Anthony Demetris

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics
    Yoshiaki Mizuguchi
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32449. 2012
  2. doi request reprint Tissue biopsy monitoring of operational tolerance in liver allograft recipients
    Anthony J Demetris
    Department of Pathology, Division of Liver and Transplantation Pathology, and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Organ Transplant 18:345-53. 2013
  3. pmc SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
    Yoshiaki Mizuguchi
    Thomas E, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    BMC Mol Biol 13:20. 2012
  4. ncbi request reprint Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease
    A J Demetris
    the Thomas E Starzl Transplantation Institute, Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore E 741, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    World J Gastroenterol 12:3512-22. 2006
  5. ncbi request reprint Wound healing in the biliary tree of liver allografts
    A J Demetris
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cell Transplant 15:S57-65. 2006
  6. doi request reprint Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective
    Anthony J Demetris
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Transpl Int 22:120-41. 2009
  7. pmc Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes
    Anthony J Demetris
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore, Room E741, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:276-88. 2008
  8. pmc Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis
    A J Demetris
    Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 28:658-69. 2004
  9. doi request reprint Evolution of hepatitis C virus in liver allografts
    Anthony J Demetris
    Division of Transplantation, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 15:S35-41. 2009
  10. ncbi request reprint Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome
    Anthony J Demetris
    Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 30:986-93. 2006

Detail Information

Publications75

  1. pmc Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics
    Yoshiaki Mizuguchi
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32449. 2012
    ..These data demonstrate a novel mechanism of miRNA regulation in mediating cell phenotype...
  2. doi request reprint Tissue biopsy monitoring of operational tolerance in liver allograft recipients
    Anthony J Demetris
    Department of Pathology, Division of Liver and Transplantation Pathology, and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Organ Transplant 18:345-53. 2013
    ..Baseline biopsies document changes before weaning and can help stratify risk of rejection or dysfunction after weaning; biopsies after weaning are used to study mechanisms of operational tolerance and to monitor for subclinical events...
  3. pmc SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
    Yoshiaki Mizuguchi
    Thomas E, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    BMC Mol Biol 13:20. 2012
    ..Since some p53-directed processes would seem to impede wound repair of barrier epithelia, we hypothesized that SPRR2A up regulation might counteract these effects and enable/promote wound repair under stressful environmental conditions...
  4. ncbi request reprint Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease
    A J Demetris
    the Thomas E Starzl Transplantation Institute, Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore E 741, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    World J Gastroenterol 12:3512-22. 2006
    ..General concepts of wound healing as they apply to the biliary tract, importance of cellular processes dependent on IL-6/gp130/STAT3 signaling pathways, unanswered questions, and future directions are discussed...
  5. ncbi request reprint Wound healing in the biliary tree of liver allografts
    A J Demetris
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cell Transplant 15:S57-65. 2006
    ..The pathobiology of biliary wound healing and therapeutic potential of interleukin-6 (IL-6) are highlighted...
  6. doi request reprint Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective
    Anthony J Demetris
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Transpl Int 22:120-41. 2009
    ....
  7. pmc Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes
    Anthony J Demetris
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore, Room E741, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:276-88. 2008
    ..Since the function of SPRR in these circumstances is unknown, we tested the exploratory hypothesis that BEC SPRR2A expression contributes to BEC barrier function and wound repair...
  8. pmc Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis
    A J Demetris
    Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 28:658-69. 2004
    ....
  9. doi request reprint Evolution of hepatitis C virus in liver allografts
    Anthony J Demetris
    Division of Transplantation, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 15:S35-41. 2009
    ....
  10. ncbi request reprint Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome
    Anthony J Demetris
    Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 30:986-93. 2006
    ..These findings suggest that portal hyperperfusion, venous pathology, and the arterial buffer response importantly contribute to early and late clinical and histopathologic manifestations of the small-for-size syndrome...
  11. doi request reprint Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance
    Kareem M Abu-Elmagd
    Intestinal Rehabilitation and Transplantation Center, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
    Transpl Int 22:96-109. 2009
    ....
  12. pmc Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, The University of Pittsburgh Medical Center, PA 15213, USA
    J Am Coll Surg 200:505-15; quiz A59-61. 2005
    ..We have suggested that transplantation outcomes can be improved by modifying the timing and dosage of immunosuppression to facilitate natural mechanisms of alloengraftment and acquired tolerance...
  13. pmc Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles
    Bijan Eghtesad
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Liver Transpl 11:1343-52. 2005
    ....
  14. ncbi request reprint Caroli's disease and orthotopic liver transplantation
    Shahid Habib
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Liver Transpl 12:416-21. 2006
    ..Survival was poor in patients with congenital hepatic fibrosis (Caroli's syndrome) and in those who had cholangitis at the time OLT...
  15. ncbi request reprint MELD and prediction of post-liver transplantation survival
    Shahid Habib
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Liver Transpl 12:440-7. 2006
    ..Pretransplant MELD scores correlate inversely with posttransplant survival. However, better prognostic models are needed that would provide an overall assessment of transplant benefit relative to the severity of hepatic dysfunction...
  16. pmc The difficulty of eliminating donor leukocyte microchimerism in rat recipients bearing established organ allografts
    Tetsuma Kiyomoto
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 81:438-44. 2006
    ..Unequivocal eradication of donor leukocyte microchimerism from recipients of long-surviving organ transplants has never been reported. Here we describe a drastic attempt to accomplish this objective...
  17. ncbi request reprint Chimerism and tolerance in rat recipients of intestinal allografts from ALS-treated donors with and without adjunct naïve-donor-strain bone-marrow cells
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Transplantation 75:1575-81. 2003
    ....
  18. pmc Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells
    Toyokazu Okuda
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Transplantation 74:103-11. 2002
    ....
  19. pmc Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation
    Hideyoshi Toyokawa
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Liver Transpl 14:346-57. 2008
    ..In conclusion, the study suggests that host cells with phagocytic activity could play significant roles in developing LT tolerance...
  20. pmc Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus
    Amadeo Marcos
    Thomas E Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA
    Transplantation 78:966-71. 2004
    ..Lymphoid depletion with alemtuzumab and minimalistic maintenance immunosuppression is a practical strategy of liver transplantation in HCV recipients but not HCV recipients...
  21. ncbi request reprint Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma
    Sydney D Finkelstein
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hepatology 37:871-9. 2003
    ....
  22. pmc Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Blood 108:1413-20. 2006
    ..These findings suggest that intestine allograft supports simultaneously infused donor (syngeneic to organ grafts) marrow stem cell engraftment, differentiation, and persistence of chimerism...
  23. ncbi request reprint Liver transplantation for severe intrahepatic noncirrhotic portal hypertension
    Alyssa M Krasinskas
    Departments of Pathology, University of Pittsburgh, PA, USA
    Liver Transpl 11:627-34; discussion 610-1. 2005
    ..Importantly, however, a diagnosis of cirrhosis is not required in this group of patients to qualify them for OLT, and these patients have good long-term graft function after OLT...
  24. pmc Regulation and function of trefoil factor family 3 expression in the biliary tree
    Isao Nozaki
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Pathol 165:1907-20. 2004
    ..Therefore, use of recombinant IL-6 or TFF3 peptides should exert a therapeutic role in preventing biliary strictures in liver allografts...
  25. pmc Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Ann Surg 238:520-5; discussion 525-7. 2003
    ..The purpose of this work was to perform kidney transplantation under a regimen of immunosuppression that facilitates rather than interferes with the recently defined mechanisms of alloengraftment and acquired tolerance...
  26. pmc Tolerogenic immunosuppression for organ transplantation
    Thomas E Starzl
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Lancet 361:1502-10. 2003
    ..We aimed to apply these principles in recipients of renal and extrarenal organ transplants...
  27. pmc Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors
    Chandrashekhar R Gandhi
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1540 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 37:340-8. 2002
    ....
  28. ncbi request reprint Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation
    Kapil B Chopra
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 76:1487-91. 2003
    ..HCV recurrence is universal after OLTx, with a highly variable course. This study aimed to find factors that affect progression of fibrosis in recurrent HCV...
  29. ncbi request reprint Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival
    J Wallis Marsh
    Department of Transplantation Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    Liver Transpl 9:664-71. 2003
    ..For the remaining 81, the combined models predicted tumor recurrence outcomes with complete accuracy. Microdissection genotyping provides powerful supplementary discriminative information for tumor-free survival...
  30. pmc Lessons of organ-induced tolerance learned from historical clinical experience
    Thomas E Starzl
    Thomas E Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 77:926-9. 2004
    ..Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression...
  31. ncbi request reprint A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis C
    Ashok Jain
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Liver Transpl 8:40-6. 2002
    ..In addition, there was no difference in HAI or fibrosis score between the two groups. Either MMF has no anti-HCV effect or its immunosuppressive properties overwhelm its antiviral effect in the clinical setting...
  32. ncbi request reprint De novo malignancies after intestinal and multivisceral transplantation
    Kareem M Abu-Elmagd
    Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15213, USA
    Transplantation 77:1719-25. 2004
    ..With more than a decade of clinical experience, this report is the first to address the risk of de novo cancer after intestinal transplantation...
  33. ncbi request reprint A validated model for predicting outcome after liver transplantation: implications on transplanting the extremely sick
    Ido Nachmany
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transpl Int 26:1108-15. 2013
    ..75 (95% CI 0.70, 0.81)]. In the VC, 53 patients (12.7%) were expected to have adverse outcome by the model. These patients had longer LOS (P < 0.0001), higher cost (<0.0001), and inferior patient and graft survival (P < 0.007)...
  34. pmc Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas
    Jian Hua Luo
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 44:1012-24. 2006
    ..In conclusion, a set of specific genes and areas of genomic instability are found across the board in liver neoplasia...
  35. ncbi request reprint Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression
    Olga Azhipa
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Clin Immunol 114:199-209. 2005
    ..The results indicate that donor MHC class II+ APC are capable of regulating recipient immune reactions under TAC. Possible involvement of the indirect pathway of allorecognition is discussed...
  36. ncbi request reprint Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation
    Adrian E Morelli
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 83:656-62. 2007
    ..HGF-induced changes reversed significantly within 7 days of Flt3L withdrawal. Therapeutic protocols that mobilize donor hematopoietic cells should consider the influence of HGF on the APC constituency of prospective organ allografts...
  37. ncbi request reprint Suprahepatic Budd-Chiari syndrome treated with thrombectomy and cavoplasty
    John Rhee
    Department of Medicine, Division of Gastroenterology and Hepatology, the Starzl Institute University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 48:1637-41. 2003
    ..Follow-up venography showed a widely opened cava with normal free hepatic vein pressures. Repeat liver biopsy at 6 months showed complete resolution of the hepatic venous congestion and a decrease in the degree of fibrosis...
  38. ncbi request reprint Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumab
    Tong Wu
    Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Gastroenterol 101:1617-24. 2006
    ....
  39. ncbi request reprint A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodies
    Tong Wu
    Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Hum Pathol 35:1332-9. 2004
    ..If recognized and treated aggressively, early graft failure can be avoided. The long-term significance of these preformed antibodies has yet to be determined...
  40. ncbi request reprint Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation
    Kei Kimizuka
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Transplant 4:482-94. 2004
    ..These results show that IL-6 is effective in protecting the intestine from cold I/R injury by maintaining graft blood flow and reducing pro-inflammatory cytokine up-regulation and neutrophil infiltration...
  41. ncbi request reprint Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progression
    Maria Parizhskaya
    Department of Pathology, Children s Hospital and University of Pittsburgh Medical Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Pediatr Dev Pathol 6:240-50. 2003
    ..It is important to recognize the persistence of "late" mucosal changes of chronic rejection so that patients are not subjected to increased immune suppression when it is unlikely to be of significant benefit...
  42. doi request reprint Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function tests
    Susan C Abraham
    Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 32:965-73. 2008
    ....
  43. doi request reprint Posttransplant adenoviral enteropathy in patients with small bowel transplantation
    Oyedele A Adeyi
    Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, USA
    Arch Pathol Lab Med 132:703-5. 2008
    ..The identification of characteristic viral inclusions in the surface or crypt epithelium points to the diagnosis of adenoviral enteropathy, in spite of the increased crypt apoptosis...
  44. ncbi request reprint Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity
    John G Lunz
    Department of Pathology, Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hepatology 46:1946-59. 2007
    ..Manipulating gut bacteria may therefore be an effective strategy for altering intrahepatic immune responses...
  45. ncbi request reprint Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation
    Isao Nozaki
    Thomas E Starzl Transplantation Institute, Divisions of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Lab Invest 85:109-23. 2005
    ..In conclusion, BEC IL-6/gp130/STAT3 signaling noncoordinately upregulates BEC SPRR2 that appears to contribute to modification of the biliary barrier under conditions of stress...
  46. doi request reprint NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells
    Daniel Zecher
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 184:6649-57. 2010
    ..Concomitant NK and T cell depletion may be undesirable in transplant recipients because of enhanced expansion of memory CD8+ T cells that increase the risk of rejection...
  47. ncbi request reprint Impact of anti-hepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosis
    Pedro P Joya-Vazquez
    Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transplantation 73:1598-602. 2002
    ..The aim of this study was to evaluate the impact of the use of anti-HBc+ grafts in patients transplanted for hepatitis B virus (HBV)-related cirrhosis...
  48. ncbi request reprint Azithromycin-induced intrahepatic cholestasis
    Sreekanth Chandrupatla
    Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
    Dig Dis Sci 47:2186-8. 2002
    ..Clinicians should be aware of this side effect of azithromycin, which is widely prescribed...
  49. ncbi request reprint Wnt'er in liver: expression of Wnt and frizzled genes in mouse
    Gang Zeng
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:195-204. 2007
    ..CONCLUSION: These data indicate that most Wnt and frizzled genes are expressed in the liver and might be playing important roles in liver pathobiology via canonical and noncanonical pathways...
  50. ncbi request reprint Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts
    Tong Wu
    Division of Transplant Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 3:1173-81. 2003
    ..Because of the extremely low frequency, interpretation was difficult. Regardless of these results, a more vigorous search for conditions that promote transdifferentiation is warranted...
  51. doi request reprint Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans
    Kumiko Isse
    Department of Pathology, Division of Transplantation, and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hepatology 51:869-80. 2010
    ..An association between these signaling pathways was demonstrated for female-predominant polycystic livers and might also influence autoimmune hepatitis, primary biliary cirrhosis, and cholangiocarcinogenesis...
  52. pmc Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    Pallavi B Limaye
    Department of Pathology, Division of Transplantation Pathology, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Lab Invest 88:865-72. 2008
    ....
  53. doi request reprint Heterotopic breast epithelial inclusion of the heart: report of a case
    Kotaro Sasaki
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Surg Pathol 34:1555-9. 2010
    ..Although the heterotopic breast tissue on the skin along the milk line is well recognized, it has not been described to involve internal organs including the heart...
  54. ncbi request reprint ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions
    Kanenori Endo
    Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
    Hepatology 36:439-50. 2002
    ..The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC...
  55. pmc Four-color flow cytometric analysis of peripheral blood donor cell chimerism
    Diana Metes
    Department of Surgery, Thomas E Starzl Tranplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Hum Immunol 64:787-95. 2003
    ..However, the detection of MHC-mismatched leukocytes of all lineages was much lower when frozen peripheral blood mononuclear cells were used...
  56. ncbi request reprint An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis
    John G Lunz
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Hepatology 41:1262-71. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  57. ncbi request reprint 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injury
    Hideyoshi Toyokawa
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Lab Invest 86:72-82. 2006
    ..The actual frequency in 3D analysis was approximately one-fourth of that seen in 2D analysis. 3D confocal imaging precisely detected BM-derived tubular epithelial cells and could be useful to study BMC contribution to tissue repair...
  58. ncbi request reprint Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches
    Oyedele A Adeyi
    Division of Transplantation Pathology and CLSI Tissue Typing Laboratory, Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 15261 USA
    Transpl Immunol 14:53-62. 2005
    ..It provides also opportunities for determining the relative immunogenicity of mismatched triplets...
  59. ncbi request reprint Early HCV-associated stellate cell activation in aggressive recurrent HCV: what can liver allografts teach about HCV pathogenesis?
    Anthony J Demetris
    Liver Transpl 11:1172-6. 2005
  60. ncbi request reprint CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allografts
    Sen Li
    Division of Cardiothoracic Surgery, University of Miami School of Medicine, Miami, Florida 33156, USA
    J Surg Res 136:238-46. 2006
    ..In this study, we investigated a non-toxic CTLA4-Ig-based protocol to induce donor-specific tolerance to cardiac allografts in rats...
  61. ncbi request reprint Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    Ju Seog Lee
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Hepatology 40:667-76. 2004
    ..g., HIF1a) for selective treatment of HCC patients. Supplementary material for this article can be found on the HEPATOLOGY Web site (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)..
  62. ncbi request reprint Acute antibody-mediated rejection of cardiac transplants
    Elaine F Reed
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 1335, Los Angeles, CA 90095, USA
    J Heart Lung Transplant 25:153-9. 2006
    ....
  63. ncbi request reprint Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction
    Michelle M Richardson
    School of Medicine, Southern Clinical Division, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Gastroenterology 133:80-90. 2007
    ..We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus...
  64. ncbi request reprint A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    Ju Seog Lee
    Lab of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 4146, Bethesda, Maryland 20892, USA
    Nat Med 12:410-6. 2006
    ..Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development...
  65. ncbi request reprint Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection
    Susan Stewart
    International Society for Heart and Lung Transplantation, Addison, Texas, USA
    J Heart Lung Transplant 24:1710-20. 2005
    ..Technical considerations in biopsy processing are also addressed. This consensus revision of the Working Formulation was approved by the ISHLT Board of Directors in December 2004...
  66. ncbi request reprint Plasma cell hepatitis in liver allografts: Variant of rejection or autoimmune hepatitis?
    Anthony J Demetris
    Liver Transpl 14:750-5. 2008
  67. ncbi request reprint Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy
    Susan C Abraham
    Department of Pathology and Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 30:1454-61. 2006
    ..The occurrence of NRH in some patients transplanted for other indications suggests it is a histologic pattern that can precede the development of clinically significant portal hypertension...
  68. ncbi request reprint Liver biopsy interpretation for causes of late liver allograft dysfunction
    Anthony J Demetris
    Hepatology 44:489-501. 2006
    ..A discussion of differential diagnosis is also presented...
  69. pmc Production of alpha 1,3-galactosyltransferase-deficient pigs
    Carol J Phelps
    PPL Therapeutics Inc, 1700 Kraft Drive, Blacksburg, VA 24060, USA
    Science 299:411-4. 2003
    ....
  70. pmc Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    Britt E Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 111:5242-51. 2008
    ..Taken together, these data argue against the hypothesis that T(EM) fail to induce GVHD because of inefficient trafficking to LN and PP...
  71. ncbi request reprint Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  72. ncbi request reprint Five cases of fulminant hepatitis due to herpes simplex virus in adults
    Antonio D Pinna
    Department of Surgery, University of Miami, Florida, USA
    Dig Dis Sci 47:750-4. 2002
    ..Early histologic diagnosis, specific antiviral treatment, and liver transplantation in selected patients may improve the clinical outcome of this almost uniformly fatal disease...
  73. ncbi request reprint Acute cholestatic hepatitis associated with long-term use of rofecoxib
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 49:459-61. 2004
  74. doi request reprint Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids
    Kyu Lim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 68:553-60. 2008
    ..Thus, utilization of omega 3-PUFAs may represent an effective and safe therapeutic approach for the chemoprevention and treatment of human cholangiocarcinoma...

Research Grants10

  1. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2003
    ..abstract_text> ..
  2. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2005
    ..abstract_text> ..
  3. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2004
    ..abstract_text> ..
  4. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2002
    ..abstract_text> ..
  5. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2000
    ..B. Use IL-6 antagonists, such as anti-IL6 monoclonal antibodies, suramin or inhibitors of intracellular second signaling molecules to determine if such interventions could have therapeutic implications for patients. ..
  6. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 1999
    ..B. Use IL-6 antagonists, such as anti-IL6 monoclonal antibodies, suramin or inhibitors of intracellular second signaling molecules to determine if such interventions could have therapeutic implications for patients. ..
  7. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2006
    ..abstract_text> ..