Research Topics
Genomes and Genes
| Eric DelwartSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Animal virus discovery: improving animal health, understanding zoonoses, and opportunities for vaccine developmentEric Delwart
Blood Systems Research Institute and University of California, San Francisco, United States
Curr Opin Virol 2:344-52. 2012..Numerous opportunities for the generation of novel vaccines will arise from a better understanding of animal viromes...- Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donorsEric Delwart
Blood Systems Research Institute, San Francisco, CA, USA
J Infect Dis 205:875-85. 2012..Recent changes in prevalence of subtypes/genotypes and drug/immune-escape variants were characterized by comparing recently infected vs more remotely infected blood donors... - Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomesEric Delwart
Blood Systems Research Institute, San Francisco, CA, USA
Virus Res 164:114-21. 2012..Future studies of the virome of single cell and multi-cellular eukaryotes are likely to further extend the known diversity and host-range of small rep-containing circular ssDNA viral genomes... - Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patientsAmit Kapoor
Blood Systems Research Institute, San Francisco, CA 94118, USA
Retrovirology 5:7. 2008.... - Temporal changes in HCV genotype distribution in three different high risk populations in San Francisco, CaliforniaPaulo Telles Dias
Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas NEPAD Universidade do Estado do Rio de Janeiro State University of Rio de Janeiro, 20940 200 Rio de Janeiro, RJ, Brasil
BMC Infect Dis 11:208. 2011..In the United States (U.S.) HCV GT 1 is reported as the most common infecting GT among chronically infected patients. In Europe, however, recent studies have suggested that the epidemiology of HCV GTs is changing... - Absence of reproducibly detectable low-level HIV viremia in highly exposed seronegative men and womenEric Delwart
Blood Systems Research Institute, University of California, San Francisco, USA
AIDS 25:619-23. 2011..We tested for very low levels of HIV RNA in 524 seronegative plasma samples from 311 highly exposed women and men from three longitudinal HIV cohorts... 
Viral metagenomicsEric L Delwart
Blood Systems Research Institute, University of California, San Francisco, CA 94118, USA
Rev Med Virol 17:115-31. 2007..Viral metagenomic approaches provide novel opportunities to generate an unbiased characterisation of the viral populations in various organisms and environments...- Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strainsEric L Delwart
Blood Systems Research Institute, San Francisco 94118, California, USA
AIDS Res Hum Retroviruses 19:1065-70. 2003..The frequency of genetically confirmed non-subtype-B HIV infection in a geographically dispersed group of infected U.S. blood donors in 1977-2000 was therefore 2.0% (6/312)... - A highly prevalent and genetically diversified Picornaviridae genus in South Asian childrenAmit Kapoor
Blood Systems Research Institute, San Francisco CA 94118, USA
Proc Natl Acad Sci U S A 105:20482-7. 2008.... - A newly identified bocavirus species in human stoolAmit Kapoor
Blood Systems Research Institute and Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
J Infect Dis 199:196-200. 2009..Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease... - Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian virusesLinlin Li
Blood Systems Research Institute 270 Masonic Ave, San Francisco, CA 94118, USA
J Virol 84:6955-65. 2010..Viral metagenomics is a useful tool for genetically characterizing viruses present in animals with the known capability of direct or indirect viral zoonosis to humans... - Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infectionsAmit Kapoor
Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, 270 Masonic Ave, San Francisco, CA 94118, USA
J Infect Dis 201:1633-43. 2010..Elucidating the possible role of the newly identified enteric bocaviruses in human diseases, including acute flaccid paralysis and diarrhea, will require further epidemiological studies... - Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee fecesLinlin Li
Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
J Virol 84:1674-82. 2010..Determining the role of cycloviruses, found in 7 to 17% of non-U.S. human stools and 3 to 55% of non-U.S. meat samples tested, in both human and animal diseases is now facilitated by knowledge of their genomes... - High levels of subgenomic HCV plasma RNA in immunosilent infectionsFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 365:446-56. 2007..The absence of immunological pressure and a high viral load may therefore promote the emergence of truncated HCV subgenomic replicons in vivo... 
Clearance of hepatitis C virus RNA from the peripheral blood mononuclear cells of blood donors who spontaneously or therapeutically control their plasma viremiaFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
Hepatology 47:1446-52. 2008..CONCLUSION: Our results indicate that PBMC are unlikely to serve as a long-lived reservoir of HCV in aviremic subjects...- Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysisJoseph G Victoria
Blood Systems Research Institute, San Francisco, California 94118, USA
J Virol 83:4642-51. 2009.... - Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: implications for blood safety, diagnostics, treatment, and molecular epidemiologyEric Delwart
Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA
J Med Virol 78:S30-5. 2006..A systematic program is proposed for the genetic characterization of viral genomes in donors with incident HIV, HCV, or HBV infections... - High variety of known and new RNA and DNA viruses of diverse origins in untreated sewageTerry Fei Fan Ng
Blood Systems Research Institute, San Francisco, California, USA
J Virol 86:12161-75. 2012.... - Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genusTung G Phan
Blood Systems Research Institute, San Francisco, California, USA
J Virol 86:11024-30. 2012..Studies of the tropism and pathogenicity of these novel parvoviruses will be facilitated by the availability of their genome sequences... - Possible cross-species transmission of circoviruses and cycloviruses among farm animalsLinlin Li
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Gen Virol 92:768-72. 2011..Further studies will be required to determine the impact of these highly prevalent infections on the health of farm animals... - The fecal virome of pigs on a high-density farmTongling Shan
BSRI, 270 Masonic Ave, San Francisco, CA 94118, USA
J Virol 85:11697-708. 2011..Viral surveys of animals can readily document the circulation of known and new viruses, facilitating the detection of emerging viruses and prospective evaluation of their pathogenic and zoonotic potentials... - Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypesBeatrix Kapusinszky
Blood Systems Research Institute, San Francisco, California, United States of America
PLoS ONE 7:e36685. 2012..The detection of a large number of HCoSV genotypes based on still limited geographic sampling indicates that the phenotypic effects of cosaviruses on infected subjects are likely to be as highly diverse as those of human enteroviruses... - A third gyrovirus species in human faecesTung G Phan
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Gen Virol 93:1356-61. 2012..Whether GyV3 can infect humans and/or chickens requires further studies... - Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfectionKimberly Page
Department of Epidemiology and Biostatistics, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
J Infect Dis 200:1216-26. 2009..Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most infections... - Discovery of a novel polyomavirus in acute diarrheal samples from childrenGuixia Yu
Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA
PLoS ONE 7:e49449. 2012..Further studies will be important to determine the association, if any, of MXPyV with disease in humans... - Frequent longitudinal sampling of hepatitis C virus infection in injection drug users reveals intermittently detectable viremia and reinfectionKimberly Page
University of California, San Francisco, San Francisco, CA 94105, USA
Clin Infect Dis 56:405-13. 2013..Detection of hepatitis C virus (HCV) reinfection and intercalation (ie, intermittent recurrent bouts of viremia with homologous virus interspersed with aviremic periods) requires extensive and frequent evaluation and viral sequencing... - New DNA viruses identified in patients with acute viral infection syndromeMorris S Jones
Blood Systems Research Institute, 270 Masonic Ave, San Francisco, California 94118, USA
J Virol 79:8230-6. 2005.... - Viruses in diarrhoeic dogs include novel kobuviruses and sapovirusesLinlin Li
Blood Systems Research Institute, San Francisco, CA, USA
J Gen Virol 92:2534-41. 2011..These results highlight the high frequency of new virus detection possible even in extensively studied animal species using metagenomics approaches, and provide viral genomes for further disease-association studies... - Genomic characterization of novel human parechovirus typeLinlin Li
Blood Systems Research Institute, San Francisco, California, USA
Emerg Infect Dis 15:288-91. 2009..Genomic characterization showed this virus was distinct enough from reported HPeV types to qualify as candidate prototype for the seventh HPeV type... - Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infectionEric Delwart
Blood Centers of the Pacific, San Francisco, California, USA
AIDS 16:189-95. 2002..Evidence for the transmission of multiple variants was detected in only one out of four women and none of 13 men undergoing primary infection with subtype B HIV-1... - The fecal viral flora of California sea lionsLinlin Li
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Virol 85:9909-17. 2011.... - Identification of a novel human gammapapillomavirus speciesLinlin Li
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Gen Virol 90:2413-7. 2009.... - Phylogenetic analysis of WNV in North American blood donors during the 2003-2004 epidemic seasonsBelinda L Herring
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 363:220-8. 2007..Amino acid mutations associated with newly expanding genetic variants reflect either selectively neutral mutational drift and/or mutations providing replicative advantages over the previously dominant forms of WNV... - Intermittent low-level viremia in very early primary HIV-1 infectionEberhard W Fiebig
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA
J Acquir Immune Defic Syndr 39:133-7. 2005..It is not known if blood is infectious during this period; however, given the low viral concentrations and transient nature of the observed viremic "blips," the risk of infectivity can be assumed to be small... - Nearly constant shedding of diverse enteric viruses by two healthy infantsBeatrix Kapusinszky
Blood Systems Research Institute, San Francisco, California, USA
J Clin Microbiol 50:3427-34. 2012..Two British siblings in the mid-1980s showed nearly constant fecal viral shedding. Our results demonstrate that frequent enteric infections with diverse viruses occur during early childhood in the absence of severe clinical symptoms... - Novel amdovirus in gray foxesLinlin Li
Blood Systems Research Institute, San Francisco, California, USA
Emerg Infect Dis 17:1876-8. 2011.... - Transfusion transmission of highly prevalent commensal human virusesFlavien Bernardin
Blood Systems Research Institute and the Department of Medicine, University of California, San Francisco, California 94118, USA
Transfusion 50:2474-83. 2010.... - Human immunodeficiency virus mutations during the first month of infection are preferentially found in known cytotoxic T-lymphocyte epitopesFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Virol 79:11523-8. 2005..5%) were found within previously reported CTL epitopes. A virus sequencing and reported CTL epitopes database analysis therefore support a model where a significant proportion of very early nonsynonymous HIV mutations are selected by CTL... - Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individualsHiroyu Hatano
Department of Medicine, University of California, San Francisco, California, USA
AIDS 24:2535-9. 2010..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear... - Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virusJoseph G Victoria
Blood Systems Research Institute, San Francisco, California 94118, USA
J Virol 84:6033-40. 2010..Deep sequencing and microarrays can therefore detect attenuated virus sequence changes, minority variants, and adventitious viruses and help maintain the current safety record of live-attenuated viral vaccines... - Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyHiroyu Hatano
San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Virol 83:329-35. 2009..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy... - Primary infection of a male plasma donor with divergent HIV variants from the same source followed by rapid fluctuations in their relative frequency and viral recombinationFlavien Bernardin
Department of Medicine, University of California, San Francisco, California 94118, USA
AIDS Res Hum Retroviruses 19:1009-15. 2003..The very rapid fluctuations of HIV-1 variant frequencies and their recombination during primary infection may reflect changes in their relative fitness in the face of developing immunological responses... - A novel bocavirus in canine liverLinlin Li
Blood Systems Research Institute, San Francisco, CA, USA
Virol J 10:54. 2013..Two species have been previously reported in dogs, minute virus of canines (MVC), associated with neonatal diseases and fertility disorders; and Canine bocavirus (CBoV), associated with respiratory disease... - From orphan virus to pathogen: the path to the clinical labLinlin Li
Blood Systems Research Institute, San Francisco, CA, USA
Curr Opin Virol 1:282-8. 2011..Current limitations on the practical use of deep sequencing for viral diagnostics are listed... - Use of the sensitive/less-sensitive (detuned) EIA strategy for targeting genetic analysis of HIV-1 to recently infected blood donorsDaisy M Machado
Blood Centers of the Pacific, San Francisco, California 94118, USA
AIDS 16:113-9. 2002.... - Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assayAmit Kapoor
Department of Medicine, University of California, San Francisco, 94118, USA
J Virol 78:7112-23. 2004..The enhanced detection of minority drug resistance variants using a sequencing-based assay may improve the efficacy of genotype-assisted salvage therapies... - Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United StatesFlorante N Dela Cruz
University of California, Davis, Davis, CA 95616, USA
Emerg Infect Dis 19:77-84. 2013..The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons... - Human immunodeficiency virus type 1 superinfection was not detected following 215 years of injection drug user exposureRose Tsui
Blood Systems Research Institute, University of California, San Francisco, San Francisco, California, USA
J Virol 78:94-103. 2004..00, 0.79; P = 0.02), indicating that existing infection conferred a statistically significant level of protection against superinfection with an HIV-1 strain of the same subtype, which was between 21 and 100%... - Wide range of quasispecies diversity during primary hepatitis C virus infectionBelinda L Herring
Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
J Virol 79:4340-6. 2005..Community-acquired HCV infection, predominantly the result of needle sharing by injection drug users, therefore appears to be frequently initiated by the successful transmission of multiple viral variants... - Novel human gammapapillomavirus species in a nasal swabTung Gia Phan
Blood Systems Research Institute, San Francisco, California, USA
Genome Announc 1:e0002213. 2013..The L1 gene of HPV-Fin864 shared <70% nucleotide identity to other reported γ-HPV genomes, provisionally qualifying it as a new species in the Gammapapillomavirus genus... - Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysisFlavien Bernardin
Department of Medicine, University of California, San Francisco, CA 94118, USA
J Immunol Methods 274:159-75. 2003.... - A novel picornavirus associated with gastroenteritisLinlin Li
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Virol 83:12002-6. 2009.... - Novel circular DNA viruses in stool samples of wild-living chimpanzeesOlga Blinkova
Blood Systems Research Institute, San Francisco and the Department of Laboratory Medicine, University of California, San Francisco, CA, USA
J Gen Virol 91:74-86. 2010..Further metagenomic studies of animal samples will greatly increase our knowledge of viral diversity and evolution... - Cardioviruses are genetically diverse and cause common enteric infections in South Asian childrenOlga Blinkova
Blood Systems Research Institute, San Francisco, California 94118, USA
J Virol 83:4631-41. 2009..Further studies are needed to examine the roles of these highly common and diverse SAFV genotypes in nonpolio AFP and other human diseases... - Rapid identification of known and new RNA viruses from animal tissuesJoseph G Victoria
Department of Molecular Virology, Blood Systems Research Institute, San Francisco, California, USA
PLoS Pathog 4:e1000163. 2008..We demonstrate that a simple, inexpensive, and rapid metagenomics approach is effective for identifying known and highly divergent new viruses in homogenized tissues of acutely infected mice... - Number of CD4+ and CD8+ T-cell CDR3 clonotypes expanding during acute infection of macaques with simian immunodeficiency virusFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 322:105-17. 2004..The lack of correlation between the number of expanding T-cell clonotypes and viremia levels may reflect the highly variable selection pressure imposed on SIV by T-cell responses targeting different epitopes in outbred macaques... - Frequent hepatitis C virus superinfection in injection drug usersBelinda L Herring
Blood Systems Research Institute, University of California, San Francisco, Califronia, USA
J Infect Dis 190:1396-403. 2004..These results suggest that no cross-protecting immunity develops during the first year of chronic infection with HCV... - Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionBrandon F Keele
Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35223, USA
Proc Natl Acad Sci U S A 105:7552-7. 2008.... - Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfectionJonathan B Angel
Ottawa Health Research Institute and The Ottawa Hospital, University of Ottawa, Ottawa, Canada
AIDS 18:331-4. 2004..Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown...
Research Grants
- Metagenomic analysis of the human viromeEric Delwart; Fiscal Year: 2007..This metagenomic survey of non-human nucleic acids in humans will therefore begin the task of determining the full range of viral diversity in humans. ..
- Metagenomic analysis of the human viromeEric L Delwart; Fiscal Year: 2010..This metagenomic survey of non-human nucleic acids in humans will therefore begin the task of determining the full range of viral diversity in humans. ..