A Demuro

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
    J Neurosci 33:3824-33. 2013
  2. pmc Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biol 195:515-24. 2011
  3. pmc Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states
    Angelo Demuro
    Department of Neurobiology and Behavior, Institute for Immunology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:17832-7. 2011
  4. pmc Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Cell Calcium 43:367-74. 2008
  5. pmc Antagonistic action of pitrazepin on human and rat GABA(A) receptors
    A Demuro
    Department of Psychobiology, University of California, Irvine 92697 4550, USA
    Br J Pharmacol 127:57-64. 1999
  6. ncbi request reprint Inhibition of nicotinic acetylcholine receptors by bicuculline
    A Demuro
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA
    Neuropharmacology 41:854-61. 2001
  7. pmc Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals
    Michiko Yamasaki-Mann
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:25053-61. 2010
  8. pmc "Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine 92697, USA
    J Gen Physiol 126:179-92. 2005
  9. pmc cADPR stimulates SERCA activity in Xenopus oocytes
    Michiko Yamasaki-Mann
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Cell Calcium 45:293-9. 2009
  10. ncbi request reprint Imaging Ca2+ signals in Xenopus oocytes
    Sheila L Dargan
    Department of Neurobiology and Behavior, McGaugh Hall, University of California Irvine, USA
    Methods Mol Biol 322:103-19. 2006

Detail Information

Publications19

  1. pmc Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
    J Neurosci 33:3824-33. 2013
    ....
  2. pmc Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biol 195:515-24. 2011
    ....
  3. pmc Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states
    Angelo Demuro
    Department of Neurobiology and Behavior, Institute for Immunology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:17832-7. 2011
    ..We conclude that the human Orai1 and Orai3 channels undergo a dimer-to-tetramer transition to form a Ca(2+)-selective pore during store-operated activation and that Orai3 forms a dimeric nonselective cation pore upon activation by 2-APB...
  4. pmc Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Cell Calcium 43:367-74. 2008
    ....
  5. pmc Antagonistic action of pitrazepin on human and rat GABA(A) receptors
    A Demuro
    Department of Psychobiology, University of California, Irvine 92697 4550, USA
    Br J Pharmacol 127:57-64. 1999
    ..Moreover, pitrazepin did not antagonize the potentiation of GABA-currents by flunitrazepam. All this suggests that pitrazepin does not affect the GABA receptor-chloride channel by interacting with the benzodiazepine receptor site...
  6. ncbi request reprint Inhibition of nicotinic acetylcholine receptors by bicuculline
    A Demuro
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA
    Neuropharmacology 41:854-61. 2001
    ..All this suggests that bicuculline may serve as a lead molecule to design new anticholinergic substances...
  7. pmc Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals
    Michiko Yamasaki-Mann
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:25053-61. 2010
    ....
  8. pmc "Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine 92697, USA
    J Gen Physiol 126:179-92. 2005
    ....
  9. pmc cADPR stimulates SERCA activity in Xenopus oocytes
    Michiko Yamasaki-Mann
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Cell Calcium 45:293-9. 2009
    ..We conclude that cADPR serves to modulate Ca(2+) sequestration by enhancing SERCA pump activity, in addition to its well-established action on RyRs to liberate Ca(2+)...
  10. ncbi request reprint Imaging Ca2+ signals in Xenopus oocytes
    Sheila L Dargan
    Department of Neurobiology and Behavior, McGaugh Hall, University of California Irvine, USA
    Methods Mol Biol 322:103-19. 2006
    ..We describe the use of high-resolution fluorescence imaging techniques to visualize Ca2+ signals in Xenopus oocytes at levels ranging from global Ca2+ waves to single-channel Ca2+ microdomains...
  11. pmc Imaging single-channel calcium microdomains
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Cell Calcium 40:413-22. 2006
    ....
  12. pmc Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    Biophys J 86:3250-9. 2004
    ....
  13. ncbi request reprint Imaging single-channel calcium microdomains by total internal reflection microscopy
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Biol Res 37:675-9. 2004
    ....
  14. ncbi request reprint Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution
    Angelo Demuro
    University of California, Irvine, Department of Neurobiology and Behavior, Irvine, California 92697 4550, USA
    J Biomed Opt 10:11002. 2005
    ..Optical single-channel recording is applicable to diverse voltage- and ligand-gated Ca(2+)-permeable channels and has potential for high-throughput functional analysis...
  15. ncbi request reprint Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Cell Calcium 34:499-509. 2003
    ..Optical single-channel recording should be applicable to diverse voltage- and ligand-gated Ca2+-permeable channels, and has the potential for high-throughput functional analysis of single channels...
  16. ncbi request reprint Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
    Angelo Demuro
    Department of Neurobiology and Behavior and Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 280:17294-300. 2005
    ....
  17. pmc Calcium signaling and amyloid toxicity in Alzheimer disease
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:12463-8. 2010
    ..Although no cause or cure is currently known, targeting Ca(2+) dyshomeostasis as an underlying and integral component of AD pathology may result in novel and effective treatments for AD...
  18. pmc SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production
    Kim N Green
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biol 181:1107-16. 2008
    ..Our results point to a physiological role for the presenilins in Ca(2+) signaling via regulation of the SERCA pump...
  19. pmc A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients
    Alejandra C Ventura
    Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biophys J 88:2403-21. 2005
    ....