Linda Demer

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics
    Ting Hsuan Chen
    Department of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    Circ Res 110:551-9. 2012
  2. ncbi request reprint Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids
    Linda L Demer
    Department of Medicine, UCLA School of Medicine, Box 951679, 10833 LeConte Ave, Los Angeles, CA 90095 1679, USA
    Int J Epidemiol 31:737-41. 2002
  3. ncbi request reprint A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells"
    Linda L Demer
    Department of Medicine, Physiology and Biomedical Engineering, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Free Radic Biol Med 44:504-5. 2008
  4. ncbi request reprint Mechanisms linking osteoporosis with cardiovascular calcification
    Linda L Demer
    Department of Medicine, BH 307 Center for Health Sciences, Los Angeles, CA 90095 1679, USA
    Curr Osteoporos Rep 7:42-6. 2009
  5. pmc The bone-vascular axis in chronic kidney disease
    Linda Demer
    Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
    Curr Opin Nephrol Hypertens 19:349-53. 2010
  6. doi request reprint Vascular calcification: pathobiology of a multifaceted disease
    Linda L Demer
    Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 117:2938-48. 2008
  7. pmc The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification
    Linda Demer
    Department of Medicine, University of California, Los Angeles, CA, USA
    Circ Res 108:1482-93. 2011
  8. ncbi request reprint Novel mechanisms in accelerated vascular calcification in renal disease patients
    Linda L Demer
    Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Curr Opin Nephrol Hypertens 11:437-43. 2002
  9. ncbi request reprint Monocyte/macrophage regulation of vascular calcification in vitro
    Yin Tintut
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Circulation 105:650-5. 2002
  10. pmc PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification
    Wendy Tseng
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:29925-31. 2010

Research Grants

Collaborators

Detail Information

Publications44

  1. pmc Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics
    Ting Hsuan Chen
    Department of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    Circ Res 110:551-9. 2012
    ..Thus, to organize LR asymmetry at multiscale levels of morphogenesis, cells with chirality must also be present in adequate numbers. However, observation of LR asymmetry is rarely reported in cultured cells...
  2. ncbi request reprint Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids
    Linda L Demer
    Department of Medicine, UCLA School of Medicine, Box 951679, 10833 LeConte Ave, Los Angeles, CA 90095 1679, USA
    Int J Epidemiol 31:737-41. 2002
  3. ncbi request reprint A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells"
    Linda L Demer
    Department of Medicine, Physiology and Biomedical Engineering, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Free Radic Biol Med 44:504-5. 2008
  4. ncbi request reprint Mechanisms linking osteoporosis with cardiovascular calcification
    Linda L Demer
    Department of Medicine, BH 307 Center for Health Sciences, Los Angeles, CA 90095 1679, USA
    Curr Osteoporos Rep 7:42-6. 2009
    ..Any or all of these factors and phenomena may contribute to the association...
  5. pmc The bone-vascular axis in chronic kidney disease
    Linda Demer
    Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
    Curr Opin Nephrol Hypertens 19:349-53. 2010
    ..This review highlights the most recent publications addressing the relationship between bone and vascular calcification in patients with chronic and end-stage kidney disease...
  6. doi request reprint Vascular calcification: pathobiology of a multifaceted disease
    Linda L Demer
    Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 117:2938-48. 2008
  7. pmc The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification
    Linda Demer
    Department of Medicine, University of California, Los Angeles, CA, USA
    Circ Res 108:1482-93. 2011
    ..These factors may have therapeutic use in osteoclastogenic removal of mineral deposits from arteries...
  8. ncbi request reprint Novel mechanisms in accelerated vascular calcification in renal disease patients
    Linda L Demer
    Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Curr Opin Nephrol Hypertens 11:437-43. 2002
    ..It is a regulated biological process following many of the cellular and molecular programs in osteogenesis. This review summarizes some of the regulatory mechanisms that may explain its severity in renal patients...
  9. ncbi request reprint Monocyte/macrophage regulation of vascular calcification in vitro
    Yin Tintut
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Circulation 105:650-5. 2002
    ..Calcification is a common complication of atherosclerosis and other chronic inflammatory processes that involves infiltration of monocytes and accumulation of macrophages...
  10. pmc PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification
    Wendy Tseng
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:29925-31. 2010
    ..These findings suggest that, as in skeletal tissues, PKA activation induces bone resorptive factors in the vasculature and that aortic SMC calcification specifically induced by PKA, is not mediated by RANKL...
  11. ncbi request reprint Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways
    Kristen Radcliff
    Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Circ Res 96:398-400. 2005
    ..These results suggest that IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of vascular cells via both ERK and PI3K pathways...
  12. ncbi request reprint Mesenchymal stem cells and the artery wall
    Moeen Abedin
    Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, CA 90095 1679, USA
    Circ Res 95:671-6. 2004
    ..A greater understanding of how mesenchymal stem cells from the bone marrow or artery wall bring about vascular regeneration and repair may lead to novel cell-based treatments for cardiovascular disease...
  13. pmc Adverse effects of hyperlipidemia on bone regeneration and strength
    Flavia Pirih
    Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA
    J Bone Miner Res 27:309-18. 2012
    ..7-fold greater in Ldlr(-/-) mice. These findings suggest that hyperlipidemia induces secondary hyperparathyroidism and impairs bone regeneration and mechanical strength...
  14. pmc Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification
    Michael S Huang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Center for the Health Sciences BH 307, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Biochem Biophys Res Commun 374:553-8. 2008
    ..These results suggest that phosphate is necessary for PKA-induced calcification of vascular cells and that the extent of PKA-induced calcification is controlled by feedback induction of the inhibitor, pyrophosphate...
  15. ncbi request reprint Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture
    Linda L Demer
    Department of Medicine, The David Geffen School of Medicine at University of California Los Angeles, 90095 1679, USA
    Arterioscler Thromb Vasc Biol 23:1739-43. 2003
    ..The review closes with a mention of therapeutic possibilities and an evolutionary paradigm to explain the reciprocal responses of vascular and bone mineralization to inflammation...
  16. ncbi request reprint Vascular calcification and its relation to bone calcification: possible underlying mechanisms
    Nilam Mody
    Departments of Medicine and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif 90095 1679, USA
    J Nucl Cardiol 10:177-83. 2003
  17. pmc Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss
    Lucia S Graham
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Clin Immunol 133:265-75. 2009
    ..These findings may help elucidate clinical associations between cardiovascular disease and decreased bone mass, and may also lead to new immune-based approaches to osteoporosis...
  18. ncbi request reprint 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway
    Yin Tintut
    Department of Medicine, School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 277:14221-6. 2002
    ..These data suggest that isoPGE2 enhances osteoclastic differentiation of marrow preosteoclasts and that this regulation occurs via the cAMP-dependent protein kinase pathway...
  19. pmc Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice
    Sean Morony
    Department of Molecular Cellular and Integrative Physiology, University of California, Los Angeles, USA
    Circulation 117:411-20. 2008
    ..However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification...
  20. doi request reprint Vitamin D and osteogenic differentiation in the artery wall
    Jeffrey J Hsu
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1679, USA
    Clin J Am Soc Nephrol 3:1542-7. 2008
    ..These findings raise interesting questions regarding the effects of vitamin D intake on atherosclerotic calcification and cardiovascular risk...
  21. ncbi request reprint High-density lipoprotein regulates calcification of vascular cells
    Farhad Parhami
    Department of Medicine, University of California, Los Angeles 90095, USA
    Circ Res 91:570-6. 2002
    ..Taken together, these results suggest that HDL regulates the osteoblastic differentiation and calcification of vascular cells and that vascular calcification may be another target of HDL action in the artery wall...
  22. ncbi request reprint Regulation of RANKL-induced osteoclastic differentiation by vascular cells
    Yin Tintut
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    J Mol Cell Cardiol 39:389-93. 2005
    ..These results suggest that vascular cells inhibit osteoclastic differentiation, and that CVC have greater inhibitory effects than BASMC...
  23. ncbi request reprint Vascular calcification: mechanisms and clinical ramifications
    Moeen Abedin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1161-70. 2004
    ..Further understanding of processes governing vascular calcification may yield new therapeutic options for vascular disease...
  24. ncbi request reprint Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses
    Tzung K Hsiai
    Department of Biomedical Engineering, Division of Cardiovascular Medicine, USC School of Engineering and School of Medicine, Los Angeles, CA 90089 1451, USA
    Ann Biomed Eng 32:189-201. 2004
    ..6 dyn/cm2 and Reynolds number between 0 and 22.2 in the presence of activated adhesion molecule and chemokine mRNA expression...
  25. ncbi request reprint Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo
    Yin Tintut
    Department of Medicine, The David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:e6-10. 2004
    ..To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice...
  26. ncbi request reprint Multilineage potential of cells from the artery wall
    Yin Tintut
    Department of Medicine, David Geffen School of Medicine, UCLA, 10833 LeConte Ave, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2505-10. 2003
    ..We now show that CVC have the potential to differentiate along other mesenchymal lineages...
  27. ncbi request reprint Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells
    Farhad Parhami
    Department of Medicine, University of California at Los Angeles, 90095, USA
    J Bone Miner Res 17:1997-2003. 2002
    ..Identification of those molecules may provide new therapeutic approaches to prevent the decline in osteoblastic activity in osteoporosis and aging...
  28. pmc Pattern formation by vascular mesenchymal cells
    Alan Garfinkel
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Proc Natl Acad Sci U S A 101:9247-50. 2004
    ..Thus, reaction-diffusion principles may play a significant role in morphogenetic processes in adult mesenchymal cells...
  29. pmc Systems biology of vascular calcification
    Andrew Sage
    Department of Medicine Cardiology, University of California Los Angeles, CA 90095 1679, USA
    Trends Cardiovasc Med 19:118-23. 2009
    ..Such systems-based models are useful in many aspects of cardiovascular medicine...
  30. pmc Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids
    Wendy Tseng
    Department of Physiological Science, University of California, Los Angeles, CA, USA
    J Lipid Res 51:1010-6. 2010
    ..Taken together, the data suggest that oxidized phospholipids induce IL-6 expression in osteoblasts in part via C/EBP...
  31. ncbi request reprint Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification
    Yin Tintut
    Department of Medicine, University of California, Los Angeles, Los Angels, CA, USA
    J Investig Med 54:395-401. 2006
    ....
  32. pmc T0901317, an LXR agonist, augments PKA-induced vascular cell calcification
    Jeffrey J Hsu
    Department of Medicine, David Geffen School of Medicine at UCLA, CHS A2 237, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    FEBS Lett 583:1344-8. 2009
    ..These results suggest that T0901317-augmented mineralization occurs downstream of PKA, involving both direct and indirect LXR-mediated pathways...
  33. pmc Hyperlipidemia impairs osteoanabolic effects of PTH
    Michael S Huang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    J Bone Miner Res 23:1672-9. 2008
    ..These results show that PTH(1-34) has adverse effects on cortical bones of the hyperlipidemic mice, suggesting that the therapeutic effects of PTH may be compromised in the presence of hyperlipidemia...
  34. pmc Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability
    Tetsuya Hoshino
    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90095 1679, USA
    Am J Physiol Heart Circ Physiol 297:H802-10. 2009
    ....
  35. pmc Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts
    Michael S Huang
    Department of Medicine, University of California at Los Angeles, California 90095, USA
    J Biol Chem 282:21237-43. 2007
    ..These results suggest that atherogenic lipids inhibit osteogenic signaling induced by BMP-2 and PTH, raising the possibility that hyperlipidemia and atherogenic phospholipids may interfere with anabolic therapy...
  36. ncbi request reprint Mechanical response of a calcified plaque model to fluid shear force
    Tiantian C Lin
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, 90089, USA
    Ann Biomed Eng 34:1535-41. 2006
    ..This model may represent the first in vitro model of mechanical rupture of atherosclerotic plaque...
  37. ncbi request reprint Murine models of atherosclerotic calcification
    Jeffrey J Hsu
    Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Drug Targets 9:224-8. 2008
    ..The aim is to briefly review current understanding of the molecular basis for atherosclerotic calcification and to discuss some murine models that may be useful in advancing knowledge of its mechanisms...
  38. ncbi request reprint Mineralocorticoid receptor activation promotes vascular cell calcification
    Iris Z Jaffe
    Tufts University School of Medicine, New England Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 80, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:799-805. 2007
    ..This study examines the effects of MR activation by aldosterone on the process of in vitro vascular calcification...
  39. ncbi request reprint Adipose rex: fat and fats that rule differentiation
    Linda L Demer
    Circ Res 90:241-3. 2002
  40. doi request reprint Nanoscale architecture in atherosclerotic calcification
    Linda L Demer
    Arterioscler Thromb Vasc Biol 28:1882-4. 2008
  41. ncbi request reprint Pitting phosphate transport inhibitors against vascular calcification
    Linda L Demer
    Circ Res 98:857-9. 2006
  42. ncbi request reprint Monocyte recruitment to endothelial cells in response to oscillatory shear stress
    Tzung K Hsiai
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, USC School of Engineering and Keck School of Medicine, Los Angeles 90089 1451, USA
    FASEB J 17:1648-57. 2003
    ..Oscillatory flow induces up-regulation of adhesion molecules and cytokines to mediate monocyte/EC interactions over a dynamic range of shear stress +/- 2.6 dyn/cm2 (P=0.50, n=10)...
  43. ncbi request reprint Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt)
    Tzung K Hsiai
    Department of Biomedical Engineering and Cardiovascular Medicine, School of Engineering and Keck School of Medicine, University of Southern California, Los Angeles 90089 1451, USA
    Ann Biomed Eng 30:646-56. 2002
    ..Furthermore, EC remodeling was faster in response to high than to low slew rates at a given tau(ave)...
  44. ncbi request reprint Return to ectopia: stem cells in the artery wall
    Linda L Demer
    Arterioscler Thromb Vasc Biol 25:1307-8. 2005

Research Grants9

  1. RANKL/OPG-Mediated Control of Vascular Calcification
    Linda L Demer; Fiscal Year: 2010
    ..Based on new supportive evidence, this research will test whether specific regulatory factors that promote loss of mineral from bone also promote gain of mineral in the artery wall. ..
  2. Lipid Regulation of Vascular and Bone Osteoclastogenesis
    Linda Demer; Fiscal Year: 2004
    ....