Steven T DeKosky

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint How should we design studies for stroke prevention?
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, PA 15213, USA
    Arch Neurol 60:778-9. 2003
  2. ncbi request reprint Pathology and pathways of Alzheimer's disease with an update on new developments in treatment
    Steven T DeKosky
    Department of Neurology, Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Geriatr Soc 51:S314-20. 2003
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  4. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
  5. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
  6. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
  7. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
  8. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
  9. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
  10. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint How should we design studies for stroke prevention?
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, PA 15213, USA
    Arch Neurol 60:778-9. 2003
  2. ncbi request reprint Pathology and pathways of Alzheimer's disease with an update on new developments in treatment
    Steven T DeKosky
    Department of Neurology, Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Geriatr Soc 51:S314-20. 2003
    ....
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  4. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
    ..To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging...
  5. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
    ..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset...
  6. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  7. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  8. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  9. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  10. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  11. pmc No association of SORL1 SNPs with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurosci Lett 440:190-2. 2008
    ..Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort...
  12. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  13. pmc Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 624 Parran Hall, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1440-4. 2006
    ..0082) effects among non-APOE*4 carriers. The three CHAT SNPs also showed a modest association with MMSE score. Our data suggest that genetic variation in the CHAT gene may be associated with AD risk and quantitative traits related to AD...
  14. pmc Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Neurol 66:646-51. 2009
    ..To examine alpha7 nicotinic acetylcholine receptor (nAChR) binding and beta-amyloid (Abeta) peptide load in superior frontal cortex (SFC) across clinical and neuropathological stages of Alzheimer disease (AD)...
  15. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  16. pmc No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 29:1602-4. 2008
    ..We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs...
  17. pmc Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 302:2663-70. 2009
    ..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
  18. pmc Amyloid imaging in dementias with atypical presentation
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:389-98. 2012
    ..We explored the potential value of amyloid imaging in patients with atypical presentations of dementia...
  19. pmc Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1435-9. 2006
    ..012). These data suggest that the ACT gene may affect AAO and disease duration of AD...
  20. ncbi request reprint X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology and Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Methods Enzymol 412:123-44. 2006
    ....
  21. ncbi request reprint Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Ave, Suite 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:541-4. 2007
    ..Changes in soluble Abeta levels and their relationship to Abeta plaque formation following TBI are unknown...
  22. pmc Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007
    ..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype...
  23. pmc Frequency and correlates of advance planning among cognitively impaired older adults
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:643-9. 2008
    ..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity...
  24. pmc Does Ginkgo biloba reduce the risk of cardiovascular events?
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
    Circ Cardiovasc Qual Outcomes 3:41-7. 2010
    ..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia...
  25. pmc Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
    Acta Neuropathol 123:433-47. 2012
    ..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal...
  26. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  27. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  28. ncbi request reprint Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:352-60. 2006
    ..Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases...
  29. pmc Marital quality in the context of mild cognitive impairment
    Linda Garand
    University of Pittsburgh, Pittsburgh, PA, USA
    West J Nurs Res 29:976-92. 2007
    ..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships...
  30. pmc No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurobiol Aging 30:1890-1. 2009
    ..We did not detect associations with AD for any variation...
  31. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  32. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  33. ncbi request reprint Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 341 Fifth Ave, Ste 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:1312-7. 2007
    ....
  34. pmc No association between CALHM1 variation and risk of Alzheimer disease
    Ryan L Minster
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Mutat 30:E566-9. 2009
    ..368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034)...
  35. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  36. pmc Anticipatory grief in new family caregivers of persons with mild cognitive impairment and dementia
    Linda Garand
    Health and Community Systems Department, 415 Victoria Building, University of Pittsburgh School of Nursing, 3500 Victoria Street, Pittsburgh, PA 15261, USA
    Alzheimer Dis Assoc Disord 26:159-65. 2012
    ..Given these findings, family caregivers of individuals with mild cognitive deficits or a new AD diagnosis may benefit from interventions specifically addressing anticipatory grief...
  37. pmc A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 21:461-6. 2011
    ..These results are consistent with a division of labor in the MTL and the dual process model...
  38. ncbi request reprint Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 811, 15213, USA
    Exp Neurol 197:437-50. 2006
    ....
  39. pmc Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) study
    Beth E Snitz
    Department of Neurology, University of Pittsburgh
    Aging Ment Health 13:171-82. 2009
    ..To identify, characterize and compare the frequency of mild cognitive impairment (MCI) subtypes at baseline in a large, late-life cohort (n = 3063) recruited into a dementia prevention trial...
  40. pmc Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  41. ncbi request reprint Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan...
  42. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  43. ncbi request reprint Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  44. pmc Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 79:1599-606. 2012
    ..9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011...
  45. pmc Association of CLU and PICALM variants with Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurobiol Aging 33:518-21. 2012
    ..Our data from an independent and large case-control sample suggest that these gene regions should be followed up by comprehensive resequencing to find functional variants...
  46. doi request reprint Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels
    Eric E Abrahamson
    Department of Neurology, Brain Trauma Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 66:407-14. 2009
    ..The ability of statins to reduce post-injury A beta load and ameliorate pathological sequelae of brain injury makes them potentially effective in reducing the risk of developing Alzheimer's disease in TBI patients...
  47. pmc Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease
    Yvette P Conley
    Department of Health Promotion and Development, University of Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 150:703-9. 2009
    ..These data support our hypothesis that the CASR has a role in AD susceptibility, particularly in individuals without an APOE4 allele...
  48. ncbi request reprint Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease
    Purnima Desai Sundar
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 28:856-62. 2007
    ..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD...
  49. ncbi request reprint Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  50. doi request reprint Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 610:353-74. 2010
    ..This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates...
  51. ncbi request reprint Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 144:79-82. 2007
    ..01) and disease duration (P = 0.006). Our data on a large number of AD cases and controls suggest that genetic variation in PLAU may affect the risk and AAO of AD...
  52. pmc Incidence and predictors of advance care planning among persons with cognitive impairment
    Linda Garand
    Department of Health and Community Systems, University of Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 19:712-20. 2011
    ..We sought to characterize advance care planning (ACP) rates over time in individuals who had no advance directives (living will or durable power of attorney) in place when they initially presented for a cognitive evaluation...
  53. pmc Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors
    Kyle B Womack
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
    Arch Neurol 68:329-37. 2011
    ....
  54. ncbi request reprint Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Neurobiol Aging 26:1161-5. 2005
    ..However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD...
  55. pmc Association studies of 22 candidate SNPs with late-onset Alzheimer's disease
    Jessica A Figgins
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 150:520-6. 2009
    ..Our data suggest that the association of the studied variants with LOAD risk, if it exists, is not statistically significant in our sample...
  56. ncbi request reprint Mild cognitive impairment, amnestic type: an epidemiologic study
    Mary Ganguli
    Division of Geriatrics and Neuropsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 63:115-21. 2004
    ..To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample...
  57. ncbi request reprint Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
    Purnima Desai
    Department of Human Genetics, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15216, USA
    Neurosci Lett 328:9-12. 2002
    ..Our data indicate that the Intron 2 polymorphism of CYP46 does not affect the risk of AD in our sample...
  58. pmc Gray matter atrophy associated with extrapyramidal signs in the Lewy body variant of Alzheimer's disease
    Seong Hye Choi
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Alzheimers Dis 32:1043-9. 2012
    ..These findings suggest that that the etiology of EPS in patients with the LB variant of AD is associated with neuronal loss in the nigrostriatal tracts. By contrast, the source of the EPS in AD alone appears to be less well localized...
  59. pmc Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, BSTWR S 521, Pittsburgh, PA 15261, USA
    J Histochem Cytochem 56:1065-73. 2008
    ..The relationship between elevated intracellular 5-LOX and hallmark AD pathological lesions provides further evidence that neuroinflammatory pathways contribute to the pathogenesis of AD...
  60. ncbi request reprint Chronic traumatic encephalopathy in a national football league player: part II
    Bennet I Omalu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurosurgery 59:1086-92; discussion 1092-3. 2006
    ..These differing pathological features underscore the need for further empirical elucidation of the pathoetiology and pathological cascades of long-term neurodegenerative sequelae of professional football...
  61. pmc Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 33:826-33. 2013
    ..Future studies examining long-term effects of simvastatin therapy on CBF and chronic neurodegenerative changes after TBI are warranted...
  62. pmc Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurosci Lett 408:170-2. 2006
    ..We examined the association of these two SNPs with LOAD risk in a large Caucasian American cohort comprising about 2000 cases and controls. Neither SNP revealed significant association with LOAD risk or age-at-onset...
  63. ncbi request reprint Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurosci Lett 406:265-9. 2006
    ..None of the SNPs examined in this fairly large case-control sample revealed significant association with AD risk. These SNPs also showed no significant association with AD quantitative traits...
  64. ncbi request reprint The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    Contemp Clin Trials 27:238-53. 2006
    ..Studies such as these are necessary for this and a variety of other potential protective agents to evaluate their effectiveness in preventing or slowing the emergence of dementia in the elderly population...
  65. ncbi request reprint Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  66. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  67. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  68. pmc The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 7:270-9. 2011
    ..Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings...
  69. ncbi request reprint Making sense of mild cognitive impairment: a qualitative exploration of the patient's experience
    Jennifer Hagerty Lingler
    Department of Psychiatry, Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, 121 University Place, Pittsburgh, PA 15260, USA
    Gerontologist 46:791-800. 2006
    ..Yet, little is known about the subjective experience of living with a diagnosis of mild cognitive impairment. This study examines, from the patient's perspective, the experience of living with and making sense of the diagnosis...
  70. ncbi request reprint Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  71. pmc Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Neuropsychologia 46:1965-78. 2008
    ..As familiarity is thought to be spared in normal aging, its measurement may provide a relatively specific marker for the early pathological changes of Alzheimer's disease...
  72. ncbi request reprint Longitudinal increase in the volume of white matter hyperintensities in late-onset depression
    Robert D Nebes
    Department of Psychiatry, WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:526-30. 2002
    ..However, at present there is little evidence that a longitudinal increase in WMH burden within an individual is associated with the onset of a late-life depression...
  73. ncbi request reprint Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease
    Robert A Sweet
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:24-30. 2002
    ..The findings support the hypothesis that these two genetic determinants of AD risk do not contribute to the risk of development of psychotic symptoms in AD...
  74. ncbi request reprint Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression
    Purnima Desai
    Department of Human Genetics, University of Pittsburgh, 624 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Neurosci Lett 379:229-34. 2005
    ..The significant effect of the C270T polymorphism observed on MMSE scores among American Blacks needs to be further explored in a larger cohort...
  75. ncbi request reprint The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:2086-92. 2003
    ..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits...
  76. ncbi request reprint Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Alzheimers Dis 5:39-48. 2003
    ..Moreover, the present findings suggest that the short-term memory loss observed in MCI is not caused by cholinergic deficits; it more likely relates to disrupted entorhinal-hippocampal connectivity...
  77. ncbi request reprint Chronic traumatic encephalopathy in a National Football League player
    Bennet I Omalu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15221, USA
    Neurosurgery 57:128-34; discussion 128-34. 2005
    ..This case draws attention to the need for further studies in the cohort of retired National Football League players to elucidate the neuropathological sequelae of repeated mild traumatic brain injury in professional football...
  78. ncbi request reprint Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Dis 20:574-82. 2005
    ..Elevated apoD in AD brain may influence Abeta aggregation, or facilitate phagocytosis and transport of Abeta fibrils from plaques to cerebral vasculature...
  79. ncbi request reprint Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  80. ncbi request reprint Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset
    Elise A Eror
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:325-30. 2005
    ..One prediction of this model would be that AD+P subjects would have evidence of increased degrees of subsyndromal psychosis before AD onset...
  81. ncbi request reprint Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort
    Anne B Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 53:1101-7. 2005
    ..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)...
  82. ncbi request reprint 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:13244-56. 2003
    ..These effects of 22R-hydroxycholesterol may provide a novel strategy to decrease amyloid beta secretion and consequently reduce the amyloid burden in the brain...
  83. ncbi request reprint Functional transitions and active life expectancy associated with Alzheimer disease
    Hiroko H Dodge
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Arch Neurol 60:253-9. 2003
    ....
  84. ncbi request reprint Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease
    Erin Luedecking-Zimmer
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 117:114-7. 2003
    ..071 vs. 0.051; P = 0.042) with an adjusted odds ratio (OR) of 0.65 (95% confidence interval [CI]: 0.43-0.96; P = 0.0498). Our data suggest that the LBP-1c/CP2/LSF polymorphism may have a moderate protective effect against the risk of AD...
  85. ncbi request reprint Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey
    Mary Ganguli
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:1668-75. 2004
    ..To identify characteristics of older primary care patients who were cognitively impaired and who underwent mental status testing by their physicians...
  86. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  87. ncbi request reprint Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  88. pmc Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment
    Linda Garand
    The University of Pittsburgh School of Nursing, Health and Community Systems Department, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:512-22. 2005
    ..We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI...
  89. ncbi request reprint Alzheimer disease and mortality: a 15-year epidemiological study
    Mary Ganguli
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 2593, USA
    Arch Neurol 62:779-84. 2005
    ..Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow-up of representative US cohorts...
  90. ncbi request reprint Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    ..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD...
  91. ncbi request reprint Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition
    Oscar L Lopez
    Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 53:83-7. 2005
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes...
  92. ncbi request reprint APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  93. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  94. ncbi request reprint Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 386:111-5. 2005
    ..Our study suggests that hnRNP A2 and B1 display different responses in the AD hippocampus, and further suggests that the post-transcriptional regulation is disturbed in neurons of the AD hippocampus...
  95. ncbi request reprint Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 64:1771-6. 2007
    ..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression...
  96. ncbi request reprint Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    Steven T DeKosky
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Ann Neurol 53:81-90. 2003
    ....
  97. ncbi request reprint Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    J Mol Neurosci 19:23-7. 2002
    ..In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD...
  98. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  99. ncbi request reprint Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls
    Xiaoyan Wang
    Department of Human Genetics, Graduate School of Public Health, 130 DeSoto Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 23:377-82. 2002
    ..In conclusion, ACT may play an important role in the AD pathogenesis and genetic variation in the ACT gene appears to have some effect on plasma ACT concentrations...
  100. ncbi request reprint Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, NE, Seattle, WA 98115, USA
    J Gerontol A Biol Sci Med Sci 62:1244-51. 2007
    ..Recent evidence suggests that physical decline and slower gait may be associated with early signs of dementia, but more information on healthy older adults is needed...
  101. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...