Research Topics
| Anthony DemetrisSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activityYoshiaki Mizuguchi
Thomas E, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
BMC Mol Biol 13:20. 2012..Since some p53-directed processes would seem to impede wound repair of barrier epithelia, we hypothesized that SPRR2A up regulation might counteract these effects and enable/promote wound repair under stressful environmental conditions...
Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver diseaseA J Demetris
the Thomas E Starzl Transplantation Institute, Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore E 741, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
World J Gastroenterol 12:3512-22. 2006..General concepts of wound healing as they apply to the biliary tract, importance of cellular processes dependent on IL-6/gp130/STAT3 signaling pathways, unanswered questions, and future directions are discussed...- Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndromeAnthony J Demetris
Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Surg Pathol 30:986-93. 2006..These findings suggest that portal hyperperfusion, venous pathology, and the arterial buffer response importantly contribute to early and late clinical and histopathologic manifestations of the small-for-size syndrome... - Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytesAnthony J Demetris
Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, UPMC Montefiore, Room E741, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Hepatol 48:276-88. 2008..Since the function of SPRR in these circumstances is unknown, we tested the exploratory hypothesis that BEC SPRR2A expression contributes to BEC barrier function and wound repair... - Wound healing in the biliary tree of liver allograftsA J Demetris
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Cell Transplant 15:S57-65. 2006..The pathobiology of biliary wound healing and therapeutic potential of interleukin-6 (IL-6) are highlighted... - Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesisA J Demetris
Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 28:658-69. 2004.... 
Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspectiveAnthony J Demetris
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
Transpl Int 22:120-41. 2009....- Evolution of hepatitis C virus in liver allograftsAnthony J Demetris
Division of Transplantation, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Liver Transpl 15:S35-41. 2009.... - Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or CampathRon Shapiro
Thomas E Starzl Transplantation Institute, The University of Pittsburgh Medical Center, PA 15213, USA
J Am Coll Surg 200:505-15; quiz A59-61. 2005..Campath was the more effective agent for pretreatment. Guidelines for spaced weaning need additional refinement... - Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principlesBijan Eghtesad
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Liver Transpl 11:1343-52. 2005.... - Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial toleranceKareem M Abu-Elmagd
Intestinal Rehabilitation and Transplantation Center, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
Transpl Int 22:96-109. 2009.... - The difficulty of eliminating donor leukocyte microchimerism in rat recipients bearing established organ allograftsTetsuma Kiyomoto
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Transplantation 81:438-44. 2006..CONCLUSIONS: It is difficult to eliminate microchimerism in organ recipients once the donor cells have settled into tissue niches... - Caroli's disease and orthotopic liver transplantationShahid Habib
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Liver Transpl 12:416-21. 2006..Survival was poor in patients with congenital hepatic fibrosis (Caroli's syndrome) and in those who had cholangitis at the time OLT... - MELD and prediction of post-liver transplantation survivalShahid Habib
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Liver Transpl 12:440-7. 2006..Pretransplant MELD scores correlate inversely with posttransplant survival. However, better prognostic models are needed that would provide an overall assessment of transplant benefit relative to the severity of hepatic dysfunction... - Chimerism and tolerance in rat recipients of intestinal allografts from ALS-treated donors with and without adjunct naïve-donor-strain bone-marrow cellsAtsunori Nakao
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
Transplantation 75:1575-81. 2003..The difference may be because of a higher number of precursor and pluripotent stem cells in BMC... - Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cellsToyokazu Okuda
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Transplantation 74:103-11. 2002.... - Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantationHideyoshi Toyokawa
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Liver Transpl 14:346-57. 2008..In conclusion, the study suggests that host cells with phagocytic activity could play significant roles in developing LT tolerance... - Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virusAmadeo Marcos
Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA
Transplantation 78:966-71. 2004..Lymphoid depletion with alemtuzumab and minimalistic maintenance immunosuppression is a practical strategy of liver transplantation in HCV recipients but not HCV recipients... - Regulation and function of trefoil factor family 3 expression in the biliary treeIsao Nozaki
Thomas E. Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Am J Pathol 165:1907-20. 2004..Therefore, use of recombinant IL-6 or TFF3 peptides should exert a therapeutic role in preventing biliary strictures in liver allografts... - Liver transplantation for severe intrahepatic noncirrhotic portal hypertensionAlyssa M Krasinskas
Departments of Pathology, University of Pittsburgh, PA, USA
Liver Transpl 11:627-34; discussion 610-1. 2005..Importantly, however, a diagnosis of cirrhosis is not required in this group of patients to qualify them for OLT, and these patients have good long-term graft function after OLT... - Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerismAtsunori Nakao
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Blood 108:1413-20. 2006..These findings suggest that intestine allograft supports simultaneously infused donor (syngeneic to organ grafts) marrow stem cell engraftment, differentiation, and persistence of chimerism... - De novo malignancies after intestinal and multivisceral transplantationKareem M Abu-Elmagd
Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15213, USA
Transplantation 77:1719-25. 2004..With more than a decade of clinical experience, this report is the first to address the risk of de novo cancer after intestinal transplantation... - Tolerogenic immunosuppression for organ transplantationThomas E Starzl
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Lancet 361:1502-10. 2003..We aimed to apply these principles in recipients of renal and extrarenal organ transplants... - Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinomaSydney D Finkelstein
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hepatology 37:871-9. 2003.... - Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survivalJ Wallis Marsh
Department of Transplantation Surgery, University of Pittsburgh Medical Center, PA 15213, USA
Liver Transpl 9:664-71. 2003..For the remaining 81, the combined models predicted tumor recurrence outcomes with complete accuracy. Microdissection genotyping provides powerful supplementary discriminative information for tumor-free survival... - Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factorsChandrashekhar R Gandhi
Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1540 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Hepatol 37:340-8. 2002.... - Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaningRon Shapiro
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Ann Surg 238:520-5; discussion 525-7. 2003..The purpose of this work was to perform kidney transplantation under a regimen of immunosuppression that facilitates rather than interferes with the recently defined mechanisms of alloengraftment and acquired tolerance... - Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantationKapil B Chopra
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 76:1487-91. 2003..CONCLUSION: Patients with HCV genotype 1a and those developing CMV postOLTx have a higher rate of hepatic fibrosis progression after OLTx for HCV-related chronic liver disease... - A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis CAshok Jain
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Liver Transpl 8:40-6. 2002..In addition, there was no difference in HAI or fibrosis score between the two groups. Either MMF has no anti-HCV effect or its immunosuppressive properties overwhelm its antiviral effect in the clinical setting... - Lessons of organ-induced tolerance learned from historical clinical experienceThomas E Starzl
Thomas E Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Transplantation 77:926-9. 2004..Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression... - A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodiesTong Wu
Department of Pathology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
Hum Pathol 35:1332-9. 2004..If recognized and treated aggressively, early graft failure can be avoided. The long-term significance of these preformed antibodies has yet to be determined... - Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumabTong Wu
Department of Pathology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Am J Gastroenterol 101:1617-24. 2006..Recognition of these unique histopathologic features will enable accurate diagnosis and ensure successful weaning of immunosuppressive drugs... - Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomasJian-Hua Luo
Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Hepatology 44:1012-24. 2006..In conclusion, a set of specific genes and areas of genomic instability are found across the board in liver neoplasia... - Suprahepatic Budd-Chiari syndrome treated with thrombectomy and cavoplastyJohn Rhee
Department of Medicine, Division of Gastroenterology and Hepatology, the Starzl Institute University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Dig Dis Sci 48:1637-41. 2003..Follow-up venography showed a widely opened cava with normal free hepatic vein pressures. Repeat liver biopsy at 6 months showed complete resolution of the hepatic venous congestion and a decrease in the degree of fibrosis... - Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantationKei Kimizuka
Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Am J Transplant 4:482-94. 2004..These results show that IL-6 is effective in protecting the intestine from cold I/R injury by maintaining graft blood flow and reducing pro-inflammatory cytokine up-regulation and neutrophil infiltration... - Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantationAdrian E Morelli
Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Transplantation 83:656-62. 2007..HGF-induced changes reversed significantly within 7 days of Flt3L withdrawal. Therapeutic protocols that mobilize donor hematopoietic cells should consider the influence of HGF on the APC constituency of prospective organ allografts... - Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppressionOlga Azhipa
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Clin Immunol 114:199-209. 2005..The results indicate that donor MHC class II+ APC are capable of regulating recipient immune reactions under TAC. Possible involvement of the indirect pathway of allorecognition is discussed... - Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progressionMaria Parizhskaya
Department of Pathology, Children s Hospital and University of Pittsburgh Medical Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Pediatr Dev Pathol 6:240-50. 2003..It is important to recognize the persistence of "late" mucosal changes of chronic rejection so that patients are not subjected to increased immune suppression when it is unlikely to be of significant benefit... - NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cellsDaniel Zecher
Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Immunol 184:6649-57. 2010..Concomitant NK and T cell depletion may be undesirable in transplant recipients because of enhanced expansion of memory CD8+ T cells that increase the risk of rejection... - Posttransplant adenoviral enteropathy in patients with small bowel transplantationOyedele A Adeyi
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, USA
Arch Pathol Lab Med 132:703-5. 2008..The identification of characteristic viral inclusions in the surface or crypt epithelium points to the diagnosis of adenoviral enteropathy, in spite of the increased crypt apoptosis... - Impact of anti-hepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosisPedro P Joya-Vazquez
Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transplantation 73:1598-602. 2002..However, patients who receive these organs are 2.5 times more likely to develop HBV recurrence. Lamivudine and HBIG combination decreases HBV recurrence 4-fold... - Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function testsSusan C Abraham
Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
Am J Surg Pathol 32:965-73. 2008.... - Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activityJohn G Lunz
Department of Pathology, Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hepatology 46:1946-59. 2007..Manipulating gut bacteria may therefore be an effective strategy for altering intrahepatic immune responses... - Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligationIsao Nozaki
Thomas E Starzl Transplantation Institute, Divisions of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Lab Invest 85:109-23. 2005..In conclusion, BEC IL-6/gp130/STAT3 signaling noncoordinately upregulates BEC SPRR2 that appears to contribute to modification of the biliary barrier under conditions of stress... - Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allograftsTong Wu
Division of Transplant Pathology, Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA, USA
Am J Transplant 3:1173-81. 2003..Because of the extremely low frequency, interpretation was difficult. Regardless of these results, a more vigorous search for conditions that promote transdifferentiation is warranted... - Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic developmentPallavi B Limaye
Department of Pathology, Division of Transplantation Pathology, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
Lab Invest 88:865-72. 2008.... - Wnt'er in liver: expression of Wnt and frizzled genes in mouseGang Zeng
Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
Hepatology 45:195-204. 2007..CONCLUSION: These data indicate that most Wnt and frizzled genes are expressed in the liver and might be playing important roles in liver pathobiology via canonical and noncanonical pathways... - Azithromycin-induced intrahepatic cholestasisSreekanth Chandrupatla
Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
Dig Dis Sci 47:2186-8. 2002..Clinicians should be aware of this side effect of azithromycin, which is widely prescribed... - Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humansKumiko Isse
Department of Pathology, Division of Transplantation, and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hepatology 51:869-80. 2010..An association between these signaling pathways was demonstrated for female-predominant polycystic livers and might also influence autoimmune hepatitis, primary biliary cirrhosis, and cholangiocarcinogenesis... - Heterotopic breast epithelial inclusion of the heart: report of a caseKotaro Sasaki
Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
Am J Surg Pathol 34:1555-9. 2010..Although the heterotopic breast tissue on the skin along the milk line is well recognized, it has not been described to involve internal organs including the heart... - An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosisJohn G Lunz
Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Hepatology 41:1262-71. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - Four-color flow cytometric analysis of peripheral blood donor cell chimerismDiana Metes
Department of Surgery, Thomas E. Starzl Tranplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Hum Immunol 64:787-95. 2003..However, the detection of MHC-mismatched leukocytes of all lineages was much lower when frozen peripheral blood mononuclear cells were used... - 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injuryHideyoshi Toyokawa
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Lab Invest 86:72-82. 2006..The actual frequency in 3D analysis was approximately one-fourth of that seen in 2D analysis. 3D confocal imaging precisely detected BM-derived tubular epithelial cells and could be useful to study BMC contribution to tissue repair... - Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatchesOyedele A Adeyi
Division of Transplantation Pathology and CLSI Tissue Typing Laboratory, Department of Pathology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 15261 USA
Transpl Immunol 14:53-62. 2005..It provides also opportunities for determining the relative immunogenicity of mismatched triplets... - ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditionsKanenori Endo
Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
Hepatology 36:439-50. 2002..The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC... - A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cellsJu-Seog Lee
Lab of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 4146, Bethesda, Maryland 20892, USA
Nat Med 12:410-6. 2006..Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development... - Classification and prediction of survival in hepatocellular carcinoma by gene expression profilingJu-Seog Lee
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
Hepatology 40:667-76. 2004..g., HIF1a) for selective treatment of HCC patients. Supplementary material for this article can be found on the HEPATOLOGY Web site (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html).. - Early HCV-associated stellate cell activation in aggressive recurrent HCV: what can liver allografts teach about HCV pathogenesis?Anthony J Demetris
Liver Transpl 11:1172-6. 2005 - Plasma cell hepatitis in liver allografts: Variant of rejection or autoimmune hepatitis?Anthony J Demetris
Liver Transpl 14:750-5. 2008 - Acute antibody-mediated rejection of cardiac transplantsElaine F Reed
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 1335, Los Angeles, CA 90095, USA
J Heart Lung Transplant 25:153-9. 2006.... - Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reactionMichelle M Richardson
School of Medicine, Southern Clinical Division, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Gastroenterology 133:80-90. 2007..We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus... - Liver biopsy interpretation for causes of late liver allograft dysfunctionAnthony J Demetris
Hepatology 44:489-501. 2006..A discussion of differential diagnosis is also presented... - Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathySusan C Abraham
Department of Pathology and Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 30:1454-61. 2006..The occurrence of NRH in some patients transplanted for other indications suggests it is a histologic pattern that can precede the development of clinically significant portal hypertension... - Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejectionSusan Stewart
International Society for Heart and Lung Transplantation, Addison, Texas, USA
J Heart Lung Transplant 24:1710-20. 2005..Technical considerations in biopsy processing are also addressed. This consensus revision of the Working Formulation was approved by the ISHLT Board of Directors in December 2004... - CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allograftsSen Li
Division of Cardiothoracic Surgery, University of Miami School of Medicine, Miami, Florida 33156, USA
J Surg Res 136:238-46. 2006..Tolerant graft histology showed no obliterative arteriopathy or chronic rejection. CONCLUSIONS: The CTLA4-Ig based conditioning regimen with donor BMT produced mixed chimerism and induced donor- specific tolerance to cardiac allografts... - Acute cholestatic hepatitis associated with long-term use of rofecoxibGeorgios I Papachristou
Department of Medicine, Division of Gastroenterology and Hepatology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Dig Dis Sci 49:459-61. 2004 - Five cases of fulminant hepatitis due to herpes simplex virus in adultsAntonio D Pinna
Department of Surgery, University of Miami, Florida, USA
Dig Dis Sci 47:750-4. 2002..Early histologic diagnosis, specific antiviral treatment, and liver transplantation in selected patients may improve the clinical outcome of this almost uniformly fatal disease... - Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejectionLorraine C Racusen
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 3:708-14. 2003..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation... - Production of alpha 1,3-galactosyltransferase-deficient pigsCarol J Phelps
PPL Therapeutics Inc, 1700 Kraft Drive, Blacksburg, VA 24060, USA
Science 299:411-4. 2003.... - Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acidsKyu Lim
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 68:553-60. 2008..Thus, utilization of omega 3-PUFAs may represent an effective and safe therapeutic approach for the chemoprevention and treatment of human cholangiocarcinoma... - Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cellsBritt E Anderson
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
Blood 111:5242-51. 2008..Taken together, these data argue against the hypothesis that T(EM) fail to induce GVHD because of inefficient trafficking to LN and PP...
Research Grants
- INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATIONAnthony Demetris; Fiscal Year: 2000..B. Use IL-6 antagonists, such as anti-IL6 monoclonal antibodies, suramin or inhibitors of intracellular second signaling molecules to determine if such interventions could have therapeutic implications for patients. ..
- INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATIONAnthony Demetris; Fiscal Year: 2006..abstract_text> ..