Loren C Denlinger
Affiliation: University of Wisconsin
- A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functionsLoren C Denlinger
Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
J Endotoxin Res 10:137-42. 2004....
- Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine productionLoren C Denlinger
Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
J Immunol 174:4424-31. 2005....
- Human P2X7 pore function predicts allele linkage disequilibriumLoren C Denlinger
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Clin Chem 52:995-1004. 2006..We hypothesized that evaluation of participants with discordance between the P2X7 genotype and pore status would disclose additional alleles, linkage disequilibrium, and novel functional correlates of genotype to phenotype...
- Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma controlLoren C Denlinger
Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
Am J Respir Crit Care Med 179:265-70. 2009..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
- Purinergic receptor regulation of LPS-induced signaling and pathophysiologyAlma N Guerra
Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706-1532, USA
J Endotoxin Res 9:256-63. 2003..These data suggest that the co-ordinate action of P2Y and P2X7 receptors are critical for controlling LPS responses in vivo and that agents directed against both receptor classes may provide the greatest therapeutic advantage...
- Protection from asthma in a high-risk birth cohort by attenuated P2X(7) functionDavid M Manthei
Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
J Allergy Clin Immunol 130:496-502. 2012..The purinergic receptor P2X(7) can enhance airway leukocyte recruitment to the airways, and P2X(7) knockout mice display a reduced asthma-like phenotype...
- Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forestsMatthew J Maenner
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, Madison, Wisconsin 53705, USA
BMC Proc 3:S88. 2009..We sought to use the random forest algorithm to identify single-nucleotide polymorphisms (SNPs) that may be involved in gene-by-smoking interactions related to the early-onset of coronary heart disease...
- Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7Lei Shi
Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Box 9988, Madison, WI 53792, USA
Am J Respir Cell Mol Biol 47:363-71. 2012..These results support the expression of functional P2X(7) in human lung epithelium, although its role in epithelial pathogen defense is likely independent of IL-1 family cytokine processing...
- Role of infection in the development and exacerbation of asthmaTheresa W Guilbert
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
Expert Rev Respir Med 4:71-83. 2010..This review discusses these various associations as they pertain to the development and exacerbation of asthma...
- Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired functionLoren C Denlinger
Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
J Immunol 171:1304-11. 2003..These data suggest that the lipid interaction motif of the P2X(7) C terminus controls receptor trafficking and modulates channel activity...
- Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education NetworkLoren C Denlinger
Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
J Allergy Clin Immunol 119:3-11; quiz 12-3. 2007....