Joseph L Demer

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Magnetic resonance imaging of differential compartmental function of horizontal rectus extraocular muscles during conjugate and converged ocular adduction
    Joseph L Demer
    Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, California and Department of Neurology, David Geffen Medical School, University of California, Los Angeles, California
    J Neurophysiol 112:845-55. 2014
  2. pmc Creep behavior of passive bovine extraocular muscle
    Lawrence Yoo
    Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, UCLA, Los Angeles, CA 90095 7002, USA
    J Biomed Biotechnol 2011:526705. 2011
  3. pmc Determination of poisson ratio of bovine extraocular muscle by computed X-ray tomography
    Hansang Kim
    Department of Mechanical and Automotive Engineering, Gachon University, Seongnam si, Gyeonggi do 461 701, Republic of Korea
    Biomed Res Int 2013:197479. 2013
  4. ncbi request reprint Magnetic resonance imaging of human extraocular muscles during static ocular counter-rolling
    Joseph L Demer
    Department of Ophthalmology, UCLA, Los Angeles, CA 90095 7002, USA
    J Neurophysiol 94:3292-302. 2005
  5. pmc Magnetic resonance imaging of innervational and extraocular muscle abnormalities in Duane-radial ray syndrome
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:5505-11. 2007
  6. pmc Functional anatomy of the extraocular muscles during vergence
    Joseph L Demer
    Jules Stein Eye Institute, David Geffen Medical School at University of California, Los Angeles, CA, USA
    Prog Brain Res 171:21-8. 2008
  7. ncbi request reprint Ocular kinematics, vergence, and orbital mechanics
    Joseph L Demer
    Departments of Ophthalmology and Neurology, and the Jules Stein Eye Institute, University of California, Los Angeles, CA 900095 7002, USA
    Strabismus 11:49-57. 2003
  8. ncbi request reprint Magnetic resonance imaging of human extraocular muscles in convergence
    Joseph L Demer
    Departments of Ophthalmology and Neurology, University of California, Los Angeles, California 90095 7002, USA
    J Neurophysiol 89:2072-85. 2003
  9. pmc Effects of intracranial trochlear neurectomy on the structure of the primate superior oblique muscle
    Joseph L Demer
    Departments of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 51:3485-93. 2010
  10. ncbi request reprint Pivotal role of orbital connective tissues in binocular alignment and strabismus: the Friedenwald lecture
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Invest Ophthalmol Vis Sci 45:729-38; 728. 2004

Research Grants

  1. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2009
  2. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2007
  3. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2006
  4. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2005
  5. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2004
  6. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2003
  7. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2002
  8. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2001
  9. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2000
  10. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 1993

Detail Information

Publications105 found, 100 shown here

  1. pmc Magnetic resonance imaging of differential compartmental function of horizontal rectus extraocular muscles during conjugate and converged ocular adduction
    Joseph L Demer
    Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, California and Department of Neurology, David Geffen Medical School, University of California, Los Angeles, California
    J Neurophysiol 112:845-55. 2014
    ..These findings suggest that the superior MR compartment is controlled differentially from the inferior compartment and suggest that its activity is reduced during convergence as a component of generally altered extraocular mechanics. ..
  2. pmc Creep behavior of passive bovine extraocular muscle
    Lawrence Yoo
    Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, UCLA, Los Angeles, CA 90095 7002, USA
    J Biomed Biotechnol 2011:526705. 2011
    ..7% following 16.67%/s ramp loading. Measured creep agrees closely with a derived QLV model of EOM relaxation, validating a previous QLV model for characterization of EOM biomechanics...
  3. pmc Determination of poisson ratio of bovine extraocular muscle by computed X-ray tomography
    Hansang Kim
    Department of Mechanical and Automotive Engineering, Gachon University, Seongnam si, Gyeonggi do 461 701, Republic of Korea
    Biomed Res Int 2013:197479. 2013
    ..The mean PR from discretized 3D models for every microscopic element in 14 EOM specimens averaged 0.457 ± 0.004 (SD). The measured PR of bovine EOM is thus near the limit of incompressibility...
  4. ncbi request reprint Magnetic resonance imaging of human extraocular muscles during static ocular counter-rolling
    Joseph L Demer
    Department of Ophthalmology, UCLA, Los Angeles, CA 90095 7002, USA
    J Neurophysiol 94:3292-302. 2005
    ..The amount of pulley reconfiguration is roughly one-half of published values of ocular torsion during static OCR, an arrangement that would cause rectus pulling directions to change by less than one-half the amount of ocular torsion...
  5. pmc Magnetic resonance imaging of innervational and extraocular muscle abnormalities in Duane-radial ray syndrome
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:5505-11. 2007
    ..The authors used magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ray (Okihiro) syndrome (DRRS) caused by mutations in the transcription factor SALL4...
  6. pmc Functional anatomy of the extraocular muscles during vergence
    Joseph L Demer
    Jules Stein Eye Institute, David Geffen Medical School at University of California, Los Angeles, CA, USA
    Prog Brain Res 171:21-8. 2008
    ..Thus, extraretinal information about eye position would appear necessary to interpret binocular correspondence, and to avoid diplopia...
  7. ncbi request reprint Ocular kinematics, vergence, and orbital mechanics
    Joseph L Demer
    Departments of Ophthalmology and Neurology, and the Jules Stein Eye Institute, University of California, Los Angeles, CA 900095 7002, USA
    Strabismus 11:49-57. 2003
    ..During convergence and during the static torsional vestibulo-ocular reflex, MRI shows that the rectus pulley array rotates around the line of sight. Oblique EOM orbital layers may implement this shift...
  8. ncbi request reprint Magnetic resonance imaging of human extraocular muscles in convergence
    Joseph L Demer
    Departments of Ophthalmology and Neurology, University of California, Los Angeles, California 90095 7002, USA
    J Neurophysiol 89:2072-85. 2003
    ..Absence of globe translation in convergence argues against overall EOM co-contraction. The reconfiguration of EOM geometry in convergence has important implications for single-unit studies of neural control...
  9. pmc Effects of intracranial trochlear neurectomy on the structure of the primate superior oblique muscle
    Joseph L Demer
    Departments of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 51:3485-93. 2010
    ..Occasional GL fiber hypertrophy suggests that at least some SO fibers extend essentially the full muscle length after trochlear neurectomy...
  10. ncbi request reprint Pivotal role of orbital connective tissues in binocular alignment and strabismus: the Friedenwald lecture
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Invest Ophthalmol Vis Sci 45:729-38; 728. 2004
  11. pmc Mechanics of the orbita
    Joseph L Demer
    Jules Stein Eye Institute, Departments of Ophthalmology and Neurology, Neuroscience Bioengineering Interdepartmental Programs, David Geffen Medical School at the University of California, Los Angeles, CA 90095 7002, USA
    Dev Ophthalmol 40:132-57. 2007
    ..This mechanical determination may imply limited possibilities for neural adaptation to some ocular motor pathologies, but indicates greater potential for surgical treatments...
  12. pmc Magnetic resonance imaging evidence for widespread orbital dysinnervation in dominant Duane's retraction syndrome linked to the DURS2 locus
    Joseph L Demer
    Department of Ophthalmology, UCLA, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:194-202. 2007
    ..High-resolution, multipositional magnetic resonance imaging (MRI) was used to demonstrate extraocular muscles (EOMs) and associated motor nerves in Duane retraction syndrome (DRS) linked to the DURS2 locus on chromosome 2...
  13. pmc Gillies Lecture: ocular motility in a time of paradigm shift
    Joseph L Demer
    Department of Ophthalmology and Neurology, Interdepartmental Program, University of California, Los Angeles, California, USA
    Clin Experiment Ophthalmol 34:822-6. 2006
    ..This perspective memorializes a lecture given in honour of Dr William Gillies, who has for decades been the paternal leader of strabismology in southern Australia...
  14. pmc High-resolution magnetic resonance imaging demonstrates abnormalities of motor nerves and extraocular muscles in patients with neuropathic strabismus
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Dye Institute, University of California, Los Angeles, California 90095 7002, and Department of Medicine, Children s Hospital Boston, MA, USA
    J AAPOS 10:135-42. 2006
    ....
  15. pmc Current concepts of mechanical and neural factors in ocular motility
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, California 90095 7002, USA
    Curr Opin Neurol 19:4-13. 2006
    ..This review considers current concepts regarding aspects of ocular motility that are mechanically determined versus those that are specified explicitly as innervation...
  16. ncbi request reprint Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 46:530-9. 2005
    ....
  17. ncbi request reprint Human angular vestibulo-ocular reflex axis disconjugacy: relationship to magnetic resonance imaging evidence of globe translation
    Joseph L Demer
    Department of Opthalmology Surgery, Jules Stein Eye Institute, University of California, CA 90095 7002, USA
    Ann N Y Acad Sci 1039:15-25. 2005
    ..Confirmation of predicted duction-dependent VOR disconjugacy supports the idea that rectus pulleys influence kinematics for all eye movements...
  18. ncbi request reprint A 12-year, prospective study of extraocular muscle imaging in complex strabismus
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles 90095, USA
    J AAPOS 6:337-47. 2002
    ..Clinical imaging of the extraocular muscles (EOMs) can now provide insight into some causes of strabismus, in some cases challenging traditional concepts of etiology and suggesting alternative treatments...
  19. pmc Evidence of an asymmetrical endophenotype in congenital fibrosis of extraocular muscles type 3 resulting from TUBB3 mutations
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 51:4600-11. 2010
    ....
  20. pmc T2-weighted fast spin-echo magnetic resonance imaging of extraocular muscles
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 7002, USA
    J AAPOS 15:17-23. 2011
    ..However, time-consuming T1 sequences are subject to motion artifacts. We evaluated an alternative T2-weighted fast spin-echo pulse sequence that emphasizes tissue-free fluid...
  21. ncbi request reprint Ocular compensation due to labyrinthine input during natural motion
    J L Demera
    Department of Ophthalmology, University of California, Los Angeles, USA
    Ann N Y Acad Sci 942:148-61. 2001
    ..Limitation of head motion during natural activities is a common strategy in those with reduced peripheral vestibular sensitivity...
  22. ncbi request reprint New tests of vestibular function
    J L Demer
    Department of Ophthalmology, University of California, Los Angeles 90095, USA
    Ann N Y Acad Sci 942:428-45. 2001
    ..The otolith VOR is bilaterally attenuated in bilateral vestibulopathy, and loses target distance dependence in cerebellar degeneration...
  23. ncbi request reprint Evidence for active control of rectus extraocular muscle pulleys
    J L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles 90095 7002, USA
    Invest Ophthalmol Vis Sci 41:1280-90. 2000
    ..This study was conducted to investigate the relationship of orbital and global EOM layers to pulleys and kinematic implications of this anatomy...
  24. ncbi request reprint The orbital pulley system: a revolution in concepts of orbital anatomy
    Joseph L Demer
    Department of Ophthalmology, and the Jules Stein Eye Institute, University of California, Los Angeles 90095 7002, USA
    Ann N Y Acad Sci 956:17-32. 2002
    ..Surgical interventions improve defective pulley function. Understanding of ocular motor control requires characterization of the behavior of the EOM pulleys as well as knowledge of angular eye orientation...
  25. pmc Expanding repertoire in the oculomotor periphery: selective compartmental function in rectus extraocular muscles
    Joseph L Demer
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California 90095 7002, USA
    Ann N Y Acad Sci 1233:8-16. 2011
    ..Computational simulation suggests that differential compartmental action in horizontal rectus EOMs could achieve more force than required by vertical fusional vergence...
  26. pmc Functional imaging of human extraocular muscles in head tilt dependent hypertropia
    Joseph L Demer
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:3023-31. 2011
    ..In this study, magnetic resonance imaging (MRI) was used to study extraocular muscle (EOM) responses to head tilt in HTDHT...
  27. ncbi request reprint Evidence for a pulley of the inferior oblique muscle
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 44:3856-65. 2003
    ..This study was undertaken to investigate evidence for a connective tissue pulley constraining the path of the inferior oblique (IO) muscle...
  28. pmc Characterization of ocular tissues using microindentation and hertzian viscoelastic models
    Lawrence Yoo
    Department of Ophthalmology, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:3475-82. 2011
    ....
  29. pmc Three dimensional kinematics of rapid compensatory eye movements in humans with unilateral vestibular deafferentation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 182:143-55. 2007
    ..ADs have kinematics that neither conform to LL nor match the VOR axis, but appear instead programmed in 3D to correct VOR axis errors...
  30. pmc Function of transected or avulsed rectus muscles following recovery using an anterior orbitotomy approach
    Stacy L Pineles
    Jules Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, California, USA
    J AAPOS 16:336-41. 2012
    ..To assess the function of muscles retrieved from a retrobulbar location using an anterior orbitotomy approach and to identify the prognostic factors favoring a good outcome...
  31. pmc Sagging eye syndrome: connective tissue involution as a cause of horizontal and vertical strabismus in older patients
    Zia Chaudhuri
    Jules Stein Eye Institute, UCLA University of California, Los Angeles, Los Angeles, CA 90095, USA
    JAMA Ophthalmol 131:619-25. 2013
    ..Recognition of sagging eye syndrome (SES) as the cause of chronic or acute acquired diplopia may avert neurologic evaluation and imaging in most cases...
  32. pmc Expansion of the CHN1 strabismus phenotype
    Noriko Miyake
    Departments of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 52:6321-8. 2011
    ..This was a study of five family members with distinctive ocular dysmotility patterns that co-segregated with a novel hyperactivating CHN1 mutation...
  33. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  34. ncbi request reprint Shifts in listing's plane produced by vertical axis rotation: sustained ocular torsion due to semicircular canal stimulation
    Benjamin T Crane
    Department of Surgery, Division of Otolaryngology, University of California, Los Angeles, California 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:2076-83. 2007
    ..The present study was conducted to determine whether whole-body yaw alters the position and orientation of LP...
  35. pmc Does inferior oblique recession cause overcorrections in laterally incomitant small hypertropias due to superior oblique palsy?
    Karen Hendler
    Department of Surgery, Division of Pediatric Ophthalmology, Olive View UCLA Medical Center, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Br J Ophthalmol 97:88-91. 2013
    ..To evaluate the effects of inferior oblique muscle recession (IOR) in cases of laterally incomitant hypertropia <10 prism dioptres (PD) in central gaze thact 2t are clinically consistent with superior oblique palsy (SOP)...
  36. pmc Independent passive mechanical behavior of bovine extraocular muscle compartments
    Andrew Shin
    Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, California 90095 7002, USA
    Invest Ophthalmol Vis Sci 53:8414-23. 2012
    ..We sought evidence of potential independent action by examining passive mechanical coupling between EOM compartments...
  37. pmc Intramuscular innervation of primate extraocular muscles: unique compartmentalization in horizontal recti
    Roberta Martins da Silva Costa
    Department of Ophthalmology, University ofCalifornia, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:2830-6. 2011
    ..To explore the anatomic potential of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possible regional selectivity in intramuscular innervation of all rectus EOMs...
  38. pmc Horizontal rectus muscle anatomy in naturally and artificially strabismic monkeys
    Anita Narasimhan
    Department of Ophthalmology, University of California, Los Angeles, CA, USA
    Invest Ophthalmol Vis Sci 48:2576-88. 2007
    ..This experiment was conducted to investigate whether such abnormalities are associated with artificial or naturally occurring strabismus in monkeys...
  39. pmc Compartmentalized innervation of primate lateral rectus muscle
    Michelle Peng
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 51:4612-7. 2010
    ..Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalization...
  40. pmc Kinematics of vertical saccades during the yaw vestibulo-ocular reflex in humans
    Benjamin T Crane
    Department of Surgery Division of Otolaryngology, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 46:2800-9. 2005
    ..This study was undertaken to investigate vertical saccade behavior after the yaw vestibulo-ocular reflex (VOR) had driven eye torsion out of LP, an initial condition causing the position and velocity domain formulations of LL to differ...
  41. ncbi request reprint Unilateral deafferentation and eye position misdirect the initial vestibulo-ocular reflex: a model-based study
    Benjamin T Crane
    Department of Surgery Division of Otolaryngology Head and Neck Surgery, University of California, Los Angeles 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:5512-22. 2007
    ..Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined...
  42. ncbi request reprint Superior oblique muscle involvement in thyroid ophthalmopathy
    Neepa M Thacker
    Jules Stein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    J AAPOS 9:174-8. 2005
    ..This study reports involvement of the superior oblique muscle as a contributory cause of restrictive strabismus in patients with thyroid ophthalmopathy...
  43. ncbi request reprint Surgical outcomes following rectus muscle plication: a potentially reversible, vessel-sparing alternative to resection
    Zia Chaudhuri
    SteinEye Institute, University of California, Los Angeles2Department of Ophthalmology, University of California, Los Angeles
    JAMA Ophthalmol 132:579-85. 2014
    ..Extraocular muscle strengthening is a common treatment for strabismus. Plication is an alternative procedure for strengthening muscles with less tissue trauma than resection...
  44. ncbi request reprint Effect of aging on the human initial interaural linear vestibulo-ocular reflex
    Jun Ru Tian
    Jules Stein Eye Institute, 100 Stein Plaza, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 145:142-9. 2002
    ..The effect of aging on the initial human LVOR is thus to: prolong latency, reduce early sensitivity, and reduce occurrence of vestibular catch-up saccades...
  45. pmc Nonclassical innervation patterns in mammalian extraocular muscles
    Roberta M da Silva Costa
    Department of Ophthalmology, University of California Los Angeles, Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095 7002, USA
    Curr Eye Res 37:761-9. 2012
    ..Motor nn are classically described as entering the EOMs in their middle thirds. We investigated EOM innervation that does not follow the classic pattern...
  46. ncbi request reprint Magnetic resonance imaging of the functional anatomy of the inferior oblique muscle in superior oblique palsy
    Reika Kono
    Department of Ophthalmology, University of California, Los Angeles, USA
    Ophthalmology 110:1219-29. 2003
    ..To study size and contractility of the normal inferior oblique (IO) muscle using high-resolution magnetic resonance imaging (MRI) and to evaluate abnormalities of the superior oblique (SO) and IO muscles in chronic SO palsy...
  47. pmc Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance
    Max A Tischfield
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 140:74-87. 2010
    ..These findings demonstrate that normal TUBB3 is required for axon guidance and maintenance in mammals...
  48. ncbi request reprint Incomitant strabismus associated with instability of rectus pulleys
    Sei Yeul Oh
    Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 43:2169-78. 2002
    ..Connective tissue pulleys serve as functional mechanical origins of the extraocular muscles (EOMs) and are normally stable relative to the orbit during gaze shifts. This study evaluated pulley stability in incomitant strabismus...
  49. pmc Orbital magnetic resonance imaging of extraocular muscles in chronic progressive external ophthalmoplegia: specific diagnostic findings
    Maria Carolina Ortube
    Jules Stein Eye Institute, Los Angeles, California 90095 7002, USA
    J AAPOS 10:414-8. 2006
    ..Molecular diagnosis is problematic because sporadic mitochondrial DNA deletions can be causative. We sought findings using magnetic resonance imaging (MRI) that might support the diagnosis of CPEO...
  50. pmc Fascicular specialization in human and monkey rectus muscles: evidence for anatomic independence of global and orbital layers
    Key Hwan Lim
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:3089-97. 2007
    ..The authors investigated insertions and anatomic relationships of fiber fascicles within rectus EOMs to clarify the relationship to their pulleys...
  51. ncbi request reprint Medial rectus pulley posterior fixation: a novel technique to augment recession
    Robert A Clark
    Jules Stein Eye Institute, Los Angeles, CA, USA
    J AAPOS 8:451-6. 2004
    ..This study examines the effectiveness of MR pulley posterior fixation for other variants of ET...
  52. pmc Temporal dynamics of ocular position dependence of the initial human vestibulo-ocular reflex
    Benjamin T Crane
    Department of Surgery Division of Otolaryngology, University of California, Los Angeles 90095 7002, USA
    Invest Ophthalmol Vis Sci 47:1426-38. 2006
    ..The present study was conducted to explore the recent proposal that the VOR's rotational axis is not collinear with the head's, but rather follows a time-dependent strategy intermediate between LL and an ideal VOR...
  53. ncbi request reprint Superior oblique muscle layers in monkeys and humans
    Reika Kono
    Ophthalmology Interdepartmental Program, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 46:2790-9. 2005
    ..This study was performed to clarify the anatomic relationships of the corresponding layers of the superior oblique (SO) muscle...
  54. pmc Vestibulo-ocular reflex to transient surge translation: complex geometric response ablated by normal aging
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    J Neurophysiol 95:2042-54. 2006
    ..The LVOR and V-LVOR were augmented by saccades in younger more than older subjects. Aging thus decreases LVOR velocity gain, response rate, and saccade augmentation, but prolongs latency...
  55. pmc Magnetic resonance imaging of the effects of horizontal rectus extraocular muscle surgery on pulley and globe positions and stability
    Robert A Clark
    Department of Ophthalmology, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 47:188-94. 2006
    ..Magnetic resonance imaging (MRI) was used to determine the effect of recessions and resections on horizontal extraocular muscle (EOM) paths and globe position...
  56. pmc Rectus muscle plication using an adjustable suture technique
    Federico G Velez
    Jules Stein Eye Institute, and Department of Ophthalmology, University of California, Los Angeles, California
    J AAPOS 17:480-3. 2013
    ..Rectus muscle plication is an alternative muscle-strengthening procedure to rectus muscle resection. Possible advantages of rectus muscle plication include a lower risk of "lost" muscles and anterior segment ischemia...
  57. pmc Lateral rectus superior compartment palsy
    Robert A Clark
    Department of Ophthalmology, University of California, Los Angeles, California David Geffen Medical School, University of California, Los Angeles, California
    Am J Ophthalmol 157:479-487.e2. 2014
    ..To employ magnetic resonance imaging (MRI) to seek evidence of compartmental lateral rectus atrophy consistent with a lesion involving selective denervation of only 1 of the 2 neuromuscular compartments of the lateral rectus...
  58. pmc Postoperative drift in patients with thyroid ophthalmopathy undergoing unilateral inferior rectus muscle recession
    Jason H Peragallo
    Jules Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, California, USA
    Strabismus 21:23-8. 2013
    ..This study reports postoperative alignment changes in patients with TO compared with patients with non-restrictive strabismus following unilateral inferior rectus muscle recession (IRR)...
  59. pmc Temporal dynamics of semicircular canal and otolith function following acute unilateral vestibular deafferentation in humans
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 178:529-41. 2007
    ..Most recovery of the human canal gain to high acceleration transients following UVD is for contralesional head rotation, occurring within 3 months as spontaneous nystagmus resolves...
  60. pmc Viscoelastic properties of bovine orbital connective tissue and fat: constitutive models
    Lawrence Yoo
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, 100 Stein Plaza, UCLA, Los Angeles, CA 90095 7002, USA
    Biomech Model Mechanobiol 10:901-14. 2011
    ..These viscoelastic models will facilitate realistic global modeling of EOM behavior in binocular alignment and strabismus...
  61. ncbi request reprint Initiation of the human heave linear vestibulo-ocular reflex
    Benjamin T Crane
    Department of Otolaryngology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 148:247-55. 2003
    ..The relatively longer latency of the human LVOR than angular VOR may be tailored to match human head movement dynamics...
  62. pmc Posterior inflection of weakened lateral rectus path: connective tissue factors reduce response to lateral rectus recession
    Robert A Clark
    Department of Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, California, USA
    Am J Ophthalmol 147:127-133.e2. 2009
    ..To determine why lateral rectus (LR) muscle recession has a variable effect on binocular alignment using magnetic resonance imaging (MRI)...
  63. pmc Mechanical interferometry imaging for creep modeling of the cornea
    Lawrence Yoo
    Department of Ophthalmology, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:8420-4. 2011
    ..A novel nanoindentation technique was used to biomechanically characterize each of three main layers of the cornea by using Hertzian viscoelastic formulation of creep, the deformation resulting from sustained-force application...
  64. pmc Magnetic resonance imaging of the functional anatomy of the inferior rectus muscle in superior oblique muscle palsy
    Li Jiang
    Department of Ophthalmology, David Geffen Medical School, University of California, Los Angeles, Los Angeles, California, USA
    Ophthalmology 115:2079-86. 2008
    ..Magnetic resonance imaging (MRI) was used to investigate if any size or contractility changes in the inferior rectus (IR) muscle may contribute...
  65. pmc Magnetic resonance imaging of the endophenotype of a novel familial Möbius-like syndrome
    Sean Dumars
    Jules Stein Eye Institute Department of Ophthalmology, Los Angeles, California, USA
    J AAPOS 12:381-9. 2008
    ..We used high-resolution magnetic resonance imaging (MRI) and genetic analysis to examine a family with features of Möbius syndrome...
  66. pmc Enhanced vertical rectus contractility by magnetic resonance imaging in superior oblique palsy
    Robert A Clark
    Pediatric Ophthalmology and Strabismus Division, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095 7002, USA
    Arch Ophthalmol 129:904-8. 2011
    ....
  67. ncbi request reprint Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)
    Koki Yamada
    Department of Medicine Genetics, Enders 5, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 35:318-21. 2003
    ..We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis...
  68. ncbi request reprint Human surge linear vestibulo-ocular reflex during tertiary gaze viewing
    Jun Ru Tian
    Department of Opthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Ann N Y Acad Sci 1039:489-93. 2005
    ..For visible targets, vertical component gain significantly increased to 0.63 +/- 0.04 (P < 0.05) with visible targets, but remained significantly less than horizontal component gain...
  69. ncbi request reprint Human angular vestibulo-ocular reflex initiation: relationship to Listing's law
    Benjamin T Crane
    Department of Surgery, University of California, Los Angeles, CA 90032, USA
    Ann N Y Acad Sci 1039:26-35. 2005
    ....
  70. ncbi request reprint Extraocular muscle damage associated with endoscopic sinus surgery: an ophthalmology perspective
    Neepa M Thacker
    Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at University of California Los Angeles, 90095 7002, USA
    Am J Rhinol 19:400-5. 2005
    ..The aim of this study was to characterize the types of extraocular muscle injury and the number of muscles involved that may complicate endoscopic sinus surgery and correlate its occurrence to factors in the surgical procedure itself...
  71. pmc High-resolution magnetic resonance imaging of the extraocular muscles and nerves demonstrates various etiologies of third nerve palsy
    Hui Chuan Kau
    Jules Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, California 90095, USA
    Am J Ophthalmol 143:280-287. 2007
    ..We used high-resolution magnetic resonance imaging (hrMRI) of the oculomotor nerve and affected extraocular muscles (EOMs) to investigate oculomotor palsy...
  72. ncbi request reprint Initiation and cancellation of the human heave linear vestibulo-ocular reflex after unilateral vestibular deafferentation
    Benjamin T Crane
    Department of Surgery Division of Otolaryngology, University of California, Los Angeles, CA, USA
    Exp Brain Res 161:519-26. 2005
    ..It is concluded that after UVD, the LVOR is bilaterally and symmetrically reduced but remains modulated by viewing distance and cancellation effort...
  73. ncbi request reprint Orbital imaging demonstrates occult blow out fracture in complex strabismus
    Maria Carolina Ortube
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA
    J AAPOS 8:264-73. 2004
    ..While strabismologists are familiar with diagnostic evaluation of suspected blow out fractures, unsuspected blow out fractures may further complicate difficult cases of strabismus not clinically supposed to be related to orbital trauma...
  74. ncbi request reprint Demonstration of systematic variation in human intraorbital optic nerve size by quantitative magnetic resonance imaging and histology
    Shaheen Karim
    Department of Ophthalmology, David Geffen Medical School at the University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 45:1047-51. 2004
    ..To use magnetic resonance imaging (MRI) to measure the diameter along the course of the intraorbital optic nerve in living subjects and cadaveric specimens, and to validate measurements histologically in the same specimens...
  75. pmc Abnormalities of the oculomotor nerve in congenital fibrosis of the extraocular muscles and congenital oculomotor palsy
    Key Hwan Lim
    Jules Stein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Invest Ophthalmol Vis Sci 48:1601-6. 2007
    ..A quantitative MRI technique was developed to study the oculomotor nerve (CN3) and applied to congenital fibrosis of extraocular muscles (CFEOM) and congenital oculomotor palsy...
  76. ncbi request reprint Dynamic visual acuity during transient and sinusoidal yaw rotation in normal and unilaterally vestibulopathic humans
    J R Tian
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 137:12-25. 2001
    ..DVA can reliably detect unilateral deafferentation only if precautions are taken to prevent compensation by predictive slow eye movements and saccades...
  77. ncbi request reprint Vestibular catch-up saccades in labyrinthine deficiency
    J Tian
    Department of Ophthalmology, University of California, Los Angeles 90095 7002, USA
    Exp Brain Res 131:448-57. 2000
    ....
  78. ncbi request reprint Quantitative analysis of rectus extraocular muscle layers in monkey and humans
    S Y Oh
    Departments of Ophthalmology and. Neurology, The Jules Stein Eye Institute, University of California, Los Angeles, CA 90095-7002, USA
    Invest Ophthalmol Vis Sci 42:10-6. 2001
    ..Numerical dissimilarity of OL fibers correlates with varying mechanical loading because of varying elasticities of connective tissues onto which these fibers insert...
  79. ncbi request reprint Structure-function correlation of laminar vascularity in human rectus extraocular muscles
    S Y Oh
    Departments of Ophthalmology and. Neurology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095-7002, USA
    Invest Ophthalmol Vis Sci 42:17-22. 2001
    ..Greater blood flow is consistent with more sustained mechanical loading of the orbital than the global layer...
  80. ncbi request reprint Impairments in the initial horizontal vestibulo-ocular reflex of older humans
    J R Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 137:309-22. 2001
    ..0 +/- 0.5 ms and 12.0 +/- 0.6 ms for younger subjects. Late VOR gain modulation with target distance was significantly attenuated in older subjects only for the higher head acceleration...
  81. ncbi request reprint Otolith function in cerebellar ataxia due to mutations in the calcium channel gene CACNA1A
    G Wiest
    Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Brain 124:2407-16. 2001
    ..These findings suggest a critical role of the cerebellum in the modulation of otolith-ocular signals that is independent of motor vergence...
  82. pmc Vestibular function in severe bilateral vestibulopathy
    G Wiest
    Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, Los Angeles, USA
    J Neurol Neurosurg Psychiatry 71:53-7. 2001
    ..Random, transient rotation is better suited than steady state rotation for quantifying vestibular function in vestibulopathic patients...
  83. ncbi request reprint Impaired linear vestibulo-ocular reflex initiation and vestibular catch-up saccades in older persons
    Jun Ru Tian
    Department of Ophthalmology, The Jules Stein Eye Institute, University of California, Los Angeles, California 90095 7002, USA
    Ann N Y Acad Sci 956:574-8. 2002
  84. pmc Evidence supporting extraocular muscle pulleys: refuting the platygean view of extraocular muscle mechanics
    Joseph L Demer
    Department of Ophthalmology and Neurology, Jules Stein Eye Institute, and Bioengineering and Neuroscience Interdepartmental Programs, University of California, Los Angeles 90095 7002, USA
    J Pediatr Ophthalmol Strabismus 43:296-305. 2006
    ..Targeted investigations of these connective tissue "pulleys" led to the formulation of the active pulley hypothesis, which proposes that pulling directions of the rectus extraocular muscles are actively controlled via connective tissues...
  85. ncbi request reprint Dynamic visual acuity during passive and self-generated transient head rotation in normal and unilaterally vestibulopathic humans
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 142:486-95. 2002
    ..Extravestibular mechanisms for compensation appear more effective during self-generated than manually imposed head rotations...
  86. ncbi request reprint Rectus extraocular muscle pulley displacement after surgical transposition and posterior fixation for treatment of paralytic strabismus
    Robert A Clark
    Department of Ophthalmology, University of California, Los Angeles, California 90095, USA
    Am J Ophthalmol 133:119-28. 2002
    ....
  87. ncbi request reprint The transcaruncular approach: surgical anatomy and technique
    Robert A Goldberg
    Jules Stein Eye Institue, UCLA School of Medicine, University of California Los Angeles, CA 90095, USA
    Arch Facial Plast Surg 9:443-7. 2007
    ..The conjunctival incision should be ample. The orbital septum should be carefully dissected from the posterior surface of the Horner muscle to minimize fat spillage, and the periosteum should be opened widely at the beginning of surgery...
  88. pmc Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis
    Joanna C Jen
    Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Science 304:1509-13. 2004
    ..Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing...
  89. ncbi request reprint Functional anatomy of the anophthalmic socket: insights from magnetic resonance imaging
    Efstathios T Detorakis
    Departments of Ophthalmology, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 44:4307-13. 2003
    ..Changes in anophthalmic socket anatomy can significantly compromise esthetics and motility after enucleation. This study evaluated such changes by using magnetic resonance imaging (MRI) of enucleated and fellow orbits...
  90. ncbi request reprint Vestibular catch-up saccades augmenting the human transient heave linear vestibulo-ocular reflex
    Jun Ru Tian
    Jules Stein Eye Institute, UCLA, 100 Stein Plaza, Los Angeles, CA 90095 7002, USA
    Exp Brain Res 151:435-45. 2003
    ..In the presence of visual information, VCUS can be generated in older and vestibulopathic subjects, albeit at prolonged latency perhaps indicating visual augmentation of deficient vestibular input...
  91. pmc Inflection in inactive lateral rectus muscle: evidence suggesting focal mechanical effects of connective tissues
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California at Los Angeles, Los Angeles, California 90095 7002, USA
    Invest Ophthalmol Vis Sci 49:4858-64. 2008
    ..Paths of inactive lateral rectus (LR) muscles were studied to investigate putative roles of orbital fat and intrinsic muscle stiffness suggested to be alternatives to connective tissue pulleys as determinants of pulling direction...
  92. ncbi request reprint Extraocular connective tissue architecture
    Joel M Miller
    The Smith Kettlewell Eye Research Institute, San Francisco, CA, USA
    J Vis 3:240-51. 2003
    ..This active structure might therefore be a factor in strabismus and a target of therapeutic intervention...
  93. pmc Bilateral abnormalities of optic nerve size and eye shape in unilateral amblyopia
    Stacy L Pineles
    Jules Stein Eye Institute and Department of Ophthalmology, UCLA, Los Angeles, California 90024, USA
    Am J Ophthalmol 148:551-557.e2. 2009
    ..To evaluate the optic nerve (ON) size and globe shape in amblyopic eyes using high-resolution magnetic resonance imaging (MRI) and to compare these values with those of the sound fellow eye and of normal control eyes...
  94. ncbi request reprint Effect of aging on human rectus extraocular muscle paths demonstrated by magnetic resonance imaging
    Robert A Clark
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Am J Ophthalmol 134:872-8. 2002
    ..To compare normal functional anatomy of rectus extraocular muscles (EOMs) and pulleys in normal older humans with previously reported findings in younger subjects...
  95. ncbi request reprint Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence
    Sean J Darcy
    David Geffen School of Medicine, the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, Los Angeles, USA
    Plast Reconstr Surg 122:921-9; discussion 930-1. 2008
    ..Multiple orbital aging models have been suggested to explain the progressive development of lower eyelid prominence. Objective data to support these theories are limited, however...
  96. ncbi request reprint Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations
    N L Sicotte
    Department of Neurology, Division of Brain Mapping, Interdepartmental Programs, UCLA, USA
    Neurology 67:519-21. 2006
    ..Mutations in the ROBO3 gene lead to a widespread lack of crossing fibers throughout the brainstem...
  97. ncbi request reprint Regarding van den Bedem, Schutte, van der Helm, and Simonsz: Mechanical properties and functional importance of pulley bands or 'Faisseaux Tendineux'
    Joseph L Demer
    Vision Res 46:3036-8; author reply 3039-40. 2006
  98. doi request reprint More respect for connective tissues
    Joseph L Demer
    J AAPOS 12:5-6. 2008
  99. doi request reprint Displacement of the rectus muscle pulleys simulating superior oblique palsy
    Reika Kono
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700 8558, Japan
    Jpn J Ophthalmol 52:36-43. 2008
    ..To investigate the structural basis of three cases of apparent superior oblique (SO) palsy caused by extraocular muscle (EOM) pulley heterotopy...
  100. ncbi request reprint Active pulleys: magnetic resonance imaging of rectus muscle paths in tertiary gazes
    Reika Kono
    Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 43:2179-88. 2002
    ..This study was designed to measure gaze-related shifts in EOM pulley locations...
  101. ncbi request reprint Medial rectus pulley posterior fixation is as effective as scleral posterior fixation for acquired esotropia with a high AC/A ratio
    Robert A Clark
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, USA
    Am J Ophthalmol 137:1026-33. 2004
    ....

Research Grants19

  1. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2009
    ..Studies will also clarify basic genetic and mechanical causes of abnormal eye movements, balance disorders, and aid development of newly-emerging surgeries for treating strabismus. ..
  2. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2007
    ..Studies will also clarify basic genetic and mechanical causes of abnormal eye movements, balance disorders, and aid development of newly-emerging surgeries for treating strabismus. ..
  3. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2006
    ..Studies will also clarify basic genetic and mechanical causes of abnormal eye movements, balance disorders, and aid development of newly-emerging surgeries for treating strabismus. ..
  4. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2005
    ..Findings will critically evaluate a new and potentially more useful paradigm for the understanding of ocular motility and treatment of strabismus. ..
  5. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2004
    ..Findings will critically evaluate a new and potentially more useful paradigm for the understanding of ocular motility and treatment of strabismus. ..
  6. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2003
    ..Findings will critically evaluate a new and potentially more useful paradigm for the understanding of ocular motility and treatment of strabismus. ..
  7. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2002
    ..Findings will critically evaluate a new and potentially more useful paradigm for the understanding of ocular motility and treatment of strabismus. ..
  8. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2001
    ..Findings will critically evaluate a new and potentially more useful paradigm for the understanding of ocular motility and treatment of strabismus. ..
  9. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 2000
    ..9) Use of alert, behaving monkeys with implanted measuring devices to explore and model effects of orbital smooth muscle stimulation and inactivation. ..
  10. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 1993
    ..We will apply the model to study the effects on alignment of post-surgical healing, using it in conjunction with longitudinal post-surgical data, to infer orbital and innervational changes...
  11. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 1992
    ..We will apply the model to study the effects on alignment of post-surgical healing, using it in conjunction with longitudinal post-surgical data, to infer orbital and innervational changes...
  12. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    Joseph Demer; Fiscal Year: 1999
    ..9) Use of alert, behaving monkeys with implanted measuring devices to explore and model effects of orbital smooth muscle stimulation and inactivation. ..
  13. BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERY
    JOSEPH LOUIS DEMER; Fiscal Year: 2010
    ..Studies will also clarify basic genetic and mechanical causes of abnormal eye movements, balance disorders, and aid development of newly-emerging surgeries for treating strabismus. ..