Affiliation: University of Pennsylvania
- Use of cyclooxygenase-2 inhibition to enhance the efficacy of immunotherapyPeter DeLong
Thoracic Oncology Laboratory, 8th Floor BRB II III, University of Pennsylvania Medical Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Res 63:7845-52. 2003....
- Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesotheliomaRobert J Kruklitis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
J Thorac Cardiovasc Surg 127:123-30. 2004....
- Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapyDaniel H Sterman
Thoracic Oncology Research Laboratory, University of Pennsylvania Medical Center, Philadelphia, PA 19104 4283, USA
Clin Cancer Res 11:7444-53. 2005..HSVtk) in combination with systemic ganciclovir...
- Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinomaPeter DeLong
Thoracic Oncology Research Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 4:342-6. 2005..These results have implications for the development of immunotherapy directed to the malignant pleural space, and suggest the need to tailor immunotherapy to overcome immunosuppressive mechanisms in tumor environments...
- Analysis of the immunologic response generated by Ad.IFN-beta during successful intraperitoneal tumor gene therapyMakoto Odaka
Thoracic Oncology Research Laboratory, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
Mol Ther 6:210-8. 2002..IFN-beta may be different in different tumor types or in different anatomic locations. However, these results demonstrate that tumor-specific CD4(+) and CD8(+) T cells are the key effector cells for tumor eradication in this model...
- Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profilingSunil Singhal
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 2:291-8. 2003..e., cdc2, cullin 4A, ZAC, p57, DP-1, GADD45, PISSLRE, cdc20) nor in any other tumors (i.e., cyclin F, cullin 5, p34). These results identified several potential cell cycle genes altered in lung cancer...
- Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon betaOmar Tliba
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:50615-23. 2003..Together these data show that TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis...