Loren C Denlinger

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions
    Loren C Denlinger
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Endotoxin Res 10:137-42. 2004
  2. ncbi Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production
    Loren C Denlinger
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 174:4424-31. 2005
  3. ncbi Human P2X7 pore function predicts allele linkage disequilibrium
    Loren C Denlinger
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Clin Chem 52:995-1004. 2006
  4. ncbi Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
  5. ncbi Purinergic receptor regulation of LPS-induced signaling and pathophysiology
    Alma N Guerra
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706-1532, USA
    J Endotoxin Res 9:256-63. 2003
  6. ncbi Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function
    David M Manthei
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    J Allergy Clin Immunol 130:496-502. 2012
  7. ncbi Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests
    Matthew J Maenner
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, Madison, Wisconsin 53705, USA
    BMC Proc 3:S88. 2009
  8. ncbi Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7
    Lei Shi
    Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Box 9988, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 47:363-71. 2012
  9. ncbi Role of infection in the development and exacerbation of asthma
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
    Expert Rev Respir Med 4:71-83. 2010
  10. ncbi Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function
    Loren C Denlinger
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Immunol 171:1304-11. 2003

Collaborators

Detail Information

Publications11

  1. ncbi A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions
    Loren C Denlinger
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Endotoxin Res 10:137-42. 2004
    ....
  2. ncbi Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production
    Loren C Denlinger
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 174:4424-31. 2005
    ....
  3. ncbi Human P2X7 pore function predicts allele linkage disequilibrium
    Loren C Denlinger
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Clin Chem 52:995-1004. 2006
    ..We hypothesized that evaluation of participants with discordance between the P2X7 genotype and pore status would disclose additional alleles, linkage disequilibrium, and novel functional correlates of genotype to phenotype...
  4. ncbi Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
    ..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
  5. ncbi Purinergic receptor regulation of LPS-induced signaling and pathophysiology
    Alma N Guerra
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706-1532, USA
    J Endotoxin Res 9:256-63. 2003
    ..These data suggest that the co-ordinate action of P2Y and P2X7 receptors are critical for controlling LPS responses in vivo and that agents directed against both receptor classes may provide the greatest therapeutic advantage...
  6. ncbi Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function
    David M Manthei
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    J Allergy Clin Immunol 130:496-502. 2012
    ..The purinergic receptor P2X(7) can enhance airway leukocyte recruitment to the airways, and P2X(7) knockout mice display a reduced asthma-like phenotype...
  7. ncbi Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests
    Matthew J Maenner
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, Madison, Wisconsin 53705, USA
    BMC Proc 3:S88. 2009
    ..We sought to use the random forest algorithm to identify single-nucleotide polymorphisms (SNPs) that may be involved in gene-by-smoking interactions related to the early-onset of coronary heart disease...
  8. ncbi Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7
    Lei Shi
    Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Box 9988, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 47:363-71. 2012
    ..These results support the expression of functional P2X(7) in human lung epithelium, although its role in epithelial pathogen defense is likely independent of IL-1 family cytokine processing...
  9. ncbi Role of infection in the development and exacerbation of asthma
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
    Expert Rev Respir Med 4:71-83. 2010
    ..This review discusses these various associations as they pertain to the development and exacerbation of asthma...
  10. ncbi Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function
    Loren C Denlinger
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Immunol 171:1304-11. 2003
    ..These data suggest that the lipid interaction motif of the P2X(7) C terminus controls receptor trafficking and modulates channel activity...
  11. ncbi Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network
    Loren C Denlinger
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    J Allergy Clin Immunol 119:3-11; quiz 12-3. 2007
    ....