ANNE DELCOUR

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. doi request reprint Electrophysiology of bacteria
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001 email
    Annu Rev Microbiol 67:179-97. 2013
  2. pmc Outer membrane permeability and antibiotic resistance
    Anne H Delcour
    Department of Biology, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    Biochim Biophys Acta 1794:808-16. 2009
  3. pmc Phenotypic characterization of pore mutants of the Vibrio cholerae porin OmpU
    Melissa Pagel
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    J Bacteriol 189:8593-600. 2007
  4. ncbi request reprint Function and modulation of bacterial porins: insights from electrophysiology
    A H Delcour
    Department of Biology, University of Houston, TX 77204 5513, USA
    FEMS Microbiol Lett 151:115-23. 1997
  5. ncbi request reprint Solute uptake through general porins
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, 369 Science Research Building 2, Houston, TX 77204 5001, USA
    Front Biosci 8:d1055-71. 2003
  6. ncbi request reprint Structure and function of pore-forming beta-barrels from bacteria
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, TX 77204 5001, USA
    J Mol Microbiol Biotechnol 4:1-10. 2002
  7. ncbi request reprint Deoxycholic acid blocks vibrio cholerae OmpT but not OmpU porin
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 281:19899-905. 2006
  8. pmc Vibrio cholerae OmpU and OmpT porins are differentially affected by bile
    Jamie A Wibbenmeyer
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Infect Immun 70:121-6. 2002
  9. pmc Cadaverine inhibition of porin plays a role in cell survival at acidic pH
    Hrissi Samartzidou
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA
    J Bacteriol 185:13-9. 2003
  10. pmc Size and dynamics of the Vibrio cholerae porins OmpU and OmpT probed by polymer exclusion
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
    Biophys J 98:1820-9. 2010

Research Grants

Collaborators

  • K E Klose
  • Hye Jeong Yeo
  • David G Thanassi
  • Jean Marie Pages
  • Guillaume Duret
  • Arnaud Basle
  • Brian Lauman
  • Melissa Pagel
  • Valérie Simonet
  • Owen S Mapingire
  • Mahsa Mehrazin
  • Jérôme Bredin
  • Valérie C Simonet
  • Hrissi Samartzidou
  • Jamie A Wibbenmeyer
  • Nadine S Henderson
  • Kyoung Jae Choi
  • Michal Szymanski
  • Mathilde Lallemand
  • Jie Li
  • Ram Iyer
  • Randa Qutub
  • Jamie Wibbenmeyer
  • Ramkumar Iyer
  • Michael J Benedik
  • Zhaohui Xu
  • Candice F Landry
  • Daniele Provenzano

Detail Information

Publications18

  1. doi request reprint Electrophysiology of bacteria
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001 email
    Annu Rev Microbiol 67:179-97. 2013
    ..This review highlights some of the electrophysiological studies that have advanced the field of transport by pore-forming proteins of bacterial origin. ..
  2. pmc Outer membrane permeability and antibiotic resistance
    Anne H Delcour
    Department of Biology, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    Biochim Biophys Acta 1794:808-16. 2009
    ..This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways...
  3. pmc Phenotypic characterization of pore mutants of the Vibrio cholerae porin OmpU
    Melissa Pagel
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    J Bacteriol 189:8593-600. 2007
    ..coli, OmpF, is a known binding determinant for these drugs. L3 loop residues also affect biofilm induction. The results are interpreted in terms of a homology model based on the structures of E. coli porins...
  4. ncbi request reprint Function and modulation of bacterial porins: insights from electrophysiology
    A H Delcour
    Department of Biology, University of Houston, TX 77204 5513, USA
    FEMS Microbiol Lett 151:115-23. 1997
    ....
  5. ncbi request reprint Solute uptake through general porins
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, 369 Science Research Building 2, Houston, TX 77204 5001, USA
    Front Biosci 8:d1055-71. 2003
    ....
  6. ncbi request reprint Structure and function of pore-forming beta-barrels from bacteria
    Anne H Delcour
    Department of Biology and Biochemistry, University of Houston, TX 77204 5001, USA
    J Mol Microbiol Biotechnol 4:1-10. 2002
    ....
  7. ncbi request reprint Deoxycholic acid blocks vibrio cholerae OmpT but not OmpU porin
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 281:19899-905. 2006
    ..The results are interpreted as deoxycholic acid acting as an open-channel blocker, which may relate to deoxycholic acid permeation...
  8. pmc Vibrio cholerae OmpU and OmpT porins are differentially affected by bile
    Jamie A Wibbenmeyer
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Infect Immun 70:121-6. 2002
    ..The insensitivity of OmpU to bile may be due to its small pore size and may provide an explanation for the resistance of OmpU-producing cells to bile in vivo...
  9. pmc Cadaverine inhibition of porin plays a role in cell survival at acidic pH
    Hrissi Samartzidou
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA
    J Bacteriol 185:13-9. 2003
    ..On the basis of these results, we propose that the inhibition of porins by excreted cadaverine represents a novel mechanism that provides bacterial cells with the ability to survive acid stress...
  10. pmc Size and dynamics of the Vibrio cholerae porins OmpU and OmpT probed by polymer exclusion
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
    Biophys J 98:1820-9. 2010
    ....
  11. doi request reprint Altered pore properties and kinetic changes in mutants of the Vibrio cholerae porin OmpU
    Brian Lauman
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Mol Membr Biol 25:498-505. 2008
    ..No strict correlations are observed, suggesting that distinct, but somewhat overlapping, molecular determinants control electrophysiological properties and substrate permeability...
  12. ncbi request reprint The Vibrio cholerae porins OmpU and OmpT have distinct channel properties
    Valérie C Simonet
    Department of Biology and of Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    J Biol Chem 278:17539-45. 2003
    ....
  13. ncbi request reprint Modulation of Vibrio cholerae porin function by acidic pH
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Channels (Austin) 1:70-9. 2007
    ..This observation suggests that coordinated events take place at the level of the trimer, and various explanations for this peculiar effect of acidic pH on porin gating and conductance are provided...
  14. ncbi request reprint Subconductance states in OmpF gating
    Arnaud Basle
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building 2, Houston, TX 77204 5001, USA
    Biochim Biophys Acta 1664:100-7. 2004
    ..A discussion of the molecular basis for this hallmark behavior of porin is presented...
  15. pmc Modulating effects of the plug, helix, and N- and C-terminal domains on channel properties of the PapC usher
    Owen S Mapingire
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 284:36324-33. 2009
    ..These observations suggest that the plug gates the usher channel closed and that the periplasmic domains and alpha-helix function to modulate the gating activity of the PapC twin pore...
  16. pmc The TpsB translocator HMW1B of haemophilus influenzae forms a large conductance channel
    Guillaume Duret
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    J Biol Chem 283:15771-8. 2008
    ..The HMW1 pro-piece containing the secretion domain, although binding to the channel with high affinity, did not induce channel opening...
  17. ncbi request reprint Deletions of single extracellular loops affect pH sensitivity, but not voltage dependence, of the Escherichia coli porin OmpF
    Arnaud Basle
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building 2, Houston, TX 77205 5001, USA
    Protein Eng Des Sel 17:665-72. 2004
    ..0 than at pH 7.0. The other deletion mutants retained a pH sensitivity similar to the wild-type channel. Possible mechanistic scenarios for the voltage- and pH dependence of E.coli OmpF porin are discussed based on these results...
  18. pmc Colicins, spermine and cephalosporins: a competitive interaction with the OmpF eyelet
    Jérôme Bredin
    EA2197, IFR48, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Biochem J 376:245-52. 2003
    ..D113 appeared to play an essential role for colicin A activity, whereas colicin N activity was more dependent on D121 than on D113...

Research Grants6

  1. MOLECULAR PROPERTIES AND MODULATION OF BACTERIAL PORINS
    ANNE DELCOUR; Fiscal Year: 2003
    ..This information on the three-dimensional structure of porins will be extremely valuable for the design of genetically engineered channels and the meaningful interpretation of the data. ..