Loren C Denlinger

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
  2. ncbi request reprint A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions
    Loren C Denlinger
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Endotoxin Res 10:137-42. 2004
  3. ncbi request reprint Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production
    Loren C Denlinger
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 174:4424-31. 2005
  4. ncbi request reprint Human P2X7 pore function predicts allele linkage disequilibrium
    Loren C Denlinger
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Clin Chem 52:995-1004. 2006
  5. doi request reprint Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines
    Stephane Esnault
    Department of Medicine, Allergy, Pulmonary, and Critical Care Medicine Division, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA Electronic address
    Clin Immunol 150:90-100. 2014
  6. ncbi request reprint Purinergic receptor regulation of LPS-induced signaling and pathophysiology
    Alma N Guerra
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706 1532, USA
    J Endotoxin Res 9:256-63. 2003
  7. pmc P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy
    Loren C Denlinger
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 187:28-33. 2013
  8. pmc The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation
    Lisa E Wickert
    Department of Biomolecular Chemistry, The University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS ONE 8:e63789. 2013
  9. pmc Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression
    Mandy E Burnham
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53792, USA
    J Immunol 191:2900-6. 2013
  10. pmc Markers of vascular perturbation correlate with airway structural change in asthma
    Mats W Johansson
    Department of Biomolecular Chemistry, University of Wisconsin, 4285A Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Am J Respir Crit Care Med 188:167-78. 2013

Collaborators

Detail Information

Publications18

  1. pmc Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
    ..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
  2. ncbi request reprint A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions
    Loren C Denlinger
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Endotoxin Res 10:137-42. 2004
    ....
  3. ncbi request reprint Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production
    Loren C Denlinger
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 174:4424-31. 2005
    ....
  4. ncbi request reprint Human P2X7 pore function predicts allele linkage disequilibrium
    Loren C Denlinger
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Clin Chem 52:995-1004. 2006
    ..We hypothesized that evaluation of participants with discordance between the P2X7 genotype and pore status would disclose additional alleles, linkage disequilibrium, and novel functional correlates of genotype to phenotype...
  5. doi request reprint Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines
    Stephane Esnault
    Department of Medicine, Allergy, Pulmonary, and Critical Care Medicine Division, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA Electronic address
    Clin Immunol 150:90-100. 2014
    ..semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma. ..
  6. ncbi request reprint Purinergic receptor regulation of LPS-induced signaling and pathophysiology
    Alma N Guerra
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706 1532, USA
    J Endotoxin Res 9:256-63. 2003
    ..These data suggest that the co-ordinate action of P2Y and P2X7 receptors are critical for controlling LPS responses in vivo and that agents directed against both receptor classes may provide the greatest therapeutic advantage...
  7. pmc P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy
    Loren C Denlinger
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 187:28-33. 2013
    ..The function of the P2X(7) nucleotide receptor protects against exacerbation in people with mild-intermittent asthma during viral illnesses, but the impact of disease severity and maintenance therapy has not been studied...
  8. pmc The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation
    Lisa E Wickert
    Department of Biomolecular Chemistry, The University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS ONE 8:e63789. 2013
    ..Mutations within the trafficking domain result in attenuated receptor activity and cell surface presentation, but the mechanisms by which amino acid changes within this region promote altered P2X7 function have not been elucidated...
  9. pmc Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression
    Mandy E Burnham
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53792, USA
    J Immunol 191:2900-6. 2013
    ..These data support a model in which IL-5 family cytokines trigger a selective downregulation mechanism in EOS(A) for JAK/STAT pathways...
  10. pmc Markers of vascular perturbation correlate with airway structural change in asthma
    Mats W Johansson
    Department of Biomolecular Chemistry, University of Wisconsin, 4285A Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Am J Respir Crit Care Med 188:167-78. 2013
    ..Vascular endothelial cell products have not been explored as a surrogate to mark structural airway changes in asthma...
  11. pmc Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function
    David M Manthei
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    J Allergy Clin Immunol 130:496-502. 2012
    ..The purinergic receptor P2X(7) can enhance airway leukocyte recruitment to the airways, and P2X(7) knockout mice display a reduced asthma-like phenotype...
  12. pmc Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge
    Stephane Esnault
    Department of Medicine, Allergy, Pulmonary, and Critical Care Medicine Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    PLoS ONE 8:e67560. 2013
    ..Genome-wide expression analysis of airway EOS by microarrays has been limited by the ability to generate high quality RNA from sufficient numbers of airway EOS...
  13. pmc Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7
    Lei Shi
    Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Box 9988, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 47:363-71. 2012
    ..These results support the expression of functional P2X(7) in human lung epithelium, although its role in epithelial pathogen defense is likely independent of IL-1 family cytokine processing...
  14. pmc Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests
    Matthew J Maenner
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, Madison, Wisconsin 53705, USA
    BMC Proc 3:S88. 2009
    ..We sought to use the random forest algorithm to identify single-nucleotide polymorphisms (SNPs) that may be involved in gene-by-smoking interactions related to the early-onset of coronary heart disease...
  15. pmc Safety of and cellular response to segmental bronchoprovocation in allergic asthma
    Loren C Denlinger
    Allergy, Pulmonary and Critical Care Division, Department of Medicine, University of Wisconsin, Madison, WI, USA
    PLoS ONE 8:e51963. 2013
    ..Despite its incorporation into research studies, the safety aspects of segmental allergen bronchoprovocation and differences in cellular response among different allergens have received limited consideration...
  16. pmc Role of infection in the development and exacerbation of asthma
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
    Expert Rev Respir Med 4:71-83. 2010
    ..This review discusses these various associations as they pertain to the development and exacerbation of asthma...
  17. ncbi request reprint Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function
    Loren C Denlinger
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Immunol 171:1304-11. 2003
    ..These data suggest that the lipid interaction motif of the P2X(7) C terminus controls receptor trafficking and modulates channel activity...
  18. pmc Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network
    Loren C Denlinger
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    J Allergy Clin Immunol 119:3-11; quiz 12-3. 2007
    ....