Research Topics
Species | D R DengelSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exerciseAaron S Kelly
University of Minnesota, Minneapolis, and St Paul Heart Clinic, St Paul, Minnesota, USA
J Pediatr 145:731-6. 2004..To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents...
Modifiable risk factors associated with bone deficits in childhood cancer survivorsLynda E Polgreen
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
BMC Pediatr 12:40. 2012..To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS...- Does the built environment relate to the metabolic syndrome in adolescents?Donald R Dengel
School of Kinesiology, University of Minnesota, 1900 University Avenue SE, 110 Cooke Hall, Minneapolis, MN 55455, USA
Health Place 15:946-51. 2009..Multivariate linear regression models revealed significant associations between an increased distance to convenience stores and the MetS. The results of this study suggest a role for the built environment in the development of the MetS... - Effect of aerobic exercise training on renal responses to sodium in hypertensivesDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Med Sci Sports Exerc 38:217-22. 2006..The exact mechanism(s) by which aerobic exercise training elicits these changes are unknown; however, it is possible that changes in renal hemodynamics may play a role... - Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adultsDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Metabolism 55:907-11. 2006..In overweight adults, 6 months of weight loss resulted in improvements in body composition, insulin sensitivity, lipid profile, and brachial artery compliance and distensibility... - Association of the home environment with cardiovascular and metabolic biomarkers in youthDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Prev Med 51:259-61. 2010..To examine the relationship between the home environment and biomarkers associated with the cardiovascular and metabolic risks in adolescents... - A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodiumD R Dengel
University of Minnesota, Minneapolis, USA
Physiol Res 56:393-401. 2007..The increase in BP during Na(+) loading in older hypertensives was associated with the eNOS genotype and may be related to changes in renal hemodynamics due to changes in NO metabolism... 
Gender differences in vascular function and insulin sensitivity in young adultsDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Clin Sci (Lond) 120:153-60. 2011..However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function...- Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adultsDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis 55455, USA
Physiol Genomics 11:73-80. 2002..4 +/- 6.2 and -3.6 +/- 2.5 mU/ml) ACE genotypes. In conclusion, we demonstrated that those older hypertensives with the ACE II genotype have the greatest improvement in insulin action following AEX... - Effect of oral glucose loading on endothelial function in normal-weight and overweight childrenDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Clin Sci (Lond) 112:493-8. 2007..6 compared with 20.2+/-2.0% respectively; P=0.019). In conclusion, these results suggest that acute elevation of glucose and insulin in overweight and normal-weight children are not associated with impairment in endothelial function... - Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensivesD R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, 55455, USA
J Hum Hypertens 20:372-8. 2006..This study demonstrates the importance of physical activity on BP sensitivity to dietary Na(+)... - Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensivesD R Dengel
School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis 55455, USA
Am J Hypertens 14:1178-84. 2001..Individuals differ in their blood pressure (BP) response to changes in dietary sodium (Na+) intake. It is possible that differences in BP responses to dietary Na+ are influenced by genes... - Endothelial function in young adult survivors of childhood acute lymphoblastic leukemiaDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
J Pediatr Hematol Oncol 30:20-5. 2008..2+/-7.1 y) adult survivors of childhood ALL who received chemotherapy without cranial radiation (n=25) or chemotherapy combined with cranial radiation (n=50) compared with a healthy control group of similar sex, age, and weight (n=59)... - Vascular structure and function in women: relationship with body mass indexThomas P Olson
Mayo Clinic and Foundation, Rochester, University of Minnesota, Minneapolis, Minnesota, USA
Am J Prev Med 30:487-92. 2006..The purpose of the present study was to compare endothelial function in lean (body mass index [BMI]=18.0-24.9 kg/m2); overweight (BMI=25-29.9 kg/m2); and obese (BMI>30 kg/m2), healthy, eumenorrheic women... - Relationships between heart rate variability, vascular function, and adiposity in childrenChristopher L Kaufman
School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
Clin Auton Res 17:165-71. 2007..To examine the relationships and interactions between cardiovascular autonomic nervous system (cANS) function, adiposity, and vascular function in children of varying levels of adiposity... - In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight childrenAaron S Kelly
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Metabolism 56:1005-9. 2007..These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children... - Moderate resistance training and vascular health in overweight womenThomas P Olson
University of Minnesota, Minneapolis, MN, USA
Med Sci Sports Exerc 38:1558-64. 2006..Thus, the aim of this study was to examine the effects of 1 yr of resistance training (RT) on vascular structure and function in overweight but otherwise healthy eumenorrheic women... - Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemiaKirsten K Ness
Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 49:975-81. 2007..We compared body composition, muscle strength, and mobility between 75 adult survivors of childhood acute lymphoblastic leukemia (ALL) and expected values based on population normative data... - Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in childrenAaron S Kelly
Departments of Pediatrics, University of Minnesota, Minneapolis, MN, USA
J Cardiometab Syndr 1:248-52. 2006..Overweight children with components of the metabolic syndrome may be at elevated risk for future cardiovascular disease... - Diet revision in overweight children: effect on autonomic and vascular functionChristopher L Kaufman
School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
Clin Auton Res 18:105-8. 2008..Changes in body composition in OW children due to dietary modification alone can result in modest improvements in indices of cardiac risk... - Automated edge detection versus manual edge measurement in analysis of brachial artery reactivity: a comparison studyEric B Williamson
General Clinical Research Center, University of Minnesota, Minneapolis, MN 55455, USA
Ultrasound Med Biol 34:1499-503. 2008..Therefore, caution should be used when comparing research utilizing different computerized edge-detection systems for measuring vascular function and structure... - Relationships of cardiac autonomic function with metabolic abnormalities in childhood obesityChristopher L Kaufman
School of Kinesiology, University of Minnesota, Minneapolis, MN 55102, USA
Obesity (Silver Spring) 15:1164-71. 2007..The objective was to examine cardiovascular autonomic (cANS) function and its potential relationships with leptin resistance, insulin resistance, oxidative stress, and inflammation in a pediatric sample with varying levels of obesity... - Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight womenT P Olson
Mayo Clinic, Division of Cardiovascular Diseases, University of Minnesota, and Minneapolis Veterans Affairs Medical Center, MN, USA
Int J Obes (Lond) 31:996-1003. 2007..This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women... - Comparison of changes in heart rate variability and blood pressure during nitroglycerin administration and head-up tilt testingTyler A Bosch
School of Kinesiology, University of Minnesota, 1900 University Avenue S E, Minneapolis, MN 55455, USA
Clin Auton Res 19:46-50. 2009..To compare the changes in heart rate variability (HRV) and blood pressure (BP) between standard head-up tilt test (HUT) and nitroglycerin administration... - Physical activity in young adults and incident hypertension over 15 years of follow-up: the CARDIA studyEmily D Parker
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Public Health 97:703-9. 2007..We sought to examine the relation between physical activity and incident hypertension in young adults over 15 years of follow-up in the Coronary Artery Risk Development in Young Adults study... - Aerobic-exercise training improves ventilatory efficiency in overweight childrenChristopher Kaufman
School of Kinesiology, University of Minnesota, MN 55455, USA
Pediatr Exerc Sci 19:82-92. 2007..8 +/- 0.80 to 31.0 +/- 0.53 vs. control = 30.3 +/- 0.88 to 31.7 +/- 0.91, p < .05). Aerobic-exercise training might help reverse the decrements in cardiopulmonary function observed over time in overweight children... - Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down syndromeChristopher C Draheim
School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA
Am J Cardiol 106:1512-6. 2010..Predictors of IMT differed for patients with DS compared to controls, which indicates that patients with DS possess a unique model of atherogenesis... - Comparison of B-mode and echo tracking methods of assessing flow-mediated dilationAaron S Kelly
University of Minnesota, Minneapolis, Minnesota 55102, USA
Ultrasound Med Biol 30:1447-9. 2004..75 +/- 0.65 mm, 4.00 +/- 0.63 mm and 6.91 +/- 2.85%, respectively. Results, as displayed by Bland-Altman graphs, indicate a strong agreement between B-mode and echo tracking methods of assessing brachial artery diameter changes via FMD... - Effects of left ventricular assist device (LVAD) placement on myocardial oxidative stress markersD L Templeton
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States
Heart Lung Circ 21:586-97. 2012..The primary purpose of this study was to examine the changes in myocardial oxidative stress during the support of a left ventricular assist device (LVAD)... - Noninvasive measurements of arterial stiffness: repeatability and interrelationships with endothelial function and arterial morphology measuresCorey J Huck
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Vasc Health Risk Manag 3:343-9. 2007..Therefore, the purpose of this study was to examine the repeatability and interrelationships between 3 different techniques to measure arterial stiffness and to compare this with forearm-mediated dilation... - Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensivesMichael D Brown
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA
J Appl Physiol 92:1434-42. 2002..Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects... - Aerobic exercise training improves insulin sensitivity independent of plasma tumor necrosis factor-alpha levels in older female hypertensivesThomas H Reynolds
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan and GRECC, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, MI, USA
Metabolism 51:1402-6. 2002..In conclusion, in this population of older hypertensive females, AEX improved insulin sensitivity and lowered blood pressure without a reduction in plasma TNF-alpha levels... - Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor necrosis factor-alpha system in older hypertensivesThomas H Reynolds
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, MI, USA
Metabolism 53:397-402. 2004..168). In conclusion, a 4-month RT program significantly increased insulin-mediated glucose disposal and LBM without a significant reduction in plasma levels of TNF-alpha, sTNF R1, and sTNF R2 in older hypertensive subjects... - Regional differences in glucose clearance: effects of insulin and resistance training on arm and leg glucose clearance in older hypertensive individualsThomas H Reynolds
Dept of Internal Medicine, University of Michigan, Ann Arbor, USA
J Appl Physiol 102:985-91. 2007..In conclusion, the greater GC in the arm than in the leg at baseline is primarily due to enhanced arm BF. Furthermore, whole body RT appears to increase GC in the leg but not in the arm... - Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adultsCathy C Lee
Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, and the GRECC VA Ann Arbor Healthcare System, 48105, USA
J Gerontol A Biol Sci Med Sci 60:872-7. 2005..CONCLUSIONS: WHR is not associated with S(I) in either men or women. Abdominal adiposity measured by DXA L1-L4 fat mass provides a sex-independent predictor of S(I) in older men and women... - Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humansGary P Van Guilder
Integrative Vascular Biology Laboratory Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
J Cardiovasc Pharmacol 47:310-3. 2006..These results indicate that the obesity-related impairment in acetylcholine-mediated vasodilation in the human forearm is not due to reduced muscarinic receptor responsiveness or sensitivity... - Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemiaJames G Gurney
Child Health Evaluation and Research CHEAR Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0456, USA
Cancer 107:1303-12. 2006.... - Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposityScott G Glickman
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, USA
J Appl Physiol 97:509-14. 2004..94, 0.97, and 0.89, respectively). In conclusion, the DXA L1-L4 region of interest compared with CT proved to be both reliable and accurate method to determine abdominal obesity... - Oxygen-uptake (VO2) kinetics and functional mobility performance in impaired older adultsNeil B Alexander
The Geriatric Research, Education and Clinical Center, Veterans Affairs Ann Arbor Health Care System, and Division of Geriatric Medicine, Department of Internal Medicine, The University of Michigan, Ann Arbor, 48109 0926, USA
J Gerontol A Biol Sci Med Sci 58:734-9. 2003.... - Effect of age on skeletal muscle proteolysis in extensor digitorum longus muscles of B6C3F1 miceThomas H Reynolds
Division of Geriatric Medicine, University of Michigan, and Veteran Affairs Ann Arbor Health Care System, Ann Arbor, USA
J Gerontol A Biol Sci Med Sci 57:B198-201. 2002..04). An inverse relationship existed between muscle mass and protein degradation (r = -.67; p =.0001). We conclude that skeletal muscle protein degradation rates decrease with maturation and increase with advancing age... - Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway in aged skeletal muscleThomas H Reynolds
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan and the GRECC, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, MI, USA
Exp Gerontol 39:379-85. 2004..001) These findings indicate the aerobic exercise training may attenuate the age-related decline in protein synthesis, a process that appears to be due, in part, to increases in mTOR and PKB...