H F DeLuca

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. DeLuca H, Plum L. UVB radiation, vitamin D and multiple sclerosis. Photochem Photobiol Sci. 2017;16:411-415 pubmed publisher
    ..Clinical trials are underway to explore the possible use of this narrow band light as a treatment to stop the progression of MS, while biochemical studies are underway to evaluate the mechanism of action of the narrow band light. ..
  2. Wang Y, Borchert M, DeLuca H. Identification of the vitamin D receptor in various cells of the mouse kidney. Kidney Int. 2012;81:993-1001 pubmed publisher
    ..Thus, identification of VDR in the proximal tubule, macula densa, and podocytes suggests that 1,25(OH)(2)D(3) plays a direct role in these cells under normal conditions. ..
  3. DeLuca H. Is there more to learn about functional vitamin D metabolism?. J Steroid Biochem Mol Biol. 2015;148:3-6 pubmed publisher
    ..This article is part of a Special Issue entitled '17th Vitamin D Workshop'. ..
  4. Wang Y, Zhu J, DeLuca H. The vitamin D receptor in the proximal renal tubule is a key regulator of serum 1α,25-dihydroxyvitamin D₃. Am J Physiol Endocrinol Metab. 2015;308:E201-5 pubmed publisher
    ..Thus, VDR in the apical brush border of the proximal convoluted tubule cells serves to "sense" the level of circulating 1,25(OH)2D3 and modulates the activity of the 1α-hydroxylase and the 24-hydroxylase accordingly. ..
  5. Wang Y, Marling S, Beaver E, Severson K, DeLuca H. UV light selectively inhibits spinal cord inflammation and demyelination in experimental autoimmune encephalomyelitis. Arch Biochem Biophys. 2015;567:75-82 pubmed publisher
    ..From these measurements, we suggest that UVR suppression of EAE prevents the migration of inflammatory cells into the CNS by a focal inhibition of chemokine CCL-5 in the CNS and a systemic elevation of immunosuppressive IL-10. ..
  6. Irving A, Duchow E, Plum L, DeLuca H. Vitamin D deficiency in the ApcPirc/+ rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective. Dis Model Mech. 2018;11: pubmed publisher
    ..This article has an associated First Person interview with the first author of the paper. ..
  7. Sundersingh F, Plum L, DeLuca H. Vitamin D deficiency independent of hypocalcemia elevates blood pressure in rats. Biochem Biophys Res Commun. 2015;461:589-91 pubmed publisher
    ..Thus, vitamin D status is one of the determining factors regulating blood pressure. ..
  8. DeLuca H. Vitamin D: Historical Overview. Vitam Horm. 2016;100:1-20 pubmed publisher
    ..The resultant increase in serum calcium and phosphate supports bone mineralization, curing rickets, and osteomalacia. There are many other functions of vitamin D that remain to be described that contribute to its health supporting role. ..
  9. DeLuca H, Plum L. Analogs of 1α,25-Dihydroxyvitamin D₃ in Clinical Use. Vitam Horm. 2016;100:151-64 pubmed publisher
    ..Finally, successful analogs of 1α,25-dihydroxyvitamin D in use in the clinic worldwide are presented including properties that have contributed to their success. ..

More Information

Publications14

  1. Irving A, Marling S, Plum L, DeLuca H. Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid. BMC Neurosci. 2017;18:8 pubmed publisher
    ..Additional work is needed to investigate alternative mechanisms by which UVB suppresses disease. ..
  2. Wang Y, Marling S, Martino V, Prahl J, DeLuca H. The absence of 25-hydroxyvitamin D3-1?-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light. J Steroid Biochem Mol Biol. 2016;163:98-102 pubmed publisher
    ..Cytokine mRNA levels in the spinal cord correlated with clinical scores in both WT and KO mice. ..
  3. Szybinski M, Sektas K, Sicinski R, Plum L, Frelek J, DeLuca H. Design, synthesis and biological properties of seco-d-ring modified 1?,25-dihydroxyvitamin D3 analogues. J Steroid Biochem Mol Biol. 2017;171:144-154 pubmed publisher
    ..The synthesized D-seco vitamins, however, proved to be inactive on bone and intestine in vivo. ..
  4. Wang Y, Marling S, Plum L, DeLuca H. Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017;114:8528-8531 pubmed publisher
    ..Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease. ..
  5. Pandey R, Zella J, Zhu J, Plum L, Clagett Dame M, Blaser W, et al. Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1?,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis. Drugs R D. 2017;17:597-605 pubmed publisher
    ..These studies support further evaluation of DP001 in longer-term treatment of secondary hyperparathyroidism. ..