T R Demeester

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Evolving concepts of reflux: the ups and downs of the LES
    Tom R Demeester
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, 90033 4612, USA
    Can J Gastroenterol 16:327-31. 2002
  2. ncbi request reprint Biology of gastroesophageal reflux disease: pathophysiology relating to medical and surgical treatment
    T R Demeester
    Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033 4612, USA
    Annu Rev Med 50:469-506. 1999
  3. doi request reprint Esophagectomy for cancer in octogenarians
    J Zehetner
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Dis Esophagus 23:666-9. 2010
  4. ncbi request reprint Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence
    R V Lord
    Department of Surgery, University of Southern California Keck School of Medicine and USC/Norris Cancer Center, Los Angeles, Calif, USA
    Surgery 129:267-76. 2001
  5. pmc Long-term outcome of antireflux surgery in patients with Barrett's esophagus
    W L Hofstetter
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, 1510 San Pablo St, Los Angeles, CA 90033-4612, USA
    Ann Surg 234:532-8; discussion 538-9. 2001
  6. doi request reprint A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold
    S Ayazi
    Division of Thoracic and Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 13:1422-9. 2009
  7. ncbi request reprint Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    J Surg Res 99:301-6. 2001
  8. doi request reprint The gene expression profile of cardia intestinal metaplasia is similar to that of Barrett's esophagus, not gastric intestinal metaplasia
    D S Oh
    Department of Surgery, University of Southern California Response Genetics Inc, Los Angeles, California 90033, USA
    Dis Esophagus 24:516-22. 2011
  9. ncbi request reprint Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus
    D Vallbohmer
    Department of Surgery, University of Southern California, Los Angeles, 90033, USA
    Dis Esophagus 19:260-6. 2006
  10. ncbi request reprint Circular stapled pyloroplasty: a fast and effective technique for pyloric disruption during esophagectomy with gastric pull-up
    A Oezcelik
    Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Dis Esophagus 24:423-9. 2011

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Evolving concepts of reflux: the ups and downs of the LES
    Tom R Demeester
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, 90033 4612, USA
    Can J Gastroenterol 16:327-31. 2002
    ..Corrective therapy requires augmentation or restoration of barrier function...
  2. ncbi request reprint Biology of gastroesophageal reflux disease: pathophysiology relating to medical and surgical treatment
    T R Demeester
    Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033 4612, USA
    Annu Rev Med 50:469-506. 1999
    ..Practical concepts regarding the treatment of gastroesophageal reflux disease are developed, based on a review of studies on the natural history of the disease and the long-term outcome of therapy...
  3. doi request reprint Esophagectomy for cancer in octogenarians
    J Zehetner
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Dis Esophagus 23:666-9. 2010
    ..9 vs 59.3 months, P= 0.31 log-rank test). Esophagectomy can be performed safely in carefully selected octogenarians with good cardiac and pulmonary function. Patients should not be denied an esophagectomy based only on their age...
  4. ncbi request reprint Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence
    R V Lord
    Department of Surgery, University of Southern California Keck School of Medicine and USC/Norris Cancer Center, Los Angeles, Calif, USA
    Surgery 129:267-76. 2001
    ..These results also suggest that a cancer field is present in the esophagus in patients with cancer and that genetic alterations can precede histopathologic alterations in this disease...
  5. pmc Long-term outcome of antireflux surgery in patients with Barrett's esophagus
    W L Hofstetter
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, 1510 San Pablo St, Los Angeles, CA 90033-4612, USA
    Ann Surg 234:532-8; discussion 538-9. 2001
    ..Importantly, dysplasia regressed in nearly half of the patients in whom it was present before surgery, intestinal metaplasia disappeared in 14% of patients, and high-grade dysplasia and adenocarcinoma were prevented in all...
  6. doi request reprint A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold
    S Ayazi
    Division of Thoracic and Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 13:1422-9. 2009
    ..The aim of this study was to use this probe to measure the pharyngeal pH environment in normal subjects and establish pH thresholds to identify abnormality...
  7. ncbi request reprint Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    J Surg Res 99:301-6. 2001
    ..The genetic basis of this process is increasingly well understood, but no studies have examined the role of the transcription factor c-myb in this disease...
  8. doi request reprint The gene expression profile of cardia intestinal metaplasia is similar to that of Barrett's esophagus, not gastric intestinal metaplasia
    D S Oh
    Department of Surgery, University of Southern California Response Genetics Inc, Los Angeles, California 90033, USA
    Dis Esophagus 24:516-22. 2011
    ..The indistinguishable gene expression profile of CIM and BE suggests that they may share a common etiology in the majority of patients with a similar biology, and calls into question the perception that CIM is an innocuous process...
  9. ncbi request reprint Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus
    D Vallbohmer
    Department of Surgery, University of Southern California, Los Angeles, 90033, USA
    Dis Esophagus 19:260-6. 2006
    ..Therefore, Cdx-2 may be a potential biomarker to detect the early transition to Barrett's esophagus...
  10. ncbi request reprint Circular stapled pyloroplasty: a fast and effective technique for pyloric disruption during esophagectomy with gastric pull-up
    A Oezcelik
    Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Dis Esophagus 24:423-9. 2011
    ..Potential advantages include the ease and simplicity of the procedure along with virtually no risk of a leak and no graft shortening. The technique is amenable to both open and minimally invasive procedures...
  11. ncbi request reprint Predictive factors of coexisting cancer in Barrett's high-grade dysplasia
    C Tharavej
    Division of Thoracic and Foregut Surgery, Department of Surgery, University of Southern California, Los Angeles, CA, USA
    Surg Endosc 20:439-43. 2006
    ..This study aimed to determine the endoscopic, histologic, and demographic features associated with the presence of occult cancer in patients with HGD...
  12. ncbi request reprint Risk factors and the prevalence of trocar site herniation after laparoscopic fundoplication
    D J Bowrey
    Department of Surgery, University of Southern California, HCC Suite 514, 1510 San Pablo St, Los Angeles, CA 90033-4612, USA
    Surg Endosc 15:663-6. 2001
    ..This method utilizes a paramedian skin incision and separate fascial incisions through anterior and posterior rectus sheathes, with retraction of the rectus abdominis muscle laterally...
  13. ncbi request reprint Bravo capsule induction of esophageal hypercontractility and chest pain
    C Tharavej
    Division of Thoracic and Foregut Surgery, Department of Surgery, University of Southern California, Los Angeles, CA, USA
    Surg Endosc 20:783-6. 2006
    ..The authors hypothesized that chest pain in this setting may be attributable to hypertensive esophageal contractions induced by the Bravo capsule...
  14. ncbi request reprint Can clinical and endoscopic findings accurately predict early-stage adenocarcinoma?
    G Portale
    Division of Thoracic and Foregut Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Surg Endosc 20:294-7. 2006
    ..Therefore, we conducted a study to determine whether symptomatic and endoscopic findings can accurately identify node-negative early-stage adenocarcinoma...
  15. ncbi request reprint En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinoma
    C Rizzetto
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Thorac Cardiovasc Surg 135:1228-36. 2008
    ..The aim of this study was to determine whether the benefits of an en bloc resection would extend to patients after neoadjuvant therapy...
  16. pmc Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies
    J A Hagen
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Los Angeles, CA 90033, USA
    Ann Surg 234:520-30; discussion 530-1. 2001
    ..Local control is excellent after en bloc resection. The extent of disease associated with tumors confined to the mucosa and submucosa provides justification for more limited and less morbid resections...
  17. doi request reprint Recurrence of intramucosal esophageal adenocarcinoma arising in a former esophagostomy site: a unique case report
    J M Leers
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Dis Esophagus 22:E17-20. 2009
    ..Biopsy revealed an implant metastasis of esophageal adenocarcinoma. Here, we review the literature and discuss the possible etiology...
  18. ncbi request reprint Laparoscopic ultrasonic epithelial ablation of the lower esophagus after nissen fundoplication in a porcine model: assessment of tissue damage and healing process
    P I Tsai
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Am Surg 67:1178-80. 2001
    ..No stricture formation was seen. We conclude that the CUSA technique can completely ablate Barrett's mucosa in the setting of a prior antireflux procedure. Healing with squamous mucosal regeneration is rapid and complete...
  19. ncbi request reprint The crura and crura-sphincter pressure dynamics in patients with isolated upright and isolated supine reflux
    F Banki
    Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am Surg 67:1150-6. 2001
    ..Higher crura-sphincter pressure gradient and larger-size hiatal hernias in patients with supine reflux results in pressurization of the hernia sac and subsequent reflux when these patients are in a supine position...
  20. ncbi request reprint Predictive factors of Barrett esophagus: multivariate analysis of 502 patients with gastroesophageal reflux disease
    G M Campos
    Department of Surgery, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Suite 7418, Los Angeles, CA 90033-0804, USA
    Arch Surg 136:1267-73. 2001
    ..Elimination of reflux with an antireflux operation in patients with 1 or more of these factors may prevent the future development of BE...
  21. ncbi request reprint Clinical value of endoscopy and histology in the diagnosis of duodenogastric reflux disease
    H J Stein
    Department of Surgery, University of Southern California, Los Angeles 90033 4612
    Surgery 112:796-803; discussion 803-4. 1992
    ..The accuracy of these criteria was evaluated in 135 patients with nonspecific symptoms in the foregut suggestive of duodenogastric reflux and no evidence for alcohol- or drug-induced gastric mucosal injury...
  22. ncbi request reprint Epigenetic patterns in the progression of esophageal adenocarcinoma
    C A Eads
    Department of Surgery, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9176, USA
    Cancer Res 61:3410-8. 2001
    ....
  23. ncbi request reprint Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9
    S A Wajed
    Department of Surgery, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA 90033, USA
    Arch Surg 136:1014-8. 2001
    ..CONCLUSION: The barrier to gastroesophageal reflux is rendered insufficient in patients who are overweight...
  24. doi request reprint Plasma DNA: a molecular marker of surgical insult and postoperative recovery in esophageal cancer
    F Banki
    Department of Surgery, University of California, Keck School of Medicine, Los Angeles, Calif, USA
    Eur Surg Res 40:273-8. 2008
    ..To assess plasma DNA changes intraoperatively, to relate plasma DNA to the magnitude of the surgical insult and to monitor the changes during the postoperative recovery period...
  25. ncbi request reprint The safety and usefulness of endoscopy for evaluation of the graft and anastomosis early after esophagectomy and reconstruction
    M S Maish
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Surg Endosc 19:1093-102. 2005
    ..The aim of this study was to review our experience with early endoscopy for evaluation of the graft and anastomosis after esophagectomy and reconstruction...
  26. ncbi request reprint Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology/Norris Comprehensive Cancer Research Center, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Gastrointest Surg 5:174-81; discussion 182. 2001
    ..early event in the development and progression of Barrett's-associated adenocarcinoma of the esophagus, and they suggest that high ODC mRNA expression levels may be a clinically useful biomarker for the detection of occult adenocarcinoma..
  27. ncbi request reprint Esophageal adenocarcinoma in patients < or = 50 years old: delayed diagnosis and advanced disease at presentation
    G Portale
    Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, California, USA
    Am Surg 70:954-8. 2004
    ..With appropriate aggressive treatment, survival is similar. Liberal use of endoscopy and aggressive diagnostic approach are paramount in young patients with dysphagia/symptoms of gastroesophageal reflux disease (GERD)...
  28. ncbi request reprint Pathologic duodenogastric reflux associated with persistence of symptoms after cholecystectomy
    P Wilson
    Department of Surgery, Creighton University School of Medicine, Omaha, NE 68131, USA
    Surgery 117:421-8. 1995
    ..The aim of this study was to determine whether increased duodenogastric reflux contributes to postcholecystectomy symptoms...
  29. ncbi request reprint Etiology of intestinal metaplasia at the gastroesophageal junction
    N S Balaji
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 514, Los Angeles, CA 90033, USA
    Surg Endosc 17:43-8. 2003
    ..We hypothesized that CIM has dual etiologies: gastroesophageal reflux in some, H. pylori infection in others, and that cytokeratin immunostaining can help to differentiate between these two etiologies...
  30. ncbi request reprint Surgical therapy for Barrett's esophagus: prevention, protection and excision
    T R Demeester
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA surgery hsc usc edu
    Dis Esophagus 15:109-16. 2002
  31. doi request reprint Home self-dilatation for esophageal strictures
    J Zehetner
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Dis Esophagus 27:1-4. 2014
    ..It was well tolerated, and there were no complications in this series. Home self-dilatation should be considered the treatment of choice in appropriate patients with refractory esophageal strictures in the cervical esophagus. ..
  32. ncbi request reprint Fibrovascular polyp of the esophagus requiring esophagectomy
    S Kanaan
    University of Southern California, Department of Cardiothoracic Surgery, Los Angeles, California 90033, USA
    Dis Esophagus 20:453-4. 2007
    ..Treatment is surgical. Only four cases in the literature underwent esophagectomy for removal. We present a female patient with a fibrovascular polyp of the esophagus who required a transhiatal esophagectomy to safely remove this mass...
  33. ncbi request reprint Redefining gastroesophageal reflux (GER)
    N S Balaji
    Department of Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Surg Endosc 17:1380-5. 2003
    ..It is clear, however that nonacid reflux can be a significant clinical problem. Recently, as impedance technology with the capacity to detect all types of reflux (acid, nonacid, liquid, mixed, and air) has been developed...
  34. ncbi request reprint Esophagectomy for benign disease: use of the colon
    S B Johnson
    Department of Surgery, University of Southern California School of Medicine, Los Angeles
    Adv Surg 27:317-34. 1994
  35. ncbi request reprint Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model
    R J Mason
    Center for Heartburn and Esophageal Disorders, Midway Hospital Medical Center, 5901 West Olympic Boulevard, Suite 101, Los Angeles, CA 90036, USA
    Surg Endosc 16:386-91. 2002
    ..The aim of the study was to demonstrate the feasibility, durability, safety, and antireflux efficacy following augmentation of the cardia with a biocompatible injectable polymer (Enteryx)...
  36. pmc DNA methylation: an alternative pathway to cancer
    S A Wajed
    Department of Surgery, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Ann Surg 234:10-20. 2001
    ....
  37. ncbi request reprint Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus
    Daniel Vallbohmer
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Gastroenterol 101:1458-66. 2006
    ..Further, we hypothesized that Cox-2 expression in the squamous mucosa would be reduced following the elimination of reflux with an antireflux operation...
  38. ncbi request reprint Gastric electrical stimulation: an alternative surgical therapy for patients with gastroparesis
    Rodney J Mason
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Arch Surg 140:841-6; discussion 847-8. 2005
    ..Gastric electrical stimulation is an alternative to gastrectomy in patients with refractory gastroparesis...
  39. ncbi request reprint The impact of reflux composition on mucosal injury and esophageal function
    Daniel S Oh
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Gastrointest Surg 10:787-96; discussion 796-7. 2006
    ..This suggests that composition of gastric juice is the primary determinant of inflammatory mucosal injury and subsequent loss of esophageal function...
  40. ncbi request reprint Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett's-like features
    Reginald V N Lord
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, Calif, USA
    Surgery 136:633-40. 2004
    ..The aims of this study were, first, to investigate whether cardiac mucosa can be acquired in the remnant cervical esophagus after esophagectomy and cervical esophagogastrostomy and, second, to characterize this mucosa if present...
  41. pmc The duodenal switch operation for the treatment of morbid obesity
    Gary J Anthone
    Department of Surgery, University of Southerm California Keck School of Medicine, Los Angeles, CA 90033 42, USA
    Ann Surg 238:618-27; discussion 627-8. 2003
    ..To determine the safety and efficacy of the duodenal switch procedure as surgical treatment of morbid obesity...
  42. ncbi request reprint Surgical management of hypertensive lower esophageal sphincter with dysphagia or chest pain
    Anand P Tamhankar
    Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
    J Gastrointest Surg 7:990-6; discussion 996. 2003
    ..A myotomy with partial fundoplication for isolated hypertensive LES relieves dysphagia and chest pain suggesting a primary sphincter dysfunction...
  43. ncbi request reprint The hypertensive lower esophageal sphincter: a motility disorder with manometric features of outflow obstruction
    Ines Gockel
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Gastrointest Surg 7:692-700. 2003
    ..Patients with HTLES have significantly elevated intrabolus and residual relaxation pressures on liquid boluses, suggesting that outflow obstruction is present...
  44. ncbi request reprint Preoperative lower esophageal sphincter pressure affects outcome of laparoscopic esophageal myotomy for achalasia
    Mustafa A Arain
    Department of Surgery, Division of Thoracic and Foregut Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 8:328-34. 2004
    ..Ninety-four percent of patients are satisfied with their surgical myotomy for achalasia. By physician assessment dysphagia was resolved in 77% of patients. A high LES resting pressure before surgery predicted resolution of dysphagia...
  45. ncbi request reprint Excellent quality of life after Nissen fundoplication depends on successful elimination of reflux symptoms and not the invasiveness of the surgical approach
    Christopher G Streets
    Department of Surgery, University of Southern California, Los Angeles, USA
    Ann Thorac Surg 74:1019-24; discussion 1024-5. 2002
    ....
  46. ncbi request reprint Microvasive gastric stapler: the device, technique, and preclinical results
    Tom R Demeester
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033 4612, USA
    Gastrointest Endosc Clin N Am 13:117-33, x. 2003
    ..The experimental development of an intraluminal transgastric valvuloplasty is discussed, and comments are made about the future role of endoscopic repairs...
  47. ncbi request reprint Physiologic mechanism and preoperative prediction of new-onset dysphagia after laparoscopic Nissen fundoplication
    Dennis Blom
    Division of Thoracic Foregut Surgery, Department of Surgery, University of Southern California, Los Angeles, CA 9033, USA
    J Gastrointest Surg 6:22-7; discussion 27-8. 2002
    ..Patients with a normal LES or high mean LES pressures are at increased risk for developing this complication and should be informed of this before laparoscopic Nissen fundoplication...
  48. ncbi request reprint Absence of gastroesophageal reflux disease in a majority of patients taking acid suppression medications after Nissen fundoplication
    Reginald V N Lord
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Gastrointest Surg 6:3-9; discussion 10. 2002
    ..Because of the limited predictive power of symptoms, objective evidence of reflux disease should be obtained before prescribing acid suppression medication for patients who have undergone antireflux surgery...
  49. ncbi request reprint Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive features
    Richard R Gurski
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
    J Am Coll Surg 196:706-12; discussion 712-3. 2003
    ..To investigate the factors leading to histologic regression of metaplastic and dysplastic Barrett's esophagus (BE)...
  50. doi request reprint Use of a magnetic sphincter for the treatment of GERD: a feasibility study
    Robert A Ganz
    Minnesota Gastroenterology, Plymouth, Minnesota 55446, USA
    Gastrointest Endosc 67:287-94. 2008
    ..We introduced a new device to treat GERD: biomechanical augmentation of the lower esophageal sphincter (LES) by use of a magnetic reinforcing appliance...
  51. ncbi request reprint Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology
    Anand P Tamhankar
    Department of Surgery, University of Southern California, Los Angeles, California, USA
    J Gastrointest Surg 8:890-7; discussion 897-8. 2004
    ..These observations may explain the persistence of symptoms and emergence of mucosal injury white on proton pump inhibitor therapy...
  52. doi request reprint High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults
    Sonali Rodrigo
    Department of Surgical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Gastroenterol 103:435-42. 2008
    ..This is based on data that the number of intraepithelial eosinophils in gastroesophageal reflux disease (GERD) is less than 20/hpf. This study tests this belief...
  53. ncbi request reprint Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus
    Reginald V N Lord
    Department of Surgery and Cardiothoracic Surgery, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Thorac Cardiovasc Surg 125:246-53. 2003
    ....
  54. ncbi request reprint Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagus
    Steven R Demeester
    Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, USA
    Am J Gastroenterol 97:2514-23. 2002
    ..We hypothesized that the immunostaining patterns of these foregut tissues would provide insight into the nature and etiology of cardiac mucosa and CIM...
  55. pmc Vagal-sparing esophagectomy: a more physiologic alternative
    Farzaneh Banki
    Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
    Ann Surg 236:324-35; discussion 335-6. 2002
    ..To evaluate the function of the vagal nerves and the gastric reservoir after vagal-sparing esophagectomy...
  56. ncbi request reprint Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia
    Daniel Vallbohmer
    Department of Surgery, University of Southern California, Los Angeles, CA, USA
    J Gastrointest Surg 11:1095-104. 2007
    ..When differences occur, it is unclear whether this effect is due to intraobserver variability in pathological diagnosis or to a genuine difference between gene expression and histopathology...
  57. ncbi request reprint Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery
    Daniel S Oh
    Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Arch Surg 142:554-9; discussion 559-60. 2007
    ..Chronic inflammation of esophageal mucosa secondary to refluxed gastric juice increases gene expression of interleukin 8 (IL-8). Antireflux surgery can reduce this overexpression...
  58. ncbi request reprint Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma
    Hidekazu Kuramochi
    From the Department of Biochemistry and Molecular Biology, USC Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Gastrointest Surg 8:1007-16; discussion 1016-7. 2004
    ..These results confirm the important role of Cox-2 amplification in the pathogenesis of esophageal adenocarcinoma, but the unexpected down-regulation of Cox-1 raises questions about its role in carcinogenesis...
  59. ncbi request reprint Editorial comment: The short esophagus: going, going, gone?
    Steven R Demeester
    Surgery 133:364-7. 2003
  60. ncbi request reprint Barrett's esophagus in females: a comparative analysis of risk factors in females and males
    Farzaneh Banki
    Department of Surgery and Cardiothoracic Surgery, Keck School of Medicine, The University of Southern California, Los Angeles, California, USA
    Am J Gastroenterol 100:560-7. 2005
    ..The reason for this disparity is unknown. The aim of this study was to determine the factors related to Barrett's in females...
  61. ncbi request reprint Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa
    Giuseppe Portale
    Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
    Arch Surg 140:570-4; discussion 574-5. 2005
    ..This has led to the belief that patients with and without Barrett mucosa may represent 2 distinct cancer types...
  62. ncbi request reprint Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus
    Nahid Hamoui
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles 90033, USA
    Arch Surg 139:712-6; discussion 716-7. 2004
    ..PATIENTS, DESIGN, AND SETTING: Prospective analysis of 61 patients initially seen with reflux symptoms at a private academic hospital...
  63. ncbi request reprint Prevalence and risk factors for ischemia, leak, and stricture of esophageal anastomosis: gastric pull-up versus colon interposition
    John W Briel
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    J Am Coll Surg 198:536-41; discussion 541-2. 2004
    ..Reports of esophageal anastomotic complications often involve more gastric than colonic reconstructions and are incomplete because of fragmented followup by physicians unfamiliar with the surgical procedure...
  64. ncbi request reprint Postprandial acid reflux is reduced by delayed gastric emptying
    Yoshinori Yamashita
    Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan
    J Smooth Muscle Res 39:87-93. 2003
    ..05). In patient with abnormal acid exposure but normal % PRT on 24 h esophageal pH monitoring, gastric emptying may be delayed...
  65. ncbi request reprint Manometry of the lower esophageal sphincter: inter- and intraindividual variability of slow motorized pull-through versus station pull-through manometry
    Guilherme M R Campos
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California 90033 4612, USA
    Dig Dis Sci 48:1057-61. 2003
    ....
  66. ncbi request reprint Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagus
    Daniel S Oh
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Am Coll Surg 203:152-61. 2006
    ..Acceptance of these alternative therapies requires an understanding of the clinical biology of IMC and the results of surgical resection modified for treatment of early disease...
  67. ncbi request reprint Ambulatory 24-hour esophageal pH monitoring: why, when, and what to do
    Christopher G Streets
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles CA, USA
    J Clin Gastroenterol 37:14-22. 2003
    ..The composite score has been shown to be the most reliable measurement of a therapeutic acid suppression regimen or an effective antireflux operation...
  68. ncbi request reprint Response of the lower esophageal sphincter to gastric distention by carbonated beverages
    Nahid Hamoui
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Gastrointest Surg 10:870-7. 2006
    ..Carbonated beverages, but not tap water, reduce the strength of the lower esophageal sphincter. This may be relevant to the pathogenesis of gastroesophageal reflux disease, especially in Western society...