D R Dengel

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise
    Aaron S Kelly
    University of Minnesota, Minneapolis, and St Paul Heart Clinic, St Paul, Minnesota, USA
    J Pediatr 145:731-6. 2004
  2. pmc Noninvasive measurements of arterial stiffness: repeatability and interrelationships with endothelial function and arterial morphology measures
    Corey J Huck
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Vasc Health Risk Manag 3:343-9. 2007
  3. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
  4. ncbi request reprint A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium
    D R Dengel
    University of Minnesota, Minneapolis, USA
    Physiol Res 56:393-401. 2007
  5. ncbi request reprint Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Metabolism 55:907-11. 2006
  6. ncbi request reprint Effect of aerobic exercise training on renal responses to sodium in hypertensives
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Med Sci Sports Exerc 38:217-22. 2006
  7. ncbi request reprint Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives
    D R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, 55455, USA
    J Hum Hypertens 20:372-8. 2006
  8. ncbi request reprint Effect of oral glucose loading on endothelial function in normal-weight and overweight children
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 112:493-8. 2007
  9. pmc Association of the home environment with cardiovascular and metabolic biomarkers in youth
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Prev Med 51:259-61. 2010
  10. doi request reprint Gender differences in vascular function and insulin sensitivity in young adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 120:153-60. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise
    Aaron S Kelly
    University of Minnesota, Minneapolis, and St Paul Heart Clinic, St Paul, Minnesota, USA
    J Pediatr 145:731-6. 2004
    ..To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents...
  2. pmc Noninvasive measurements of arterial stiffness: repeatability and interrelationships with endothelial function and arterial morphology measures
    Corey J Huck
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Vasc Health Risk Manag 3:343-9. 2007
    ..Therefore, the purpose of this study was to examine the repeatability and interrelationships between 3 different techniques to measure arterial stiffness and to compare this with forearm-mediated dilation...
  3. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
    ..To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS...
  4. ncbi request reprint A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium
    D R Dengel
    University of Minnesota, Minneapolis, USA
    Physiol Res 56:393-401. 2007
    ..The increase in BP during Na(+) loading in older hypertensives was associated with the eNOS genotype and may be related to changes in renal hemodynamics due to changes in NO metabolism...
  5. ncbi request reprint Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Metabolism 55:907-11. 2006
    ..In overweight adults, 6 months of weight loss resulted in improvements in body composition, insulin sensitivity, lipid profile, and brachial artery compliance and distensibility...
  6. ncbi request reprint Effect of aerobic exercise training on renal responses to sodium in hypertensives
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Med Sci Sports Exerc 38:217-22. 2006
    ..The exact mechanism(s) by which aerobic exercise training elicits these changes are unknown; however, it is possible that changes in renal hemodynamics may play a role...
  7. ncbi request reprint Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives
    D R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, 55455, USA
    J Hum Hypertens 20:372-8. 2006
    ..This study demonstrates the importance of physical activity on BP sensitivity to dietary Na(+)...
  8. ncbi request reprint Effect of oral glucose loading on endothelial function in normal-weight and overweight children
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 112:493-8. 2007
    ..6 compared with 20.2+/-2.0% respectively; P=0.019). In conclusion, these results suggest that acute elevation of glucose and insulin in overweight and normal-weight children are not associated with impairment in endothelial function...
  9. pmc Association of the home environment with cardiovascular and metabolic biomarkers in youth
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Prev Med 51:259-61. 2010
    ..To examine the relationship between the home environment and biomarkers associated with the cardiovascular and metabolic risks in adolescents...
  10. doi request reprint Gender differences in vascular function and insulin sensitivity in young adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 120:153-60. 2011
    ..However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function...
  11. ncbi request reprint Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis 55455, USA
    Physiol Genomics 11:73-80. 2002
    ..4 +/- 6.2 and -3.6 +/- 2.5 mU/ml) ACE genotypes. In conclusion, we demonstrated that those older hypertensives with the ACE II genotype have the greatest improvement in insulin action following AEX...
  12. pmc Does the built environment relate to the metabolic syndrome in adolescents?
    Donald R Dengel
    School of Kinesiology, University of Minnesota, 1900 University Avenue SE, 110 Cooke Hall, Minneapolis, MN 55455, USA
    Health Place 15:946-51. 2009
    ..Multivariate linear regression models revealed significant associations between an increased distance to convenience stores and the MetS. The results of this study suggest a role for the built environment in the development of the MetS...
  13. ncbi request reprint Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensives
    D R Dengel
    School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis 55455, USA
    Am J Hypertens 14:1178-84. 2001
    ..Individuals differ in their blood pressure (BP) response to changes in dietary sodium (Na+) intake. It is possible that differences in BP responses to dietary Na+ are influenced by genes...
  14. doi request reprint Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
    J Pediatr Hematol Oncol 30:20-5. 2008
    ..2+/-7.1 y) adult survivors of childhood ALL who received chemotherapy without cranial radiation (n=25) or chemotherapy combined with cranial radiation (n=50) compared with a healthy control group of similar sex, age, and weight (n=59)...
  15. ncbi request reprint Vascular structure and function in women: relationship with body mass index
    Thomas P Olson
    Mayo Clinic and Foundation, Rochester, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Prev Med 30:487-92. 2006
    ..The purpose of the present study was to compare endothelial function in lean (body mass index [BMI]=18.0-24.9 kg/m2); overweight (BMI=25-29.9 kg/m2); and obese (BMI>30 kg/m2), healthy, eumenorrheic women...
  16. ncbi request reprint Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children
    Aaron S Kelly
    Departments of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Cardiometab Syndr 1:248-52. 2006
    ..Overweight children with components of the metabolic syndrome may be at elevated risk for future cardiovascular disease...
  17. ncbi request reprint In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Metabolism 56:1005-9. 2007
    ..These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children...
  18. doi request reprint Diet revision in overweight children: effect on autonomic and vascular function
    Christopher L Kaufman
    School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
    Clin Auton Res 18:105-8. 2008
    ..Changes in body composition in OW children due to dietary modification alone can result in modest improvements in indices of cardiac risk...
  19. ncbi request reprint Relationships of cardiac autonomic function with metabolic abnormalities in childhood obesity
    Christopher L Kaufman
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55102, USA
    Obesity (Silver Spring) 15:1164-71. 2007
    ..The objective was to examine cardiovascular autonomic (cANS) function and its potential relationships with leptin resistance, insulin resistance, oxidative stress, and inflammation in a pediatric sample with varying levels of obesity...
  20. ncbi request reprint Relationships between heart rate variability, vascular function, and adiposity in children
    Christopher L Kaufman
    School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
    Clin Auton Res 17:165-71. 2007
    ..To examine the relationships and interactions between cardiovascular autonomic nervous system (cANS) function, adiposity, and vascular function in children of varying levels of adiposity...
  21. doi request reprint Automated edge detection versus manual edge measurement in analysis of brachial artery reactivity: a comparison study
    Eric B Williamson
    General Clinical Research Center, University of Minnesota, Minneapolis, MN 55455, USA
    Ultrasound Med Biol 34:1499-503. 2008
    ..Therefore, caution should be used when comparing research utilizing different computerized edge-detection systems for measuring vascular function and structure...
  22. ncbi request reprint Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia
    Kirsten K Ness
    Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 49:975-81. 2007
    ..We compared body composition, muscle strength, and mobility between 75 adult survivors of childhood acute lymphoblastic leukemia (ALL) and expected values based on population normative data...
  23. ncbi request reprint Moderate resistance training and vascular health in overweight women
    Thomas P Olson
    University of Minnesota, Minneapolis, MN, USA
    Med Sci Sports Exerc 38:1558-64. 2006
    ..Thus, the aim of this study was to examine the effects of 1 yr of resistance training (RT) on vascular structure and function in overweight but otherwise healthy eumenorrheic women...
  24. ncbi request reprint Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women
    T P Olson
    Mayo Clinic, Division of Cardiovascular Diseases, University of Minnesota, and Minneapolis Veterans Affairs Medical Center, MN, USA
    Int J Obes (Lond) 31:996-1003. 2007
    ..This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women...
  25. pmc Physical activity in young adults and incident hypertension over 15 years of follow-up: the CARDIA study
    Emily D Parker
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am J Public Health 97:703-9. 2007
    ..We sought to examine the relation between physical activity and incident hypertension in young adults over 15 years of follow-up in the Coronary Artery Risk Development in Young Adults study...
  26. doi request reprint Comparison of changes in heart rate variability and blood pressure during nitroglycerin administration and head-up tilt testing
    Tyler A Bosch
    School of Kinesiology, University of Minnesota, 1900 University Avenue S E, Minneapolis, MN 55455, USA
    Clin Auton Res 19:46-50. 2009
    ..To compare the changes in heart rate variability (HRV) and blood pressure (BP) between standard head-up tilt test (HUT) and nitroglycerin administration...
  27. ncbi request reprint Aerobic-exercise training improves ventilatory efficiency in overweight children
    Christopher Kaufman
    School of Kinesiology, University of Minnesota, MN 55455, USA
    Pediatr Exerc Sci 19:82-92. 2007
    ..8 +/- 0.80 to 31.0 +/- 0.53 vs. control = 30.3 +/- 0.88 to 31.7 +/- 0.91, p < .05). Aerobic-exercise training might help reverse the decrements in cardiopulmonary function observed over time in overweight children...
  28. ncbi request reprint Comparison of B-mode and echo tracking methods of assessing flow-mediated dilation
    Aaron S Kelly
    University of Minnesota, Minneapolis, Minnesota 55102, USA
    Ultrasound Med Biol 30:1447-9. 2004
    ..75 +/- 0.65 mm, 4.00 +/- 0.63 mm and 6.91 +/- 2.85%, respectively. Results, as displayed by Bland-Altman graphs, indicate a strong agreement between B-mode and echo tracking methods of assessing brachial artery diameter changes via FMD...
  29. doi request reprint Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down syndrome
    Christopher C Draheim
    School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 106:1512-6. 2010
    ..Predictors of IMT differed for patients with DS compared to controls, which indicates that patients with DS possess a unique model of atherogenesis...
  30. doi request reprint Effects of left ventricular assist device (LVAD) placement on myocardial oxidative stress markers
    D L Templeton
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States
    Heart Lung Circ 21:586-97. 2012
    ..The primary purpose of this study was to examine the changes in myocardial oxidative stress during the support of a left ventricular assist device (LVAD)...
  31. ncbi request reprint Aerobic exercise training improves insulin sensitivity independent of plasma tumor necrosis factor-alpha levels in older female hypertensives
    Thomas H Reynolds
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan and GRECC, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, MI, USA
    Metabolism 51:1402-6. 2002
    ..In conclusion, in this population of older hypertensive females, AEX improved insulin sensitivity and lowered blood pressure without a reduction in plasma TNF-alpha levels...
  32. ncbi request reprint Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives
    Michael D Brown
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA
    J Appl Physiol (1985) 92:1434-42. 2002
    ..Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects...
  33. ncbi request reprint Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor necrosis factor-alpha system in older hypertensives
    Thomas H Reynolds
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, MI, USA
    Metabolism 53:397-402. 2004
    ..168). In conclusion, a 4-month RT program significantly increased insulin-mediated glucose disposal and LBM without a significant reduction in plasma levels of TNF-alpha, sTNF R1, and sTNF R2 in older hypertensive subjects...
  34. ncbi request reprint Regional differences in glucose clearance: effects of insulin and resistance training on arm and leg glucose clearance in older hypertensive individuals
    Thomas H Reynolds
    Dept of Internal Medicine, University of Michigan, Ann Arbor, USA
    J Appl Physiol (1985) 102:985-91. 2007
    ..In conclusion, the greater GC in the arm than in the leg at baseline is primarily due to enhanced arm BF. Furthermore, whole body RT appears to increase GC in the leg but not in the arm...
  35. ncbi request reprint Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adults
    Cathy C Lee
    Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, and the GRECC VA Ann Arbor Healthcare System, 48105, USA
    J Gerontol A Biol Sci Med Sci 60:872-7. 2005
    ..The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women...
  36. ncbi request reprint Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humans
    Gary P Van Guilder
    Integrative Vascular Biology Laboratory Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Cardiovasc Pharmacol 47:310-3. 2006
    ..These results indicate that the obesity-related impairment in acetylcholine-mediated vasodilation in the human forearm is not due to reduced muscarinic receptor responsiveness or sensitivity...
  37. ncbi request reprint Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia
    James G Gurney
    Child Health Evaluation and Research CHEAR Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0456, USA
    Cancer 107:1303-12. 2006
    ....
  38. pmc Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway in aged skeletal muscle
    Thomas H Reynolds
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan and the GRECC, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, MI, USA
    Exp Gerontol 39:379-85. 2004
    ..001) These findings indicate the aerobic exercise training may attenuate the age-related decline in protein synthesis, a process that appears to be due, in part, to increases in mTOR and PKB...
  39. ncbi request reprint Oxygen-uptake (VO2) kinetics and functional mobility performance in impaired older adults
    Neil B Alexander
    The Geriatric Research, Education and Clinical Center, Veterans Affairs Ann Arbor Health Care System, and Division of Geriatric Medicine, Department of Internal Medicine, The University of Michigan, Ann Arbor, 48109 0926, USA
    J Gerontol A Biol Sci Med Sci 58:734-9. 2003
    ....
  40. pmc Effect of age on skeletal muscle proteolysis in extensor digitorum longus muscles of B6C3F1 mice
    Thomas H Reynolds
    Division of Geriatric Medicine, University of Michigan, and Veteran Affairs Ann Arbor Health Care System, Ann Arbor, USA
    J Gerontol A Biol Sci Med Sci 57:B198-201. 2002
    ..04). An inverse relationship existed between muscle mass and protein degradation (r = -.67; p =.0001). We conclude that skeletal muscle protein degradation rates decrease with maturation and increase with advancing age...
  41. ncbi request reprint Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity
    Scott G Glickman
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, USA
    J Appl Physiol 97:509-14. 2004
    ..94, 0.97, and 0.89, respectively). In conclusion, the DXA L1-L4 region of interest compared with CT proved to be both reliable and accurate method to determine abdominal obesity...