Wenbin Deng

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Electrically guiding migration of human induced pluripotent stem cells
    Jiaping Zhang
    Department of Dermatology and Department of Ophthalmology, Institute for Regenerative Cures, UC Davis School of Medicine, Davis, CA 95817, USA
    Stem Cell Rev 7:987-96. 2011
  2. pmc hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
    Peng Jiang
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California 95817, USA
    Nat Commun 4:2196. 2013
  3. pmc A TSPO ligand is protective in a mouse model of multiple sclerosis
    Daniel J Daugherty
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA
    EMBO Mol Med 5:891-903. 2013
  4. pmc Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
    Mangala M Soundarapandian
    Departments of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, California 95817, USA
    Sci Rep 1:2. 2011
  5. pmc Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum
    S H Chung
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
    Cell Death Dis 4:e546. 2013
  6. ncbi request reprint Neurobiology of injury to the developing brain
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Nat Rev Neurol 6:328-36. 2010
  7. doi request reprint AID in reprogramming: quick and efficient: identification of a key enzyme called AID, and its activity in DNA demethylation, may help to overcome a pivotal epigenetic barrier in reprogramming somatic cells toward pluripotency
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, CA, USA
    Bioessays 32:385-7. 2010
  8. pmc Genome integrity: linking pluripotency and tumorgenicity
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Trends Genet 25:425-7. 2009
  9. ncbi request reprint Exploiting pluripotency for therapeutic gain
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Panminerva Med 52:167-73. 2010
  10. pmc Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord
    Olga V Chechneva
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, 2425 Stockton Blvd, Sacramento, 95817 CA, USA
    Neurobiol Dis 44:63-72. 2011

Collaborators

Detail Information

Publications28

  1. pmc Electrically guiding migration of human induced pluripotent stem cells
    Jiaping Zhang
    Department of Dermatology and Department of Ophthalmology, Institute for Regenerative Cures, UC Davis School of Medicine, Davis, CA 95817, USA
    Stem Cell Rev 7:987-96. 2011
    ..Our current finding may lead to techniques for applying EFs in vivo to guide migration of transplanted stem cells...
  2. pmc hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
    Peng Jiang
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California 95817, USA
    Nat Commun 4:2196. 2013
    ....
  3. pmc A TSPO ligand is protective in a mouse model of multiple sclerosis
    Daniel J Daugherty
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA
    EMBO Mol Med 5:891-903. 2013
    ..g. etifoxine, could be a potential new therapeutic option for MS with benefits that could be comparable to the administration of systemic steroids but potentially avoiding the detrimental side effects of long-term direct use of steroids...
  4. pmc Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
    Mangala M Soundarapandian
    Departments of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, California 95817, USA
    Sci Rep 1:2. 2011
    ..Together, these findings identify a previously unreported role for Zfp488 in adult oligodendrogenesis and functional remyelination after injury...
  5. pmc Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum
    S H Chung
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
    Cell Death Dis 4:e546. 2013
    ....
  6. ncbi request reprint Neurobiology of injury to the developing brain
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Nat Rev Neurol 6:328-36. 2010
    ..Further research is warranted to examine the translational potential of preclinical therapeutic strategies for controlling such injury and preserving the integrity of motor pathways in preterm infants...
  7. doi request reprint AID in reprogramming: quick and efficient: identification of a key enzyme called AID, and its activity in DNA demethylation, may help to overcome a pivotal epigenetic barrier in reprogramming somatic cells toward pluripotency
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, CA, USA
    Bioessays 32:385-7. 2010
    ..Together, these findings provide new insights into how cells are reprogrammed, identify the specific role of AID in cell fate reversal, and advance the field of regenerative medicine...
  8. pmc Genome integrity: linking pluripotency and tumorgenicity
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Trends Genet 25:425-7. 2009
    ..Therefore, it is also crucial to determine the tumorgenicity of the cells derived from iPSCs for any future therapeutic use...
  9. ncbi request reprint Exploiting pluripotency for therapeutic gain
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Panminerva Med 52:167-73. 2010
    ....
  10. pmc Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord
    Olga V Chechneva
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, 2425 Stockton Blvd, Sacramento, 95817 CA, USA
    Neurobiol Dis 44:63-72. 2011
    ..Our study is the first report to show that low dose DM is effective in treating EAE of moderate severity. Our findings reveal that low dose morphinan DM treatment may represent a new promising protective strategy for treating MS...
  11. pmc Axon-glia synapses are highly vulnerable to white matter injury in the developing brain
    Yan Shen
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci Res 90:105-21. 2012
    ..More broadly, the study of white matter development and injury has general implications for a variety of neurological diseases, including PVL, stroke, spinal cord injury, and multiple sclerosis...
  12. pmc Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells
    Peng Jiang
    Department of Biochemistry and Molecular Medicine, School of Medicine, Sacramento, California, USA Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, California, USA
    Stem Cells 31:2620-31. 2013
    ....
  13. pmc Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia
    Wei Liu
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA
    Exp Neurol 230:227-39. 2011
    ....
  14. doi request reprint Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury
    Xiao Bo Liu
    Department of Biochemistry and Molecular Medicine, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Neurosci Bull 29:229-38. 2013
    ..Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities...
  15. pmc PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate
    Jennifer M Plane
    Department of Biochemistry and Molecular Medicine, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci Res 90:1489-506. 2012
    ..Together, our results show that PARP-1 deletion promotes SVZ neural stem cells toward a glial fate and suggest that future studies target PARP-1 as a potential therapeutic strategy for demyelinating diseases...
  16. pmc Electrophysiological properties of human induced pluripotent stem cells
    Peng Jiang
    Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children of North America, Sacramento, CA, USA
    Am J Physiol Cell Physiol 298:C486-95. 2010
    ..Our results reveal further differences and similarities between human iPSCs and hESCs. A better understanding of the basic biology of iPSCs may facilitate their ultimate clinical application...
  17. pmc PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis
    Vimal Selvaraj
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Biol Chem 284:26070-84. 2009
    ....
  18. pmc Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration
    Seung Hyuk Chung
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neurobiol Dis 41:445-57. 2011
    ..This study is the first to link AIF and mitochondrial fusion, both of which might play important roles in neurodegeneration...
  19. pmc Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies
    Vimal Selvaraj
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Trends Biotechnol 28:214-23. 2010
    ..This article reviews landmark developments in cell reprogramming, current knowledge, and technological developments now on the horizon with significant promise for biomedical applications...
  20. pmc Prospects for minocycline neuroprotection
    Jennifer M Plane
    Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, 95817, USA
    Arch Neurol 67:1442-8. 2010
    ..Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system...
  21. pmc DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres
    Marco Calafiore
    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, California, USA
    J Neurosci Res 90:559-67. 2012
    ..Our findings reveal a novel role of DNA pol-β in Aβ(42) -induced neurogenesis and identify DNA pol-β as a key mechanistic link between the neurogenic effect of Aβ(42) on NPCs and the proapoptotic effect of Aβ(42) on mature neurons...
  22. pmc Blood-brain barrier breakdown and repair by Src after thrombin-induced injury
    Da Zhi Liu
    Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
    Ann Neurol 67:526-33. 2010
    ..Thrombin mediates the life-threatening cerebral edema that occurs after intracerebral hemorrhage. Therefore, we examined the mechanisms of thrombin-induced injury to the blood-brain barrier (BBB) and subsequent mechanisms of BBB repair...
  23. pmc Progress in periventricular leukomalacia
    Wenbin Deng
    Department of Neurology, UC Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA
    Arch Neurol 65:1291-5. 2008
    ..Studies in animal models of PVL suggest that pharmacologic interventions that target these toxic molecules will be useful in diminishing the severity of PVL...
  24. pmc PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum
    Jiho Sohn
    Institute for Pediatric Regenerative Medicine, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    J Neurosci 32:12152-64. 2012
    ....
  25. pmc Oligodendrocyte progenitor cells derived from mouse embryonic stem cells give rise to type-1 and type-2 astrocytes in vitro
    Chen Chen
    Department of Neurology, Institute of Neurology, Tianjin General Hospital of Tianjin Medical University, Tianjin, China
    Neurosci Lett 523:180-5. 2012
    ..These results challenge the dogma that OPCs in culture can only generate type-2, but not type-1 astrocytes, and support the in vivo finding that during perinatal development, OPCs can give rise to a subset of type-1 astrocytes...
  26. doi request reprint PARylation: strengthening the connection between cancer and pluripotency
    Wenbin Deng
    Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California Davis, 2425 Stockton Boulevard, Sacramento, CA 95817, USA
    Cell Stem Cell 5:349-50. 2009
    ..2009; Gottschalk et al., 2009), combined with the demonstration that p53 serves as a barrier to pluripotency (Banito et al., 2009), further strengthen this connection...

Research Grants8

  1. Oligodendrocytes, Glutamate Receptors, and Lead Neurotoxicity
    Wenbin Deng; Fiscal Year: 2007
    ....
  2. Glutamate Receptors in Hypoxic-ischemic Injury to Developing Oligodendrocytes
    Wenbin Deng; Fiscal Year: 2009
    ..The scientific knowledge to be acquired through this project is of likely benefit to the development of preventive strategies for PVL and the care of children with cerebral palsy. ..
  3. Oligodendrocytes, Glutamate Receptors, and Lead Neurotoxicity
    Wenbin Deng; Fiscal Year: 2009
    ....
  4. Glutamate Receptors in Hypoxic-ischemic Injury to Developing Oligodendrocytes
    Wenbin Deng; Fiscal Year: 2010
    ..The scientific knowledge to be acquired through this project is of likely benefit to the development of preventive strategies for PVL and the care of children with cerebral palsy. ..
  5. Oligodendrocytes, Glutamate Receptors, and Lead Neurotoxicity
    Wenbin Deng; Fiscal Year: 2009
    ..abstract_text> ..
  6. Oligodendrocytes, Glutamate Receptors, and Lead Neurotoxicity
    Wenbin Deng; Fiscal Year: 2010
    ....