Guoren Deng

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Quantitation of erbB-2 gene copy number in breast cancer by an improved polymerase chain reaction (PCR) technique, competitively differential PCR
    G Deng
    Department of Medicine, University of California and VA Medical Center, San Francisco 94121, USA
    Breast Cancer Res Treat 58:213-7. 1999
  2. ncbi request reprint BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
    Guoren Deng
    Department of Medicine, Veteran Affairs Medical Center and Cancer Center, University of California San Francisco, California, USA
    Clin Cancer Res 10:191-5. 2004
  3. ncbi request reprint Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
    G Deng
    Gastrointestinal Research Laboratory, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California, CA 94121, USA
    Oncogene 20:7120-7. 2001
  4. pmc Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
    G Deng
    Gastrointestinal Research Laboratory, 151M2 Veteran Affairs Medical Center, University of California, San Francisco, 4150 Clement Street, San Francisco, California, CA 94121, USA
    Br J Cancer 86:574-9. 2002
  5. pmc miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, CA 94121, USA
    Clin Cancer Res 19:73-84. 2013
  6. pmc Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e58929. 2013
  7. pmc Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43812. 2012
  8. ncbi request reprint Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer
    Guoren Deng
    Gastrointestinal Research Laboratory, Veteran Affairs Medical Center and Department of Medicine, University of California San Francisco, 94121, USA
    Int J Cancer 118:2999-3005. 2006
  9. ncbi request reprint Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 17:5287-98. 2011
  10. pmc MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e55502. 2013

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Quantitation of erbB-2 gene copy number in breast cancer by an improved polymerase chain reaction (PCR) technique, competitively differential PCR
    G Deng
    Department of Medicine, University of California and VA Medical Center, San Francisco 94121, USA
    Breast Cancer Res Treat 58:213-7. 1999
    ..CD-PCR also overcomes the problems involved in variation of PCR efficiencies and DNA concentrations in tumor samples, and the problems caused by the plateau effect in PCR...
  2. ncbi request reprint BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
    Guoren Deng
    Department of Medicine, Veteran Affairs Medical Center and Cancer Center, University of California San Francisco, California, USA
    Clin Cancer Res 10:191-5. 2004
    ..In this study, we sought to compare the frequencies of BRAF mutations in sporadic colorectal cancer with MSI with those in hereditary nonpolyposis colorectal cancer (HNPCC)...
  3. ncbi request reprint Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
    G Deng
    Gastrointestinal Research Laboratory, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California, CA 94121, USA
    Oncogene 20:7120-7. 2001
    ..We conclude that methylation of an adjacent CpG site inhibits binding of the CBF transcription to the corresponding CCAAT box, and is one of the causes of hMLH1 gene silencing in colon cancer cells...
  4. pmc Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
    G Deng
    Gastrointestinal Research Laboratory, 151M2 Veteran Affairs Medical Center, University of California, San Francisco, 4150 Clement Street, San Francisco, California, CA 94121, USA
    Br J Cancer 86:574-9. 2002
    ....
  5. pmc miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, CA 94121, USA
    Clin Cancer Res 19:73-84. 2013
    ..miRNAs can act as oncomirs or tumor-suppressor miRs in cancer. This study was undertaken to investigate the status and role of miR-34b in prostate cancer...
  6. pmc Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e58929. 2013
    ..Our results show that genistein up-regulates tumor suppressor miR-574-3p expression targeting several cell signaling pathways. These findings enhance understanding of how genistein regulates with miRNA in PCa...
  7. pmc Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43812. 2012
    ..This study suggests that genistein mediated suppression of oncogenic miRNAs can be an important dietary therapeutic strategy for the treatment of PCa...
  8. ncbi request reprint Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer
    Guoren Deng
    Gastrointestinal Research Laboratory, Veteran Affairs Medical Center and Department of Medicine, University of California San Francisco, 94121, USA
    Int J Cancer 118:2999-3005. 2006
    ....
  9. ncbi request reprint Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 17:5287-98. 2011
    ..The main objective of the present study was to identify microRNA (miRNA) genes that regulate metastatic PCa...
  10. pmc MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e55502. 2013
    ..Also knock down of miR-182-5p in order to increase expression of tumor suppressor genes FOXF2, RECK and MTSS1 may be of therapeutic benefit in prostate cancer treatment...
  11. doi request reprint miRNA-708 control of CD44(+) prostate cancer-initiating cells
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer Res 72:3618-30. 2012
    ..miR-708 therefore may represent a novel therapeutic target or diagnostic and prognostic biomarker in prostate cancer...
  12. pmc MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California, USA
    PLoS ONE 8:e67686. 2013
    ..Furthermore, re-expression of miR-23b may be a beneficial therapeutic strategy for the treatment of human bladder cancer. ..
  13. pmc Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer
    Mohd Saif Zaman
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e50203. 2012
    ..miR-23b is located on chromosome number 9 and plays different roles in different organs especially with regards to cancer development. However, the functional significance of miR-23b-3p in renal cell carcinoma (RCC) has not been reported...
  14. pmc Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, USA
    Cancer Prev Res (Phila) 4:1698-709. 2011
    ..Our study suggests that curcumin may offer a therapeutic advantage in the clinical management of refractory bladder cancer over other standard treatment modalities...
  15. doi request reprint Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability
    Sanjay Kakar
    Department of Pathology, Veterans Affairs Medical Center and University ofCalifornia at San Francisco, San Francisco, Calif, USA
    Arch Pathol Lab Med 132:958-64. 2008
    ..The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite instability and chromosomal instability, are not present in 20% to 37% of cases...
  16. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
    ..Genistein, a potential nontoxic chemopreventive agent, restores expression of ARHI and may be an important dietary therapeutic agent for treating prostate cancer...
  17. ncbi request reprint BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer
    Hirofumi Tanaka
    Department of Medicine, Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 118:2765-71. 2006
    ..01). The more frequent occurrence and closer association among MSI, CIMP and BRAF mutation in mucinous CRC observed in our study further supports the idea that its pathogenesis may involve distinct genetic and epigenetic changes...
  18. pmc miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California 94121, USA
    Cancer Res 72:6435-46. 2012
    ..Loss of miR-23b may confer proliferative advantage and promote prostate cancer migration and invasion, and reexpression of miR-23b may contribute to the epigenetic therapy for prostate cancer...
  19. pmc MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer
    Seong O Suh
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 32:772-8. 2011
    ..The apoptotic cells are increased after WT p53 transfection. In summary, this is the first report documenting that downregulation of miR-145 is through DNA methylation and p53 mutation pathways in prostate cancer...
  20. ncbi request reprint Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs
    Guoren Deng
    Gastrointestinal Research Laboratory 151M2, Veteran Affairs Medical Center of San Francisco, Department of Medicine, University of California San Franicisco, San Francisco, CA 94121, USA
    Clin Cancer Res 15:1519-26. 2009
    ..In melanoma cells, epigenetic silencing of OSM receptor (OSMR) by histone deacetylation contributes to escape of cell growth control by OSM. However, the silencing of OSMR by DNA methylation in any cancer has not been examined...
  21. doi request reprint Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics
    Guoren Deng
    Gastrointestinal Research Laboratory 151M2, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Eur J Cancer 44:1290-301. 2008
    ..However, the frequency and the pattern of these alterations in proximal and distal colon cancers have not been examined in detail...
  22. doi request reprint Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells
    Inik Chang
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Cancer Ther 12:1049-59. 2013
    ..Together, our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak...
  23. ncbi request reprint Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics
    Geun Am Song
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Oncol 26:745-50. 2005
    ..11%, p=0.01). These results indicate that mucinous carcinomas of the colorectum exhibit distinct molecular genetic characteristics and may arise from distinct pathogenic pathways...
  24. pmc MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer
    Shahana Majid
    Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
    PLoS ONE 7:e46743. 2012
    ..Various compounds are currently being used as ROCK1 inhibitors; therefore restoration of tumor suppressor miR-1280 might be therapeutically useful either alone or in combination with these compounds in the treatment of bladder cancer...
  25. pmc MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells
    Soichiro Yamamura
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e29722. 2012
    ....
  26. doi request reprint Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma
    Sanjay Kakar
    Department of Pathology, Veteran Affairs Medical Center and University of California, San Francisco, San Francisco, CA, USA
    Mod Pathol 25:1040-7. 2012
    ..The high frequency of methylation and BRAF V600E mutation suggests that many signet ring cell carcinomas may be related to the serrated pathway of carcinogenesis...
  27. pmc Up-regulation of microRNA-21 correlates with lower kidney cancer survival
    Mohd Saif Zaman
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e31060. 2012
    ..MicroRNA-21 is up-regulated in a variety of cancers like, breast, colorectal, lung, head and neck etc. However, the regulation of miR-21 in renal cell carcinoma (RCC) has not yet been studied systematically...
  28. pmc MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases
    Sumit Arora
    Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e78023. 2013
    ..In conclusion, we have identified a novel microRNA that mediates regulation of Abl kinases in prostate cancer. This study suggests that miR-4723 may be an attractive target for therapeutic intervention in prostate cancer. ..
  29. doi request reprint Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway
    Inik Chang
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 33:420-6. 2012
    ..Together, these findings show that COMT in the presence of 4-OHE(2) prevents RCC cell proliferation by enhancing apoptosis and that GADD45α plays a critical role in the COMT-mediated inhibition of RCC...
  30. doi request reprint Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps
    Yong Ho Kim
    Gastrointestinal Research Laboratory 151M2, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Cancer 123:2587-93. 2008
    ..BRAF mutation occurs independently of CIMP and MSI in all types of serrated polyps and may serve as a marker of serrated pathway of colorectal carcinogenesis...
  31. ncbi request reprint Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor
    Guoren Deng
    Gastrointestinal Research Laboratory, Veteran Affairs Medical Center and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Cancer Res 64:2692-8. 2004
    ..In summary, methylation of CpG sites around CCAAT box in APC promoter inhibits the gene expression by changing the chromatin conformation and interfering with the binding of transcription factor CBF to CCAAT box...
  32. ncbi request reprint Regulation of SRC Kinases by microRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer
    Sharanjot Saini
    Authors Affiliation Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, California
    Mol Cancer Ther 13:1952-63. 2014
    ..Mol Cancer Ther; 13(7); 1952-63. ©2014 AACR. ..
  33. doi request reprint Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    Int J Cancer 128:1793-803. 2011
    ..In conclusion, this is the first report to show that DKK1 expression is epigenetically silenced in kidney cancer and its reexpression induces apoptosis and cell cycle arrest in RCC...
  34. ncbi request reprint Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Cancer 122:1253-60. 2008
    ..In addition, the expression of both SOX2 and MUC5AC in serrated polyps supports the hypothesis that these polyps may be predominant precursors of mucinous and signet ring cell carcinomas of the colorectum...
  35. pmc Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells
    Takeshi Chiyomaru
    From the Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121
    J Biol Chem 289:12550-65. 2014
    ..These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner. ..
  36. doi request reprint Tumor histology helps to identify Lynch syndrome among colorectal cancer patients
    Brindusa Truta
    Department of Medicine, Gastroenterology Division, University California San Francisco, 2330 Post St, Suite 610, San Francisco, CA 94115, USA
    Fam Cancer 7:267-74. 2008
    ..To determine the value of histology in identifying Lynch syndrome among those patients with early onset of colorectal cancer (CRC)...
  37. ncbi request reprint CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component
    Sanjay Kakar
    Department of Pathology, Veteran Affairs Medical Center and University of California at San Francisco, San Francisco, CA 94121, USA
    Hum Pathol 39:30-6. 2008
    ..Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma. BRAF mutations are absent in tubulovillous/villous adenomas...
  38. ncbi request reprint The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer
    Koji Matsuzaki
    Department of Medicine, Gastrointestinal Research Laboratory, Veteran Affairs Medical Center, Medicine and Anatomic Pathology, University of California San Francisco, San Francisco, California 94121, USA
    Clin Cancer Res 11:8564-9. 2005
    ..The aim of this study was to investigate the relationship between global methylation status, loss of heterozygosity (LOH), and MSI in sporadic colorectal cancer...
  39. ncbi request reprint Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells
    Jenny J L Ho
    Gastrointestinal Research Laboratory 151 M2, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Oncol 22:273-9. 2003
    ..In summary, the expression of MUC2 gene products correlated well with methylation of the proximal region of the promoter whereas expression of MUC5AC may involve additional regions or other mechanisms...
  40. pmc MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA
    Cancer 116:5637-49. 2010
    ..In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin (IL) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters...
  41. doi request reprint Cytochrome P450 17 (CYP17) is involved in endometrial cancinogenesis through apoptosis and invasion pathways
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 50:16-23. 2011
    ..Further studies are required to understand the detailed mechanisms underlying CYP17-mediated regulation of these components...
  42. pmc Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia
    Young S Kim
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, USA
    Gut Liver 1:1-11. 2007
    ..Therefore, these epigenetically acting drugs should be evaluated for their chemopreventive and therapeutic potential for colorectal cancers...
  43. pmc Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography
    Dajun Deng
    Peking University School of Oncology and Beijing Institute for Cancer Research, Beijing, 100034, China
    Nucleic Acids Res 30:E13. 2002
    ..In conclusion, methylation in homoallelic and heteroallelic CpG islands could be detected rapidly and reliably by bisulfite-DHPLC. A SNP in the target sequence could also be detected at the same time...
  44. doi request reprint Aberrant expression of carbohydrate antigens in cancer: the role of genetic and epigenetic regulation
    Young S Kim
    Gastroenterology 135:305-9. 2008