Kris A DeMali

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Vinculin--a dynamic regulator of cell adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Biochem Sci 29:565-7. 2004
  2. pmc Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 159:881-91. 2002
  3. ncbi request reprint Coupling membrane protrusion and cell adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    J Cell Sci 116:2389-97. 2003
  4. ncbi request reprint Integrin signaling to the actin cytoskeleton
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 15:572-82. 2003
  5. ncbi request reprint IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:39534-41. 2006
  6. pmc SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
    Shawn M Ellerbroek
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:3309-19. 2004
  7. ncbi request reprint Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration
    Joshua C Sandquist
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:35873-83. 2006

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Vinculin--a dynamic regulator of cell adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Biochem Sci 29:565-7. 2004
    ..Two new crystal structures reveal that vinculin exhibits a high degree of structural plasticity upon ligand binding that might promote rapid changes in cell adhesion...
  2. pmc Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 159:881-91. 2002
    ..The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion...
  3. ncbi request reprint Coupling membrane protrusion and cell adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    J Cell Sci 116:2389-97. 2003
    ..However, there are also physical links between the cellular machineries that mediate cell adhesion and membrane protrusion, such as vinculin...
  4. ncbi request reprint Integrin signaling to the actin cytoskeleton
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 15:572-82. 2003
    ..Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion...
  5. ncbi request reprint IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:39534-41. 2006
    ..The combination of these two effects, namely weakened adhesion and increased contractility, account for the loss of actin stress fibers and cell rounding observed in cells exposed to IpaA...
  6. pmc SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
    Shawn M Ellerbroek
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:3309-19. 2004
    ..Together, this work establishes SGEF as a RhoG exchange factor and provides evidence that both SGEF and RhoG regulate membrane dynamics in promotion of macropinocytosis...
  7. ncbi request reprint Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration
    Joshua C Sandquist
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:35873-83. 2006
    ..Our data suggest that the myosin IIA and IIB isoforms are regulated by different signaling pathways to perform distinct cellular activities and that myosin IIA is preferentially required for Rho-mediated contractile functions...