RALPH DELFINO

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617 7555, USA
    Epidemiology 21:892-902. 2010
  2. pmc Mitochondrial genetic background modifies the relationship between traffic-related air pollution exposure and systemic biomarkers of inflammation
    Sharine Wittkopp
    Occupational and Environmental Medicine Division, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e64444. 2013
  3. pmc Modeling personal particle-bound polycyclic aromatic hydrocarbon (pb-pah) exposure in human subjects in Southern California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, CA, USA
    Environ Health 11:47. 2012
  4. pmc Personal and ambient air pollution exposures and lung function decrements in children with asthma
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 116:550-8. 2008
  5. pmc Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 116:898-906. 2008
  6. doi request reprint The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003
    R J Delfino
    Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
    Occup Environ Med 66:189-97. 2009
  7. doi request reprint Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the home
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine 92617 7555, USA
    Ann Allergy Asthma Immunol 102:138-44. 2009
  8. pmc Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
    Environ Health Perspect 117:1232-8. 2009
  9. pmc Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 118:756-62. 2010
  10. pmc Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617, USA
    Epidemiology 21:396-404. 2010

Research Grants

Detail Information

Publications40

  1. pmc Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617 7555, USA
    Epidemiology 21:892-902. 2010
    ....
  2. pmc Mitochondrial genetic background modifies the relationship between traffic-related air pollution exposure and systemic biomarkers of inflammation
    Sharine Wittkopp
    Occupational and Environmental Medicine Division, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e64444. 2013
    ..We previously showed that traffic-related air pollutants were associated with biomarkers of systemic inflammation in a cohort panel of subjects with CAD in the Los Angeles air basin...
  3. pmc Modeling personal particle-bound polycyclic aromatic hydrocarbon (pb-pah) exposure in human subjects in Southern California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, CA, USA
    Environ Health 11:47. 2012
    ..In this study we developed models to estimate personal inhalation exposures to particle-bound PAH (PB-PAH) using data from global positioning system (GPS) time-activity tracking data, traffic activity, and questionnaire information...
  4. pmc Personal and ambient air pollution exposures and lung function decrements in children with asthma
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 116:550-8. 2008
    ..5 microm in diameter (PM(2.5)). Independent effects of specific pollutants have been difficult to detect because most studies have relied on highly correlated central-site measurements...
  5. pmc Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 116:898-906. 2008
    ..Biomarkers of systemic inflammation have been associated with risk of cardiovascular morbidity and mortality...
  6. doi request reprint The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003
    R J Delfino
    Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
    Occup Environ Med 66:189-97. 2009
    ..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated...
  7. doi request reprint Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the home
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine 92617 7555, USA
    Ann Allergy Asthma Immunol 102:138-44. 2009
    ..There are fewer data on relationships between repeated hospital encounters and traffic-related air pollution near the home...
  8. pmc Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
    Environ Health Perspect 117:1232-8. 2009
    ..Experimental evidence suggests that organic components and ultrafine particles (UFP) are important...
  9. pmc Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 118:756-62. 2010
    ..25 microm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin...
  10. pmc Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617, USA
    Epidemiology 21:396-404. 2010
    ..We address these gaps in a study of 64 elderly subjects with coronary artery disease, living in retirement communities in the Los Angeles basin...
  11. pmc Electrocardiographic ST-segment depression and exposure to traffic-related aerosols in elderly subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 119:196-202. 2011
    ....
  12. pmc Personal endotoxin exposure in a panel study of school children with asthma
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, CA 92617 7555, USA
    Environ Health 10:69. 2011
    ..The relation between personal endotoxin and personal air pollution exposures is also unknown...
  13. pmc Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 114:1736-43. 2006
    ..Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined...
  14. ncbi request reprint Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype
    R J Delfino
    Epidemiology Division, Department of Medicine, College of Medicine, 224 Irvine Hall, University of California, Irvine, CA 92697 7550, USA
    Carcinogenesis 21:607-15. 2000
    ..There was no interaction between NAT2 and HAAs. These findings do not support a role for HAAs from meat or NAT2 in the etiology of breast cancer. Further research is needed to explain the white meat association...
  15. pmc Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, College of Medicine, University of California at Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
    Environ Health Perspect 112:932-41. 2004
    ..FEV1 was weakly associated with NO2 but not with O3. Results suggest mixed respiratory effects of PM in asthmatic children from both ambient background exposures and personal exposures in various microenvironments...
  16. ncbi request reprint Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, College of Medicine, University of California, Irvine, California 92697, USA
    J Expo Anal Environ Epidemiol 13:348-63. 2003
    ..Alternatively, the low sample size of symptom responses (15-21 responses per 108 breath samples) may have led to the nonsignificant results for breath VOCs...
  17. pmc Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697 7550, USA
    Environ Health Perspect 113:934-46. 2005
    ..To advance this, we discuss in a companion article (Sioutas C, Delfino RJ, Singh M. 2005. Environ Health Perspect 113:947-955) the need for and methods of UFP exposure assessment...
  18. pmc Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, College of Medicine, University of California, Irvine, California 92697 7550, USA
    Environ Health Perspect 111:647-56. 2003
    ..89), but PM10 decreased from 1.45 to 1.0. There were no significant associations with PEF. Findings support the view that air toxins in the pollutant mix from traffic and industrial sources may have adverse effects on asthma in children...
  19. pmc Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697 7550, USA
    Environ Health Perspect 110:A607-17. 2002
    ..The divergence of exposure-response relationships by anti-inflammatory medication use is consistent with experimental data on inflammatory mechanisms of airborne pollutants and allergens...
  20. pmc Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, University of California, Irvine, California 92697 7550, USA
    Environ Health Perspect 110:573-89. 2002
    ..Community studies should focus on air toxics expected to have adverse respiratory effects based on biological mechanisms, particularly irritant and immunological pathways to asthma onset and exacerbation...
  21. ncbi request reprint Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotype
    R J Delfino
    Department of Medicine, University of California, Irvine 92697 7550, USA
    Pharmacogenetics 10:461-9. 2000
    ..The results were similar when restricting the analysis to invasive cancers. These findings do not support the hypothesis that NAT2 is a risk factor for breast cancer or that it alters susceptibility to tobacco smoke...
  22. doi request reprint Characterization of the asthmatic population of St. Vincent and the Grenadines: asthma severity levels and atopic sensitization
    Christina D Schwindt
    School of Medicine, Department of Pediatrics, University of California, Irvine, CA, USA
    J Asthma 47:871-7. 2010
    ..The developing country of St. Vincent and the Grenadines (SVG) reported a 4.5-fold increase in wheezing incidence between 1986 and 2002. It is unknown whether aeroallergens play a significant role in asthma in SVG...
  23. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth...
  24. ncbi request reprint Anxiety, affect, and activity in teenagers: monitoring daily life with electronic diaries
    Barbara Henker
    Department of Psychology, University of California, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 41:660-70. 2002
    ..The everyday experiences of a community sample of adolescents differing in anxiety level were compared by means of electronic diaries...
  25. pmc Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect
    Katrine A Gorham
    Department of Chemistry, University of California, Irvine, CA 92697, USA
    Biomarkers 14:17-25. 2009
    ..Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress...
  26. ncbi request reprint The ADHD spectrum and everyday life: experience sampling of adolescent moods, activities, smoking, and drinking
    Carol K Whalen
    Department of Psychology and Social Behavior, University of California, Irvine, 92697, USA
    Child Dev 73:209-27. 2002
    ..Even at subclinical levels, ADHD characteristics were associated with behavioral patterns and contexts that may promote peer deviancy training, unhealthy lifestyle behaviors, and vulnerability to nicotine dependence...
  27. ncbi request reprint Association of atopy to asthma severity and medication use in children
    Christina D Schwindt
    Department of Pediatrics, University Children s Hospital, University of California, Irvine, USA
    J Asthma 43:439-46. 2006
    ..Mold was associated with increased asthma symptoms. Degree of atopy and reactivity to mold and pollens plays a significant role in asthma severity in asthmatic children...
  28. ncbi request reprint A miniaturized active sampler for the assessment of personal exposure to nitrogen dioxide
    Norbert Staimer
    Epidemiology Division, Department of Medicine, School of Medicine, University of California at Irvine, Irvine, CA 92617, USA
    Anal Bioanal Chem 383:955-62. 2005
    ..It is useful for personal monitoring of NO2 in environmental epidemiology studies where daily measurements are desired...
  29. ncbi request reprint Assessing physical activity in children with asthma: convergent validity between accelerometer and electronic diary data
    Josh N Floro
    Department of Psychology and Social Behavior, University of California Irvine, CA 92612, USA
    Res Q Exerc Sport 80:153-63. 2009
    ..0001), but moderate did not differ from strenuous activity (p = .70). Moderate validity between accelerometer and electronic diary data supports the use of ADA with short-term recall to capture gross changes in daily activity...
  30. pmc Automated time activity classification based on global positioning system (GPS) tracking data
    Jun Wu
    Program in Public Health, University of California, Irvine, USA
    Environ Health 10:101. 2011
    ..We developed and evaluated models to classify people's major time activity patterns from continuous GPS tracking data...
  31. doi request reprint Slope of the intracranial pressure waveform after traumatic brain injury
    Franklin D Westhout
    Department of Neurological Surgery, School of Medicine, University of California Irvine, Orange, CA, USA
    Surg Neurol 70:70-4; discussion 74. 2008
    ..This study used digital methods to examine ICP and the slope of the ICP waveform in relation to the respiratory cycle in subjects with TBI...
  32. ncbi request reprint Evaluation of daily home spirometry for school children with asthma: new insights
    Rohan Thompson
    Department of Medicine, Pediatric Pulmonology Division, Miller Children s Hospital, Long Beach, California, USA
    Pediatr Pulmonol 41:819-28. 2006
    ..Region, age, and multiple indicators of persistent asthma, predict ability to perform reliable and accurate lung function maneuvers...
  33. ncbi request reprint Effects of sampling artifacts and operating parameters on the performance of a semicontinuous particulate elemental carbon/organic carbon monitor
    Mohammad Arhami
    Department of Civil and Environmental Engineering, University of Southern California, 3620 South Vermont Avenue, Los Angeles, California 90089, USA
    Environ Sci Technol 40:945-54. 2006
    ..Evolution of OC at different temperatures of the thermal analysis showed higher volatility OC in larger particles...
  34. ncbi request reprint Who are the children with asthma most susceptible to air pollution?
    Ralph J Delfino
    Am J Respir Crit Care Med 173:1054-5. 2006
  35. ncbi request reprint Evaluation and quality control of personal nephelometers in indoor, outdoor and personal environments
    Chang Fu Wu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    J Expo Anal Environ Epidemiol 15:99-110. 2005
    ..We also recommend that outdoor pDRs be operated in the active mode without a heater and that the RH effect be corrected with an RH correction equation...
  36. ncbi request reprint Indoor/Outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles Basin
    Andrea Polidori
    Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA
    J Air Waste Manag Assoc 57:366-79. 2007
    ..On average, 36% (G2P1) to 44% (G1P1) of measured indoor OC was composed of outdoor-generated primary OC...
  37. pmc Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research
    Constantinos Sioutas
    Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, California 90089, USA
    Environ Health Perspect 113:947-55. 2005
    ..In the present review, we provide a detailed discussion of key characteristics of UFPs, their sources and formation mechanisms, and methodologic approaches to assessing population exposures...
  38. ncbi request reprint Breast cancer risk and methylenetetrahydrofolate reductase polymorphism
    Jan C Semenza
    School of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR, USA
    Breast Cancer Res Treat 77:217-23. 2003
    ..Because breast-cell division occurs in women with active ovulatory cycles, polymorphisms in the MTHFR gene could be a risk factor for breast cancer...
  39. ncbi request reprint Power calculations for generalized linear models in observational longitudinal studies: a simulation approach in SAS
    Victor M Gastañaga
    Amgen, Inc, Thousand Oaks, CA, USA
    Comput Methods Programs Biomed 84:27-33. 2006
    ....
  40. pmc Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma
    Penelope J E Quintana
    San Diego State University Graduate School of Public Health, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
    Environ Health Perspect 112:854-61. 2004
    ..Given the persistence of pesticides in the environment, these findings are still relevant today...

Research Grants13

  1. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  2. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  3. Ultrafine Particulate Matter & Cardiorespiratory Health
    RALPH DELFINO; Fiscal Year: 2007
    ..Our results are expected to clarify findings in the literature of associations between ambient particulate air pollution (PM10 and PM2.5) and severe cardiovascular outcomes, including mortality and hospital admissions. ..