using a fluorescence-based detection method that measures the peroxidase activity associated with the beads...
  48. pmc Toll-like receptors control autophagy
    Monica A Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
    EMBO J 27:1110-21. 2008
    ....
  49. ncbi request reprint Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatment
    Jens Poschet
    Dept of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Trends Mol Med 8:512-9. 2002
    ..The increased acidity of the intracellular organelles and of the lung lining in CF could be linked, and both represent potential therapeutic targets...
  50. doi request reprint Autophagosome and phagosome
    Vojo Deretic
    Health Sciences Center, Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Methods Mol Biol 445:1-10. 2008
    ..Autophagy and phagocytosis cooperate in the latter two processes. In this chapter, we briefly review the regulatory and execution stages of both autophagy and phagocytosis...
  51. pmc Nonclassical pathway of Pseudomonas aeruginosa DNA-induced interleukin-8 secretion in cystic fibrosis airway epithelial cells
    Monica A Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Infect Immun 74:2975-84. 2006
    ..Our findings also show that treatments with drugs diminishing organellar acidification may reduce the inflammatory response in cystic fibrosis...
  52. ncbi request reprint Ay, there's the Rab: organelle maturation by Rab conversion
    Vojo Deretic
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Dev Cell 9:446-8. 2005
    ....
  53. ncbi request reprint Autophagy in innate and adaptive immunity
    Vojo Deretic
    Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Trends Immunol 26:523-8. 2005
    ..A protective role has recently been demonstrated in infectious diseases, which represents a previously unrecognized immune mechanism acting against intracellular microbes. This review reviews autophagy as an immune mechanism...
  54. pmc Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa
    Aaron M Firoved
    College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Bacteriol 186:4046-50. 2004
    ..NO* consumption however, showed that both strains mount functional, protein synthesis-dependent NO*-consumptive responses...
  55. pmc Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
    George B Kyei
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Cell Biol 186:255-68. 2009
    ..The role of Nef in the latter process enhances yields of infectious HIV and may be of significance for progression to clinical AIDS...
  56. doi request reprint Autophagic proteolysis of long-lived proteins in nonliver cells
    Esteban A Roberts
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Methods Mol Biol 445:111-7. 2008
    ..Here we describe a protocol to quantify autophagic degradation of longlived proteins in macrophages. This chapter details the method of analyzing autophagic proteolysis in RAW264.7 mouse macrophages...

Research Grants40

  1. Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS
    VOJO P DERETIC; Fiscal Year: 2010
    ..Our project will lead to novel treatments of difficult cases such as drug resistant MTB in AIDS patients. ..
  2. M. tuberculosis defenses against host oxidant systems.
    Vojo Deretic; Fiscal Year: 2003
    ..The phenomena addressed in this proposal will provide a foundation for development of new therapies that will improve present treatments of tuberculosis. ..
  3. M. tuberculosis defenses against host oxidant systems.
    Vojo Deretic; Fiscal Year: 2006
    ..The phenomena addressed in this proposal will provide a foundation for development of new therapies that will improve present treatments of tuberculosis. ..
  4. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2003
    ..abstract_text> ..
  5. M. tuberculosis defenses against host oxidant systems.
    Vojo Deretic; Fiscal Year: 2007
    ..The phenomena addressed in this proposal will provide a foundation for development of new therapies that will improve present treatments of tuberculosis. ..
  6. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  7. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2007
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  8. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2006
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  9. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2005
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  10. LOSS OF OXYR IN M TUBERCULOSIS
    Vojo Deretic; Fiscal Year: 2001
    ..The proposed studies are expected to improve understanding of the elusive virulence attributes of M. tuberculosis, and may help explain, at least in part, its high sensitivity to the front-line antituberculosis agent INH. ..
  11. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2010
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  12. PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDY
    Vojo Deretic; Fiscal Year: 2001
    ..aeruginosa virulence and pathogenesis in CF with implications for pharmacological or immunological intervention. ..
  13. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2002
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  14. LOSS OF OXYR IN M TUBERCULOSIS
    Vojo Deretic; Fiscal Year: 2002
    ..The proposed studies are expected to improve understanding of the elusive virulence attributes of M. tuberculosis, and may help explain, at least in part, its high sensitivity to the front-line antituberculosis agent INH. ..
  15. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2004
    ..abstract_text> ..
  16. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2005
    ..abstract_text> ..
  17. PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDY
    Vojo Deretic; Fiscal Year: 1999
    ..aeruginosa virulence and pathogenesis in CF with implications for pharmacological or immunological intervention. ..
  18. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2005
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  19. Autophagy in Tuberculosis
    Vojo Deretic; Fiscal Year: 2009
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  20. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2006
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  21. PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDY
    Vojo Deretic; Fiscal Year: 2001
    ..aeruginosa virulence and pathogenesis in CF with implications for pharmacological or immunological intervention. ..
  22. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2004
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  23. PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDY
    Vojo Deretic; Fiscal Year: 2000
    ..aeruginosa virulence and pathogenesis in CF with implications for pharmacological or immunological intervention. ..
  24. Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS
    Vojo Deretic; Fiscal Year: 2009
    ..Our project will lead to novel treatments of difficult cases such as drug resistant MTB in AIDS patients. ..
  25. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2002
    ..abstract_text> ..
  26. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2003
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  27. Autophagy in Tuberculosis
    Vojo Deretic; Fiscal Year: 2007
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  28. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2004
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  29. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  30. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..