Loren C Denlinger
Affiliation: University of Wisconsin
- P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapyLoren C Denlinger
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Am J Respir Crit Care Med 187:28-33. 2013..The function of the P2X(7) nucleotide receptor protects against exacerbation in people with mild-intermittent asthma during viral illnesses, but the impact of disease severity and maintenance therapy has not been studied...
- Lower airway rhinovirus burden and the seasonal risk of asthma exacerbationLoren C Denlinger
Department of Medicine Allergy, Pulmonary and Critical Care, University of Wisconsin Madison, 53792, USA
Am J Respir Crit Care Med 184:1007-14. 2011..It is unclear whether human rhinovirus (HRV)–induced exacerbations are associated with greater viral replication and neutrophilic inflammation compared with HRV colds...
- Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forestsMatthew J Maenner
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, Madison, Wisconsin 53705, USA
BMC Proc 3:S88. 2009..We sought to use the random forest algorithm to identify single-nucleotide polymorphisms (SNPs) that may be involved in gene-by-smoking interactions related to the early-onset of coronary heart disease...
- Human P2X7 pore function predicts allele linkage disequilibriumLoren C Denlinger
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Clin Chem 52:995-1004. 2006..We hypothesized that evaluation of participants with discordance between the P2X7 genotype and pore status would disclose additional alleles, linkage disequilibrium, and novel functional correlates of genotype to phenotype...
- Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma controlLoren C Denlinger
Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
Am J Respir Crit Care Med 179:265-70. 2009..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
- Protection from asthma in a high-risk birth cohort by attenuated P2X(7) functionDavid M Manthei
Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
J Allergy Clin Immunol 130:496-502. 2012..The purinergic receptor P2X(7) can enhance airway leukocyte recruitment to the airways, and P2X(7) knockout mice display a reduced asthma-like phenotype...
- Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7Lei Shi
Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Box 9988, Madison, WI 53792, USA
Am J Respir Cell Mol Biol 47:363-71. 2012..These results support the expression of functional P2X(7) in human lung epithelium, although its role in epithelial pathogen defense is likely independent of IL-1 family cytokine processing...
- Markers of vascular perturbation correlate with airway structural change in asthmaMats W Johansson
Department of Biomolecular Chemistry, University of Wisconsin, 4285A Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
Am J Respir Crit Care Med 188:167-78. 2013..Vascular endothelial cell products have not been explored as a surrogate to mark structural airway changes in asthma...
- Safety of and cellular response to segmental bronchoprovocation in allergic asthmaLoren C Denlinger
Allergy, Pulmonary and Critical Care Division, Department of Medicine, University of Wisconsin, Madison, WI, USA
PLoS ONE 8:e51963. 2013..Despite its incorporation into research studies, the safety aspects of segmental allergen bronchoprovocation and differences in cellular response among different allergens have received limited consideration...
- Human Airway Eosinophils Exhibit Preferential Reduction in STAT Signaling Capacity and Increased CISH ExpressionMandy E Burnham
Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53792
J Immunol 191:2900-6. 2013..These data support a model in which IL-5 family cytokines trigger a selective downregulation mechanism in EOSA for JAK/STAT pathways. ..
- Role of infection in the development and exacerbation of asthmaTheresa W Guilbert
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 944, CSC 4108, Madison, WI 53792, USA
Expert Rev Respir Med 4:71-83. 2010..This review discusses these various associations as they pertain to the development and exacerbation of asthma...
- The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylationLisa E Wickert
Department of Biomolecular Chemistry, The University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS ONE 8:e63789. 2013..Mutations within the trafficking domain result in attenuated receptor activity and cell surface presentation, but the mechanisms by which amino acid changes within this region promote altered P2X7 function have not been elucidated...
- Identification of genes expressed by human airway eosinophils after an in vivo allergen challengeStephane Esnault
Department of Medicine, Allergy, Pulmonary, and Critical Care Medicine Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
PLoS ONE 8:e67560. 2013..Genome-wide expression analysis of airway EOS by microarrays has been limited by the ability to generate high quality RNA from sufficient numbers of airway EOS...
- Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine productionLoren C Denlinger
Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
J Immunol 174:4424-31. 2005....