Research Topics
| Steven DeMeesterSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
The impact of reflux composition on mucosal injury and esophageal functionDaniel S Oh
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Gastrointest Surg 10:787-96; discussion 796-7. 2006..This suggests that composition of gastric juice is the primary determinant of inflammatory mucosal injury and subsequent loss of esophageal function...- New options for the therapy of Barrett's high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomySteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Los Angeles, California 90033, USA
Ann Thorac Surg 85:S747-50. 2008 
Vagal-sparing esophagectomy: is it a useful addition?Steven R Demeester
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Ann Thorac Surg 89:S2156-8. 2010..Given these advantages, a vagal-sparing esophagectomy should be the preferred method of esophageal resection in appropriate patients...- Evaluation and treatment of superficial esophageal cancerSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Los Angeles, CA 90033, USA
J Gastrointest Surg 14:S94-100. 2010..The evaluation and treatment of these superficial cancers differs from local and regionally advanced lesions... - Invited commentary. Surgical correction of a hernia has to be identified in the early postoperative period, regardless of symptomsSteven DeMeester
Department of Cardiothoracic Surgery, The University of Southern California, 1510 San Pablo St, No. 514, Los Angeles CA90033, USA
Ann Thorac Surg 84:1852-3. 2007 - Invited commentarySteven R Demeester
Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA90033, USA
Ann Thorac Surg 86:440. 2008 - Endoscopic mucosal resection and vagal-sparing esophagectomy for high-grade dysplasia and adenocarcinoma of the esophagusSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
Semin Thorac Cardiovasc Surg 17:320-5. 2005..A vagal-sparing esophagectomy accomplishes the goal of removing the diseased esophagus while minimizing the physiologic impact of an esophagectomy in patients with early-stage esophageal cancer... - Adenocarcinoma of the esophagus and cardia: a review of the disease and its treatmentSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, 1510 San Pablo Street, Suite 514, Los Angeles, California, 90033, USA
Ann Surg Oncol 13:12-30. 2006.... - Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinomaParakrama Chandrasoma
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Am J Surg Pathol 36:1-7. 2012..Inadequate sampling is a powerful reason why the near absolute association between intestinal metaplasia and adenocarcinoma is not seen in some studies... - The dilated distal esophagus: a new entity that is the pathologic basis of early gastroesophageal reflux diseaseParakrama Chandrasoma
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Surg Pathol 35:1873-81. 2011..Its recognition allows for accurate and evidence-based interpretation of biopsies from this region and removes the present confusion and permits the development of a reproducible pathologic diagnostic method... - Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinomaReginald V N Lord
Department of Surgery, University of Southern California Keck School of Medicine Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Surgery 138:924-31. 2005..This study was undertaken to investigate the expression pattern of these critical morphogenesis genes in the Barrett's multistage carcinogenesis model... - Survivin, a potential biomarker in the development of Barrett's adenocarcinomaDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
Surgery 138:701-6; discussion 706-7. 2005..The aim of this study was to measure survivin gene expression in normal squamous/columnar epithelium and in the various stages of development of Barrett's adenocarcinoma... - Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2Daisuke Shimizu
Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Int J Cancer 119:765-70. 2006..0053, p = 0.0220) and adenocarcinoma (p < 0.0001, p < 0.0001) compared to squamous epithelium or reflux-esophagitis. Furthermore, there is a significant correlation between these two genes, especially in carcinoma (p < 0.0001)... - Modern 5-year survival of resectable esophageal adenocarcinoma: single institution experience with 263 patientsGiuseppe Portale
Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
J Am Coll Surg 202:588-96; discussion 596-8. 2006..Improvements in survival are associated with increased detection of early stage disease, and a liberal use of en bloc resection. Nonsurgical treatments should be compared with these contemporary outcomes measures... - Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagusDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Am J Gastroenterol 101:1458-66. 2006..Further, we hypothesized that Cox-2 expression in the squamous mucosa would be reduced following the elimination of reflux with an antireflux operation... - Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagusDaniel S Oh
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Am Coll Surg 203:152-61. 2006..A vagal-sparing technique had less morbidity than other forms of resection and no mortality. Survival after all types of resection was similar. Outcomes of endoscopic techniques should be compared with this benchmark... - EMR for intramucosal adenocarcinoma of the esophagus: does one size fit all?Steven R Demeester
Gastrointest Endosc 65:14-5. 2007 - Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgeryDaniel S Oh
Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
Arch Surg 142:554-9; discussion 559-60. 2007..Chronic inflammation of esophageal mucosa secondary to refluxed gastric juice increases gene expression of interleukin 8 (IL-8). Antireflux surgery can reduce this overexpression... - The location of intestinal metaplasia within a columnar-lined esophagusSteven R Demeester
Am J Gastroenterol 103:250-1. 2008 - Circumferential ablation of Barrett's esophagus that contains high-grade dysplasia: a U.S. Multicenter RegistryRobert A Ganz
Minnesota Gastroenterology, Plymouth, Minnesota 55446, USA
Gastrointest Endosc 68:35-40. 2008..The management strategies for Barrett's esophagus (BE) that contains high-grade dysplasia (HGD) include intensive endoscopic surveillance, photodynamic therapy, thermal ablation, EMR, and esophagectomy... - Vagal-sparing esophagectomy: the ideal operation for intramucosal adenocarcinoma and barrett with high-grade dysplasiaChristian G Peyre
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Ann Surg 246:665-71; discussion 671-4. 2007..Our aim was to compare outcome of vagal-sparing esophagectomy with transhiatal and en bloc esophagectomy in patients with intramucosal adenocarcinoma or high-grade dysplasia... - The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resectionChristian G Peyre
Department of Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
Ann Surg 248:549-56. 2008..Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship in esophageal cancer... - Surgical therapy for Barrett's esophagusCarl-Christian A Jackson
Department of Surgery, The University of Southern California, Keck School of Medicine, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
Thorac Surg Clin 15:429-36. 2005..It is only with excellent control of reflux that any differences in the risk of progression to dysplasia and cancer become apparent, and significant, between medically and surgically treated patients... - Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosaGiuseppe Portale
Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
Arch Surg 140:570-4; discussion 574-5. 2005..This suggests the possibility that tumors without Barrett mucosa are not of a different origin, but rather are larger tumors that may have overgrown areas of Barrett mucosa... - Surgical management of hypertensive lower esophageal sphincter with dysphagia or chest painAnand P Tamhankar
Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
J Gastrointest Surg 7:990-6; discussion 996. 2003..A myotomy with partial fundoplication for isolated hypertensive LES relieves dysphagia and chest pain suggesting a primary sphincter dysfunction... - Lymph node involvement in esophageal adenocarcinoma: if you see one, have you seen them all?Steven R Demeester
J Thorac Cardiovasc Surg 126:947-9. 2003 - Increasing esophageal length: a comparison of laparoscopic versus transthoracic esophageal mobilization with and without vagal trunk division in pigsSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
J Am Coll Surg 197:558-64. 2003..Transthoracic mobilization alone likely will allow successful reduction of the gastroesophageal junction below the diaphragm in many patients who might otherwise require a Collis gastroplasty... - Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive featuresRichard R Gurski
Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles, CA 90033, USA
J Am Coll Surg 196:706-12; discussion 712-3. 2003..Regression is dependent on the length of the columnar-lined esophagus and time of followup after antireflux surgery... - Preoperative lower esophageal sphincter pressure affects outcome of laparoscopic esophageal myotomy for achalasiaMustafa A Arain
Department of Surgery, Division of Thoracic and Foregut Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
J Gastrointest Surg 8:328-34. 2004..Ninety-four percent of patients are satisfied with their surgical myotomy for achalasia. By physician assessment dysphagia was resolved in 77% of patients. A high LES resting pressure before surgery predicted resolution of dysphagia... - Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagusReginald V N Lord
Department of Surgery and Cardiothoracic Surgery, University of Southern California Keck School of Medicine, Los Angeles, USA
J Thorac Cardiovasc Surg 125:246-53. 2003..Basic fibroblast growth factor protein expression pattern is similar to the messenger RNA expression pattern, but unlike the messenger RNA findings, vascular endothelial growth factor protein expression is strongest in goblet cells... - Excellent quality of life after Nissen fundoplication depends on successful elimination of reflux symptoms and not the invasiveness of the surgical approachChristopher G Streets
Department of Surgery, University of Southern California, Los Angeles, USA
Ann Thorac Surg 74:1019-24; discussion 1024-5. 2002..These findings support the continued use of a transthoracic antireflux procedure in patients with advanced gastroesophageal reflux disease... - Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagusSteven R Demeester
Department of Cardiothoracic Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, USA
Am J Gastroenterol 97:2514-23. 2002..This suggests that cardiac mucosa, like Barrett's, may be acquired. Likewise, immunostaining similarities between CIM and Barrett's biopsies point to the possibility of a reflux etiology for CIM in some patients... 
Vagal-sparing esophagectomy: a more physiologic alternativeFarzaneh Banki
Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
Ann Surg 236:324-35; discussion 335-6. 2002..It is an ideal procedure for patients with end-stage benign disease, Barrett's esophagus with high-grade dysplasia, or esophageal carcinoma limited to the lamina propria...- Physiologic mechanism and preoperative prediction of new-onset dysphagia after laparoscopic Nissen fundoplicationDennis Blom
Division of Thoracic/Foregut Surgery, Department of Surgery, University of Southern California, Los Angeles, CA 9033, USA
J Gastrointest Surg 6:22-7; discussion 27-8. 2002..Patients with a normal LES or high mean LES pressures are at increased risk for developing this complication and should be informed of this before laparoscopic Nissen fundoplication... - Absence of gastroesophageal reflux disease in a majority of patients taking acid suppression medications after Nissen fundoplicationReginald V N Lord
Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Gastrointest Surg 6:3-9; discussion 10. 2002..Because of the limited predictive power of symptoms, objective evidence of reflux disease should be obtained before prescribing acid suppression medication for patients who have undergone antireflux surgery... - Barrett's esophagusJeffrey H Peters
Department of Surgery, University of Southern California, Los Angeles, California, USA
J Gastrointest Surg 8:1-17. 2004 - The prognostic importance of immunohistochemically detected node metastases in resected esophageal adenocarcinomaTara A Waterman
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Ann Thorac Surg 78:1161-9; discussion 1161-9. 2004..IHC-detected micrometastases are not of prognostic importance in N0 patients or those with greater than 10% nodal metastases on H&E... - Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett's-like featuresReginald V N Lord
Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, Calif, USA
Surgery 136:633-40. 2004..These findings are applicable to the development of similar changes at the gastroesophageal junction... - Endoscopic mucosal resection as a staging technique to determine the depth of invasion of esophageal adenocarcinomaMary S Maish
Department of Surgery, The University of Southern California, Keck School of Medicine, Los Angeles, California, USA
Ann Thorac Surg 78:1777-82. 2004.... - The mutagenic potential of duodenoesophageal refluxJorg Theisen
Department of Surgery, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
Ann Surg 241:63-8. 2005..Despite this link, little is known about the mutagenic potential of refluxed material on the esophageal mucosa. We hypothesize that the reflux of gastric and duodenal content causes mutations in esophageal mucosa in vivo... - Barrett's esophagus in females: a comparative analysis of risk factors in females and malesFarzaneh Banki
Department of Surgery and Cardiothoracic Surgery, Keck School of Medicine, The University of Southern California, Los Angeles, California, USA
Am J Gastroenterol 100:560-7. 2005..Esophageal bilirubin exposure is the major risk factor for the presence of Barrett's in patients with reflux disease... - Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagusNahid Hamoui
Department of Surgery, Division of Thoracic and Foregut Surgery, University of Southern California, Los Angeles 90033, USA
Arch Surg 139:712-6; discussion 716-7. 2004..The changes in gene expression occur before any metaplastic changes in the tissue are apparent, and may in the future be useful in predicting which patients will progress through a metaplasia-dysplasia carcinoma sequence... - En bloc vs transhiatal esophagectomy for stage T3 N1 adenocarcinoma of the distal esophagusJan Johansson
Department of Surgery, Lund University Hospital, Lund, Sweden
Arch Surg 139:627-31; discussion 631-3. 2004..001). CONCLUSION: En bloc esophagectomy confers a better survival than THE in patients with T3 N1 disease and fewer than 9 lymph node metastases... - Prevalence and risk factors for ischemia, leak, and stricture of esophageal anastomosis: gastric pull-up versus colon interpositionJohn W Briel
Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
J Am Coll Surg 198:536-41; discussion 541-2. 2004..Anastomotic leak and strictures are more common and the strictures are more severe after gastric pull-up compared with colon interposition. Dilatation is a safe and effective treatment... - Indications and technique of colon and jejunal interpositions for esophageal diseaseMary S Maish
Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA 90033, USA
Surg Clin North Am 85:505-14. 2005.... - Plasma DNA as a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancerFarzaneh Banki
Division of Thoracic Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California Los Angeles, 1950 San Pablo, Los Angeles, CA 90033, USA
Arch Surg 142:533-8; discussion 538-9. 2007..To identify a marker for completeness of resection and recurrent disease in patients with esophageal cancer... - Complications of achalasia surgeryAndrew E Luckey
The University of Southern California Keck School of Medicine, Los Angeles 90033, USA
Thorac Surg Clin 16:95-8. 2006..Further studies on the best location for the myotomy as well as the best type of fundoplication will help refine the procedure for future generations of patients... - High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adultsSonali Rodrigo
Department of Surgical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Gastroenterol 103:435-42. 2008..This is based on data that the number of intraepithelial eosinophils in gastroesophageal reflux disease (GERD) is less than 20/hpf. This study tests this belief... - Molecular determinants in targeted therapy for esophageal adenocarcinomaDaniel Vallbohmer
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA
Arch Surg 141:476-81; discussion 481-2. 2006..Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma... - Editorial comment: The short esophagus: going, going, gone?Steven R Demeester
Surgery 133:364-7. 2003 - Plasma DNA is more reliable than carcinoembryonic antigen for diagnosis of recurrent esophageal cancerFarzaneh Banki
Department of Surgery, University of California, Keck School of Medicine, Los Angeles, CA, USA
J Am Coll Surg 207:30-5. 2008..The sensitivity and specificity of these markers in the diagnosis of recurrent esophageal cancer have not been compared...