Robert John Denver

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Neuroendocrinology of amphibian metamorphosis
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan, USA
    Curr Top Dev Biol 103:195-227. 2013
  2. pmc Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neurons
    Pia Bagamasbad
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109 1048, USA
    Endocrinology 153:5334-45. 2012
  3. doi request reprint Structural and functional evolution of vertebrate neuroendocrine stress systems
    Robert John Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Ann N Y Acad Sci 1163:1-16. 2009
  4. doi request reprint Stress hormones mediate environment-genotype interactions during amphibian development
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, 3065C Kraus Building, Ann Arbor, MI 48109 1048, USA
    Gen Comp Endocrinol 164:20-31. 2009
  5. pmc Identification of a thyroid hormone response element in the mouse Kruppel-like factor 9 gene to explain its postnatal expression in the brain
    Robert J Denver
    Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 150:3935-43. 2009
  6. doi request reprint Chordate metamorphosis: ancient control by iodothyronines
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Curr Biol 18:R567-9. 2008
  7. ncbi request reprint Endocannabinoids link rapid, membrane-mediated corticosteroid actions to behavior
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, 3065C Kraus Natural Science Building, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 148:490-2. 2007
  8. ncbi request reprint Thyroid hormone-dependent gene expression program for Xenopus neural development
    R J Denver
    Department of Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:8179-88. 1997
  9. ncbi request reprint Hormonal correlates of environmentally induced metamorphosis in the Western spadefoot toad, Scaphiopus hammondii
    R J Denver
    Department of Biology, The University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
    Gen Comp Endocrinol 110:326-36. 1998
  10. ncbi request reprint Evolution of the corticotropin-releasing hormone signaling system and its role in stress-induced phenotypic plasticity
    R J Denver
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    Ann N Y Acad Sci 897:46-53. 1999

Research Grants

Collaborators

Detail Information

Publications40

  1. doi request reprint Neuroendocrinology of amphibian metamorphosis
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan, USA
    Curr Top Dev Biol 103:195-227. 2013
    ..CRF neurons transduce the signals of environmental change (e.g., pond drying, resource availability, etc.) on metamorphic timing by regulating TSH and ACTH secretion, and consequently the production of TH and CS...
  2. pmc Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neurons
    Pia Bagamasbad
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109 1048, USA
    Endocrinology 153:5334-45. 2012
    ..KLF9 may play a key role in GC actions on hippocampal development and plasticity...
  3. doi request reprint Structural and functional evolution of vertebrate neuroendocrine stress systems
    Robert John Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Ann N Y Acad Sci 1163:1-16. 2009
    ..Glucocorticoids are the downstream effectors of the HPA axis, playing essential roles in development, energy balance and behavior, and feedback actions on the activity of the HPA axis...
  4. doi request reprint Stress hormones mediate environment-genotype interactions during amphibian development
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, 3065C Kraus Building, Ann Arbor, MI 48109 1048, USA
    Gen Comp Endocrinol 164:20-31. 2009
    ..Persistent effects of stress hormone actions early in life may have important fitness consequences...
  5. pmc Identification of a thyroid hormone response element in the mouse Kruppel-like factor 9 gene to explain its postnatal expression in the brain
    Robert J Denver
    Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 150:3935-43. 2009
    ..Our study identifies a functional DR-4 T(3)RE located in the mouse Klf9 gene to explain its regulation by T(3) during mammalian brain development...
  6. doi request reprint Chordate metamorphosis: ancient control by iodothyronines
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Curr Biol 18:R567-9. 2008
    ..Iodothyronine-induced metamorphosis may be an ancestral feature of the chordates...
  7. ncbi request reprint Endocannabinoids link rapid, membrane-mediated corticosteroid actions to behavior
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, 3065C Kraus Natural Science Building, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 148:490-2. 2007
  8. ncbi request reprint Thyroid hormone-dependent gene expression program for Xenopus neural development
    R J Denver
    Department of Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:8179-88. 1997
    ..The gene identities allow predictions about the gene regulatory networks underlying TH action on the brain, and the cloned cDNAs provide tools for understanding the basic molecular mechanisms underlying neural cell differentiation...
  9. ncbi request reprint Hormonal correlates of environmentally induced metamorphosis in the Western spadefoot toad, Scaphiopus hammondii
    R J Denver
    Department of Biology, The University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
    Gen Comp Endocrinol 110:326-36. 1998
    ..Furthermore, this response is rapid, occurring within 48 h after exposure to the desiccating environment...
  10. ncbi request reprint Evolution of the corticotropin-releasing hormone signaling system and its role in stress-induced phenotypic plasticity
    R J Denver
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    Ann N Y Acad Sci 897:46-53. 1999
    ..The response to CRH is mediated by at least two different receptor subtypes and may also be modulated by a secreted binding protein...
  11. ncbi request reprint Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowth
    R J Denver
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:23128-34. 1999
    ..However, other T(3)-dependent changes were not altered; i.e. overexpression of BTEB had no effect on the rate of cell proliferation nor on the expression of acetylcholinesterase activity...
  12. ncbi request reprint The molecular basis of thyroid hormone-dependent central nervous system remodeling during amphibian metamorphosis
    R J Denver
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119:219-28. 1998
    ..Recent studies suggest a critical, evolutionarily conserved role for the TH-induced transcription factor genes in controling neural cell proliferation and differentiation...
  13. doi request reprint Programming neuroendocrine stress axis activity by exposure to glucocorticoids during postembryonic development of the frog, Xenopus laevis
    Fang Hu
    Department of Molecular, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 149:5470-81. 2008
    ..Taken together, our findings suggest that long-term, stable phenotypic changes in response to elevated glucocorticoids early in life are an ancient and conserved feature of the vertebrate lineage...
  14. ncbi request reprint Corticotropin-releasing factor is cytoprotective in Xenopus tadpole tail: coordination of ligand, receptor, and binding protein in tail muscle cell survival
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 147:1498-507. 2006
    ..The inhibitory binding protein for CRF is regulated by hormones or by environmental stressors and can modulate CRF bioactivity...
  15. ncbi request reprint Small changes in whole-body corticosterone content affect larval Rana pipiens fitness components
    Karen Ann Glennemeier
    Department of Biology, 3065C Natural Science Building, University of Michigan, Ann Arbor 48109 1048, USA
    Gen Comp Endocrinol 127:16-25. 2002
    ..Our results also demonstrate that even small changes in corticosterone content can have important implications for amphibian fitness...
  16. ncbi request reprint Roles of stress hormones in food intake regulation in anuran amphibians throughout the life cycle
    Erica J Crespi
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Comp Biochem Physiol A Mol Integr Physiol 141:381-90. 2005
    ..Juvenile toads do not respond to food deprivation by activating the HPI axis, but instead pursue a strategy of energy conservation that involves a reduction in plasma corticosterone concentration...
  17. ncbi request reprint Regulation of pituitary thyrotropin gene expression during Xenopus metamorphosis: negative feedback is functional throughout metamorphosis
    Richard G Manzon
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Endocrinol 182:273-85. 2004
    ..g. CRF) of hypothalamic or pituitary origin, increased pituitary sensitivity to neuropeptides through upregulation of their receptors, and intrapituitary TH levels...
  18. doi request reprint Characterization of an alarm pheromone secreted by amphibian tadpoles that induces behavioral inhibition and suppression of the neuroendocrine stress axis
    Michael E Fraker
    Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 48109 1048, USA
    Horm Behav 55:520-9. 2009
    ..We also provide a neuroendocrine mechanism by which the behavioral inhibition caused by exposure to the alarm pheromone is maintained until the threat subsides...
  19. ncbi request reprint Ancient origins of human developmental plasticity
    Erica J Crespi
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Hum Biol 17:44-54. 2005
    ..The integrated neuroendocrine response to stress, and its role in timing critical life history transitions and establishing long-term phenotypic expression, arose early in the evolution of vertebrates...
  20. ncbi request reprint Ontogeny of corticotropin-releasing factor effects on locomotion and foraging in the Western spadefoot toad (Spea hammondii)
    Erica J Crespi
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Horm Behav 46:399-410. 2004
    ..Furthermore, the opposing actions of CRF and CORT on foraging suggest that they are important regulators of energy balance and food intake in amphibians throughout development...
  21. pmc Molecular mechanisms of corticosteroid synergy with thyroid hormone during tadpole metamorphosis
    Ronald M Bonett
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Gen Comp Endocrinol 168:209-19. 2010
    ..Concurrently, TH enhances tissue sensitivity to CS by upregulating GR and MR. Environmental stressors can modulate the timing of tadpole metamorphosis in part by CS enhancing the response of tadpole tissues to the actions of TH...
  22. ncbi request reprint Expression and hypophysiotropic actions of corticotropin-releasing factor in Xenopus laevis
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 137:272-82. 2004
    ..laevis as in other vertebrates. Furthermore, we provide evidence for a dual hypophysiotropic action of CRF on the thyroid and interrenal axes in X. laevis as has been shown previously in other amphibian species...
  23. pmc Stressor and glucocorticoid-dependent induction of the immediate early gene kruppel-like factor 9: implications for neural development and plasticity
    Ronald M Bonett
    Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 150:1757-65. 2009
    ..Our results support that KLF9 is a direct, GC receptor target gene that is induced by stress, and functions as an intermediary in the actions of GCs on brain gene expression and neuronal structure...
  24. ncbi request reprint Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolution
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, 3065C Kraus Natural Science Building, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 146:4851-60. 2005
    ..Our findings show that the functional relationships among CRF ligands and binding proteins, and their anorexigenic actions mediated by the CRF2 receptor, arose early in vertebrate evolution...
  25. doi request reprint Evolutionarily conserved glucocorticoid regulation of corticotropin-releasing factor expression
    Meng Yao
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 149:2352-60. 2008
    ....
  26. doi request reprint Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis
    Robert J Denver
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, USA
    Dev Biol 326:155-68. 2009
    ..Our findings support the view that T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha...
  27. doi request reprint Distribution and corticosteroid regulation of glucocorticoid receptor in the brain of Xenopus laevis
    Meng Yao
    Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Comp Neurol 508:967-82. 2008
    ..Our results show that the central distribution of GR-ir and regulation by corticosteroids are highly conserved among vertebrates...
  28. ncbi request reprint A role for basic transcription element-binding protein 1 (BTEB1) in the autoinduction of thyroid hormone receptor beta
    Pia Bagamasbad
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 283:2275-85. 2008
    ..Cooperation among the protein products of immediate early genes may be a common mechanism for driving developmental signaling pathways...
  29. ncbi request reprint Basic transcription element binding protein is a thyroid hormone-regulated transcription factor expressed during metamorphosis in Xenopus laevis
    Eric D Hoopfer
    3065C Natural Science Building, Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109 1048, USA
    Dev Growth Differ 44:365-81. 2002
    ....
  30. ncbi request reprint Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptides
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 48109 1048, USA
    Gen Comp Endocrinol 146:9-18. 2006
    ..Thus, CRF peptides may play diverse roles in physiology and development, and these functions likely arose early in vertebrate evolution...
  31. ncbi request reprint Acceleration of Ambystoma tigrinum metamorphosis by corticotropin-releasing hormone
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Exp Zool 293:94-8. 2002
    ..These findings suggest that the neuroendocrine mechanisms controlling metamorphosis are evolutionarily conserved across amphibian taxa...
  32. pmc Leptin (ob gene) of the South African clawed frog Xenopus laevis
    Erica J Crespi
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 103:10092-7. 2006
    ..Furthermore, the isolation and characterization of leptin and its receptor in a nonamniote provides an essential foundation for elucidating the structural and functional evolution of this important hormone...
  33. ncbi request reprint Structural and functional conservation of vertebrate corticotropin-releasing factor genes: evidence for a critical role for a conserved cyclic AMP response element
    Meng Yao
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Endocrinology 148:2518-31. 2007
    ..Our findings show that the basic regulatory elements of the CRF gene responsible for stressor-induced activation arose early in vertebrate evolution and have been maintained by strong positive selection...
  34. ncbi request reprint Role for corticoids in mediating the response of Rana pipiens tadpoles to intraspecific competition
    Karen Ann Glennemeier
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Exp Zool 292:32-40. 2002
    ..Our results suggest that elevated corticoid biosynthesis mediates the negative effect of increased population density (i.e., increased intraspecific competition) on tadpole growth...
  35. ncbi request reprint Plasma thyroid hormone concentrations in a wintering passerine bird: their relationship to geographic variation, environmental factors, metabolic rate, and body fat
    Michael F Burger
    School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI, 48109, USA
    Physiol Biochem Zool 75:187-99. 2002
    ..We conclude, therefore, that there is latitudinal variation in metabolic parameters in cardinals but that this variation is not explained by variation in plasma TH concentrations...
  36. ncbi request reprint Regulation of vertebrate corticotropin-releasing factor genes
    Meng Yao
    Department of Molecular, Cellular and Developmental Biology, 3065C Kraus Natural Science Building, The University of Michigan, Ann Arbor, MI 48109 1048, USA
    Gen Comp Endocrinol 153:200-16. 2007
    ..We also discuss evolutionarily conserved molecular mechanisms that operate at the level of CRF gene transcription...
  37. ncbi request reprint Involvement of the corticotropin-releasing factor (CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland
    Reiko Okada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, Tokyo 169 8050, Japan
    Gen Comp Endocrinol 150:437-44. 2007
    ..Conversely, the type 1 CRF receptor-specific antagonist antalarmin had no effect on TSH secretion. Our results support the hypothesis that CRF-induced TSH release by the amphibian pituitary gland is mediated by the CRF2...
  38. ncbi request reprint Evidence that urocortin I acts as a neurohormone to stimulate alpha MSH release in the toad Xenopus laevis
    Marinella Calle
    Department of Cellular Animal Physiology, Radboud University Nijmegen, Nijmegen, The Netherlands
    Brain Res 1040:14-28. 2005
    ..laevis, UCN1 released from neurohemal axon terminals in the pituitary neural lobe functions as a stimulatory neurohormone for alphaMSH release from melanotrope cells of the pituitary intermediate lobe...
  39. ncbi request reprint Molecular cloning and developmental expression of corticotropin-releasing factor in the chicken
    Kristien Vandenborne
    Laboratory of Comparative Endocrinology, Zoological Institute, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Endocrinology 146:301-8. 2005
    ..Changes in CRF production just before hatching may be causally related to the regulation of the thyroid and interrenal axes at this stage of chicken development...
  40. ncbi request reprint Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosus
    Rachid Safi
    CNRS UMR 5161, INRA LA 913, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, France
    Evol Dev 8:284-92. 2006
    ..Rather, the absence of metamorphosis may be due to the loss of TH-dependent control of key genes required for tissue transformation...

Research Grants3

  1. Hormone and Activity-Dependent Neural Gene Expression
    Robert Denver; Fiscal Year: 2007
    ....