J A Dempsey

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Are type III-IV muscle afferents required for a normal steady-state exercise hyperpnoea in humans?
    Jerome A Dempsey
    J A Dempsey University of Wisconsin Madison, 1300 University Ave, Room 4245 MSC, Madison, WI 53706 1532, USA
    J Physiol 592:463-74. 2014
  2. doi request reprint Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea
    Jerome A Dempsey
    Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
    Adv Exp Med Biol 758:343-9. 2012
  3. pmc New perspectives concerning feedback influences on cardiorespiratory control during rhythmic exercise and on exercise performance
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, 1300 University Ave, Room 4245 MSC, Madison, WI 53706 1532, USA
    J Physiol 590:4129-44. 2012
  4. pmc The ventilatory responsiveness to CO(2) below eupnoea as a determinant of ventilatory stability in sleep
    Jerome A Dempsey
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, 53726 2368, USA
    J Physiol 560:1-11. 2004
  5. doi request reprint Respiratory system determinants of peripheral fatigue and endurance performance
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Med Sci Sports Exerc 40:457-61. 2008
  6. doi request reprint Update in the understanding of respiratory limitations to exercise performance in fit, active adults
    Jerome A Dempsey
    University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Chest 134:613-22. 2008
  7. pmc Is the healthy respiratory system (always) built for exercise?
    Jerome A Dempsey
    University of Wisconsin Madison, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Rm 4245 Medical Sciences, 1300 University Ave, Madison, WI 53726 2368, USA
    J Physiol 576:339-40. 2006
  8. ncbi request reprint Exercise-induced respiratory muscle work: effects on blood flow, fatigue and performance
    J A Dempsey
    University of Wisconsin Madison, John Rankin Laboratory of Pulmonary Medicine, USA
    Adv Exp Med Biol 605:209-12. 2008
  9. doi request reprint Pathophysiology of sleep apnea
    Jerome A Dempsey
    The John Rankin Laboratory of Pulmonary Medicine, Departments of Population Health Sciences and of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Rev 90:47-112. 2010
  10. ncbi request reprint Challenges for future research in exercise physiology as applied to the respiratory system
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
    Exerc Sport Sci Rev 34:92-8. 2006

Research Grants

  1. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 2000
  2. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
  3. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2006
  4. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2007
  5. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 1980
  6. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome A Dempsey; Fiscal Year: 2010

Detail Information

Publications93

  1. doi request reprint Are type III-IV muscle afferents required for a normal steady-state exercise hyperpnoea in humans?
    Jerome A Dempsey
    J A Dempsey University of Wisconsin Madison, 1300 University Ave, Room 4245 MSC, Madison, WI 53706 1532, USA
    J Physiol 592:463-74. 2014
    ..We discuss the limitations of these studies, the reasons for their disagreement with previous negative findings, the nature of the muscle afferent feedback stimulus and the need for future investigations. ..
  2. doi request reprint Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea
    Jerome A Dempsey
    Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
    Adv Exp Med Biol 758:343-9. 2012
    ..Finally, we discuss the effects of preventing transient hypocapnia (via selective increases in FICO(2)) on centrally mediated types of periodic breathing and even some varieties of cyclical obstructive sleep apnea...
  3. pmc New perspectives concerning feedback influences on cardiorespiratory control during rhythmic exercise and on exercise performance
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, 1300 University Ave, Room 4245 MSC, Madison, WI 53706 1532, USA
    J Physiol 590:4129-44. 2012
    ..Locomotor muscle afferents also appear to provide feedback concerning the metabolic state of the muscle to influence central motor output, thereby limiting peripheral fatigue development...
  4. pmc The ventilatory responsiveness to CO(2) below eupnoea as a determinant of ventilatory stability in sleep
    Jerome A Dempsey
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, 53726 2368, USA
    J Physiol 560:1-11. 2004
    ..Finally, we review growing evidence that chemoreceptor-induced instability in respiratory motor output during sleep contributes significantly to the major clinical problem of cyclical obstructive sleep apnoea...
  5. doi request reprint Respiratory system determinants of peripheral fatigue and endurance performance
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Med Sci Sports Exerc 40:457-61. 2008
    ..We also address how a compromised O2 transport exacerbates the rate of development of peripheral muscle fatigue and, in turn, precipitates central fatigue and exercise limitation...
  6. doi request reprint Update in the understanding of respiratory limitations to exercise performance in fit, active adults
    Jerome A Dempsey
    University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Chest 134:613-22. 2008
    ..Exercise in the hypoxic environments of even moderately high altitudes will greatly exacerbate the negative influences of these respiratory system limitations to exercise performance, especially in highly fit individuals...
  7. pmc Is the healthy respiratory system (always) built for exercise?
    Jerome A Dempsey
    University of Wisconsin Madison, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Rm 4245 Medical Sciences, 1300 University Ave, Madison, WI 53726 2368, USA
    J Physiol 576:339-40. 2006
  8. ncbi request reprint Exercise-induced respiratory muscle work: effects on blood flow, fatigue and performance
    J A Dempsey
    University of Wisconsin Madison, John Rankin Laboratory of Pulmonary Medicine, USA
    Adv Exp Med Biol 605:209-12. 2008
  9. doi request reprint Pathophysiology of sleep apnea
    Jerome A Dempsey
    The John Rankin Laboratory of Pulmonary Medicine, Departments of Population Health Sciences and of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Rev 90:47-112. 2010
    ..We discuss future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae...
  10. ncbi request reprint Challenges for future research in exercise physiology as applied to the respiratory system
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
    Exerc Sport Sci Rev 34:92-8. 2006
    ..To solve many of these difficult basic problems and to understand how systems operate alone and in combination in an integrated fashion, truly experimental integrative physiological approaches are required in both humans and animals...
  11. ncbi request reprint Consequences of exercise-induced respiratory muscle work
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 151:242-50. 2006
    ..Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined...
  12. ncbi request reprint Crossing the apnoeic threshold: causes and consequences
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, 1300 University Avenue, Rm 4245 MSC, Madison, WI, USA
    Exp Physiol 90:13-24. 2005
    ..Finally, evidence is presented which points to a significant role for unstable, central respiratory motor output as a significant contributor to upper airway narrowing and obstruction during sleep...
  13. ncbi request reprint Superior laryngeal nerve section alters responses to upper airway distortion in sleeping dogs
    A K Curran
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 83:768-75. 1997
    ....
  14. ncbi request reprint Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise
    C A Harms
    Department of Preventive Medicine, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 85:609-18. 1998
    ....
  15. ncbi request reprint Effect of upper airway negative pressure on inspiratory drive during sleep
    P R Eastwood
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 84:1063-75. 1998
    ..This inhibition of inspiratory motor output is alinear within an inspiration and reflects the activation of UA pressure-sensitive receptors by UA distortion, with greater distortion possibly occurring later in the effort...
  16. ncbi request reprint Effects of exhaustive endurance exercise on pulmonary gas exchange and airway function in women
    T J Wetter
    Department of Preventive Medicine, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 91:847-58. 2001
    ....
  17. pmc Non-chemical inhibition of respiratory motor output during mechanical ventilation in sleeping humans
    C R Wilson
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    J Physiol 518:605-18. 1999
    ....
  18. pmc Inhibition of inspiratory motor output by high-frequency low-pressure oscillations in the upper airway of sleeping dogs
    P R Eastwood
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison, WI 53705, USA
    J Physiol 517:259-71. 1999
    ..This reflex may help maintain UA patency by decreasing the collapsing pressure generated by the inspiratory pump muscles and transmitted to the UA...
  19. ncbi request reprint Hemodynamic effects of pressures applied to the upper airway during sleep
    P R Eastwood
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, Madison 53705, USA
    J Appl Physiol (1985) 89:537-48. 2000
    ..These findings suggest that activation of UA pressure-sensitive receptors does not contribute directly to the pressor response associated with sleep-disordered breathing events...
  20. ncbi request reprint Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects
    H C Haverkamp
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Appl Physiol (1985) 99:1843-52. 2005
    ....
  21. pmc Exercise-induced arterial hypoxaemia in healthy young women
    C A Harms
    Department of Preventive Medicine, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison 53705, USA
    J Physiol 507:619-28. 1998
    ....
  22. ncbi request reprint Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep
    Hideaki Nakayama
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine, Madison 53705, USA
    Am J Respir Crit Care Med 165:1251-60. 2002
    ....
  23. ncbi request reprint Sleep-induced breathing instability. University of Wisconsin-Madison Sleep and respiration Research Group
    J A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin-Madison 53705, USA
    Sleep 19:236-47. 1996
    ....
  24. ncbi request reprint Negative pressure-induced deformation of the upper airway causes central apnea in awake and sleeping dogs
    C A Harms
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison 53705, USA
    J Appl Physiol (1985) 80:1528-39. 1996
    ..We conclude that UA closure and deformation will cause significant TE prolongation during all states of consciousness and activation of the genioglossus muscle during wakefulness and NREM sleep but not during REM sleep...
  25. ncbi request reprint Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia
    J R Rodman
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 91:328-35. 2001
    ....
  26. pmc Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans
    C M St Croix
    John Rankin Laboratory of Pulmonary Medicine, Departments of Preventive Medicine and Surgery, University of Wisconsin, Madison, WI 53705, USA
    J Physiol 529:493-504. 2000
    ....
  27. ncbi request reprint Effects of respiratory muscle work on exercise performance
    C A Harms
    John Rankin Laboratory of Pulmonary Medicine, Department Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 89:131-8. 2000
    ....
  28. ncbi request reprint Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue
    Lee M Romer
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, USA
    Adv Exp Med Biol 588:47-55. 2006
    ..These effects of EIAH were confirmed in mild environmental hypoxia (FIO2 .17, SaO2 88%) which significantly augmented the magnitude of exercise-induced quadriceps fatigue observed in normoxia...
  29. ncbi request reprint Inspiratory muscles do not limit maximal incremental exercise performance in healthy subjects
    Lee M Romer
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, Medical Sciences Center, 1300 University Avenue, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 156:353-61. 2007
    ..Therefore, our data do not support a role for either inspiratory muscle work or fatigue per se in the limitation of maximal incremental exercise...
  30. pmc Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans
    A W Sheel
    Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI, USA
    J Physiol 537:277-89. 2001
    ..Q(L) and increases in LVR. We attribute these changes to a metaboreflex originating in the diaphragm. Diaphragm and forearm muscle fatigue showed very similar time-dependent effects on LVR and .Q(L)...
  31. ncbi request reprint Response time and sensitivity of the ventilatory response to CO2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors
    C A Smith
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, School of Medicine, Rm 4245 MSC, University of Wisconsin, 1300 Univ Ave, Madison, Wisconsin 53706, USA
    J Appl Physiol (1985) 100:13-9. 2006
    ....
  32. pmc Respiratory muscle recruitment during selective central and peripheral chemoreceptor stimulation in awake dogs
    K W Saupe
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison
    J Physiol 448:613-31. 1992
    ....
  33. ncbi request reprint Nonchemical elimination of inspiratory motor output via mechanical ventilation in sleep
    M Satoh
    John Rankin Laboratory of Pulmonary Medicine and Department of Preventive Medicine, University of Wisconsin, Madison, WI 53706-2368, USA
    Am J Respir Crit Care Med 163:1356-64. 2001
    ....
  34. ncbi request reprint Blood pressure perturbations caused by subclinical sleep-disordered breathing
    B J Morgan
    Department of Surgery, University of Wisconsin, Madison, USA
    Sleep 21:737-46. 1998
    ..We speculate that these fluctuations may play a role in the pathogenesis of hypertension in individuals with subclinical sleep-disordered breathing...
  35. ncbi request reprint Effect of exercise-induced arterial O2 desaturation on VO2max in women
    C A Harms
    Department Preventive Medicine, University of Wisconsin, Madison 53705, USA
    Med Sci Sports Exerc 32:1101-8. 2000
    ..We questioned whether EIAH affected VO2max in this population and whether the effect was similar to that reported in men...
  36. ncbi request reprint Chronic intermittent hypoxia increases the CO2 reserve in sleeping dogs
    Keisho Katayama
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    J Appl Physiol 103:1942-9. 2007
    ..We conclude that 3-wk CIH reduced the sensitivity of the ventilatory response to transient hypocapnia and thereby increased the CO(2) reserve, i.e., the propensity for apnea was reduced...
  37. pmc Somatosensory feedback from the limbs exerts inhibitory influences on central neural drive during whole body endurance exercise
    Markus Amann
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    J Appl Physiol (1985) 105:1714-24. 2008
    ....
  38. ncbi request reprint Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance
    Lee M Romer
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Clin Exp Pharmacol Physiol 33:391-4. 2006
    ..5. We conclude that the normal exercise-induced O(2) desaturation during heavy-intensity endurance exercise contributes significantly to exercise performance limitation in part because of its effect on locomotor muscle fatigue...
  39. ncbi request reprint [The John Sutton Lecture: CSEP, 2002]. Pulmonary system limitations to exercise in health
    Jerome A Dempsey
    Dept of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Can J Appl Physiol 28:S2-24. 2003
    ..In this brief review, we describe the characteristics and causes of each of these proposed pulmonary limitations and their consequences to maximal O2 uptake and exercise performance...
  40. pmc Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humans
    A Xie
    University of Wisconsin, Department of Medicine, Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    J Physiol 535:269-78. 2001
    ..01 for the apnoeic threshold). We concluded that hypoxia causes a narrowing of the difference between the baseline P(ET,CO2) and the hypopnoea/apnoeic threshold P(ET,CO2), which could increase the likelihood of ventilatory instability...
  41. ncbi request reprint The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. central chemoreceptors
    C A Smith
    John Rankin Laboratory of Pulmonary Medicine and Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Appl Physiol (1985) 103:578-86. 2007
    ..J Appl Physiol 94: 155-164, 2003). We conclude that hypocapnia sensed at the carotid body chemoreceptor is required for the initiation of apnea following a transient ventilatory overshoot in non-rapid eye movement sleep...
  42. ncbi request reprint Apnea prolongation via short-term inhibition
    J A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin-Madison 53706, USA
    Sleep 19:S160-3. 1996
    ..We provide evidence that suggests that this apnea prolongation represents a central inertia in the control system mediated by reciprocal inhibition of inspiration...
  43. ncbi request reprint Assessment of nitric oxide formation during exercise
    C M St Croix
    Department of Preventive Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 159:1125-33. 1999
    ....
  44. ncbi request reprint Threshold effects of respiratory muscle work on limb vascular resistance
    A William Sheel
    University of Wisconsin Madison, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin 53705, USA
    Am J Physiol Heart Circ Physiol 282:H1732-8. 2002
    ..We attribute the limb vasoconstriction to a metaboreflex originating in the diaphragm, which reaches its threshold for activation during fatiguing contractions...
  45. pmc Effect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humans
    Lee M Romer
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, Medical Sciences Center, University of Wisconsin, Madison 53706, USA
    J Physiol 571:425-39. 2006
    ..In conclusion, peripheral fatigue of locomotor muscles resulting from high-intensity sustained exercise is, in part, due to the accompanying high levels of respiratory muscle work...
  46. pmc Impact of pulmonary system limitations on locomotor muscle fatigue in patients with COPD
    Markus Amann
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 299:R314-24. 2010
    ....
  47. ncbi request reprint Carotid body denervation eliminates apnea in response to transient hypocapnia
    Hideaki Nakayama
    John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin 53726, USA
    J Appl Physiol 94:155-64. 2003
    ..We conclude that, during non-rapid eye movement sleep, carotid chemoreceptors are required to produce apneas that normally occur after a transient ventilatory overshoot and for PB...
  48. pmc Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans
    Ailiang Xie
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    J Physiol 577:319-29. 2006
    ....
  49. ncbi request reprint Effects of respiratory muscle unloading on exercise-induced diaphragm fatigue
    Mark A Babcock
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison 53706 2368, USA
    J Appl Physiol 93:201-6. 2002
    ....
  50. ncbi request reprint Controlled versus assisted mechanical ventilation effects on respiratory motor output in sleeping humans
    Anthony J Rice
    Department of Population Health Sciences, The John Rankin Laboratory of Pulmonary Medicine, 504 North Walnut Street, Madison, WI 53726 2368, USA
    Am J Respir Crit Care Med 168:92-101. 2003
    ..Controlled mechanical ventilation at increased frequency plus moderate elevations in VT reset respiratory rhythm and inhibited respiratory motor output to a much greater extent than did increased VT alone...
  51. ncbi request reprint Adaptations and limitations in the pulmonary system during exercise
    J A Dempsey
    Department of Preventive Medicine, University of Wisconsin, Madison
    Chest 97:81S-87S. 1990
    ....
  52. ncbi request reprint Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes
    Thomas J Wetter
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, Clinical Sciences Center, University of Wisconsin, Madison 53705, USA
    J Appl Physiol (1985) 93:116-26. 2002
    ..We conclude that airway inflammation is of insufficient magnitude to cause impairments in gas exchange and does not appear to be linked to EIAH in healthy young athletes...
  53. ncbi request reprint Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise
    Keisho Katayama
    The John Rankin Laboratory of Pulmonary Medicine, Department of Health, University of Wisconsin Madison, 4245 Medical Science Center, 1300 University Ave, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1279-86. 2007
    ..2%) or hyperoxia (6.7%). These results demonstrate that quadriceps muscle fatigability during isolated muscle exercise is exacerbated in acute hypoxia, and these effects are independent of the relative exercise intensity...
  54. ncbi request reprint Exercise-induced diaphragmatic fatigue in healthy humans
    B D Johnson
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison 53705
    J Physiol 460:385-405. 1993
    ..The magnitude of the fatigue and the likelihood of its occurrence increases as the relative intensity of the exercise exceeds 85% of VO2, max...
  55. ncbi request reprint Gas exchange during exercise in habitually active asthmatic subjects
    H C Haverkamp
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Appl Physiol (1985) 99:1938-50. 2005
    ....
  56. ncbi request reprint Effects of expiratory muscle work on muscle sympathetic nerve activity
    P Alexander Derchak
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol 92:1539-52. 2002
    ..The evidence suggests that these effects are mediated primarily via a muscle metaboreflex with a minor, variable contribution from augmented central expiratory motor output...
  57. ncbi request reprint Effects of augmented respiratory muscle pressure production on locomotor limb venous return during calf contraction exercise
    Jordan D Miller
    John Rankin Laboratory of Pulmonary Medicine, Medical Sciences Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Appl Physiol (1985) 99:1802-15. 2005
    ....
  58. pmc Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2)
    Gregory M Blain
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    J Physiol 588:2455-71. 2010
    ..We conclude that the gain of the CNS CO(2)/H(+) chemoreceptors in dogs is critically dependent on CB afferent activity and that CNS-CB interaction results in hyperadditive ventilatory responses to central hypercapnia...
  59. ncbi request reprint Exercise-induced arterial hypoxemia
    J A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 87:1997-2006. 1999
    ....
  60. ncbi request reprint The assessment of upper airway patency during apnea using cardiogenic oscillations in the airflow signal
    M J Morrell
    William S. Middleton Memorial Veterans Hospital, Department of Medicine, Madison, Wisconsin, USA
    Sleep 18:651-8. 1995
    ..We conclude that cardiogenic oscillations cannot be used to predict airway patency during apnea...
  61. pmc An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control
    Curtis A Smith
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Respir Physiol Neurobiol 173:288-97. 2010
    ..The limitations of current approaches addressing this question are discussed and future studies are suggested...
  62. ncbi request reprint Influence of arterial O2 on the susceptibility to posthyperventilation apnea during sleep
    Ailiang Xie
    Department of Medicine, University of Wisconsin, Madison, USA
    J Appl Physiol (1985) 100:171-7. 2006
    ..These findings indicate that posthyperventilation apnea is initiated by the peripheral chemoreceptors and that the varying susceptibility to apnea during hypoxia vs. hyperoxia is influenced by the relative activity of these receptors...
  63. pmc Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans
    Markus Amann
    University of Wisconsin Medical School, John Rankin Laboratory of Pulmonary Medicine, Madison, WI, USA
    J Physiol 581:389-403. 2007
    ....
  64. ncbi request reprint Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure
    Michael K Stickland
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WI, USA
    Circ Res 100:1371-8. 2007
    ..These results establish an important role for the CCs in cardiovascular control in the healthy animal during exercise and in the CHF animal both at rest and during exercise...
  65. pmc Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog
    Gregory M Blain
    The John Rankin Laboratory of Pulmonary Medicine, 1300 Univ Ave, 4245 MSC, Madison, WI 53706, USA
    J Appl Physiol (1985) 106:1564-73. 2009
    ....
  66. pmc Influence of cerebral blood flow on breathing stability
    Ailiang Xie
    Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 106:850-6. 2009
    ..06 +/- 0.10 vs. 1.61 +/- 0.27 l x min(-1) x mmHg(-1), P < 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep...
  67. ncbi request reprint Effects of arterial oxygen content on peripheral locomotor muscle fatigue
    Markus Amann
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, 4245 Medical Science Center, 1300 Univ Ave, Madison, Wisconsin 53706, USA
    J Appl Physiol (1985) 101:119-27. 2006
    ..32). We conclude that deltaCa(O2) during strenuous systemic exercise at equal workloads and durations affects the rate of locomotor muscle fatigue development...
  68. ncbi request reprint Inspiratory muscle work in acute hypoxia influences locomotor muscle fatigue and exercise performance of healthy humans
    Markus Amann
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2036-45. 2007
    ....
  69. pmc Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
    Markus Amann
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 586:161-73. 2008
    ..35). We suggest that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level...
  70. ncbi request reprint Exercise-induced intrapulmonary arteriovenous shunting in healthy humans
    Marlowe W Eldridge
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Medical School, Madison, Wisconsin 53792 4108, USA
    J Appl Physiol (1985) 97:797-805. 2004
    ..They may also act as a protective parallel vascular network limiting the rise in regional pulmonary vascular pressure while preserving cardiac output during exercise...
  71. ncbi request reprint Cerebrovascular response to carbon dioxide in patients with congestive heart failure
    Ailiang Xie
    Department of Medicine, University of Wisconsin, Madison, 53705, USA
    Am J Respir Crit Care Med 172:371-8. 2005
    ..However, there are no studies relating cerebral circulation abnormality to the presence or absence of central sleep apnea in patients with heart failure...
  72. ncbi request reprint The essential role of carotid body chemoreceptors in sleep apnea
    Curtis A Smith
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine, 504 North Walnut Street, Madison, WI 53726 2368 USA
    Can J Physiol Pharmacol 81:774-9. 2003
    ..Observations in both humans and animals are cited to demonstrate the marked plasticity of the CO2 reserve and, therefore, the propensity for apneas and periodic breathing, in response to changing background ventilatory stimuli...
  73. pmc Mechanisms of the cerebrovascular response to apnoea in humans
    Tadeusz Przybyłowski
    Department of Population Health Sciences, University of Wisconsin Madison, The John Rankin Laboratory of Pulmonary Medicine, and the Middleton Veterans Administration Hospital, 53705, USA
    J Physiol 548:323-32. 2003
    ....
  74. pmc Skeletal muscle pump versus respiratory muscle pump: modulation of venous return from the locomotor limb in humans
    Jordan D Miller
    University of Wisconsin, John Rankin Laboratory of Pulmonary Medicine, 4245 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 563:925-43. 2005
    ....
  75. ncbi request reprint Respiratory influences on sympathetic vasomotor outflow in humans
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, 504 N Walnut Street, Madison, WI 53706, USA
    Respir Physiol Neurobiol 130:3-20. 2002
    ..Recent evidence suggests that these respiratory influences contribute significantly to sympathetic vasomotor outflow and to the distribution of systemic vascular conductances and blood flow in the exercising human...
  76. ncbi request reprint Anatomic determinants of sleep-disordered breathing across the spectrum of clinical and nonclinical male subjects
    Jerome A Dempsey
    Department of Population Health Sciences, University of Wisconsin, Madison 53705, USA
    Chest 122:840-51. 2002
    ..We also determined the interactive effects of body mass index (BMI) and age on the relationship between airway dimensions and SDB...
  77. pmc Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans
    Markus Amann
    The John Rankin Laboratory of Pulmonary Medicine, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 575:937-52. 2006
    ....
  78. ncbi request reprint Apnea-hypopnea threshold for CO2 in patients with congestive heart failure
    Ailiang Xie
    Department of Medicine, University of Wisconsin, and the Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    Am J Respir Crit Care Med 165:1245-50. 2002
    ..The resultant narrowed DeltaPET(CO2) predisposes the patient to the development of apnea and subsequent breathing instability...
  79. pmc On the normal variability of gas exchange efficiency during exercise: does sex matter?
    Hans C Haverkamp
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
    J Physiol 557:345. 2004
  80. ncbi request reprint Effects of respiratory muscle training versus placebo on endurance exercise performance
    D A Sonetti
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, 504 N. Walnut Street, Madison, WI 53705, USA
    Respir Physiol 127:185-99. 2001
    ..Significant placebo and test familiarization effects must be accounted for in experimental designs utilizing performance tests which are critically dependent on volitional effort...
  81. ncbi request reprint Expiratory threshold loading impairs cardiovascular function in health and chronic heart failure during submaximal exercise
    Jordan D Miller
    University of Wisconsin Madison, John Rankin Laboratory of Pulmonary Medicine, USA
    J Appl Physiol (1985) 101:213-27. 2006
    ..We conclude that increases in expiratory P(ITP) production-similar to those observed during severe expiratory flow limitation-reduce cardiac output and hindlimb blood flow during submaximal exercise in health and CHF...
  82. pmc Sympathetic restraint of muscle blood flow during hypoxic exercise
    Michael K Stickland
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1538-46. 2009
    ..These findings indicate that there is considerable hypoxia-induced sympathetic restraint of muscle blood flow during both mild and moderate exercise, which helps to maintain arterial blood pressure in hypoxia...
  83. ncbi request reprint Ventilatory responsiveness to CO2 above & below eupnea: relative importance of peripheral chemoreception
    Curtis A Smith
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine, Madison, WI 53726 2368, USA
    Adv Exp Med Biol 551:65-70. 2004
  84. ncbi request reprint Exercise carbon dioxide retention in chronic obstructive pulmonary disease: a case for ventilation/perfusion mismatch combined with hyperinflation
    Jerome A Dempsey
    Am J Respir Crit Care Med 166:634-5. 2002
  85. ncbi request reprint Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans
    Lee M Romer
    Centre for Sports Medicine and Human Performance, Brunel University, Middlesex, UB8 3PH, UK
    Am J Physiol Regul Integr Comp Physiol 292:R598-606. 2007
    ..NORM-EXH. We conclude that severe hypoxia exacerbates peripheral fatigue of limb locomotor muscles and that this effect may contribute, in part, to the early termination of exercise...
  86. ncbi request reprint Treatment of airway inflammation improves exercise pulmonary gas exchange and performance in asthmatic subjects
    Hans C Haverkamp
    Department of Medicine, University of Vermont, Vermont Lung Center, Burlington, VT 05405, USA
    J Allergy Clin Immunol 120:39-47. 2007
    ..Asthma is an inflammatory disease of the airways that can lead to impaired arterial blood oxygenation during exercise...
  87. ncbi request reprint Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog
    Bruno J Chenuel
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, Universite Henri Poincare, Nancy, France
    J Appl Physiol (1985) 101:76-83. 2006
    ..We conclude that acute pulmonary hypertension during sleep results in a narrowed CO2 reserve and thus predisposes toward apnea/unstable breathing and may, therefore, contribute to the breathing instability observed in CHF...
  88. ncbi request reprint Increased propensity for apnea via dopamine-induced carotid body inhibition in sleeping dogs
    Bruno J Chenuel
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, Ave de la Forêt de Haye, B P 184, 54505 Vandoeuvre Les Nancy Cedex, France
    J Appl Physiol (1985) 98:1732-9. 2005
    ..These findings have implications for the role of chemoreceptor inhibition/stimulation in the genesis of apnea and breathing periodicity during sleep...
  89. ncbi request reprint Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans
    Lee M Romer
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, UK
    Am J Physiol Regul Integr Comp Physiol 290:R365-75. 2006
    ..We conclude that the arterial O2 desaturation that occurs in fit subjects during high-intensity exercise in normoxia (-6 +/- 1% DeltaSa(O2) from rest) contributes significantly toward quadriceps muscle fatigue via a peripheral mechanism...
  90. ncbi request reprint Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise
    Joshua R Rodman
    Department of Population Healh Sciences, The University of Wisconsin Madison, Wisconsin 53726, USA
    J Appl Physiol (1985) 95:1159-69. 2003
    ..When activated via metabolite production, the respiratory muscle metaboreflex may contribute to the increased sympathetic tone and redistribution of blood flow during exercise...
  91. pmc Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans
    Michael K Stickland
    Division of Pulmonary Medicine, Department of Medicine, 2E4 42 Walter C Mackenzie, Health Sciences Centre, University of Alberta, Edmonton, Alberta, Canada
    J Physiol 586:1743-54. 2008
    ..Consistent with previous animal work, these data indicate that the CC contributes to exercise-induced increases in sympathetic vasoconstrictor outflow...
  92. ncbi request reprint The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure
    Jordan D Miller
    Univ of Iowa, 200 Hawkins Dr, 340B Eckstein Medical Research Bldg, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 292:H580-92. 2007
    ....
  93. ncbi request reprint Measurement of the CO2 apneic threshold
    Magdy Younes
    Am J Respir Crit Care Med 167:472; author relpy 472-3. 2003

Research Grants28

  1. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 2000
    ....
  2. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  3. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2006
    ....
  4. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2007
    ....
  5. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 1980
    ....
  6. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome A Dempsey; Fiscal Year: 2010
    ....