Research Topics
Species | Robert John DenverSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Neuroendocrinology of amphibian metamorphosisRobert J Denver
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan, USA
Curr Top Dev Biol 103:195-227. 2013..CRF neurons transduce the signals of environmental change (e.g., pond drying, resource availability, etc.) on metamorphic timing by regulating TSH and ACTH secretion, and consequently the production of TH and CS...
Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neuronsPia Bagamasbad
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109 1048, USA
Endocrinology 153:5334-45. 2012..KLF9 may play a key role in GC actions on hippocampal development and plasticity...- Structural and functional evolution of vertebrate neuroendocrine stress systemsRobert John Denver
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Ann N Y Acad Sci 1163:1-16. 2009..Glucocorticoids are the downstream effectors of the HPA axis, playing essential roles in development, energy balance and behavior, and feedback actions on the activity of the HPA axis... - Stress hormones mediate environment-genotype interactions during amphibian developmentRobert J Denver
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, 3065C Kraus Building, Ann Arbor, MI 48109 1048, USA
Gen Comp Endocrinol 164:20-31. 2009..Persistent effects of stress hormone actions early in life may have important fitness consequences... - Identification of a thyroid hormone response element in the mouse Kruppel-like factor 9 gene to explain its postnatal expression in the brainRobert J Denver
Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 150:3935-43. 2009..Our study identifies a functional DR-4 T(3)RE located in the mouse Klf9 gene to explain its regulation by T(3) during mammalian brain development... - Chordate metamorphosis: ancient control by iodothyroninesRobert J Denver
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Curr Biol 18:R567-9. 2008..Iodothyronine-induced metamorphosis may be an ancestral feature of the chordates... 
Endocannabinoids link rapid, membrane-mediated corticosteroid actions to behaviorRobert J Denver
Department of Molecular, Cellular and Developmental Biology, 3065C Kraus Natural Science Building, The University of Michigan, Ann Arbor, Michigan 48109-1048, USA
Endocrinology 148:490-2. 2007- Thyroid hormone-dependent gene expression program for Xenopus neural developmentR J Denver
Department of Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 272:8179-88. 1997..The gene identities allow predictions about the gene regulatory networks underlying TH action on the brain, and the cloned cDNAs provide tools for understanding the basic molecular mechanisms underlying neural cell differentiation... - Hormonal correlates of environmentally induced metamorphosis in the Western spadefoot toad, Scaphiopus hammondiiR J Denver
Department of Biology, The University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
Gen Comp Endocrinol 110:326-36. 1998..Furthermore, this response is rapid, occurring within 48 h after exposure to the desiccating environment... - Evolution of the corticotropin-releasing hormone signaling system and its role in stress-induced phenotypic plasticityR J Denver
Department of Biology, University of Michigan, Ann Arbor 48109, USA
Ann N Y Acad Sci 897:46-53. 1999..The response to CRH is mediated by at least two different receptor subtypes and may also be modulated by a secreted binding protein... - Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowthR J Denver
Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 274:23128-34. 1999..However, other T(3)-dependent changes were not altered; i.e. overexpression of BTEB had no effect on the rate of cell proliferation nor on the expression of acetylcholinesterase activity... - The molecular basis of thyroid hormone-dependent central nervous system remodeling during amphibian metamorphosisR J Denver
Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119:219-28. 1998..Recent studies suggest a critical, evolutionarily conserved role for the TH-induced transcription factor genes in controling neural cell proliferation and differentiation... - Programming neuroendocrine stress axis activity by exposure to glucocorticoids during postembryonic development of the frog, Xenopus laevisFang Hu
Department of Molecular, The University of Michigan, Ann Arbor, Michigan 48109, USA
Endocrinology 149:5470-81. 2008..Taken together, our findings suggest that long-term, stable phenotypic changes in response to elevated glucocorticoids early in life are an ancient and conserved feature of the vertebrate lineage... - Corticotropin-releasing factor is cytoprotective in Xenopus tadpole tail: coordination of ligand, receptor, and binding protein in tail muscle cell survivalGraham C Boorse
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 147:1498-507. 2006..The inhibitory binding protein for CRF is regulated by hormones or by environmental stressors and can modulate CRF bioactivity... - Small changes in whole-body corticosterone content affect larval Rana pipiens fitness componentsKaren Ann Glennemeier
Department of Biology, 3065C Natural Science Building, University of Michigan, Ann Arbor 48109-1048, USA
Gen Comp Endocrinol 127:16-25. 2002..Our results also demonstrate that even small changes in corticosterone content can have important implications for amphibian fitness... - Roles of stress hormones in food intake regulation in anuran amphibians throughout the life cycleErica J Crespi
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Comp Biochem Physiol A Mol Integr Physiol 141:381-90. 2005..Juvenile toads do not respond to food deprivation by activating the HPI axis, but instead pursue a strategy of energy conservation that involves a reduction in plasma corticosterone concentration... - Regulation of pituitary thyrotropin gene expression during Xenopus metamorphosis: negative feedback is functional throughout metamorphosisRichard G Manzon
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Endocrinol 182:273-85. 2004..g. CRF) of hypothalamic or pituitary origin, increased pituitary sensitivity to neuropeptides through upregulation of their receptors, and intrapituitary TH levels... - Characterization of an alarm pheromone secreted by amphibian tadpoles that induces behavioral inhibition and suppression of the neuroendocrine stress axisMichael E Fraker
Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 48109 1048, USA
Horm Behav 55:520-9. 2009..We also provide a neuroendocrine mechanism by which the behavioral inhibition caused by exposure to the alarm pheromone is maintained until the threat subsides... - Ancient origins of human developmental plasticityErica J Crespi
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Hum Biol 17:44-54. 2005..The integrated neuroendocrine response to stress, and its role in timing critical life history transitions and establishing long-term phenotypic expression, arose early in the evolution of vertebrates... - Ontogeny of corticotropin-releasing factor effects on locomotion and foraging in the Western spadefoot toad (Spea hammondii)Erica J Crespi
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Horm Behav 46:399-410. 2004..Furthermore, the opposing actions of CRF and CORT on foraging suggest that they are important regulators of energy balance and food intake in amphibians throughout development... - Molecular mechanisms of corticosteroid synergy with thyroid hormone during tadpole metamorphosisRonald M Bonett
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Gen Comp Endocrinol 168:209-19. 2010..Concurrently, TH enhances tissue sensitivity to CS by upregulating GR and MR. Environmental stressors can modulate the timing of tadpole metamorphosis in part by CS enhancing the response of tadpole tissues to the actions of TH... - Expression and hypophysiotropic actions of corticotropin-releasing factor in Xenopus laevisGraham C Boorse
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Gen Comp Endocrinol 137:272-82. 2004..laevis as in other vertebrates. Furthermore, we provide evidence for a dual hypophysiotropic action of CRF on the thyroid and interrenal axes in X. laevis as has been shown previously in other amphibian species... - Stressor and glucocorticoid-dependent induction of the immediate early gene kruppel-like factor 9: implications for neural development and plasticityRonald M Bonett
Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 150:1757-65. 2009..Our results support that KLF9 is a direct, GC receptor target gene that is induced by stress, and functions as an intermediary in the actions of GCs on brain gene expression and neuronal structure... - Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolutionGraham C Boorse
Department of Ecology and Evolutionary Biology, 3065C Kraus Natural Science Building, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 146:4851-60. 2005..Our findings show that the functional relationships among CRF ligands and binding proteins, and their anorexigenic actions mediated by the CRF2 receptor, arose early in vertebrate evolution... - Evolutionarily conserved glucocorticoid regulation of corticotropin-releasing factor expressionMeng Yao
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 149:2352-60. 2008.... - Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevisRobert J Denver
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, USA
Dev Biol 326:155-68. 2009..Our findings support the view that T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha... - Distribution and corticosteroid regulation of glucocorticoid receptor in the brain of Xenopus laevisMeng Yao
Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Comp Neurol 508:967-82. 2008..Our results show that the central distribution of GR-ir and regulation by corticosteroids are highly conserved among vertebrates... - A role for basic transcription element-binding protein 1 (BTEB1) in the autoinduction of thyroid hormone receptor betaPia Bagamasbad
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 283:2275-85. 2008..Cooperation among the protein products of immediate early genes may be a common mechanism for driving developmental signaling pathways... - Basic transcription element binding protein is a thyroid hormone-regulated transcription factor expressed during metamorphosis in Xenopus laevisEric D Hoopfer
3065C Natural Science Building, Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109-1048, USA
Dev Growth Differ 44:365-81. 2002.... - Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptidesGraham C Boorse
Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 48109-1048, USA
Gen Comp Endocrinol 146:9-18. 2006..Thus, CRF peptides may play diverse roles in physiology and development, and these functions likely arose early in vertebrate evolution... - Acceleration of Ambystoma tigrinum metamorphosis by corticotropin-releasing hormoneGraham C Boorse
Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, Michigan 48109-1048, USA
J Exp Zool 293:94-8. 2002..These findings suggest that the neuroendocrine mechanisms controlling metamorphosis are evolutionarily conserved across amphibian taxa... - Leptin (ob gene) of the South African clawed frog Xenopus laevisErica J Crespi
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
Proc Natl Acad Sci U S A 103:10092-7. 2006..Furthermore, the isolation and characterization of leptin and its receptor in a nonamniote provides an essential foundation for elucidating the structural and functional evolution of this important hormone... - Structural and functional conservation of vertebrate corticotropin-releasing factor genes: evidence for a critical role for a conserved cyclic AMP response elementMeng Yao
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Endocrinology 148:2518-31. 2007..Our findings show that the basic regulatory elements of the CRF gene responsible for stressor-induced activation arose early in vertebrate evolution and have been maintained by strong positive selection... - Role for corticoids in mediating the response of Rana pipiens tadpoles to intraspecific competitionKaren Ann Glennemeier
Department of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA
J Exp Zool 292:32-40. 2002..Our results suggest that elevated corticoid biosynthesis mediates the negative effect of increased population density (i.e., increased intraspecific competition) on tadpole growth... - Plasma thyroid hormone concentrations in a wintering passerine bird: their relationship to geographic variation, environmental factors, metabolic rate, and body fatMichael F Burger
School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI, 48109, USA
Physiol Biochem Zool 75:187-99. 2002..We conclude, therefore, that there is latitudinal variation in metabolic parameters in cardinals but that this variation is not explained by variation in plasma TH concentrations... - Regulation of vertebrate corticotropin-releasing factor genesMeng Yao
Department of Molecular, Cellular and Developmental Biology, 3065C Kraus Natural Science Building, The University of Michigan, Ann Arbor, MI 48109 1048, USA
Gen Comp Endocrinol 153:200-16. 2007..We also discuss evolutionarily conserved molecular mechanisms that operate at the level of CRF gene transcription... - Involvement of the corticotropin-releasing factor (CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary glandReiko Okada
Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, Tokyo 169 8050, Japan
Gen Comp Endocrinol 150:437-44. 2007..Conversely, the type 1 CRF receptor-specific antagonist antalarmin had no effect on TSH secretion. Our results support the hypothesis that CRF-induced TSH release by the amphibian pituitary gland is mediated by the CRF2... - Evidence that urocortin I acts as a neurohormone to stimulate alpha MSH release in the toad Xenopus laevisMarinella Calle
Department of Cellular Animal Physiology, Radboud University Nijmegen, Nijmegen, The Netherlands
Brain Res 1040:14-28. 2005..laevis, UCN1 released from neurohemal axon terminals in the pituitary neural lobe functions as a stimulatory neurohormone for alphaMSH release from melanotrope cells of the pituitary intermediate lobe... - Molecular cloning and developmental expression of corticotropin-releasing factor in the chickenKristien Vandenborne
Laboratory of Comparative Endocrinology, Zoological Institute, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
Endocrinology 146:301-8. 2005..Changes in CRF production just before hatching may be causally related to the regulation of the thyroid and interrenal axes at this stage of chicken development... - Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosusRachid Safi
CNRS UMR 5161, INRA LA 913, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, France
Evol Dev 8:284-92. 2006..Rather, the absence of metamorphosis may be due to the loss of TH-dependent control of key genes required for tissue transformation...
Research Grants
- Hormone and Activity-Dependent Neural Gene ExpressionRobert Denver; Fiscal Year: 2007....