Research Topics
| Linda DemerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanicsTing Hsuan Chen
Department of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
Circ Res 110:551-9. 2012..Thus, to organize LR asymmetry at multiscale levels of morphogenesis, cells with chirality must also be present in adequate numbers. However, observation of LR asymmetry is rarely reported in cultured cells...
Vascular calcification and osteoporosis: inflammatory responses to oxidized lipidsLinda L Demer
Department of Medicine, UCLA School of Medicine, Box 951679, 10833 LeConte Ave, Los Angeles, CA 90095-1679, USA
Int J Epidemiol 31:737-41. 2002- A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells"Linda L Demer
Department of Medicine, Physiology and Biomedical Engineering, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1679, USA
Free Radic Biol Med 44:504-5. 2008 - Mechanisms linking osteoporosis with cardiovascular calcificationLinda L Demer
Department of Medicine, BH 307 Center for Health Sciences, Los Angeles, CA 90095 1679, USA
Curr Osteoporos Rep 7:42-6. 2009..Any or all of these factors and phenomena may contribute to the association... - The bone-vascular axis in chronic kidney diseaseLinda Demer
Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
Curr Opin Nephrol Hypertens 19:349-53. 2010..This review highlights the most recent publications addressing the relationship between bone and vascular calcification in patients with chronic and end-stage kidney disease... - Vascular calcification: pathobiology of a multifaceted diseaseLinda L Demer
Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095-1679, USA
Circulation 117:2938-48. 2008 - The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcificationLinda Demer
Department of Medicine, University of California, Los Angeles, CA, USA
Circ Res 108:1482-93. 2011..These factors may have therapeutic use in osteoclastogenic removal of mineral deposits from arteries... - Novel mechanisms in accelerated vascular calcification in renal disease patientsLinda L Demer
Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
Curr Opin Nephrol Hypertens 11:437-43. 2002..It is a regulated biological process following many of the cellular and molecular programs in osteogenesis. This review summarizes some of the regulatory mechanisms that may explain its severity in renal patients... - Monocyte/macrophage regulation of vascular calcification in vitroYin Tintut
Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
Circulation 105:650-5. 2002..CONCLUSIONS: These results suggest that M/Ms enhance in vitro vascular calcification via 2 independent mechanisms: cell-cell interaction and production of soluble factors such as tumor necrosis factor-alpha... - PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcificationWendy Tseng
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
J Biol Chem 285:29925-31. 2010..These findings suggest that, as in skeletal tissues, PKA activation induces bone resorptive factors in the vasculature and that aortic SMC calcification specifically induced by PKA, is not mediated by RANKL... - Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathwaysKristen Radcliff
Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
Circ Res 96:398-400. 2005..These results suggest that IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of vascular cells via both ERK and PI3K pathways... - Mesenchymal stem cells and the artery wallMoeen Abedin
Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, CA 90095-1679, USA
Circ Res 95:671-6. 2004..A greater understanding of how mesenchymal stem cells from the bone marrow or artery wall bring about vascular regeneration and repair may lead to novel cell-based treatments for cardiovascular disease... - Adverse effects of hyperlipidemia on bone regeneration and strengthFlavia Pirih
Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA
J Bone Miner Res 27:309-18. 2012..7-fold greater in Ldlr(-/-) mice. These findings suggest that hyperlipidemia induces secondary hyperparathyroidism and impairs bone regeneration and mechanical strength... - Phosphate and pyrophosphate mediate PKA-induced vascular cell calcificationMichael S Huang
Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Center for the Health Sciences BH 307, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
Biochem Biophys Res Commun 374:553-8. 2008..These results suggest that phosphate is necessary for PKA-induced calcification of vascular cells and that the extent of PKA-induced calcification is controlled by feedback induction of the inhibitor, pyrophosphate... - Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lectureLinda L Demer
Department of Medicine, The David Geffen School of Medicine at University of California Los Angeles, 90095-1679, USA
Arterioscler Thromb Vasc Biol 23:1739-43. 2003..The review closes with a mention of therapeutic possibilities and an evolutionary paradigm to explain the reciprocal responses of vascular and bone mineralization to inflammation... - Vascular calcification and its relation to bone calcification: possible underlying mechanismsNilam Mody
Departments of Medicine and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif. 90095-1679, USA
J Nucl Cardiol 10:177-83. 2003 - Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone lossLucia S Graham
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
Clin Immunol 133:265-75. 2009..These findings may help elucidate clinical associations between cardiovascular disease and decreased bone mass, and may also lead to new immune-based approaches to osteoporosis... - 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathwayYin Tintut
Department of Medicine, School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 277:14221-6. 2002..These data suggest that isoPGE2 enhances osteoclastic differentiation of marrow preosteoclasts and that this regulation occurs via the cAMP-dependent protein kinase pathway... - Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) miceSean Morony
Department of Molecular Cellular and Integrative Physiology, University of California, Los Angeles, USA
Circulation 117:411-20. 2008..However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification... 
Vitamin D and osteogenic differentiation in the artery wallJeffrey J Hsu
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1679, USA
Clin J Am Soc Nephrol 3:1542-7. 2008..These findings raise interesting questions regarding the effects of vitamin D intake on atherosclerotic calcification and cardiovascular risk...- High-density lipoprotein regulates calcification of vascular cellsFarhad Parhami
Department of Medicine, University of California, Los Angeles 90095, USA
Circ Res 91:570-6. 2002..Taken together, these results suggest that HDL regulates the osteoblastic differentiation and calcification of vascular cells and that vascular calcification may be another target of HDL action in the artery wall... - Regulation of RANKL-induced osteoclastic differentiation by vascular cellsYin Tintut
Department of Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
J Mol Cell Cardiol 39:389-93. 2005..These results suggest that vascular cells inhibit osteoclastic differentiation, and that CVC have greater inhibitory effects than BASMC... - Vascular calcification: mechanisms and clinical ramificationsMoeen Abedin
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095-1679, USA
Arterioscler Thromb Vasc Biol 24:1161-70. 2004..Further understanding of processes governing vascular calcification may yield new therapeutic options for vascular disease... - Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responsesTzung K Hsiai
Department of Biomedical Engineering, Division of Cardiovascular Medicine, USC School of Engineering and School of Medicine, Los Angeles, CA 90089 1451, USA
Ann Biomed Eng 32:189-201. 2004..6 dyn/cm2 and Reynolds number between 0 and 22.2 in the presence of activated adhesion molecule and chemokine mRNA expression... - Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivoYin Tintut
Department of Medicine, The David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
Arterioscler Thromb Vasc Biol 24:e6-10. 2004..To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice... - Multilineage potential of cells from the artery wallYin Tintut
Department of Medicine, David Geffen School of Medicine, UCLA, 10833 LeConte Ave, Los Angeles, Calif 90095 1679, USA
Circulation 108:2505-10. 2003..We now show that CVC have the potential to differentiate along other mesenchymal lineages... - Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cellsFarhad Parhami
Department of Medicine, University of California at Los Angeles, 90095, USA
J Bone Miner Res 17:1997-2003. 2002..Identification of those molecules may provide new therapeutic approaches to prevent the decline in osteoblastic activity in osteoporosis and aging... - Pattern formation by vascular mesenchymal cellsAlan Garfinkel
Department of Medicine, University of California, Los Angeles, 90095, USA
Proc Natl Acad Sci U S A 101:9247-50. 2004..Thus, reaction-diffusion principles may play a significant role in morphogenetic processes in adult mesenchymal cells... - Systems biology of vascular calcificationAndrew Sage
Department of Medicine Cardiology, University of California Los Angeles, CA 90095 1679, USA
Trends Cardiovasc Med 19:118-23. 2009..Such systems-based models are useful in many aspects of cardiovascular medicine... - Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipidsWendy Tseng
Department of Physiological Science, University of California, Los Angeles, CA, USA
J Lipid Res 51:1010-6. 2010..Taken together, the data suggest that oxidized phospholipids induce IL-6 expression in osteoblasts in part via C/EBP... - Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcificationYin Tintut
Department of Medicine, University of California, Los Angeles, Los Angels, CA, USA
J Investig Med 54:395-401. 2006.... - T0901317, an LXR agonist, augments PKA-induced vascular cell calcificationJeffrey J Hsu
Department of Medicine, David Geffen School of Medicine at UCLA, CHS A2 237, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
FEBS Lett 583:1344-8. 2009..These results suggest that T0901317-augmented mineralization occurs downstream of PKA, involving both direct and indirect LXR-mediated pathways... - Hyperlipidemia impairs osteoanabolic effects of PTHMichael S Huang
Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
J Bone Miner Res 23:1672-9. 2008..These results show that PTH(1-34) has adverse effects on cortical bones of the hyperlipidemic mice, suggesting that the therapeutic effects of PTH may be compromised in the presence of hyperlipidemia... - Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerabilityTetsuya Hoshino
Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90095 1679, USA
Am J Physiol Heart Circ Physiol 297:H802-10. 2009.... - Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblastsMichael S Huang
Department of Medicine, University of California at Los Angeles, California 90095, USA
J Biol Chem 282:21237-43. 2007..These results suggest that atherogenic lipids inhibit osteogenic signaling induced by BMP-2 and PTH, raising the possibility that hyperlipidemia and atherogenic phospholipids may interfere with anabolic therapy... - Mechanical response of a calcified plaque model to fluid shear forceTiantian C Lin
Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, 90089, USA
Ann Biomed Eng 34:1535-41. 2006..This model may represent the first in vitro model of mechanical rupture of atherosclerotic plaque... - Murine models of atherosclerotic calcificationJeffrey J Hsu
Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Curr Drug Targets 9:224-8. 2008..The aim is to briefly review current understanding of the molecular basis for atherosclerotic calcification and to discuss some murine models that may be useful in advancing knowledge of its mechanisms... - Mineralocorticoid receptor activation promotes vascular cell calcificationIris Z Jaffe
Tufts University School of Medicine, New England Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 80, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 27:799-805. 2007..This study examines the effects of MR activation by aldosterone on the process of in vitro vascular calcification... - Adipose rex: fat and fats that rule differentiationLinda L Demer
Circ Res 90:241-3. 2002 - Nanoscale architecture in atherosclerotic calcificationLinda L Demer
Arterioscler Thromb Vasc Biol 28:1882-4. 2008 - Pitting phosphate transport inhibitors against vascular calcificationLinda L Demer
Circ Res 98:857-9. 2006 - Monocyte recruitment to endothelial cells in response to oscillatory shear stressTzung K Hsiai
Department of Biomedical Engineering and Division of Cardiovascular Medicine, USC School of Engineering and Keck School of Medicine, Los Angeles 90089 1451, USA
FASEB J 17:1648-57. 2003..Oscillatory flow induces up-regulation of adhesion molecules and cytokines to mediate monocyte/EC interactions over a dynamic range of shear stress +/- 2.6 dyn/cm2 (P=0.50, n=10)... - Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt)Tzung K Hsiai
Department of Biomedical Engineering and Cardiovascular Medicine, School of Engineering and Keck School of Medicine, University of Southern California, Los Angeles 90089 1451, USA
Ann Biomed Eng 30:646-56. 2002..Furthermore, EC remodeling was faster in response to high than to low slew rates at a given tau(ave)... - Return to ectopia: stem cells in the artery wallLinda L Demer
Arterioscler Thromb Vasc Biol 25:1307-8. 2005
Research Grants
- RANKL/OPG-Mediated Control of Vascular CalcificationLinda L Demer; Fiscal Year: 2010..Based on new supportive evidence, this research will test whether specific regulatory factors that promote loss of mineral from bone also promote gain of mineral in the artery wall. ..
- Lipid Regulation of Vascular and Bone OsteoclastogenesisLinda Demer; Fiscal Year: 2004....