Ruitang Deng

Summary

Affiliation: University of Rhode Island
Country: USA

Publications

  1. pmc Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
    J Lipid Res 49:973-84. 2008
  2. pmc A review of the hypoglycemic effects of five commonly used herbal food supplements
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Recent Pat Food Nutr Agric 4:50-60. 2012
  3. ncbi request reprint Food and food supplements with hypocholesterolemic effects
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Recent Pat Food Nutr Agric 1:15-24. 2009
  4. ncbi request reprint Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor
    Ruitang Deng
    Department of Biological and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, 02881, USA
    J Pharmacol Exp Ther 317:317-25. 2006
  5. ncbi request reprint The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Fogarty Hall, 41 Lower College Road, Kingston, RI 02881, USA
    J Pharmacol Exp Ther 320:1153-62. 2007
  6. pmc Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Cardiovasc Ther 28:e33-45. 2010
  7. ncbi request reprint Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Cardiovasc Drug Rev 25:375-90. 2007
  8. pmc Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881
    J Lipid Res 54:3030-44. 2013
  9. pmc Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump
    Dongfang Yang
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881, USA
    J Lipid Res 53:529-39. 2012
  10. ncbi request reprint The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha
    Fu Jun Liu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Biochem J 409:243-50. 2008

Research Grants

Collaborators

  • Jian Yang
  • Geoffrey D Bothun
  • Yuan Chen
  • Yurong Lai
  • Dongfang Yang
  • Bingfang Yan
  • Xiulong Song
  • Rajani Kaimal
  • Jianrong Li
  • Justin Gharavi
  • Deshi Shi
  • Fu Jun Liu
  • Yuzhong Ma
  • Yaowei Huang
  • Lian Yu
  • Xueya Liang
  • Ruchi Verma
  • Leila Valanejad
  • Matthew Stoner
  • Brett Kingsborough
  • Kelly Moran
  • Mindy Levine
  • Patrick Marks
  • Chris Black
  • Da Xiao
  • Xiliang Wang
  • Roberta King
  • Clinton O Chichester
  • Karuna Sachdeva
  • Yuxin Li
  • Jirong Liu
  • Ronghui Xie
  • Songshu Meng
  • Mijia Lu
  • Long Li

Detail Information

Publications19

  1. pmc Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
    J Lipid Res 49:973-84. 2008
    ..These results suggest that LRH-1 plays a supporting role to FXR in maintaining hepatic bile acid levels by coordinately regulating CYP7A1 and BSEP for bile acid synthesis and elimination, respectively...
  2. pmc A review of the hypoglycemic effects of five commonly used herbal food supplements
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Recent Pat Food Nutr Agric 4:50-60. 2012
    ..Future studies with more defined participants, standardized preparation and dose, and improved trial design and size are warranted...
  3. ncbi request reprint Food and food supplements with hypocholesterolemic effects
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Recent Pat Food Nutr Agric 1:15-24. 2009
    ..However, additional clinical studies are required to establish the safety profiles of certain probiotic bacteria as food supplements...
  4. ncbi request reprint Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor
    Ruitang Deng
    Department of Biological and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, 02881, USA
    J Pharmacol Exp Ther 317:317-25. 2006
    ..In conclusion, oxysterol 22(R)-OHC functions as an FXR ligand to induce BSEP expression and differs in the binding with FXR from CDCA...
  5. ncbi request reprint The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Fogarty Hall, 41 Lower College Road, Kingston, RI 02881, USA
    J Pharmacol Exp Ther 320:1153-62. 2007
    ..The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated hypolipidemic effect...
  6. pmc Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Cardiovasc Ther 28:e33-45. 2010
    ..However, rare cases of side-effects in human have been reported. Quality control in the growth and process of Spirulina to avoid contamination is mandatory to guarantee the safety of Spirulina products...
  7. ncbi request reprint Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits
    Ruitang Deng
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Cardiovasc Drug Rev 25:375-90. 2007
    ..Such repression of NF-kappaB activation by guggulsterone has been proposed as a mechanism of the antiinflammatory effect of guggulsterone...
  8. pmc Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881
    J Lipid Res 54:3030-44. 2013
    ....
  9. pmc Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump
    Dongfang Yang
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881, USA
    J Lipid Res 53:529-39. 2012
    ....
  10. ncbi request reprint The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha
    Fu Jun Liu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Biochem J 409:243-50. 2008
    ..The difference in responding to HNF-4alpha suggests that the magnitude of the induction is under control through various transcriptional networks...
  11. pmc Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor
    Dongfang Yang
    Department of Biomedical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881, USA
    Br J Pharmacol 164:1547-57. 2011
    ..The aim of this study was to determine whether scoparone induces the expression of human UGT1A1. In addition, the expression of the bile salt export pump (BSEP), a transporter of bile acids, was determined...
  12. ncbi request reprint Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23
    Yuzhong Ma
    Department of Biomedical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Biochem Pharmacol 69:1363-71. 2005
    ..The interaction between PXR inducer and ligand provides a novel mechanism on how functionally and structurally distinct chemicals cooperatively regulate the expression of xenobiotic-metabolizing enzymes and transporters...
  13. pmc Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones
    Rajani Kaimal
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, 41 Lower College Rd, Kingston, RI 02881, USA
    J Pharmacol Exp Ther 330:125-34. 2009
    ..Such differential modulation of FXR signaling pathway by TZDs may represent one of the mechanisms for member-specific, PPARgamma-independent activities and toxicity...
  14. pmc Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor
    Dongfang Yang
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island Kingston, RI 02881, USA
    Toxicol Appl Pharmacol 237:49-58. 2009
    ..g., lambda-cyhalothrin), suggesting that induction of PXR target genes by these pyrethroids varies depending on polymorphic variants and the PXR species identity...
  15. pmc Chiral cationic polyamines for chiral microcapsules and siRNA delivery
    Justin Gharavi
    Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, United States
    Bioorg Med Chem Lett 23:5919-22. 2013
    ..Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts. ..
  16. pmc Low-dose chemotherapy of hepatocellular carcinoma through triggered-release from bilayer-decorated magnetoliposomes
    Yanjing Chen
    Department of Chemical Engineering, University of Rhode Island, 16 Greenhouse Road, Kingston, RI 02881, United States
    Colloids Surf B Biointerfaces 116:452-8. 2014
    ..The therapeutic mechanism was intracellular RF-triggered DOX release from the dMLs and not intracellular hyperthermia due to nanoparticle heating via magnetic losses...
  17. pmc Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma
    Yuan Chen
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Hepatology 57:1530-41. 2013
    ..Treatment of Huh7 cells with IL-6 and TNF-α resulted in a marked increase in FXR-α1/FXR-α2 ratio, concurrent with a significant decrease in BSEP expression...
  18. ncbi request reprint Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2
    Jianrong Li
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310029, PR China
    Virology 329:89-100. 2004
    ..These results strongly indicate that the efficacy of avian DNA vaccine can be modulated by co-administration of a plasmid encoding chIL-2...
  19. ncbi request reprint Plasmid DNA encoding antigens of infectious bursal disease viruses induce protective immune responses in chickens: factors influencing efficacy
    Jianrong Li
    Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, PR China
    Virus Res 98:63-74. 2003
    ....

Research Grants1

  1. Crosstalk between estrogen and bile acid signaling pathway
    Ruitang Deng; Fiscal Year: 2010
    ..Understanding the mechanisms and pathological consequences will provide a molecular basis to develop new drugs to treat or prevent those diseases. ..