Sue E Delos

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint A single glycosylation site within the receptor-binding domain of the avian sarcoma/leukosis virus glycoprotein is critical for receptor binding
    Sue E Delos
    Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
    Virology 294:354-63. 2002
  2. pmc Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 82:3131-4. 2008
  3. pmc Studies of the "chain reversal regions" of the avian sarcoma/leukosis virus (ASLV) and ebolavirus fusion proteins: analogous residues are important, and a His residue unique to EnvA affects the pH dependence of ASLV entry
    Sue E Delos
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 84:5687-94. 2010
  4. pmc Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 79:3488-99. 2005
  5. pmc Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry
    Derek Dube
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 107:16637-42. 2010
  6. pmc Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
    Matthew Brecher
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    J Virol 86:364-72. 2012
  7. ncbi request reprint Receptor-activated binding of viral fusion proteins to target membranes
    Laurie J Earp
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, Virginia 22908, USA
    Methods Enzymol 372:428-40. 2003
  8. pmc Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex
    Christina Ochsenbauer-Jambor
    Department of Microbiology, School of Medicine, University of Alabama at Birmingham, 35294, USA
    J Virol 76:7518-27. 2002
  9. pmc The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding
    Derek Dube
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    J Virol 83:2883-91. 2009
  10. ncbi request reprint The single ligand-binding repeat of Tva, a low density lipoprotein receptor-related protein, contains two ligand-binding surfaces
    Susana Contreras-Alcantara
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    J Biol Chem 281:22827-38. 2006

Collaborators

  • Judith White
  • Christopher Broder
  • Jens H Kuhn
  • Eric Hunter
  • Amy Bouton
  • PAUL F BATES
  • Kathryn L Schornberg
  • Derek Dube
  • Charles J Shoemaker
  • Laurie J Earp
  • Matthew Brecher
  • Sonia M Gregory
  • Tzanko S Stantchev
  • Susana Contreras-Alcantara
  • Christina Ochsenbauer-Jambor
  • Corinne Scully
  • Hassan Pajouhesh
  • Lisa M Johansen
  • Gene G Olinger
  • Erica Ollmann Saphire
  • Marnie L Fusco
  • Erisa Harada
  • Binyong Liang
  • Lukas K Tamm
  • Kathleen A Clouse
  • Sean C Rose
  • Matthew B Brecher
  • Michelle Y Abshire
  • Edward W Park
  • Matthew I Bonaparte
  • Jesse A Godby
  • Lorraine D Hernandez
  • Robert C Netter
  • Mary Ann Accavitti

Detail Information

Publications16

  1. ncbi request reprint A single glycosylation site within the receptor-binding domain of the avian sarcoma/leukosis virus glycoprotein is critical for receptor binding
    Sue E Delos
    Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
    Virology 294:354-63. 2002
    ..This work has therefore identified a single N-linked glycosylation site in the SU domain of EnvA that is critical for binding between EnvA and its receptor, Tva...
  2. pmc Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 82:3131-4. 2008
    ..These findings indicate that the cysteines flanking the internal fusion peptide of EnvA (and perhaps by analogy Ebola virus glycoprotein) are important for the foldback stage of the conformational changes that lead to membrane merger...
  3. pmc Studies of the "chain reversal regions" of the avian sarcoma/leukosis virus (ASLV) and ebolavirus fusion proteins: analogous residues are important, and a His residue unique to EnvA affects the pH dependence of ASLV entry
    Sue E Delos
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 84:5687-94. 2010
    ..We further found that a His residue that is unique to the chain reversal region of ASLV EnvA controls the pH at which ASLV entry occurs...
  4. pmc Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 79:3488-99. 2005
    ..Low pH does not alter the off rate for the complex, further alter the secondary structure of SU-A, or induce measurable changes in tryptophan environment. The implications of these findings for fusion are discussed...
  5. pmc Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry
    Derek Dube
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 107:16637-42. 2010
    ..g., lymphocytes and macrophages)...
  6. pmc Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
    Matthew Brecher
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    J Virol 86:364-72. 2012
    ..Our findings also indicate that low pH and an additional endosomal factor (possibly reduction or possibly a process mimicked by reduction) act as fusion triggers...
  7. ncbi request reprint Receptor-activated binding of viral fusion proteins to target membranes
    Laurie J Earp
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, Virginia 22908, USA
    Methods Enzymol 372:428-40. 2003
  8. pmc Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex
    Christina Ochsenbauer-Jambor
    Department of Microbiology, School of Medicine, University of Alabama at Birmingham, 35294, USA
    J Virol 76:7518-27. 2002
    ..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope...
  9. pmc The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding
    Derek Dube
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    J Virol 83:2883-91. 2009
    ....
  10. ncbi request reprint The single ligand-binding repeat of Tva, a low density lipoprotein receptor-related protein, contains two ligand-binding surfaces
    Susana Contreras-Alcantara
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    J Biol Chem 281:22827-38. 2006
    ..Furthermore, sTva could bind both RAP and SUA simultaneously. These results show that the single LBR of Tva has two ligand-binding sites, raising the possibility that other LBRs may also...
  11. pmc The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH
    Laurie J Earp
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 77:3058-66. 2003
    ..Possible roles for low pH at subsequent stages of viral entry are discussed...
  12. pmc Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins
    Kathryn L Schornberg
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
    Proc Natl Acad Sci U S A 106:8003-8. 2009
    ....
  13. pmc Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
    Judith M White
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    Crit Rev Biochem Mol Biol 43:189-219. 2008
    ..Clearly, highly divergent proteins have converged on the same overall strategy to mediate fusion, an essential step in the life cycle of every enveloped virus...
  14. pmc Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection
    Charles J Shoemaker
    Departmentof Cell BIology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e56265. 2013
    ..47. Our findings suggest that there are minimally two ways of perturbing NPC1-dependent pathways that can block EBOV entry, increasing the attractiveness of NPC1 as an anti-filoviral therapeutic target...
  15. pmc Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2
    Sonia M Gregory
    Center for Membrane Biology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:11211-6. 2011
    ..We propose that these changes facilitate disruption of lipids at the site of virus-host cell membrane contact and, hence, initiate Ebov fusion...
  16. pmc Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infection
    Derek Dube
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 82:7238-42. 2008
    ..Furthermore, with 293F cells the acquisition of EboV RBD binding paralleled cell spreading and did not require new mRNA or protein synthesis...