MARK L DELL'ACQUA

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling
    Seth F Oliveria
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Neuron 55:261-75. 2007
  2. pmc Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy
    Seth F Oliveria
    Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Cell Biol 160:101-12. 2003
  3. ncbi request reprint Regulation of neuronal PKA signaling through AKAP targeting dynamics
    MARK L DELL'ACQUA
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center at Fitzsimons, P O Box 6511, Mail Stop 8303, Aurora, CO 80045 0508, USA
    Eur J Cell Biol 85:627-33. 2006
  4. pmc AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors
    Jennifer L Sanderson
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 32:15036-52. 2012
  5. pmc Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex
    Holly R Robertson
    Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Neurosci 29:7929-43. 2009
  6. ncbi request reprint Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
    Lisa L Gomez
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 22:7027-44. 2002
  7. ncbi request reprint cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein
    Karen E Smith
    Department of Pharmacology, University of Colorado at Denver, Health Sciences Center, Aurora, Colorado 80045, USA
    J Neurosci 26:2391-402. 2006
  8. pmc Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms
    Dove J Keith
    Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Neurosci 32:7119-36. 2012
  9. pmc Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels
    Seth F Oliveria
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 32:15328-37. 2012
  10. pmc CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage
    Isabelle Buard
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 30:8214-20. 2010

Collaborators

Detail Information

Publications21

  1. pmc AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling
    Seth F Oliveria
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Neuron 55:261-75. 2007
    ..Additionally, activation of the transcription factor NFATc4 via local Ca2+ influx through L-type channels requires AKAP79/150, suggesting that this signaling complex promotes neuronal L channel signaling to the nucleus through NFATc4...
  2. pmc Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy
    Seth F Oliveria
    Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Cell Biol 160:101-12. 2003
    ..Finally, we demonstrated AKAP79-regulated membrane localization of the MAGUK synapse-associated protein 97 (SAP97), suggesting that AKAP79 functions to organize even larger signaling complexes...
  3. ncbi request reprint Regulation of neuronal PKA signaling through AKAP targeting dynamics
    MARK L DELL'ACQUA
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center at Fitzsimons, P O Box 6511, Mail Stop 8303, Aurora, CO 80045 0508, USA
    Eur J Cell Biol 85:627-33. 2006
    ....
  4. pmc AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors
    Jennifer L Sanderson
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 32:15036-52. 2012
    ..Thus, AKAP150-anchored CaN opposes PKA phosphorylation of GluA1 to restrict synaptic incorporation of Ca(2+)-permeable AMPARs both basally and during LTP and LTD...
  5. pmc Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex
    Holly R Robertson
    Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Neurosci 29:7929-43. 2009
    ..Overall, these results demonstrate a novel structural role for AKAP79/150 in which the N-terminal targeting domain induces dendritic filopodia and binding to MAGUKs promotes spine enlargement and AMPAR recruitment...
  6. ncbi request reprint Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
    Lisa L Gomez
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 22:7027-44. 2002
    ....
  7. ncbi request reprint cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein
    Karen E Smith
    Department of Pharmacology, University of Colorado at Denver, Health Sciences Center, Aurora, Colorado 80045, USA
    J Neurosci 26:2391-402. 2006
    ..In addition, our observations demonstrate that AKAPs serve not solely as stationary anchors in cells but also as dynamic signaling components...
  8. pmc Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms
    Dove J Keith
    Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Neurosci 32:7119-36. 2012
    ..These findings emphasize the emerging importance of palmitoylation in controlling synaptic function and reveal novel roles for the AKAP79/150 signaling complex in dendritic endosomes...
  9. pmc Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels
    Seth F Oliveria
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 32:15328-37. 2012
    ..Hence, our investigation of AKAP79/150-anchored CaN reconciles the CaM-based model of CDI with an earlier, seemingly contradictory model based on dephosphorylation signaling...
  10. pmc CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage
    Isabelle Buard
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 30:8214-20. 2010
    ..Thus, CaMKII autonomy provides a short-term molecular memory that is important in the signal computation leading to memory formation, but is not required as long-term memory store...
  11. pmc Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells
    Jessica A Gorski
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Mol Biol Cell 16:3574-90. 2005
    ..This neuronal regulation of AKAP79/150 targeting to cadherins may be important in functional and structural synaptic modifications underlying plasticity...
  12. pmc Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure
    Peter Clapp
    University of Colorado Denver, School of Medicine, MS 8303, P O Box 6511, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 332:720-9. 2010
    ....
  13. ncbi request reprint Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression
    Eric A Horne
    Department of Pharmacology, School of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    J Neurosci 27:3523-34. 2007
    ..Thus, PLC signaling is required for structural and functional changes in spine actin, PSD scaffolding, and AMPAR trafficking underlying postsynaptic expression of LTD...
  14. pmc Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection
    Steven J Coultrap
    Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA
    Cell Rep 6:431-7. 2014
    ..Thus, requirement of autonomous CaMKII in opposing forms of plasticity involves distinct substrate classes that are differentially regulated to enable stimulus-dependent substrate-site preference. ..
  15. pmc AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling
    Jonathan G Murphy
    Department of Pharmacology, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA Neuroscience Program, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Rep 7:1577-88. 2014
    ..Thus, LTCC-NFAT transcriptional signaling in neurons requires precise organization and balancing of PKA and CaN activities in the channel nanoenvironment, which is only made possible by AKAP79/150 scaffolding...
  16. doi request reprint A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons
    Katherine E Brandao
    Program in Neuroscience, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Comp Neurol 520:81-99. 2012
    ..Thus AKAP150 is expressed in small, nociceptive DRG neurons, where it is targeted to membrane regions and where it may play a role in the modulation of ion channel phosphorylation states required for hyperalgesia...
  17. pmc Anchored phosphatases modulate glucose homeostasis
    Simon A Hinke
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    EMBO J 31:3991-4004. 2012
    ..Thus anchored signalling events that facilitate insulin secretion and glucose homeostasis may be set by AKAP150 associated phosphatase activity...
  18. ncbi request reprint Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits
    Chelsea E Corser-Jensen
    Neuroscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
    Exp Neurol 256:7-16. 2014
    ..FLAP inhibitors represent a novel anti-inflammatory approach for treating human TBI that is feasible for both intervention and prevention of brain injury and neurologic deficits. ..
  19. ncbi request reprint Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A
    Philip J Dittmer
    Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8315, 12800 East 19 th Avenue, Aurora, CO 80045, USA
    Cell Rep 7:1410-6. 2014
    ....
  20. pmc AKAP signaling complexes in regulation of excitatory synaptic plasticity
    Jennifer L Sanderson
    Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA
    Neuroscientist 17:321-36. 2011
    ....
  21. pmc CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin
    Steven J Coultrap
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 285:17930-7. 2010
    ..Such regulation still allows molecular memory of previous Ca(2+) signals, but prevents complete uncoupling from subsequent cellular stimulation...