Wen tao Deng

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse
    Wen tao Deng
    Department of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 33:11745-53. 2013
  2. ncbi request reprint Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats
    Wen tao Deng
    Department of Ophthalmology, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Invest Ophthalmol Vis Sci 53:1895-904. 2012
  3. ncbi request reprint Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
    Wen tao Deng
    Department of Ophthalmology and Powell Gene Therapy Center, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 16:1247-54. 2005
  4. pmc Functional interchangeability of rod and cone transducin alpha-subunits
    Wen tao Deng
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:17681-6. 2009
  5. pmc Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
    Hilda Petrs-Silva
    Department of Ophthalmology, University of Florida, Gainesville, FL, USA
    Mol Ther 19:293-301. 2011
  6. ncbi request reprint Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: effects of serotype and site of administration
    Ji Jing Pang
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Vision Res 48:377-85. 2008
  7. pmc AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia
    Ji Jing Pang
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e35250. 2012
  8. pmc Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa
    Thomas J Conlon
    Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther Clin Dev 24:23-8. 2013
  9. pmc Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept
    Astra Dinculescu
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 23:367-76. 2012
  10. doi request reprint Gene therapy in the rd6 mouse model of retinal degeneration
    Astra Dinculescu
    Department of Ophthalmology, College of Medicine, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
    Adv Exp Med Biol 801:711-8. 2014

Collaborators

Detail Information

Publications11

  1. pmc Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse
    Wen tao Deng
    Department of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 33:11745-53. 2013
    ..Together, these results demonstrate that cone PDE6α' can functionally substitute for rod PDEαβ in vivo, conferring treated rods with distinct physiological properties. ..
  2. ncbi request reprint Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats
    Wen tao Deng
    Department of Ophthalmology, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Invest Ophthalmol Vis Sci 53:1895-904. 2012
    ..In the present study, we evaluated whether delivery of a MERTK transgene using a tyrosine-mutant AAV8 capsid could lead to more robust and longer-term therapeutic outcomes than previously reported...
  3. ncbi request reprint Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
    Wen tao Deng
    Department of Ophthalmology and Powell Gene Therapy Center, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 16:1247-54. 2005
    ..The results demonstrated that exon 6- and 7-derived VEGF peptides effectively inhibited oxygen-induced retinal NV. Therefore, these VEGF peptides have potential in the treatment of angiogenesis-associated retinal diseases in humans...
  4. pmc Functional interchangeability of rod and cone transducin alpha-subunits
    Wen tao Deng
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:17681-6. 2009
    ..Additionally, the technology used here could be adapted for any such homologue swap desired...
  5. pmc Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
    Hilda Petrs-Silva
    Department of Ophthalmology, University of Florida, Gainesville, FL, USA
    Mol Ther 19:293-301. 2011
    ..Such novel vectors may be useful in developing valuable new therapeutic strategies for the treatment of many genetic diseases...
  6. ncbi request reprint Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: effects of serotype and site of administration
    Ji Jing Pang
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Vision Res 48:377-85. 2008
    ....
  7. pmc AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia
    Ji Jing Pang
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e35250. 2012
    ..The results provide the foundation for development of an AAV5-based gene therapy trial for human CNGA3 achromatopsia...
  8. pmc Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa
    Thomas J Conlon
    Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther Clin Dev 24:23-8. 2013
    ..Our results demonstrate the potency and safety of the AAV2-VMD2-hMERTK vector in animal models tested. A GMP vector has been manufactured and is presently in clinical trial...
  9. pmc Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept
    Astra Dinculescu
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 23:367-76. 2012
    ..The clinical features of MFRP-RP and our preliminary data indicating a response to gene therapy in the rd6 mouse suggest that this form of RP is a potential target for gene-based therapy...
  10. doi request reprint Gene therapy in the rd6 mouse model of retinal degeneration
    Astra Dinculescu
    Department of Ophthalmology, College of Medicine, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
    Adv Exp Med Biol 801:711-8. 2014
    ..In spite of preserving retinal morphology, the effects of gene therapy on retinal function were minimal, suggesting that the scAAV8 (Y733F) vector may be more efficient for the treatment of RP caused by Mfrp mutations. ..
  11. ncbi request reprint Molecular characterization of the Arabidopsis 9-cis epoxycarotenoid dioxygenase gene family
    Bao Cai Tan
    Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32611, USA
    Plant J 35:44-56. 2003
    ..In addition, differential membrane-binding capacity of AtNCEDs is a potential means of post-translational regulation of NCED activity...