Melissa Delbello

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Traumatic brain injury in individuals convicted of sexual offenses with and without bipolar disorder
    M P Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Psychiatry Res 89:281-6. 1999
  2. ncbi Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
    Nick C Patel
    College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
    J Child Adolesc Psychopharmacol 18:132-9. 2008
  3. ncbi Health-related quality of life in adolescents with bipolar I disorder
    Jennifer Rademacher
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 17:97-103. 2007
  4. ncbi Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
    Arch Gen Psychiatry 64:57-64. 2007
  5. ncbi Anterior cingulate subregion volumes and executive function in bipolar disorder
    Molly E Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02912, USA
    Bipolar Disord 8:281-8. 2006
  6. ncbi Review of studies of child and adolescent offspring of bipolar parents
    M P Delbello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 3:325-34. 2001
  7. ncbi Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder
    Melissa P DelBello
    University of Cincinnati College of Medicine, Department of Psychiatry, Cincinnati, Ohio 045267, USA
    J Child Adolesc Psychopharmacol 18:491-9. 2008
  8. ncbi Effects of race on psychiatric diagnosis of hospitalized adolescents: a retrospective chart review
    M P Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Child Adolesc Psychopharmacol 11:95-103. 2001
  9. ncbi Prior stimulant treatment in adolescents with bipolar disorder: association with age at onset
    M P Delbello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 3:53-7. 2001
  10. ncbi Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 31:1264-73. 2006

Research Grants

  1. Brain Abnormalities in Adolescent Bipolar Disorder
    Melissa Delbello; Fiscal Year: 2006
  2. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2007
  3. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2007

Detail Information

Publications86

  1. ncbi Traumatic brain injury in individuals convicted of sexual offenses with and without bipolar disorder
    M P Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Psychiatry Res 89:281-6. 1999
    ..TBI predated the first sexual offense and/or the onset of bipolar disorder in most subjects...
  2. ncbi Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
    Nick C Patel
    College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
    J Child Adolesc Psychopharmacol 18:132-9. 2008
    ..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression...
  3. ncbi Health-related quality of life in adolescents with bipolar I disorder
    Jennifer Rademacher
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 17:97-103. 2007
    ..To examine abnormalities in health-related quality of life (HRQOL) and to determine whether pharmacological intervention with divalproex or quetiapine alters HRQOL abnormalities in bipolar adolescents...
  4. ncbi Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
    Arch Gen Psychiatry 64:57-64. 2007
    ..Cannabis use disorders commonly co-occur in bipolar disorder; however, the effects of cannabis abuse on outcome have been minimally studied...
  5. ncbi Anterior cingulate subregion volumes and executive function in bipolar disorder
    Molly E Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02912, USA
    Bipolar Disord 8:281-8. 2006
    ....
  6. ncbi Review of studies of child and adolescent offspring of bipolar parents
    M P Delbello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 3:325-34. 2001
    ..The authors reviewed studies of child and adolescent offspring of bipolar (BP) parents. Findings from these studies are critically discussed with respect to methodological issues that can inform future designs...
  7. ncbi Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder
    Melissa P DelBello
    University of Cincinnati College of Medicine, Department of Psychiatry, Cincinnati, Ohio 045267, USA
    J Child Adolesc Psychopharmacol 18:491-9. 2008
    ..This study characterizes the tolerability of ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder...
  8. ncbi Effects of race on psychiatric diagnosis of hospitalized adolescents: a retrospective chart review
    M P Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Child Adolesc Psychopharmacol 11:95-103. 2001
    ....
  9. ncbi Prior stimulant treatment in adolescents with bipolar disorder: association with age at onset
    M P Delbello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 3:53-7. 2001
    ....
  10. ncbi Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 31:1264-73. 2006
    ..Additionally, olanzapine-induced increases in choline may lead to alteration of abnormalities in cell membrane metabolism or second messenger pathways that are thought to be involved in the pathophysiology of bipolar disorder...
  11. ncbi A double-blind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania
    Melissa P DelBello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 41:1216-23. 2002
    ..It was hypothesized that DVP in combination with quetiapine would be more effective than DVP alone for treating mania associated with adolescent bipolar disorder. Furthermore, it was hypothesized that quetiapine would be well tolerated...
  12. ncbi A double-blind randomized pilot study comparing quetiapine and divalproex for adolescent mania
    Melissa P DelBello
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 45:305-13. 2006
    ..To determine the comparative efficacy of quetiapine and divalproex for the treatment of adolescent mania...
  13. ncbi Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode
    Melissa P DelBello
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 164:582-90. 2007
    ..The aim of this study was to examine the 12-month outcome of bipolar adolescents following an initial hospitalization for a manic or mixed episode...
  14. ncbi The neurophysiology of childhood and adolescent bipolar disorder
    Melissa P DelBello
    Division of Bipolar Disorder Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    CNS Spectr 11:298-311. 2006
    ....
  15. ncbi Pharmacological interventions for bipolar youth: developmental considerations
    Melissa P DelBello
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Dev Psychopathol 18:1231-46. 2006
    ..Recently, studies have begun to characterize prodromal manifestations of bipolar disorder and identify early intervention strategies for treating children and adolescents with an elevated risk for developing bipolar disorder...
  16. ncbi Adjunctive topiramate treatment for pediatric bipolar disorder: a retrospective chart review
    Melissa P DelBello
    Bipolar and Psychiatric Disorders Research Program, Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 12:323-30. 2002
    ..The objective of this study was to evaluate the effectiveness, safety, and tolerability of the anticonvulsant agent, topiramate, as adjunctive treatment for children and adolescents with bipolar disorders...
  17. ncbi Neurochemical predictors of response to pharmacologic treatments for bipolar disorder
    Melissa P DelBello
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267, USA
    Curr Psychiatry Rep 6:466-72. 2004
    ..We will review recent MRS investigations that have evaluated the neurochemical effects of pharmacologic treatments and predictors of treatment response in patients with bipolar disorder...
  18. ncbi Phenomenology and epidemiology of childhood psychiatric disorders that may necessitate treatment with atypical antipsychotics
    Melissa Delbello
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 65:12-9. 2004
    ..We also describe the differences in the clinical presentation of these disorders between youth and adults...
  19. ncbi Parametric neurocognitive task design: a pilot study of sustained attention in adolescents with bipolar disorder
    Melissa P DelBello
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Bethesda Ave, P O Box 670559, Cincinnati, OH 45267 0559, USA
    J Affect Disord 82:S79-88. 2004
    ..Additionally, we hypothesized that the groups would exhibit a similar decline in task performance as level of task difficulty increased and that within each level of task difficulty there would be similar performance among groups...
  20. ncbi Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder
    Melissa P DelBello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Bipolar Disord 6:43-52. 2004
    ..We hypothesized that adolescents with bipolar disorder would exhibit abnormalities in brain regions that are involved in the regulation of mood including the amygdala, globus pallidus, caudate, putamen, and thalamus...
  21. ncbi A pilot controlled trial of topiramate for mania in children and adolescents with bipolar disorder
    Melissa P DelBello
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 44:539-47. 2005
    ..To assess the efficacy of topiramate monotherapy for acute mania in children and adolescents with bipolar disorder type I...
  22. ncbi A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 3200, ML 559, Cincinnati, OH 45219, USA
    Bipolar Disord 11:483-93. 2009
    ..To conduct a pilot study comparing the effects of quetiapine and placebo for the treatment of depressive episodes in adolescents with bipolar I disorder...
  23. ncbi Rates and predictors of developing a manic or hypomanic episode 1 to 2 years following a first hospitalization for major depression with psychotic features
    Melissa P DelBello
    The Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Child Adolesc Psychopharmacol 13:173-85. 2003
    ....
  24. ncbi Pharmacological management of new-onset bipolar disorder
    Christopher J Kratochvil
    Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198-5581, USA
    J Am Acad Child Adolesc Psychiatry 44:1198-200. 2005
  25. ncbi Neurochemical alteration in the caudate: implications for the pathophysiology of bipolar disorder
    Nasrin Shahana
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    Psychiatry Res 193:107-12. 2011
    ..While speculative, these results suggest that AAP do not cause oxidative injury to neuronal membranes...
  26. ncbi The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
    S M Strakowski
    Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Mol Psychiatry 10:105-16. 2005
    ..Future prospective and longitudinal studies focusing on these specific relationships are necessary to clarify the functional neuroanatomy of bipolar disorder...
  27. ncbi Brain magnetic resonance imaging of structural abnormalities in bipolar disorder
    S M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    Arch Gen Psychiatry 56:254-60. 1999
    ..We examined differences in brain structural volumes associated with these pathways between patients with bipolar disorder hospitalized with mania and healthy community volunteers...
  28. ncbi Evaluation of bipolar disorder in inpatients with prelingual deafness
    N A Shapira
    Department of Psychiatry, University of Cincinnati College of Medicine, USA
    Am J Psychiatry 156:1267-9. 1999
    ..This study retrospectively examined the occurrence of bipolar disorder in patients with prelingual deafness who were hospitalized for a psychiatric disorder...
  29. ncbi The co-occurrence of bipolar and substance use disorders
    S M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Clin Psychol Rev 20:191-206. 2000
    ..Additional studies are warranted to clarify the complex relationships between these two conditions as better understanding of this co-occurrence could lead to better treatment for patients afflicted with both disorders...
  30. ncbi Eight-month functional outcome from mania following a first psychiatric hospitalization
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Psychiatr Res 34:193-200. 2000
    ..Further clarification of recovery of these different areas of function may lead to better integrated treatments that maximize functional improvement early in the course of bipolar disorder...
  31. ncbi Is impaired outcome following a first manic episode due to mood-incongruent psychosis?
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 45267 0559, Cincinnati, OH, USA
    J Affect Disord 61:87-94. 2000
    ..Mood-incongruent psychosis during the course of bipolar disorder has been associated with poor outcome. However, it remains unknown whether this is secondary to persistent affective or psychotic symptoms or both...
  32. ncbi Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype
    B Geller
    Department of Psychiatry, Washington University School of Medicine, St Louis 63110, USA
    J Am Acad Child Adolesc Psychiatry 39:1543-8. 2000
    ..To compare psychosocial functioning (PF) in a prepubertal and early adolescent bipolar disorder phenotype (PEA-BP) sample to two comparison groups, i.e., attention-deficit/hyperactivity disorder (ADHD) and community controls (CC)...
  33. ncbi Neuroimaging in bipolar disorder
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 2:148-64. 2000
    ..The authors reviewed neuroimaging studies of bipolar disorder in order to evaluate how this literature contributes to the current understanding of the neurophysiology of the illness...
  34. ncbi Human response to repeated low-dose d-amphetamine: evidence for behavioral enhancement and tolerance
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 25:548-54. 2001
    ..These effects were greater in women. Progressive changes in subjective responses following repeated d-amphetamine administration may occur in healthy human subjects, although this effect may be greater for women...
  35. ncbi Comparative efficacy and tolerability of drug treatments for bipolar disorder
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    CNS Drugs 15:701-18. 2001
    ..Identifying a specific treatment for a specific patient requires a careful individualised assessment of the risk of adverse effects for that patient's unique circumstances...
  36. ncbi Frontosubcortical neuroanatomy and the continuous performance test in mania
    K W Sax
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 156:139-41. 1999
    ..The authors examined whether Continuous Performance Test scores correlate with frontosubcortical volumes in bipolar disorder...
  37. ncbi Academic and cognitive abilities in children of parents with bipolar disorder: a test of the nonverbal learning disability model
    Patricia McDonough-Ryan
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH, USA
    J Clin Exp Neuropsychol 24:280-5. 2002
    ..These findings replicate and extend the current literature on the cognitive functioning of children of parents with Bipolar disorder (BPD). The results, however, do not support the presence of NLD in these children...
  38. ncbi Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty and comorbid attention deficit hyperactivity disorder
    B Geller
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Adolesc Psychopharmacol 10:157-64. 2000
    ....
  39. ncbi One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype
    B Geller
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 158:303-5. 2001
    ..The study examined 1-year recovery and relapse rates for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenotype...
  40. ncbi Six-month stability and outcome of a prepubertal and early adolescent bipolar disorder phenotype
    B Geller
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Adolesc Psychopharmacol 10:165-73. 2000
    ..Six-month follow-up data are provided on a prepubertal and early adolescent bipolar disorder phenotype (PEA-BP). Stabilities were defined as continuous presence of PEA-BP and of individual mania criteria between baseline and 6 months...
  41. ncbi Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections
    B Geller
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 40:450-5. 2001
    ..To investigate the reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections...
  42. ncbi A retrospective chart review of intramuscular ziprasidone for agitation in children and adolescents on psychiatric units: prospective studies are needed
    Drew H Barzman
    Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, Cincinnati, Ohio 45229 3039, USA
    J Child Adolesc Psychopharmacol 17:503-9. 2007
    ..Our secondary objective was to examine demographic and clinical factors associated with treatment response...
  43. ncbi Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study
    Glen E Getz
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 55:55-9. 2002
    ..Patients diagnosed with SCA exhibited regional abnormalities on the striatum that resemble those seen in BPD. This study suggests that SCA has some neuroanatomical characteristics similar to BPD...
  44. ncbi Psychopathology in children of bipolar parents
    Manpreet K Singh
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Affect Disord 102:131-6. 2007
    ..Few studies have examined the psychopathological profiles of child offspring of bipolar parents. Such investigations are useful as a first step to identifying potential prodromal manifestations of bipolar disorder...
  45. ncbi The efficacy and tolerability of quetiapine versus divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorder(s)
    Drew H Barzman
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Child Adolesc Psychopharmacol 16:665-70. 2006
    ..The aim of this study was to compare the efficacy and tolerability of quetiapine and divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorders...
  46. ncbi DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls
    Barbara Geller
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Adolesc Psychopharmacol 12:11-25. 2002
    ....
  47. ncbi Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
    ..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression...
  48. ncbi Voxel-based study of structural changes in first-episode patients with bipolar disorder
    Caleb M Adler
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Biol Psychiatry 61:776-81. 2007
    ..In this study, we used VBM to explore structural brain changes in first-episode bipolar patients...
  49. ncbi Concurrent tracking of alcohol use and bipolar disorder symptoms
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:338-44. 2006
    ..The primary aim of this analysis was to examine concurrent symptom tracking and how the relative onsets of AUD and BD influence the concurrent tracking of symptoms...
  50. ncbi Response and remission in adolescent mania: signal detection analyses of the young mania rating scale
    Nick C Patel
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0004, USA
    J Am Acad Child Adolesc Psychiatry 46:628-35. 2007
    ..The purpose of this study was to determine optimal criteria for defining response and remission in adolescents with acute mania...
  51. ncbi A 12-week single-blind trial of quetiapine for the treatment of mood symptoms in adolescents at high risk for developing bipolar I disorder
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:789-95. 2007
    ..To investigate the effectiveness and tolerability of quetiapine for the treatment of adolescents at high risk for developing bipolar I disorder...
  52. ncbi Rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder
    Drew H Barzman
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, OH 45229 3039, USA
    Bipolar Disord 9:339-44. 2007
    ..To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD)...
  53. ncbi Mood disorders: assessment, risk factors, and outcome
    Melissa P DelBello
    J Clin Psychiatry 69:830. 2008
  54. ncbi Tricyclic antidepressant immunoassays may reflect quetiapine adherence
    Michael A Cerullo
    Am J Psychiatry 165:919-20. 2008
  55. ncbi Neuroanatomical characterization of child offspring of bipolar parents
    Manpreet K Singh
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 47:526-31. 2008
    ..We hypothesized that at-risk (AR) children would exhibit abnormalities in brain regions that are involved in mood regulation...
  56. ncbi Hyperthermia and rhabdomyolysis in an adolescent treated with topiramate and olanzapine
    Jeffrey R Strawn
    J Child Adolesc Psychopharmacol 18:116-8. 2008
  57. ncbi Olanzapine for the treatment of bipolar disorder in children and adolescents
    Jeffrey R Strawn
    Department of Psychiatry, University of Cincinnati, Box 670559, Cincinnati, OH 45267 0559, USA
    Expert Opin Pharmacother 9:467-74. 2008
    ....
  58. ncbi Outcome following a first manic episode: cross-national US and Taiwan comparison
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:820-7. 2007
    ..Therefore, the aim of this study was to identify differential and shared outcome predictors in first-episode manic bipolar patients in Cincinnati, OH, USA and Taipei, Taiwan...
  59. ncbi Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task
    Stephen M Strakowski
    Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0583, USA
    Am J Psychiatry 162:1697-705. 2005
    ..Cognitive probes, coupled with neuroimaging, provide an approach toward clarifying the neurophysiology of bipolar disorder...
  60. ncbi Body mass indexes and lipid profiles in hospitalized children and adolescents exposed to atypical antipsychotics
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, and Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Ohio 45267 0004, USA
    J Child Adolesc Psychopharmacol 17:303-11. 2007
    ..The purpose of this study was to examine body mass indexes (BMI) and lipid profiles of children and adolescents hospitalized for a psychiatric illness and exposed to an atypical antipsychotic...
  61. ncbi Topiramate for co-occurring bipolar disorder and disruptive behavior disorders
    Drew H Barzman
    Am J Psychiatry 163:1451-2. 2006
  62. ncbi Preliminary study of relationships among measures of depressive symptoms in adolescents with bipolar disorder
    Nick C Patel
    College of Pharmacy, Department of Psychiatry, University of Cincinnati College of Medicine, 3225 Eden Avenue, Cincinnati, OH 45267, USA
    J Child Adolesc Psychopharmacol 16:327-35. 2006
    ..We hypothesized that CDRS-R and HAM-D scores would be significantly correlated and both scales would be sensitive to change resulting from treatment...
  63. ncbi Obstetrical complications in children at high risk for bipolar disorder
    Manpreet K Singh
    Center for Bipolar Disorders Research, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, Cincinnati, OH 45267 0559, United States
    J Psychiatr Res 41:680-5. 2007
    ..Additionally, within this "at-risk" (AR) sample, we hypothesized that obstetrical complications would be associated with the development of psychiatric disorders...
  64. ncbi Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
    ..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe...
  65. ncbi Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:549-53. 2005
    ..We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms...
  66. ncbi Parental reports of executive dysfunction in adolescents with bipolar disorder
    Paula K Shear
    Department of Psychology, University of Cincinnati, OH 45221, USA
    Child Neuropsychol 8:285-95. 2002
    ..The findings suggest that adolescents with BPD have functional deficits on tasks requiring executive functioning skills that are not explicable solely on the basis of comorbid ADHD...
  67. ncbi Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Arch Gen Psychiatry 62:851-8. 2005
    ..Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome...
  68. ncbi MRI analysis of cerebellar vermal abnormalities in bipolar disorder
    Neil P Mills
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 162:1530-2. 2005
    ..The authors sought to expand previous findings of vermal abnormalities in bipolar disorder patients...
  69. ncbi Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Adolesc Psychopharmacol 13:545-55. 2003
    ....
  70. ncbi Pharmacotherapy of children and adolescents with bipolar disorder
    Robert A Kowatch
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267, USA
    Psychiatr Clin North Am 28:385-97. 2005
    ..There are multiple ongoing trials of mood stabilizers and atypical antipsychotics that will provide important controlled data that are currently lacking in the field...
  71. ncbi Selective attention in schizoaffective disorder: pilot data
    David E Fleck
    Schizophr Res 68:109-10. 2004
  72. ncbi Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..CONCLUSIONS: Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity. Whether early intervention might modify this risk merits further investigation...
  73. ncbi A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, University of Cincinnati College of Medicine, OH 45267 0583, USA
    Neuropsychopharmacology 29:1734-40. 2004
    ..Since the differences occurred in euthymia, they may represent trait, rather than state, abnormalities of brain function in bipolar disorder...
  74. ncbi Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 159:1841-7. 2002
    ..In addition, it is unknown whether ventriculomegaly in bipolar disorder reflects acquired volume loss or underdevelopment of periventricular structures...
  75. ncbi Pediatric bipolar disorder: emerging diagnostic and treatment approaches
    Robert A Kowatch
    Department of Psychiatry and Pediatrics, University of Cincinnati Medical Center and Cincinnati Children s Hospital Medical Center, MSB 7261, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Child Adolesc Psychiatr Clin N Am 15:73-108. 2006
    ..It is becoming apparent that bipolar disorder is often a chronic disorder in children and adolescents, much like diabetes, and is best managed with a combination of medications and psychosocial therapy...
  76. ncbi Adjunctive topiramate in hospitalized children and adolescents with bipolar disorders
    Drew H Barzman
    Cincinnati Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, and Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 15:931-7. 2005
    ..The aim of this study was to assess topiramate as adjunctive treatment in children and adolescents hospitalized with bipolar disorders...
  77. ncbi Brain network dysfunction in bipolar disorder
    Caleb M Adler
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    CNS Spectr 11:312-20; quiz 323-4. 2006
    ..As neuroimaging techniques continue to improve, the underlying neural basis of bipolar disorder will be clarified...
  78. ncbi Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?
    Stephen M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 4:80-8. 2002
    ..This hypothesis remains speculative as much more research is needed to specifically examine how morphometric brain abnormalities translate into the neurophysiologic deficits that produce mood disorders...
  79. ncbi Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment
    Cesar A Soutullo
    University of Cincinnati, Department of Psychiatry, Biological Psychiatry and Psychotic and Bipolar Disorders Research Programs, PO Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 70:323-7. 2002
    ..Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants...
  80. ncbi Open-label lithium for the treatment of adolescents with bipolar depression
    Nick C Patel
    College of Pharmacy and Department of Psychiatry, University of Cincinnati, OH 45267 0004, USA
    J Am Acad Child Adolesc Psychiatry 45:289-97. 2006
    ..We hypothesized that patients receiving open-label treatment with lithium during a 6-week period would experience a statistically and clinically significant decrease in depressive symptoms and tolerate lithium treatment fairly well...
  81. ncbi Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study
    Caleb M Adler
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 163:322-4. 2006
    ..In this study the authors utilized diffusion tensor imaging to study white matter tracts of adolescents in their first episode of mania to address whether abnormalities are present in early bipolar disorder...
  82. ncbi Ethnic differences in symptom presentation of youths with bipolar disorder
    Nick C Patel
    The College of Pharmacy, University of Cincinnati, OH 45267 0004, USA
    Bipolar Disord 8:95-9. 2006
    ..To compare symptom profiles of African-American and white adolescents with a diagnosis of bipolar disorder...
  83. ncbi Phenomenology associated with age at onset in patients with bipolar disorder at their first psychiatric hospitalization
    Nick C Patel
    College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267 0004, USA
    Bipolar Disord 8:91-4. 2006
    ..To compare the clinical presentation of patients with early-onset (age <18 years) and typical-onset (age 20-30 years) bipolar disorder at the time of first hospitalization...
  84. ncbi Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task
    Caleb M Adler
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Bipolar Disord 7:577-88. 2005
    ..In this study we utilized functional magnetic resonance imaging (fMRI) to compare activation patterns during performance of a simple attention task between bipolar adolescents with and without ADHD...
  85. ncbi Ethnic differences in maintenance antipsychotic prescription among adolescents with bipolar disorder
    Nick C Patel
    Department of Psychiatry, University of Cincinnati, and the General Clinical Research Center and Mental Health Service Line, Cincinnati Veterans Affairs Medical Center, Ohio 45267 0004, USA
    J Child Adolesc Psychopharmacol 15:938-46. 2005
    ..The aim of this study was to compare the longitudinal use of psychotropic medications in African-American and Caucasian adolescents with a diagnosis of bipolar disorder following their first psychiatric hospitalization...
  86. ncbi Voxel-based morphometry in adolescents with bipolar disorder: first results
    Marko Wilke
    Imaging Research Center and Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Psychiatry Res 131:57-69. 2004
    ..VBM confirmed bilaterally larger basal ganglia. Localized gray matter deficits in bipolar subjects were found in the medial temporal lobe, orbito-frontal cortex, and the anterior cingulate, confirming and extending earlier studies...

Research Grants7

  1. Brain Abnormalities in Adolescent Bipolar Disorder
    Melissa Delbello; Fiscal Year: 2006
    This NIMH Mentored Patient-Oriented Research Career Development application is to support Dr. Melissa DelBello's long-term career objective of developing expertise integrating innovative neuroimaging techniques and longitudinal outcome ..
  2. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2007
    ..The preliminary data from this project will inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..
  3. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2007
    ..The preliminary data from this projectwill inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..