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Genomes and Genes | Sue E DelosSummaryAffiliation: University of Virginia Country: USA Publications
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A single glycosylation site within the receptor-binding domain of the avian sarcoma/leukosis virus glycoprotein is critical for receptor bindingSue E Delos
Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
Virology 294:354-63. 2002..This work has therefore identified a single N-linked glycosylation site in the SU domain of EnvA that is critical for binding between EnvA and its receptor, Tva...
Studies of the "chain reversal regions" of the avian sarcoma/leukosis virus (ASLV) and ebolavirus fusion proteins: analogous residues are important, and a His residue unique to EnvA affects the pH dependence of ASLV entrySue E Delos
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
J Virol 84:5687-94. 2010..We further found that a His residue that is unique to the chain reversal region of ASLV EnvA controls the pH at which ASLV entry occurs...- Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activationSue E Delos
Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
J Virol 79:3488-99. 2005..Low pH does not alter the off rate for the complex, further alter the secondary structure of SU-A, or induce measurable changes in tryptophan environment. The implications of these findings for fusion are discussed... - Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiencySue E Delos
Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
J Virol 82:3131-4. 2008..These findings indicate that the cysteines flanking the internal fusion peptide of EnvA (and perhaps by analogy Ebola virus glycoprotein) are important for the foldback stage of the conformational changes that lead to membrane merger... - Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entryDerek Dube
Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 107:16637-42. 2010..g., lymphocytes and macrophages)... - Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational changeMatthew Brecher
Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
J Virol 86:364-72. 2012..Our findings also indicate that low pH and an additional endosomal factor (possibly reduction or possibly a process mimicked by reduction) act as fusion triggers... - Receptor-activated binding of viral fusion proteins to target membranesLaurie J Earp
Department of Cell Biology, UVA Health System, School of Medicine, P.O. Box 800732, Charlottesville, Virginia 22908, USA
Methods Enzymol 372:428-40. 2003 - The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell bindingDerek Dube
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
J Virol 83:2883-91. 2009.... - Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complexChristina Ochsenbauer-Jambor
Department of Microbiology, School of Medicine, University of Alabama at Birmingham, 35294, USA
J Virol 76:7518-27. 2002..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope... - The single ligand-binding repeat of Tva, a low density lipoprotein receptor-related protein, contains two ligand-binding surfacesSusana Contreras-Alcantara
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908-0732, USA
J Biol Chem 281:22827-38. 2006..Furthermore, sTva could bind both RAP and SUA simultaneously. These results show that the single LBR of Tva has two ligand-binding sites, raising the possibility that other LBRs may also... - The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pHLaurie J Earp
Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Virol 77:3058-66. 2003..Possible roles for low pH at subsequent stages of viral entry are discussed... - Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common themeJudith M White
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
Crit Rev Biochem Mol Biol 43:189-219. 2008..Clearly, highly divergent proteins have converged on the same overall strategy to mediate fusion, an essential step in the life cycle of every enveloped virus... - Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsinsKathryn L Schornberg
Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
Proc Natl Acad Sci U S A 106:8003-8. 2009.... - Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2Sonia M Gregory
Center for Membrane Biology, University of Virginia, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 108:11211-6. 2011..We propose that these changes facilitate disruption of lipids at the site of virus-host cell membrane contact and, hence, initiate Ebov fusion... - Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infectionDerek Dube
Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
J Virol 82:7238-42. 2008..Furthermore, with 293F cells the acquisition of EboV RBD binding paralleled cell spreading and did not require new mRNA or protein synthesis...