Michael Denison

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists
    Scott R Nagy
    Department of Environmental Toxicology, Meyer Hall, University of California, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 65:200-10. 2002
  2. ncbi request reprint Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells
    J Thomas Sanderson
    Institute for Risk Assessment Sciences IRAS, Utrecht University, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 82:70-9. 2004
  3. ncbi request reprint Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results
    Isabelle Windal
    Scientific Institute of Public Health, rue J Wytsman 14, B 1050 Brussels, Belgium
    Environ Sci Technol 39:7357-64. 2005
  4. pmc 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines
    Jennifer C Brennan
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA
    BMC Complement Altern Med 13:133. 2013
  5. pmc Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Toxicol Sci 124:1-22. 2011
  6. ncbi request reprint Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor
    M S Denison
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Toxicol Appl Pharmacol 152:406-14. 1998
  7. ncbi request reprint Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Annu Rev Pharmacol Toxicol 43:309-34. 2003
  8. ncbi request reprint Ligand binding and activation of the Ah receptor
    Michael S Denison
    Department of Environmental Toxicology, Meyer Hall, One Shields Avenue, University of California, Davis 95616 8588, USA
    Chem Biol Interact 141:3-24. 2002
  9. ncbi request reprint Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay
    Scott R Nagy
    Department of Environmental Toxicology, University of California, Davis 95616, USA
    Biochemistry 41:861-8. 2002
  10. ncbi request reprint Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells
    Jane M Rogers
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Mol Pharmacol 61:1393-403. 2002

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists
    Scott R Nagy
    Department of Environmental Toxicology, Meyer Hall, University of California, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 65:200-10. 2002
    ..This bioassay system has numerous advantages over currently available AhR-based bioassays including increased rapidity and ease of use, low reagent cost, and application for high-throughput screening...
  2. ncbi request reprint Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells
    J Thomas Sanderson
    Institute for Risk Assessment Sciences IRAS, Utrecht University, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 82:70-9. 2004
    ..3 promoter-specific aromatase transcripts. These results shed light on the structure-activity relationships for aromatase inhibition as well as mechanisms of induction in human H295R cells...
  3. ncbi request reprint Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results
    Isabelle Windal
    Scientific Institute of Public Health, rue J Wytsman 14, B 1050 Brussels, Belgium
    Environ Sci Technol 39:7357-64. 2005
    ..A greater understanding of these characteristics will lead to increased accuracy, precision, and reproducibility of the widely used CALUX bioassay within and between research laboratories...
  4. pmc 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines
    Jennifer C Brennan
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA
    BMC Complement Altern Med 13:133. 2013
    ..Although phytoestrogen content has been analyzed in the rhizomes of various Fallopia sp., seeds of a Fallopia sp. have never been examined for phytoestrogen presence...
  5. pmc Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Toxicol Sci 124:1-22. 2011
    ....
  6. ncbi request reprint Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor
    M S Denison
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Toxicol Appl Pharmacol 152:406-14. 1998
    ..Our results confirm that carbaryl is both a weak AhR ligand and inducer of AhR-dependent gene expression and argue against its proposed ligand-independent mechanism of AhR activation...
  7. ncbi request reprint Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Annu Rev Pharmacol Toxicol 43:309-34. 2003
    ....
  8. ncbi request reprint Ligand binding and activation of the Ah receptor
    Michael S Denison
    Department of Environmental Toxicology, Meyer Hall, One Shields Avenue, University of California, Davis 95616 8588, USA
    Chem Biol Interact 141:3-24. 2002
    ..In this review we describe the current state of knowledge with respect to naturally occurring AhR ligands and present and discuss the first theoretical model of the AhR LBD based on crystal structures of homologous PAS family members...
  9. ncbi request reprint Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay
    Scott R Nagy
    Department of Environmental Toxicology, University of California, Davis 95616, USA
    Biochemistry 41:861-8. 2002
    ..Overall, these results have not only allowed the identification of novel activators of the AhR but also demonstrate the utility of the recombinant H1G1.1c3 cell bioassay for high-throughput chemical screening...
  10. ncbi request reprint Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells
    Jane M Rogers
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Mol Pharmacol 61:1393-403. 2002
    ..Overall, our results are consistent with the action of a TCDD-induced protein at a step(s) after ER-DNA binding, most likely at the level of gene transcription...
  11. pmc Newspapers and newspaper ink contain agonists for the ah receptor
    Jessica E S Bohonowych
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Toxicol Sci 102:278-90. 2008
    ..Given the large amount of recycling and reprocessing of newspapers throughout the world, release of these easily extractable AhR agonists into the environment should be examined and their potential effects on aquatic organisms assessed...
  12. ncbi request reprint Comparison of recombinant cell bioassays for the detection of Ah receptor agonists
    Dalho Han
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Biofactors 20:11-22. 2004
    ..Given the above differences between cell lines and reporters, the choice of which cell line to use will certainly be dependent on the specific questions and issues being examined...
  13. ncbi request reprint The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression
    S Renée Rushing
    Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USA
    Arch Biochem Biophys 403:189-201. 2002
    ..Furthermore, the interaction between SMRT and the AhR may have implications in pathways other than the AhR signaling pathway...
  14. pmc Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors
    Christophe Morisseau
    Department of Entomology and Cancer Center, University of California at Davis, Davis, California 95616, USA
    Environ Health Perspect 117:1867-72. 2009
    ..Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective toxicologic evaluation of xenobiotics...
  15. pmc Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus)
    Amanda J Palumbo
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California 95616, USA
    Environ Toxicol Chem 28:1749-55. 2009
    ..Furthermore, suppression of natural estrogen signaling by AhR agonists may have significant effects on fish reproduction...
  16. pmc Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border
    Daniel E Arrieta
    Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas, USA
    Environ Health Perspect 111:1299-305. 2003
    ..Further work is needed to understand the sources, exposure, and effects of PM10 and particulate organic material in the Paso del Norte airshed...
  17. pmc Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks
    Johanna R Rochester
    Department of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, United States
    Reprod Toxicol 27:63-71. 2009
    ..Thus, phytoestrogens may affect reproductive development in wild birds, and environmental stressors may influence levels of phytoestrogens in the field...
  18. ncbi request reprint Application of the luciferase cell culture bioassay for the detection of refined petroleum products
    Michael H Ziccardi
    Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Mar Pollut Bull 44:983-91. 2002
    ..Additionally, weathering of products reduced their induction potency. Based on the high I-EQ estimates of many products, biological effects associated with exposure may have been previously underestimated using other diagnostic methods...
  19. pmc Interaction of diuron and related substituted phenylureas with the Ah receptor pathway
    Bin Zhao
    Department of Environmental Toxicology, University of California, Davis, CA 95616 8588, USA
    J Biochem Mol Toxicol 20:103-13. 2006
    ..These results demonstrate not only that diuron and related substituted phenylureas are AhR ligands but also that exposure to these chemicals could induce/inhibit AhR-dependent biological effects...
  20. ncbi request reprint Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons
    Michael H Ziccardi
    Wildlife Health Center, School of Veterinary Medicine, University of California, Davis 95616, USA
    Environ Toxicol Chem 21:2027-33. 2002
    ..Overall, our results strongly support the use of this system for the detection and relative quantitation of Ah receptor-active PAHs...
  21. ncbi request reprint Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids
    Dal Ho Han
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Biosci Biotechnol Biochem 66:1479-87. 2002
    ..The suppressive effect of flavonoids suggests that these compounds have anti-estrogenic and anti-cancer activities...
  22. pmc Persistent binding of ligands to the aryl hydrocarbon receptor
    Jessica E Bohonowych
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Toxicol Sci 98:99-109. 2007
    ..Our studies suggest that AhR binding affinity/occupancy has little effect on the observed differences in the persistence of gene expression by HAHs and PAHs...
  23. ncbi request reprint Validation of a cell culture bioassay for detection of petroleum exposure in mink (Mustela vison) as a model for detection in sea otters (Enhydra lutris)
    Michael H Ziccardi
    Wildlife Health Center, Department of Pathology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:963-8. 2002
    ..To validate a luciferase bioassay, which is based on a recombinant mouse hepatoma cell line, for the detection of exposure to petroleum in mustelid species...
  24. ncbi request reprint Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells
    Scott A Monk
    Department of Environmental Toxicology, University of California, Davis, CA 95616 8588, USA
    Arch Biochem Biophys 419:158-69. 2003
    ..Together, these results demonstrate a novel mechanism of CYP1A1 transcriptional repression that does not involve any previously reported negative regulatory elements for CYP1A1...
  25. ncbi request reprint Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells
    Phillip C C Liu
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    J Biochem Mol Toxicol 16:70-83. 2002
    ....
  26. pmc Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens
    Kala Natarajan
    Center for Health and the Environment, University of California, Davis, California 95616 8615, USA
    Environ Health Perspect 110:791-5. 2002
    ..However, when steroidal estrogens were removed by immunoprecipitation, we detected the estrogenic activity of NP in the bioassay. Thus, this approach is appropriate for detecting exogenous, nonsteroidal estrogens in serum samples...
  27. ncbi request reprint Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits
    Anoek Jeuken
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    J Agric Food Chem 51:5478-87. 2003
    ..Overall, these results demonstrate that dietary products can be a major source of naturally occurring AhR ligands to which animals and humans are chronically exposed...
  28. pmc Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor
    Anatoly Soshilov
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    J Biol Chem 283:32995-3005. 2008
    ..This study provides insights into mechanisms of AhR transformation, dimerization of PAS domain proteins, and Hsp90 dissociation in activation of its client proteins...
  29. pmc In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens
    Ki Chang Ahn
    Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
    Environ Health Perspect 116:1203-10. 2008
    ..Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects...
  30. ncbi request reprint Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging
    Matthew R Lashley
    Department of Chemistry, University of California, Davis 95616, USA
    Bioorg Med Chem 10:4075-82. 2002
    ..The results show that while the relative affinity of HOTam-DTPA for the estrogen receptor is approximately 10-fold lower than that of tamoxifen, it still remains a potent ligand at relatively low concentrations...
  31. ncbi request reprint Specificity of nuclear protein binding to a CYP1A1 negative regulatory element
    Scott R Nagy
    Department of Environmental Toxicology, Meyer Hall, One Shields Avenue, University of California, Davis, CA 95616 8588, USA
    Biochem Biophys Res Commun 296:799-805. 2002
    ..These results suggest that repression of CYP1A1 gene expression in high passage keratinocytes may involve the interplay between at least two specific NeRD binding factors...
  32. ncbi request reprint Atmospheric concentrations of polybrominated diphenyl ethers at near-source sites
    Thomas M Cahill
    Department of Integrated Natural Sciences, Arizona State University West Campus, P O Box 37100, Phoenix, Arizona 85069, USA
    Environ Sci Technol 41:6370-7. 2007
    ..S. Environmental Protection Agency. More research is needed on the potential health effects of PBDEs...
  33. pmc Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro
    Wenyue Hu
    Iconix Biosciences, Inc, 325 E Middlefield Road, Mountain View, CA 94043, USA
    Mol Pharmacol 71:1475-86. 2007
    ....
  34. pmc Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis
    Alessandro Pandini
    Dipartimento di Scienze dell Ambiente e del Territorio, Universita degli Studi di Milano Bicocca, Piazza della Scienza, 1, 20126 Milano, Italy
    Biochemistry 46:696-708. 2007
    ....
  35. ncbi request reprint Analysis of Ah receptor pathway activation by brominated flame retardants
    David J Brown
    Xenobiotic Detection Systems Inc, 1601 East Geer Street, Suite S, Durham, NC 27704, USA
    Chemosphere 55:1509-18. 2004
    ..When tested in the CALUX assay these compounds were found to be equivalent to, or more active than their chlorinated analogues. Relative effective potency values were determined from dose response curves for these brominated HAHs...
  36. ncbi request reprint Rapid bioassay for the determination of dioxins and dioxin-like PCDFs and PCBs in meat and animal feeds
    Sang Hee Jeong
    Toxicology Laboratory, National Veterinary Research and Quarantine Service, 480, Anyang, 430 016, Korea
    J Anal Toxicol 29:156-62. 2005
    ..1 times higher in bioassay than HR-GC-MS. Overall, these results demonstrated that the recombinant cell bioassay can be used for the rapid detection and quantitation of PCDDs and dioxin-like PCDFs and PCBs in meats and animal feeds...
  37. pmc Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity in vitro
    Gail P Klein
    Department of Pharmacology, Centre for Urban Health Initiatives, University of Toronto, and Program in Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Environ Health Perspect 114:697-703. 2006
    ..Our results suggest that mechanistic studies of the health effects of ambient air must consider gas and particulate phases because chemicals present in both phases can affect AHR and ER signaling pathways...
  38. pmc Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound
    B Paige Lawrence
    Department of Environmental Medicine, University of Rochester, NY, USA
    Blood 112:1158-65. 2008
    ..These data identify the AhR protein as key molecular target of VAF347 and its essential role for mediating the anti-inflammatory effects of the compound in vitro and in vivo...
  39. pmc Analysis of dioxins in contaminated soils with the calux and caflux bioassays, an immunoassay, and gas chromatography/high-resolution mass spectrometry
    Malin Nording
    Environmental Chemistry, Umea University, SE 901 87 Umea, Sweden
    Environ Toxicol Chem 26:1122-9. 2007
    ....
  40. pmc Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data
    David J Brown
    Xenobiotic Detection Systems, 1601 East Geer Street, Suite S, Durham, North Carolina 27704, USA
    Environ Sci Technol 41:4354-60. 2007
    ..The ability of XDS-CALUX bioassay data to predict GC/MS-derived TEQ data should make this procedure useful in risk assessment and management decisions...

Research Grants13

  1. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2007
    ..abstract_text> ..
  2. Analysis and Effect of Persistent Ah Receptor Activation
    Michael Denison; Fiscal Year: 2007
    ..abstract_text> ..
  3. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2006
    ..abstract_text> ..
  4. Analysis and Effect of Persistent Ah Receptor Activation
    Michael Denison; Fiscal Year: 2006
    ..abstract_text> ..
  5. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2005
    ..abstract_text> ..
  6. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2002
    ..abstract_text> ..
  7. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2001
    ..abstract_text> ..
  8. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2000
    ..abstract_text> ..
  9. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Denison; Fiscal Year: 2009
    ..abstract_text> ..