Eric Delwart

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Novel amdovirus in gray foxes
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    Emerg Infect Dis 17:1876-8. 2011
  2. pmc The viruses of wild pigeon droppings
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, California, United States of America Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e72787. 2013
  3. pmc Genomic characterization of novel human parechovirus type
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    Emerg Infect Dis 15:288-91. 2009
  4. pmc Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypes
    Beatrix Kapusinszky
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS ONE 7:e36685. 2012
  5. pmc Novel human gammapapillomavirus species in a nasal swab
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, California, USA
    Genome Announc 1:e0002213. 2013
  6. pmc The fecal viral flora of wild rodents
    Tung G Phan
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS Pathog 7:e1002218. 2011
  7. pmc Animal virus discovery: improving animal health, understanding zoonoses, and opportunities for vaccine development
    Eric Delwart
    Blood Systems Research Institute and University of California, San Francisco, United States
    Curr Opin Virol 2:344-52. 2012
  8. pmc Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donors
    Eric Delwart
    Blood Systems Research Institute, San Francisco, CA, USA
    J Infect Dis 205:875-85. 2012
  9. pmc Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes
    Eric Delwart
    Blood Systems Research Institute, San Francisco, CA, USA
    Virus Res 164:114-21. 2012
  10. pmc Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients
    Amit Kapoor
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Retrovirology 5:7. 2008

Research Grants

  1. Metagenomic analysis of the human virome
    Eric Delwart; Fiscal Year: 2009
  2. Metagenomic analysis of the human virome
    Eric Delwart; Fiscal Year: 2007
  3. Metagenomic analysis of the human virome
    Eric L Delwart; Fiscal Year: 2010

Detail Information

Publications73

  1. pmc Novel amdovirus in gray foxes
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    Emerg Infect Dis 17:1876-8. 2011
    ....
  2. pmc The viruses of wild pigeon droppings
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, California, United States of America Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e72787. 2013
    ..This study provides an initial assessment of the enteric virome in the droppings of pigeons, a feral urban species with frequent human contact. ..
  3. pmc Genomic characterization of novel human parechovirus type
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    Emerg Infect Dis 15:288-91. 2009
    ..Genomic characterization showed this virus was distinct enough from reported HPeV types to qualify as candidate prototype for the seventh HPeV type...
  4. pmc Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypes
    Beatrix Kapusinszky
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS ONE 7:e36685. 2012
    ..The detection of a large number of HCoSV genotypes based on still limited geographic sampling indicates that the phenotypic effects of cosaviruses on infected subjects are likely to be as highly diverse as those of human enteroviruses...
  5. pmc Novel human gammapapillomavirus species in a nasal swab
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, California, USA
    Genome Announc 1:e0002213. 2013
    ..The L1 gene of HPV-Fin864 shared <70% nucleotide identity to other reported γ-HPV genomes, provisionally qualifying it as a new species in the Gammapapillomavirus genus...
  6. pmc The fecal viral flora of wild rodents
    Tung G Phan
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS Pathog 7:e1002218. 2011
    ..This study increases our understanding of the viral diversity in wild rodents and highlights the large number of still uncharacterized viruses in mammals...
  7. pmc Animal virus discovery: improving animal health, understanding zoonoses, and opportunities for vaccine development
    Eric Delwart
    Blood Systems Research Institute and University of California, San Francisco, United States
    Curr Opin Virol 2:344-52. 2012
    ..Numerous opportunities for the generation of novel vaccines will arise from a better understanding of animal viromes...
  8. pmc Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donors
    Eric Delwart
    Blood Systems Research Institute, San Francisco, CA, USA
    J Infect Dis 205:875-85. 2012
    ..Recent changes in prevalence of subtypes/genotypes and drug/immune-escape variants were characterized by comparing recently infected vs more remotely infected blood donors...
  9. pmc Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes
    Eric Delwart
    Blood Systems Research Institute, San Francisco, CA, USA
    Virus Res 164:114-21. 2012
    ..Future studies of the virome of single cell and multi-cellular eukaryotes are likely to further extend the known diversity and host-range of small rep-containing circular ssDNA viral genomes...
  10. pmc Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients
    Amit Kapoor
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Retrovirology 5:7. 2008
    ....
  11. pmc Temporal changes in HCV genotype distribution in three different high risk populations in San Francisco, California
    Paulo Telles Dias
    Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas NEPAD Universidade do Estado do Rio de Janeiro State University of Rio de Janeiro, 20940 200 Rio de Janeiro, RJ, Brasil
    BMC Infect Dis 11:208. 2011
    ..In the United States (U.S.) HCV GT 1 is reported as the most common infecting GT among chronically infected patients. In Europe, however, recent studies have suggested that the epidemiology of HCV GTs is changing...
  12. ncbi request reprint Viral metagenomics
    Eric L Delwart
    Blood Systems Research Institute, University of California, San Francisco, CA 94118, USA
    Rev Med Virol 17:115-31. 2007
    ..Viral metagenomic approaches provide novel opportunities to generate an unbiased characterisation of the viral populations in various organisms and environments...
  13. ncbi request reprint Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strains
    Eric L Delwart
    Blood Systems Research Institute, San Francisco 94118, California, USA
    AIDS Res Hum Retroviruses 19:1065-70. 2003
    ..The frequency of genetically confirmed non-subtype-B HIV infection in a geographically dispersed group of infected U.S. blood donors in 1977-2000 was therefore 2.0% (6/312)...
  14. pmc Absence of reproducibly detectable low-level HIV viremia in highly exposed seronegative men and women
    Eric Delwart
    Blood Systems Research Institute, University of California, San Francisco, USA
    AIDS 25:619-23. 2011
    ..We tested for very low levels of HIV RNA in 524 seronegative plasma samples from 311 highly exposed women and men from three longitudinal HIV cohorts...
  15. pmc A highly prevalent and genetically diversified Picornaviridae genus in South Asian children
    Amit Kapoor
    Blood Systems Research Institute, San Francisco CA 94118, USA
    Proc Natl Acad Sci U S A 105:20482-7. 2008
    ....
  16. pmc A newly identified bocavirus species in human stool
    Amit Kapoor
    Blood Systems Research Institute and Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
    J Infect Dis 199:196-200. 2009
    ..Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease...
  17. pmc Circovirus in tissues of dogs with vasculitis and hemorrhage
    Linlin Li
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA
    Emerg Infect Dis 19:534-41. 2013
    ..Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs...
  18. pmc Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses
    Linlin Li
    Blood Systems Research Institute 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 84:6955-65. 2010
    ..Viral metagenomics is a useful tool for genetically characterizing viruses present in animals with the known capability of direct or indirect viral zoonosis to humans...
  19. pmc Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections
    Amit Kapoor
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Infect Dis 201:1633-43. 2010
    ..Elucidating the possible role of the newly identified enteric bocaviruses in human diseases, including acute flaccid paralysis and diarrhea, will require further epidemiological studies...
  20. pmc Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis
    Joseph G Victoria
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Virol 83:4642-51. 2009
    ....
  21. pmc A novel bocavirus in canine liver
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA, USA
    Virol J 10:54. 2013
    ..Two species have been previously reported in dogs, minute virus of canines (MVC), associated with neonatal diseases and fertility disorders; and Canine bocavirus (CBoV), associated with respiratory disease...
  22. pmc Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces
    Linlin Li
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 84:1674-82. 2010
    ..Determining the role of cycloviruses, found in 7 to 17% of non-U.S. human stools and 3 to 55% of non-U.S. meat samples tested, in both human and animal diseases is now facilitated by knowledge of their genomes...
  23. pmc High levels of subgenomic HCV plasma RNA in immunosilent infections
    Flavien Bernardin
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 365:446-56. 2007
    ..The absence of immunological pressure and a high viral load may therefore promote the emergence of truncated HCV subgenomic replicons in vivo...
  24. doi request reprint Clearance of hepatitis C virus RNA from the peripheral blood mononuclear cells of blood donors who spontaneously or therapeutically control their plasma viremia
    Flavien Bernardin
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Hepatology 47:1446-52. 2008
    ..The absence of detectable PBMC HCV RNA detection in all 69 aviremic donors reported here contrasts with prior studies, possibly as a result of the higher sensitivity of the TMA assay used to test for plasma viremia...
  25. ncbi request reprint Rosavirus: the prototype of a proposed new genus of the Picornaviridae family
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, CA, 94118, USA
    Virus Genes 47:556-8. 2013
    ..Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family. ..
  26. pmc A third gyrovirus species in human faeces
    Tung G Phan
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Gen Virol 93:1356-61. 2012
    ..Whether GyV3 can infect humans and/or chickens requires further studies...
  27. pmc Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus
    Tung G Phan
    Blood Systems Research Institute, San Francisco, California, USA
    J Virol 86:11024-30. 2012
    ..Studies of the tropism and pathogenicity of these novel parvoviruses will be facilitated by the availability of their genome sequences...
  28. pmc Frequent longitudinal sampling of hepatitis C virus infection in injection drug users reveals intermittently detectable viremia and reinfection
    Kimberly Page
    University of California, San Francisco, San Francisco, CA 94105, USA
    Clin Infect Dis 56:405-13. 2013
    ..Detection of hepatitis C virus (HCV) reinfection and intercalation (ie, intermittent recurrent bouts of viremia with homologous virus interspersed with aviremic periods) requires extensive and frequent evaluation and viral sequencing...
  29. ncbi request reprint Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: implications for blood safety, diagnostics, treatment, and molecular epidemiology
    Eric Delwart
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA
    J Med Virol 78:S30-5. 2006
    ..A systematic program is proposed for the genetic characterization of viral genomes in donors with incident HIV, HCV, or HBV infections...
  30. pmc Feline fecal virome reveals novel and prevalent enteric viruses
    Terry Fei Fan Ng
    Blood Systems Research Institute, San Francisco, San Francisco, CA, USA Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA
    Vet Microbiol 171:102-11. 2014
    ..Availability of the genome sequences of these viruses will facilitate future tropism and feline disease association studies. ..
  31. pmc AIDS alters the commensal plasma virome
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    J Virol 87:10912-5. 2013
    ..The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses. ..
  32. pmc New DNA viruses identified in patients with acute viral infection syndrome
    Morris S Jones
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, California 94118, USA
    J Virol 79:8230-6. 2005
    ....
  33. pmc Possible cross-species transmission of circoviruses and cycloviruses among farm animals
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Gen Virol 92:768-72. 2011
    ..Further studies will be required to determine the impact of these highly prevalent infections on the health of farm animals...
  34. pmc High variety of known and new RNA and DNA viruses of diverse origins in untreated sewage
    Terry Fei Fan Ng
    Blood Systems Research Institute, San Francisco, California, USA
    J Virol 86:12161-75. 2012
    ....
  35. pmc The fecal virome of pigs on a high-density farm
    Tongling Shan
    BSRI, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 85:11697-708. 2011
    ..Viral surveys of animals can readily document the circulation of known and new viruses, facilitating the detection of emerging viruses and prospective evaluation of their pathogenic and zoonotic potentials...
  36. pmc Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection
    Kimberly Page
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
    J Infect Dis 200:1216-26. 2009
    ..Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most infections...
  37. pmc Cyclovirus in nasopharyngeal aspirates of Chilean children with respiratory infections
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Gen Virol 95:922-7. 2014
    ..This report increases the current knowledge of the genetic diversity of cycloviruses whose detection in multiple NPAs may reflect a tropism for human respiratory tissues. ..
  38. pmc Viruses in diarrhoeic dogs include novel kobuviruses and sapoviruses
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA, USA
    J Gen Virol 92:2534-41. 2011
    ..These results highlight the high frequency of new virus detection possible even in extensively studied animal species using metagenomics approaches, and provide viral genomes for further disease-association studies...
  39. pmc Divergent astrovirus associated with neurologic disease in cattle
    Linlin Li
    Blood Systems Research Institute, San Francisco, California, USA
    Emerg Infect Dis 19:1385-92. 2013
    ..These results suggest that infection with BoAstV-NeuroS1 is a potential cause of neurologic disease in cattle. ..
  40. pmc Divergent gyroviruses in the feces of Tunisian children
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, CA 94118, USA Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA
    Virology 446:346-8. 2013
    ..Previous reports of gyrovirus DNA in human blood and on human skins warrant studies of possible human tropisms for these newly characterized gyroviruses. ..
  41. pmc Discovery of a novel polyomavirus in acute diarrheal samples from children
    Guixia Yu
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e49449. 2012
    ..Further studies will be important to determine the association, if any, of MXPyV with disease in humans...
  42. pmc The fecal viral flora of California sea lions
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 85:9909-17. 2011
    ....
  43. pmc Identification of a novel human gammapapillomavirus species
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Gen Virol 90:2413-7. 2009
    ....
  44. ncbi request reprint Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection
    Eric Delwart
    Blood Centers of the Pacific, San Francisco, California, USA
    AIDS 16:189-95. 2002
    ..To measure HIV-1 quasispecies diversity in very recently infected male and female plasma donors...
  45. ncbi request reprint Phylogenetic analysis of WNV in North American blood donors during the 2003-2004 epidemic seasons
    Belinda L Herring
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 363:220-8. 2007
    ..Amino acid mutations associated with newly expanding genetic variants reflect either selectively neutral mutational drift and/or mutations providing replicative advantages over the previously dominant forms of WNV...
  46. ncbi request reprint Intermittent low-level viremia in very early primary HIV-1 infection
    Eberhard W Fiebig
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 39:133-7. 2005
    ..It is not known if blood is infectious during this period; however, given the low viral concentrations and transient nature of the observed viremic "blips," the risk of infectivity can be assumed to be small...
  47. ncbi request reprint Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysis
    Flavien Bernardin
    Department of Medicine, University of California, San Francisco, CA 94118, USA
    J Immunol Methods 274:159-75. 2003
    ....
  48. pmc Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United States
    Florante N Dela Cruz
    University of California, Davis, Davis, CA 95616, USA
    Emerg Infect Dis 19:77-84. 2013
    ..The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons...
  49. pmc Nearly constant shedding of diverse enteric viruses by two healthy infants
    Beatrix Kapusinszky
    Blood Systems Research Institute, San Francisco, California, USA
    J Clin Microbiol 50:3427-34. 2012
    ..Two British siblings in the mid-1980s showed nearly constant fecal viral shedding. Our results demonstrate that frequent enteric infections with diverse viruses occur during early childhood in the absence of severe clinical symptoms...
  50. pmc Human immunodeficiency virus mutations during the first month of infection are preferentially found in known cytotoxic T-lymphocyte epitopes
    Flavien Bernardin
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 79:11523-8. 2005
    ..5%) were found within previously reported CTL epitopes. A virus sequencing and reported CTL epitopes database analysis therefore support a model where a significant proportion of very early nonsynonymous HIV mutations are selected by CTL...
  51. doi request reprint Transfusion transmission of highly prevalent commensal human viruses
    Flavien Bernardin
    Blood Systems Research Institute and the Department of Medicine, University of California, San Francisco, California 94118, USA
    Transfusion 50:2474-83. 2010
    ....
  52. pmc Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus
    Joseph G Victoria
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Virol 84:6033-40. 2010
    ..Deep sequencing and microarrays can therefore detect attenuated virus sequence changes, minority variants, and adventitious viruses and help maintain the current safety record of live-attenuated viral vaccines...
  53. pmc Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals
    Hiroyu Hatano
    Department of Medicine, University of California, San Francisco, California, USA
    AIDS 24:2535-9. 2010
    ..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear...
  54. ncbi request reprint Primary infection of a male plasma donor with divergent HIV variants from the same source followed by rapid fluctuations in their relative frequency and viral recombination
    Flavien Bernardin
    Department of Medicine, University of California, San Francisco, California 94118, USA
    AIDS Res Hum Retroviruses 19:1009-15. 2003
    ..The very rapid fluctuations of HIV-1 variant frequencies and their recombination during primary infection may reflect changes in their relative fitness in the face of developing immunological responses...
  55. pmc Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    Hiroyu Hatano
    San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 83:329-35. 2009
    ..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
  56. pmc Identification of an astrovirus commonly infecting laboratory mice in the US and Japan
    Terry Fei Fan Ng
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS ONE 8:e66937. 2013
    ..This study demonstrates the need for metagenomic screening of laboratory animals to identify adventitious infections that may affect experimental outcomes. ..
  57. pmc From orphan virus to pathogen: the path to the clinical lab
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA, USA
    Curr Opin Virol 1:282-8. 2011
    ..Current limitations on the practical use of deep sequencing for viral diagnostics are listed...
  58. pmc Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assay
    Amit Kapoor
    Department of Medicine, University of California, San Francisco, 94118, USA
    J Virol 78:7112-23. 2004
    ..The enhanced detection of minority drug resistance variants using a sequencing-based assay may improve the efficacy of genotype-assisted salvage therapies...
  59. ncbi request reprint Use of the sensitive/less-sensitive (detuned) EIA strategy for targeting genetic analysis of HIV-1 to recently infected blood donors
    Daisy M Machado
    Blood Centers of the Pacific, San Francisco, California 94118, USA
    AIDS 16:113-9. 2002
    ....
  60. pmc New astrovirus in human feces from Burkina Faso
    Tung Gia Phan
    Blood Systems Research Institute, San Francisco, CA 94118, USA Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA
    J Clin Virol 60:161-4. 2014
    ..A significant fraction of cases of diarrhea, a leading cause of childhood mortality worldwide, remain unexplained...
  61. pmc Wide range of quasispecies diversity during primary hepatitis C virus infection
    Belinda L Herring
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 79:4340-6. 2005
    ..Community-acquired HCV infection, predominantly the result of needle sharing by injection drug users, therefore appears to be frequently initiated by the successful transmission of multiple viral variants...
  62. pmc Human immunodeficiency virus type 1 superinfection was not detected following 215 years of injection drug user exposure
    Rose Tsui
    Blood Systems Research Institute, University of California, San Francisco, San Francisco, California, USA
    J Virol 78:94-103. 2004
    ..00, 0.79; P = 0.02), indicating that existing infection conferred a statistically significant level of protection against superinfection with an HIV-1 strain of the same subtype, which was between 21 and 100%...
  63. pmc Structure-based search reveals hammerhead ribozymes in the human microbiome
    Randi M Jimenez
    Department of Pharmaceutical Sciences, University of California, Irvine, California 92697, USA
    J Biol Chem 286:7737-43. 2011
    ..We demonstrate that a structure-based search for a known functional RNA is a powerful tool for analysis of metagenomic datasets, complementing sequence alignments...
  64. pmc Rapid identification of known and new RNA viruses from animal tissues
    Joseph G Victoria
    Department of Molecular Virology, Blood Systems Research Institute, San Francisco, California, USA
    PLoS Pathog 4:e1000163. 2008
    ..We demonstrate that a simple, inexpensive, and rapid metagenomics approach is effective for identifying known and highly divergent new viruses in homogenized tissues of acutely infected mice...
  65. pmc Cardioviruses are genetically diverse and cause common enteric infections in South Asian children
    Olga Blinkova
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Virol 83:4631-41. 2009
    ..Further studies are needed to examine the roles of these highly common and diverse SAFV genotypes in nonpolio AFP and other human diseases...
  66. pmc A novel picornavirus associated with gastroenteritis
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 83:12002-6. 2009
    ....
  67. pmc Novel circular DNA viruses in stool samples of wild-living chimpanzees
    Olga Blinkova
    Blood Systems Research Institute, San Francisco and the Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    J Gen Virol 91:74-86. 2010
    ..Further metagenomic studies of animal samples will greatly increase our knowledge of viral diversity and evolution...
  68. ncbi request reprint Number of CD4+ and CD8+ T-cell CDR3 clonotypes expanding during acute infection of macaques with simian immunodeficiency virus
    Flavien Bernardin
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 322:105-17. 2004
    ..The lack of correlation between the number of expanding T-cell clonotypes and viremia levels may reflect the highly variable selection pressure imposed on SIV by T-cell responses targeting different epitopes in outbred macaques...
  69. ncbi request reprint Frequent hepatitis C virus superinfection in injection drug users
    Belinda L Herring
    Blood Systems Research Institute, University of California, San Francisco, Califronia, USA
    J Infect Dis 190:1396-403. 2004
    ..These results suggest that no cross-protecting immunity develops during the first year of chronic infection with HCV...
  70. pmc Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    Brandon F Keele
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35223, USA
    Proc Natl Acad Sci U S A 105:7552-7. 2008
    ....
  71. ncbi request reprint Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection
    Jonathan B Angel
    Ottawa Health Research Institute and The Ottawa Hospital, University of Ottawa, Ottawa, Canada
    AIDS 18:331-4. 2004
    ..Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown...

Research Grants10

  1. Metagenomic analysis of the human virome
    Eric Delwart; Fiscal Year: 2009
    ..This metagenomic survey of non-human nucleic acids in humans will therefore begin the task of determining the full range of viral diversity in humans. ..
  2. Metagenomic analysis of the human virome
    Eric Delwart; Fiscal Year: 2007
    ..This metagenomic survey of non-human nucleic acids in humans will therefore begin the task of determining the full range of viral diversity in humans. ..
  3. Metagenomic analysis of the human virome
    Eric L Delwart; Fiscal Year: 2010
    ..This metagenomic survey of non-human nucleic acids in humans will therefore begin the task of determining the full range of viral diversity in humans. ..