Research Topics
| RALPH DELFINOSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotypeR J Delfino
Epidemiology Division, Department of Medicine, College of Medicine, 224 Irvine Hall, University of California, Irvine, CA 92697 7550, USA
Carcinogenesis 21:607-15. 2000..There was no interaction between NAT2 and HAAs. These findings do not support a role for HAAs from meat or NAT2 in the etiology of breast cancer. Further research is needed to explain the white meat association...
Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular healthRalph J Delfino
Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697 7550, USA
Environ Health Perspect 113:934-46. 2005..To advance this, we discuss in a companion article (Sioutas C, Delfino RJ, Singh M. 2005. Environ Health Perspect 113:947-955) the need for and methods of UFP exposure assessment...
Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohortRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617 7555, USA
Epidemiology 21:892-902. 2010....- Traffic-related air pollution and blood pressure in elderly subjects with coronary artery diseaseRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617, USA
Epidemiology 21:396-404. 2010..We address these gaps in a study of 64 elderly subjects with coronary artery disease, living in retirement communities in the Los Angeles basin... - Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particlesRalph J Delfino
Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
Environ Health Perspect 118:756-62. 2010..25 microm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin... - Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanismsRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
Environ Health Perspect 117:1232-8. 2009..Experimental evidence suggests that organic components and ultrafine particles (UFP) are important... - Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthmaRalph J Delfino
Epidemiology Division, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
Environ Health Perspect 114:1736-43. 2006..Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined... - Personal and ambient air pollution exposures and lung function decrements in children with asthmaRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
Environ Health Perspect 116:550-8. 2008..5 microm in diameter (PM(2.5)). Independent effects of specific pollutants have been difficult to detect because most studies have relied on highly correlated central-site measurements... - Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery diseaseRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
Environ Health Perspect 116:898-906. 2008..Biomarkers of systemic inflammation have been associated with risk of cardiovascular morbidity and mortality... - The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003R J Delfino
Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
Occup Environ Med 66:189-97. 2009..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated... - Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matterRalph J Delfino
Epidemiology Division, Department of Medicine, College of Medicine, University of California at Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
Environ Health Perspect 112:932-41. 2004..FEV1 was weakly associated with NO2 but not with O3. Results suggest mixed respiratory effects of PM in asthmatic children from both ambient background exposures and personal exposures in various microenvironments... - Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the homeRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine 92617 7555, USA
Ann Allergy Asthma Immunol 102:138-44. 2009..There are fewer data on relationships between repeated hospital encounters and traffic-related air pollution near the home... - Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotypeR J Delfino
Department of Medicine, University of California, Irvine 92697 7550, USA
Pharmacogenetics 10:461-9. 2000..The results were similar when restricting the analysis to invasive cancers. These findings do not support the hypothesis that NAT2 is a risk factor for breast cancer or that it alters susceptibility to tobacco smoke... - Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution researchRalph J Delfino
Epidemiology Division, Department of Medicine, University of California, Irvine, California 92697 7550, USA
Environ Health Perspect 110:573-89. 2002..Community studies should focus on air toxics expected to have adverse respiratory effects based on biological mechanisms, particularly irritant and immunological pathways to asthma onset and exacerbation... - Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication useRalph J Delfino
Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697 7550, USA
Environ Health Perspect 110:A607-17. 2002..The divergence of exposure-response relationships by anti-inflammatory medication use is consistent with experimental data on inflammatory mechanisms of airborne pollutants and allergens... - Personal endotoxin exposure in a panel study of school children with asthmaRalph J Delfino
Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, CA 92617 7555, USA
Environ Health 10:69. 2011..The relation between personal endotoxin and personal air pollution exposures is also unknown... - Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutantsRalph J Delfino
Epidemiology Division, Department of Medicine, College of Medicine, University of California, Irvine, California 92697 7550, USA
Environ Health Perspect 111:647-56. 2003..89), but PM10 decreased from 1.45 to 1.0. There were no significant associations with PEF. Findings support the view that air toxins in the pollutant mix from traffic and industrial sources may have adverse effects on asthma in children... - Electrocardiographic ST-segment depression and exposure to traffic-related aerosols in elderly subjects with coronary artery diseaseRalph J Delfino
Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
Environ Health Perspect 119:196-202. 2011.... - Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient airRalph J Delfino
Epidemiology Division, Department of Medicine, College of Medicine, University of California, Irvine, California 92697, USA
J Expo Anal Environ Epidemiol 13:348-63. 2003..Alternatively, the low sample size of symptom responses (15-21 responses per 108 breath samples) may have led to the nonsignificant results for breath VOCs... - Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of CaliforniaJun Wu
Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
Environ Health Perspect 117:1773-9. 2009..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth... - Anxiety, affect, and activity in teenagers: monitoring daily life with electronic diariesBarbara Henker
Department of Psychology, University of California, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 41:660-70. 2002..CONCLUSION: Even when anxiety problems fall below diagnostic thresholds, the daily lives of anxious adolescents differ meaningfully from those of their peers in affective, behavioral, and contextual domains... - The ADHD spectrum and everyday life: experience sampling of adolescent moods, activities, smoking, and drinkingCarol K Whalen
Department of Psychology and Social Behavior, University of California, Irvine, 92697, USA
Child Dev 73:209-27. 2002..Even at subclinical levels, ADHD characteristics were associated with behavioral patterns and contexts that may promote peer deviancy training, unhealthy lifestyle behaviors, and vulnerability to nicotine dependence... - Ethane and n-pentane in exhaled breath are biomarkers of exposure not effectKatrine A Gorham
Department of Chemistry, University of California, Irvine, CA 92697, USA
Biomarkers 14:17-25. 2009..Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress... - A miniaturized active sampler for the assessment of personal exposure to nitrogen dioxideNorbert Staimer
Epidemiology Division, Department of Medicine, School of Medicine, University of California at Irvine, Irvine, CA 92617, USA
Anal Bioanal Chem 383:955-62. 2005..It is useful for personal monitoring of NO2 in environmental epidemiology studies where daily measurements are desired... - Association of atopy to asthma severity and medication use in childrenChristina D Schwindt
Department of Pediatrics, University Children s Hospital, University of California, Irvine, USA
J Asthma 43:439-46. 2006..Mold was associated with increased asthma symptoms. Degree of atopy and reactivity to mold and pollens plays a significant role in asthma severity in asthmatic children... - Characterization of the asthmatic population of St. Vincent and the Grenadines: asthma severity levels and atopic sensitizationChristina D Schwindt
School of Medicine, Department of Pediatrics, University of California, Irvine, CA, USA
J Asthma 47:871-7. 2010..The developing country of St. Vincent and the Grenadines (SVG) reported a 4.5-fold increase in wheezing incidence between 1986 and 2002. It is unknown whether aeroallergens play a significant role in asthma in SVG... - Assessing physical activity in children with asthma: convergent validity between accelerometer and electronic diary dataJosh N Floro
Department of Psychology and Social Behavior, University of California Irvine, CA 92612, USA
Res Q Exerc Sport 80:153-63. 2009..0001), but moderate did not differ from strenuous activity (p = .70). Moderate validity between accelerometer and electronic diary data supports the use of ADA with short-term recall to capture gross changes in daily activity... - Automated time activity classification based on global positioning system (GPS) tracking dataJun Wu
Program in Public Health, University of California, Irvine, USA
Environ Health 10:101. 2011..We developed and evaluated models to classify people's major time activity patterns from continuous GPS tracking data... - Slope of the intracranial pressure waveform after traumatic brain injuryFranklin D Westhout
Department of Neurological Surgery, School of Medicine, University of California Irvine, Orange, CA, USA
Surg Neurol 70:70-4; discussion 74. 2008..This study used digital methods to examine ICP and the slope of the ICP waveform in relation to the respiratory cycle in subjects with TBI... - Evaluation of daily home spirometry for school children with asthma: new insightsRohan Thompson
Department of Medicine, Pediatric Pulmonology Division, Miller Children's Hospital, Long Beach, California, USA
Pediatr Pulmonol 41:819-28. 2006..Region, age, and multiple indicators of persistent asthma, predict ability to perform reliable and accurate lung function maneuvers... - Evaluation and quality control of personal nephelometers in indoor, outdoor and personal environmentsChang Fu Wu
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
J Expo Anal Environ Epidemiol 15:99-110. 2005..We also recommend that outdoor pDRs be operated in the active mode without a heater and that the RH effect be corrected with an RH correction equation... - Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic researchConstantinos Sioutas
Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, California 90089, USA
Environ Health Perspect 113:947-55. 2005..In the present review, we provide a detailed discussion of key characteristics of UFPs, their sources and formation mechanisms, and methodologic approaches to assessing population exposures... - Effects of sampling artifacts and operating parameters on the performance of a semicontinuous particulate elemental carbon/organic carbon monitorMohammad Arhami
Department of Civil and Environmental Engineering, University of Southern California, 3620 South Vermont Avenue, Los Angeles, California 90089, USA
Environ Sci Technol 40:945-54. 2006..Evolution of OC at different temperatures of the thermal analysis showed higher volatility OC in larger particles... - Who are the children with asthma most susceptible to air pollution?Ralph J Delfino
Am J Respir Crit Care Med 173:1054-5. 2006 - Indoor/Outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles BasinAndrea Polidori
Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA
J Air Waste Manag Assoc 57:366-79. 2007..On average, 36% (G2P1) to 44% (G1P1) of measured indoor OC was composed of outdoor-generated primary OC... - Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphomaPenelope J E Quintana
San Diego State University Graduate School of Public Health, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
Environ Health Perspect 112:854-61. 2004..Given the persistence of pesticides in the environment, these findings are still relevant today... - Breast cancer risk and methylenetetrahydrofolate reductase polymorphismJan C Semenza
School of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR, USA
Breast Cancer Res Treat 77:217-23. 2003..Because breast-cell division occurs in women with active ovulatory cycles, polymorphisms in the MTHFR gene could be a risk factor for breast cancer... - Power calculations for generalized linear models in observational longitudinal studies: a simulation approach in SASVictor M Gastañaga
Amgen, Inc, Thousand Oaks, CA, USA
Comput Methods Programs Biomed 84:27-33. 2006....
Research Grants
- Pediatric Asthma, Particulate Air Pollution and NO2RALPH DELFINO; Fiscal Year: 2006..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
- ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUTRALPH DELFINO; Fiscal Year: 2001..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
- Ultrafine Particulate Matter & Cardiorespiratory HealthRALPH DELFINO; Fiscal Year: 2007..Our results are expected to clarify findings in the literature of associations between ambient particulate air pollution (PM10 and PM2.5) and severe cardiovascular outcomes, including mortality and hospital admissions. ..