Robert Dempsey

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Repairing brain after stroke: a review on post-ischemic neurogenesis
    Charles Wiltrout
    Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA
    Neurochem Int 50:1028-41. 2007
  2. ncbi request reprint Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurosurg 98:867-73. 2003
  3. ncbi request reprint Ischemia-induced neurogenesis: role of growth factors
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, CSC K4 818, 600 Highland Avenue, Madison, WI 53792, USA
    Neurosurg Clin N Am 18:183-90, xi. 2007
  4. pmc A review of carotid atherosclerosis and vascular cognitive decline: a new understanding of the keys to symptomology
    Robert J Dempsey
    University of Wisconsin School of Medicine and Public Health, Department of Neurological Surgery, Madison, Wisconsin 53792, USA
    Neurosurgery 67:484-93; discussion 493-4. 2010
  5. doi request reprint Art, passion, and neurosurgery: the role of the Society of Neurological Surgeons in academic neurosurgery
    Robert J Dempsey
    Department of Neurosurgery, University of Wisconsin, Madison, Wisconsin, USA
    World Neurosurg 76:378-84. 2011
  6. doi request reprint Galectin-3 mediates post-ischemic tissue remodeling
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, 600 Highland Ave Madison, WI 53792, USA
    Brain Res 1288:116-24. 2009
  7. ncbi request reprint Preconditioning-induced ischemic tolerance stimulates growth factor expression and neurogenesis in adult rat hippocampus
    Michelle Naylor
    Department of Neurological Surgery, University of Wisconsin Madison, K4 8 Mail code CSC 8660, 600 Highland Ave, Madison, WI 53792, USA
    Neurochem Int 47:565-72. 2005
  8. ncbi request reprint Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurochem 87:586-97. 2003
  9. doi request reprint Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, WI 53792, United States
    Neurochem Int 55:826-32. 2009
  10. ncbi request reprint Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, WI 53792, USA
    Eur J Neurosci 24:45-54. 2006

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Repairing brain after stroke: a review on post-ischemic neurogenesis
    Charles Wiltrout
    Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA
    Neurochem Int 50:1028-41. 2007
    ....
  2. ncbi request reprint Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurosurg 98:867-73. 2003
    ..In the present study the authors investigate whether CDP-choline protects hippocampal neurons after controlled cortical impact (CCI)-induced TBI in adult rats...
  3. ncbi request reprint Ischemia-induced neurogenesis: role of growth factors
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, CSC K4 818, 600 Highland Avenue, Madison, WI 53792, USA
    Neurosurg Clin N Am 18:183-90, xi. 2007
    ..It seems that a combinational therapy of factors or their inhibitors may provide powerful therapeutic potential for enhancing stroke-induced neurogenesis and restoring the damaged tissue to function...
  4. pmc A review of carotid atherosclerosis and vascular cognitive decline: a new understanding of the keys to symptomology
    Robert J Dempsey
    University of Wisconsin School of Medicine and Public Health, Department of Neurological Surgery, Madison, Wisconsin 53792, USA
    Neurosurgery 67:484-93; discussion 493-4. 2010
    ..A linear relationship between the process of mechanically unstable areas of carotid plaques and cognitive decline suggests a contributory role for such a process in silent strokes...
  5. doi request reprint Art, passion, and neurosurgery: the role of the Society of Neurological Surgeons in academic neurosurgery
    Robert J Dempsey
    Department of Neurosurgery, University of Wisconsin, Madison, Wisconsin, USA
    World Neurosurg 76:378-84. 2011
    ....
  6. doi request reprint Galectin-3 mediates post-ischemic tissue remodeling
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, 600 Highland Ave Madison, WI 53792, USA
    Brain Res 1288:116-24. 2009
    ..These results suggest that Gal-3 expressed by activated microglia/infiltrating macrophages and astrocytes in the ischemic brain may play a role in post-ischemic tissue remodeling by enhancing angiogenesis and neurogenesis...
  7. ncbi request reprint Preconditioning-induced ischemic tolerance stimulates growth factor expression and neurogenesis in adult rat hippocampus
    Michelle Naylor
    Department of Neurological Surgery, University of Wisconsin Madison, K4 8 Mail code CSC 8660, 600 Highland Ave, Madison, WI 53792, USA
    Neurochem Int 47:565-72. 2005
    ..Induction of growth factor expression and neurogenesis by PC might be a positive adaptation for an efficient repair and plasticity in the event of an ischemic insult...
  8. ncbi request reprint Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF
    Robert J Dempsey
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurochem 87:586-97. 2003
    ..05) and GDNF (by 91 +/- 5%, p < 0.05), compared to vehicle. In the growth factor treated rats subjected to transient MCAO, several BrdU+ cells formed in the first week survived up to the third week...
  9. doi request reprint Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, WI 53792, United States
    Neurochem Int 55:826-32. 2009
    ..These results suggest that up-regulated expression of OPN produced by macrophages/microglia in the ischemic brain is an attractant and inducer for the lateral migration of neuroblasts from the SVZ to the injured region...
  10. ncbi request reprint Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, WI 53792, USA
    Eur J Neurosci 24:45-54. 2006
    ..These results indicate that IGF-1 formed in the ischemic penumbra might be one of the diffusible factors that mediate post-ischemic neural progenitor proliferation...
  11. ncbi request reprint D609 inhibits the proliferation of neural progenitor cells
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Neuroreport 21:700-3. 2010
    ..These results suggest that D609 inhibits the proliferation of neural progenitor cells by reducing the cyclin D1 content resulting in decreased phosphorylation of retinoblastoma and subsequent inhibition of cell division...
  12. pmc Creating physical 3D stereolithograph models of brain and skull
    Daniel J Kelley
    Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Madison, Wisconsin, United States of America
    PLoS ONE 2:e1119. 2007
    ..Compared to 2D images, VR and stereolithograph models provide an extra dimension that enhances both the quality of visual information and utility of surface visualization in neuroscience and medicine...
  13. ncbi request reprint Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
    Eur J Neurosci 25:1041-8. 2007
    ..The decrease in the cyclin D1 content in conjunction with the inhibition of nestin expression by ERK inhibitor confirms the role of ERK in the proliferation of cells...
  14. doi request reprint IGFBP-3 inhibits the proliferation of neural progenitor cells
    Haviryaji S G Kalluri
    Department of Neurosurgery, University of Wisconsin, Madison, WI 53792, USA
    Neurochem Res 36:406-11. 2011
    ..In addition, IGFBP-3 also decreased the content of nestin in the neural progenitor cells indicating its potential role in neurogenesis...
  15. ncbi request reprint Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    J Cereb Blood Flow Metab 27:1213-24. 2007
    ..These results show that MCP-1 is one of the factors that attract the migration of newly formed neuroblasts from neurogenic regions to the damaged regions of brain after focal ischemia...
  16. ncbi request reprint Increased expression of genes that control ionic homeostasis, second messenger signaling and metabolism in the carotid plaques from patients with symptomatic stroke
    Raghu Vemuganti
    Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    J Neurochem 97:92-6. 2006
    ..The implications of these findings are that both diagnosis and prevention of stroke symptoms may become possible at the genetic level...
  17. ncbi request reprint Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, University of Wisconsin, Madison, WI 53792, USA
    Antioxid Redox Signal 5:647-54. 2003
    ..These results suggest that citicoline provides neuroprotection by attenuating the stimulation of PLA2...
  18. ncbi request reprint Polyamines and central nervous system injury: spermine and spermidine decrease following transient focal cerebral ischemia in spontaneously hypertensive rats
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, H4 330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin Madison, Madison, WI 53792 3232, USA
    Brain Res 938:81-6. 2002
    ..Based on our and other studies, we propose a tentative antioxidant mechanism of spermine neuroprotection...
  19. ncbi request reprint Inhibition of intercellular adhesion molecule-1 protein expression by antisense oligonucleotides is neuroprotective after transient middle cerebral artery occlusion in rat
    Raghu Vemuganti
    Department of Neurological Surgery, University of Wisconsin at Madison, H4 334 CSC, 600 Highland Ave, Madison, WI 53792, USA
    Stroke 35:179-84. 2004
    ..The present study was performed to determine whether antisense inhibition of intercellular adhesion molecule-1 (ICAM-1) protein expression decreases focal ischemic brain damage...
  20. ncbi request reprint Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurosci Res 76:390-6. 2004
    ..01 compared to saline). These data indicate that PtdCho synthesis is impaired after brain ischemia, and CDP-choline may increase PtdCho levels by attenuating the loss of CCT activity and lyso-PtdCho formation...
  21. ncbi request reprint Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage
    Yiping Yan
    Department of Neurological Surgery, University of Wisconsin Medical School, Madison, WI 53792, USA
    Brain Res 961:22-31. 2003
    ..These results suggest that inhibition of NKCC1 attenuates cytotoxic edema and necrotic neuronal death during focal ischemia. Activation of NKCC1 activity plays a role in the early stage of ischemic damage...
  22. ncbi request reprint Transient focal cerebral ischemia-induced neurogenesis in the dentate gyrus of the adult mouse
    Kudret Tureyen
    Department of Neurological Surgery and Cardiovascular Research Center, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurosurg 101:799-805. 2004
    ..To facilitate such studies the authors characterized the proliferation, survival, and maturation of progenitor cells in the DG of adult mice following transient focal cerebral ischemia...
  23. ncbi request reprint Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis
    Vemuganti L Raghavendra Rao
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurosci Res 71:208-19. 2003
    ..Real-time PCR analysis confirmed the GeneChip data for many of these transcripts. The novel physiologically relevant gene expression changes observed here might explain some of the molecular mechanisms of TBI-induced neuronal damage...
  24. ncbi request reprint Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia
    Vemuganti L Raghavendra Rao
    Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    J Neurochem 83:1072-86. 2002
    ..Antisense knockdown of ischemia-induced SOCS-3 protein expression exacerbated transient MCAO-induced infarct volume assigning a neuroprotective role to SOCS-3, a gene not heretofore implicated in ischemic neuronal damage...
  25. ncbi request reprint GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats
    Guoqing Song
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurosci Res 68:730-7. 2002
    ..Of importance was that the increased heme oxygenase-1 and decreased Cu,Zn-superoxide dismutase expression observed raise the possibility of oxidative stress playing a pathogenic role in chronic HE...
  26. pmc In vivo attenuation and equivalent scatterer size parameters for atherosclerotic carotid plaque: preliminary results
    Hairong Shi
    Department of Medical Physics, The University of Wisconsin Madison, Madison, WI 53706, USA
    Ultrasonics 49:779-85. 2009
    ..In the frequency bandwidth ranging from 2.5 to 7.5 MHz, the attenuation coefficient for calcified regions lies between 1.4 and 2.5 dB/cm/MHz, while that for softer regions lies between 0.3 and 1.3 dB/cm/MHz...
  27. ncbi request reprint Lack of response to epidermal growth factor in adult neural progenitor cells
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
    Neuroreport 16:835-8. 2005
    ..However, the lack of response by epidermal growth factor in our study could be because of the culture conditions, and may not reflect the physiological condition...
  28. ncbi request reprint EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain
    Kudret Tureyen
    Department of, Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    Neurosurgery 57:1254-63; discussion 1254-63. 2005
    ....
  29. pmc Impaired neurogenesis in adult type-2 diabetic rats
    Bradley T Lang
    Department of Neurological Surgery, University of Wisconsin K4 8 Mail code CSC 8660 600 Highland avenue Madison, WI 53792, USA
    Brain Res 1258:25-33. 2009
    ..05). These results indicate that hyperglycemic environment induces proliferation of adult neural progenitors, but detrimental to their survival. Impaired neurogenesis might be a promoter of the decreased brain function in type-2 diabetes...
  30. pmc Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging
    Barbara B Bendlin
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Neuroimage 42:503-14. 2008
    ....
  31. ncbi request reprint Increased angiogenesis and angiogenic gene expression in carotid artery plaques from symptomatic stroke patients
    Kudret Tureyen
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    Neurosurgery 58:971-7; discussion 971-7. 2006
    ..The aim of this study is to determine the role of angiogenesis and angiogenesis-related gene expression in symptomatic carotid plaque...
  32. pmc Oxygen glucose deprivation inhibits the growth and ERK phosphorylation of neural progenitor cells in vitro
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
    Neurosci Lett 426:145-8. 2007
    ..Inhibition of the ERK pathway for 4h using U0126 (10 microM) also decreased the growth of progenitor cells. These data suggest that a decline in the phospho-ERK content might decrease the growth of progenitor cells following OGD...
  33. ncbi request reprint Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions
    Seung Won Park
    Department of Neurological Surgery, University of Wisconsin Madison, Wisconsin 53792, USA
    J Neurosurg 107:593-9. 2007
    ..The authors tested the potential of the neuropeptide substance P (SP) acting via the neurokinin-1 receptor (NK1R) in promoting the proliferation of adult rat neural progenitor cells (NPCs)...
  34. doi request reprint Persistent migration of neuroblasts from the subventricular zone to the injured striatum mediated by osteopontin following intracerebral hemorrhage
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurochem 109:1624-35. 2009
    ..These results suggest that increased OPN expression in the injured striatum plays a significant role in the lateral migration of neuroblasts following ICH...
  35. ncbi request reprint Ideal suture diameter is critical for consistent middle cerebral artery occlusion in mice
    Kudret Tureyen
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Neurosurgery 56:196-200; discussion 196-200. 2005
    ..We attempted to determine the ideal suture diameter to produce consistent occlusion in the MCA of adult male C57BL/6 mice...
  36. ncbi request reprint Infarct volume quantification in mouse focal cerebral ischemia: a comparison of triphenyltetrazolium chloride and cresyl violet staining techniques
    Kudret Tureyen
    Department of Neurological Surgery, University of Wisconsin Madison, K4 822 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    J Neurosci Methods 139:203-7. 2004
    ..05). TTC and CV staining showed a high degree of correlation in infarct area and volume indicating that both methods are suitable for producing accurate measurements of cerebral experimental infarcts...
  37. doi request reprint The potential of neural stem cells to repair stroke-induced brain damage
    Yi Ping Liu
    Department of Neurological Surgery, University of Wisconsin, K4 8 Mail code CSC 8660, 600 Highland Ave, Madison, WI, 53792, USA
    Acta Neuropathol 117:469-80. 2009
    ..Using exogenous stem cells in addition to modulating endogenous neurogenesis, we may be able to repair the injured brain after a devastating stroke. This article reviewed the current literature of these two issues...
  38. pmc Relationship between ultrasonic attenuation, size and axial strain parameters for ex vivo atherosclerotic carotid plaque
    Hairong Shi
    Department of Medical Physics, The University of Wisconsin Madison, Madison, WI 53706, USA
    Ultrasound Med Biol 34:1666-77. 2008
    ..These parameters can be estimated from radio-frequency data acquired under in vivo conditions and may help the clinician decide on appropriate interventional techniques...
  39. doi request reprint Growth factors, stem cells, and stroke
    Haviryaji S G Kalluri
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Neurosurg Focus 24:E14. 2008
    ..In this article the authors discuss the role of growth factors and stem cells following stroke...
  40. pmc Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma
    Mehul A Trivedi
    William S Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center GRECC, Madison, Wisconsin 53705, USA
    J Neurotrauma 24:766-71. 2007
    ..Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued structural change for several months post-injury...
  41. pmc Preliminary in vivo atherosclerotic carotid plaque characterization using the accumulated axial strain and relative lateral shift strain indices
    Hairong Shi
    Department of Medical Physics, The University of Wisconsin Madison, Madison, WI 53706, USA
    Phys Med Biol 53:6377-94. 2008
    ....
  42. ncbi request reprint Ornithine decarboxylase activity in in vivo and in vitro models of cerebral ischemia
    G Nagesh Babu
    Department of Neurology, SGPG Institute of Medical Sciences, Lucknow, UP, 226014, India
    Neurochem Res 28:1851-7. 2003
    ....
  43. ncbi request reprint Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion
    Cuneyt Temiz
    Department of Neurosurgery, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
    J Clin Neurosci 12:449-52. 2005
    ....
  44. ncbi request reprint L-arginine in focal cerebral ischemia
    Cuneyt Temiz
    Ankara University Medical Faculty, Department of Neurosurgery, Ankara, Turkey
    Neurol Res 25:465-70. 2003
    ..L-arginine's protective effect on cerebrovascular ischemia shows a dose dependent effect on infract size and tissue water content that may prove beneficial in the treatment of ischemia. However, further dose-dependent studies are needed...

Research Grants4

  1. Neurogenesis after Stroke:Effect of Growth Factors
    Robert Dempsey; Fiscal Year: 2003
    ..Information from these studies will allow us to enhance this natural process of cell proliferation at the time of ischemia and lay the groundwork for stimulation of neuroplasticity after focal cerebral ischemia. ..
  2. Structural Stability of Carotid Plaque and Symptomatology
    Robert J Dempsey; Fiscal Year: 2010
    ..If successful, this study will greatly increase our understanding of the pathophysiology of symptoms from atherosclerosis, as well as, lead to the development of potential new measures to detect this disorder noninvasively. ..