RODNEY PETER DEKOTER

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Analysis of gene expression and Ig transcription in PU.1/Spi-B-deficient progenitor B cell lines
    Brock L Schweitzer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Medical Sciences Building 3006, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Immunol 172:144-54. 2004
  2. ncbi Spi-C has opposing effects to PU.1 on gene expression in progenitor B cells
    Brock L Schweitzer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Immunol 177:2195-207. 2006
  3. ncbi Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells
    Rodney P DeKoter
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Biol Chem 282:14194-204. 2007
  4. pmc Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models
    Rodney P DeKoter
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, The University of Cincinnati, 231 Albert Sabin Way, MSB 3256, Cincinnati, OH 45267 0524, USA
    Blood Cells Mol Dis 39:316-20. 2007
  5. pmc Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality
    Isaac B Houston
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Exp Hematol 35:1056-68. 2007
  6. ncbi PU.1 immortalizes hematopoietic progenitors in a GM-CSF-dependent manner
    Isaac B Houston
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Exp Hematol 35:374-384. 2007
  7. doi Transgenic expression of Spi-C impairs B-cell development and function by affecting genes associated with BCR signaling
    Xiang Zhu
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Eur J Immunol 38:2587-99. 2008

Collaborators

  • David A Hildeman
  • C Bonifer
  • Brock L Schweitzer
  • Isaac B Houston
  • Xiang Zhu
  • Meghana B Kamath
  • Kelly J Huang
  • Eric J Romer
  • Courtney E W Sulentic
  • Timothy M Chlon
  • Serena R Jennings
  • Barbara K Birshtein
  • Alexander V Emelyanov

Detail Information

Publications7

  1. ncbi Analysis of gene expression and Ig transcription in PU.1/Spi-B-deficient progenitor B cell lines
    Brock L Schweitzer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Medical Sciences Building 3006, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Immunol 172:144-54. 2004
    ..Taken together, our observations suggest that reduction of PU.1 and/or Spi-B activity in pro-B cells promotes their differentiation to a stage intermediate between late pro-B cells and large pre-B cells...
  2. ncbi Spi-C has opposing effects to PU.1 on gene expression in progenitor B cells
    Brock L Schweitzer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Immunol 177:2195-207. 2006
    ..Overall, these studies suggest that Spi-C may promote B cell differentiation by modulating the activity of PU.1-dependent genes...
  3. ncbi Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells
    Rodney P DeKoter
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Biol Chem 282:14194-204. 2007
    ..1 is uniquely required to initiate transcription of the Il7r locus at the earliest stages of progenitor B cell generation. In summary, these results suggest that Il7r transcription is regulated by both PU.1 and GABP in developing B cells...
  4. pmc Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models
    Rodney P DeKoter
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, The University of Cincinnati, 231 Albert Sabin Way, MSB 3256, Cincinnati, OH 45267 0524, USA
    Blood Cells Mol Dis 39:316-20. 2007
    ..1 concentration in the myeloid lineages leads to failed differentiation, abnormal proliferation, and leukemia. In this review, we summarize recent studies to develop a new model of PU.1 function in hematopoiesis...
  5. pmc Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality
    Isaac B Houston
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Exp Hematol 35:1056-68. 2007
    ..We utilized an allele of Sfpi1 (termed BN) with a mutation in the first coding exon, which resulted in a reduction of PU.1 expression in order to test this hypothesis...
  6. ncbi PU.1 immortalizes hematopoietic progenitors in a GM-CSF-dependent manner
    Isaac B Houston
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Exp Hematol 35:374-384. 2007
    ..1 immortalizes fetal liver progenitor cells in response to granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. In this study, we sought to characterize PU.1-immortalized progenitor (PIP) cells...
  7. doi Transgenic expression of Spi-C impairs B-cell development and function by affecting genes associated with BCR signaling
    Xiang Zhu
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Eur J Immunol 38:2587-99. 2008
    ..Taken together, these data indicate that ectopic expression of Spi-C can impair B-cell development and function by affecting genes associated with BCR signaling...