Gregory Del Zoppo

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Plasminogen activators and ischemic stroke: conditions for acute delivery
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Semin Thromb Hemost 39:406-25. 2013
  2. doi request reprint Toward the neurovascular unit. A journey in clinical translation: 2012 Thomas Willis Lecture
    Gregory J del Zoppo
    Department of Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA
    Stroke 44:263-9. 2013
  3. pmc Aging and the neurovascular unit
    Gregory J del Zoppo
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Ann N Y Acad Sci 1268:127-33. 2012
  4. pmc Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Cereb Blood Flow Metab 32:919-32. 2012
  5. pmc Heterogeneity in the penumbra
    Gregory J del Zoppo
    Department of Medicine Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Cereb Blood Flow Metab 31:1836-51. 2011
  6. doi request reprint Acute anti-inflammatory approaches to ischemic stroke
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Ann N Y Acad Sci 1207:143-8. 2010
  7. doi request reprint The neurovascular unit, matrix proteases, and innate inflammation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:46-9. 2010
  8. doi request reprint Innate inflammation as the common pathway of risk factors leading to TIAs and stroke
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:8-10. 2010
  9. pmc The neurovascular unit in the setting of stroke
    G J del Zoppo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Intern Med 267:156-71. 2010
  10. pmc Relationship of neurovascular elements to neuron injury during ischemia
    Gregory J del Zoppo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Cerebrovasc Dis 27:65-76. 2009

Research Grants

Detail Information

Publications13

  1. pmc Plasminogen activators and ischemic stroke: conditions for acute delivery
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Semin Thromb Hemost 39:406-25. 2013
    ..Several questions remain open that concern the manner in which PAs can be applied acutely in ischemic stroke and how injury development can be limited...
  2. doi request reprint Toward the neurovascular unit. A journey in clinical translation: 2012 Thomas Willis Lecture
    Gregory J del Zoppo
    Department of Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA
    Stroke 44:263-9. 2013
    ....
  3. pmc Aging and the neurovascular unit
    Gregory J del Zoppo
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Ann N Y Acad Sci 1268:127-33. 2012
    ..These considerations indicate the need for a coordinated research effort to understand the origins of the variability in recanalization outcome...
  4. pmc Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Cereb Blood Flow Metab 32:919-32. 2012
    ..Astrocytes alone do not generate pro-MMP-9. These events explain the appearance of MMP-9 antigen in association with ischemia-induced cerebral hemorrhage and edema...
  5. pmc Heterogeneity in the penumbra
    Gregory J del Zoppo
    Department of Medicine Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Cereb Blood Flow Metab 31:1836-51. 2011
    ..Recent observations with updated imaging techniques and data processing support these dynamic changes within the core and the penumbra in humans following focal ischemia...
  6. doi request reprint Acute anti-inflammatory approaches to ischemic stroke
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Ann N Y Acad Sci 1207:143-8. 2010
    ....
  7. doi request reprint The neurovascular unit, matrix proteases, and innate inflammation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:46-9. 2010
    ..Recent experimental work suggests specific cell sources for MMP-9 generation and for matrix proteases from four distinct families that could impact neurovascular unit integrity...
  8. doi request reprint Innate inflammation as the common pathway of risk factors leading to TIAs and stroke
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:8-10. 2010
    ....
  9. pmc The neurovascular unit in the setting of stroke
    G J del Zoppo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Intern Med 267:156-71. 2010
    ..This presentation summarizes evidence and thoughts on this topic. These support the need to understand component interactions within the neurovascular unit...
  10. pmc Relationship of neurovascular elements to neuron injury during ischemia
    Gregory J del Zoppo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Cerebrovasc Dis 27:65-76. 2009
    ....
  11. pmc Hyperfibrinogenemia and functional outcome from acute ischemic stroke
    Gregory J del Zoppo
    Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Stroke 40:1687-91. 2009
    ..Epidemiological studies have found strong correlations between elevated plasma fibrinogen levels and both ischemic stroke incidence and stroke mortality. Little is known about the influence of fibrinogen levels on functional stroke outcome...
  12. pmc Virchow's triad: the vascular basis of cerebral injury
    Gregory J del Zoppo
    Department of Medicine, University of Washington, Seattle, WA, USA
    Rev Neurol Dis 5:S12-21. 2008
    ..It is, therefore, possible that addressing the processes of Virchow's triad in the setting of focal ischemia could promote neurovascular function...
  13. ncbi request reprint Thrombolysis: from the experimental findings to the clinical practice
    Gregory J del Zoppo
    Department of Molecular and Experimental Medicine, Scripps Research Institute, and Division of Hematology Medical Oncology, Department of Medicine, Scripps Clinic, La Jolla, CA 92037, USA
    Cerebrovasc Dis 17:144-52. 2004
    ..Experimental work suggests that improved outcome is also possible with acute intervention using other antithrombotic agents. There is considerable opportunity to explore safe strategies which could further benefit stroke outcome...

Research Grants28

  1. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  2. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2007
    ..Understanding the mechanisms of their expression and disruption is likely to lead to new testable approaches to preserve or selectively alter barrier function and microvessel integrity in other neurovascular degenerative disorders. ..
  3. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2007
    ..These studies are likely to lead to new testable therapeutic approaches to preserve mlcrovascular and neuron function which will have relevance to other vascular neuron degenerative disorders. ..
  4. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2009
    ..abstract_text> ..
  5. MICROVASCULAR OCCLUSIONS--ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 1991
    ..This approach may have significant consequences for acute stroke patient management...
  6. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 1993
    ..In view of clinical studies demonstrating successful cerebral arterial recanalization, the approaches in this proposal may have significant consequences for future acute stroke patient management and outcome...
  7. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 1999
    ..In view of clinical studies demonstrating successful cerebral arterial recanalization, the approaches in this proposal may have significant consequences for future acute stroke patient management and outcome. ..
  8. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory J del Zoppo; Fiscal Year: 2010
    ..abstract_text> ..