Steven T DeKosky

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  2. ncbi Looking backward to move forward: early detection of neurodegenerative disorders
    Steven T DeKosky
    Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Science 302:830-4. 2003
  3. ncbi Similar enzymes, different mechanisms: COX-1 and COX-2 enzymes in neurologic disease
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Neurol 60:632-3. 2003
  4. ncbi Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 21:491-500. 2004
  5. ncbi Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 90:998-1004. 2004
  6. ncbi The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    Contemp Clin Trials 27:238-53. 2006
  7. ncbi Statin therapy in the treatment of Alzheimer disease: what is the rationale?
    Steven T DeKosky
    Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Med 118:48-53. 2005
  8. ncbi Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Ave, Suite 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:541-4. 2007
  9. ncbi Maintaining adherence and retention in dementia prevention trials
    Steven T DeKosky
    Alzheimer Disease Research Center, Department of Neurology, University of Pittsburgh, Pttsburgh, Pennsylvania 15213, USA
    Neurology 67:S14-6. 2006
  10. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013

Research Grants

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Detail Information

Publications93

  1. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  2. ncbi Looking backward to move forward: early detection of neurodegenerative disorders
    Steven T DeKosky
    Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Science 302:830-4. 2003
    ..Early detection of these slowly progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications for use early in disease and during the presymptomatic period...
  3. ncbi Similar enzymes, different mechanisms: COX-1 and COX-2 enzymes in neurologic disease
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Neurol 60:632-3. 2003
  4. ncbi Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 21:491-500. 2004
    ..These data demonstrate a complex temporal spectrum of antioxidant enzyme activation following secondary brain injury in the hippocampus, and suggest a selective regulatory role for NGF in this response...
  5. ncbi Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 90:998-1004. 2004
    ..These results have implications for clinical treatment of TBI, demonstrating that moderate hypothermia suppresses NGF and the antioxidant response after TBI; the latter cannot be countered by exogenous NGF administration...
  6. ncbi The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    Contemp Clin Trials 27:238-53. 2006
    ..Studies such as these are necessary for this and a variety of other potential protective agents to evaluate their effectiveness in preventing or slowing the emergence of dementia in the elderly population...
  7. ncbi Statin therapy in the treatment of Alzheimer disease: what is the rationale?
    Steven T DeKosky
    Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Med 118:48-53. 2005
    ..Two randomized double-blind statin trials in patients with AD to assess the potential for statins to slow disease progression are currently under way. If successful, statin AD primary prevention trials may be developed...
  8. ncbi Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Ave, Suite 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:541-4. 2007
    ..Changes in soluble Abeta levels and their relationship to Abeta plaque formation following TBI are unknown...
  9. ncbi Maintaining adherence and retention in dementia prevention trials
    Steven T DeKosky
    Alzheimer Disease Research Center, Department of Neurology, University of Pittsburgh, Pttsburgh, Pennsylvania 15213, USA
    Neurology 67:S14-6. 2006
    ..In this section methods by which compliance and adherence can be optimized are discussed. Research on the effectiveness of these and other evolving methods will be of help in assuring success of such large scale studies in the future...
  10. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
    ..To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging...
  11. ncbi Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Dis 20:574-82. 2005
    ..Elevated apoD in AD brain may influence Abeta aggregation, or facilitate phagocytosis and transport of Abeta fibrils from plaques to cerebral vasculature...
  12. ncbi Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 811, 15213, USA
    Exp Neurol 197:437-50. 2006
    ....
  13. ncbi Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  14. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  15. ncbi Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  16. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  17. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  18. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
    ..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset...
  19. ncbi Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    ..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD...
  20. ncbi Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  21. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  22. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  23. ncbi Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  24. ncbi Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  25. pmc Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1435-9. 2006
    ..012). These data suggest that the ACT gene may affect AAO and disease duration of AD...
  26. pmc Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Neurol 66:646-51. 2009
    ..To examine alpha7 nicotinic acetylcholine receptor (nAChR) binding and beta-amyloid (Abeta) peptide load in superior frontal cortex (SFC) across clinical and neuropathological stages of Alzheimer disease (AD)...
  27. ncbi The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:2086-92. 2003
    ..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits...
  28. ncbi Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Exp Neurol 190:192-203. 2004
    ....
  29. ncbi Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  30. ncbi Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  31. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  32. pmc Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 624 Parran Hall, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1440-4. 2006
    ..0082) effects among non-APOE*4 carriers. The three CHAT SNPs also showed a modest association with MMSE score. Our data suggest that genetic variation in the CHAT gene may be associated with AD risk and quantitative traits related to AD...
  33. pmc No association of SORL1 SNPs with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurosci Lett 440:190-2. 2008
    ..Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort...
  34. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  35. pmc Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007
    ..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype...
  36. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  37. pmc Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 302:2663-70. 2009
    ..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
  38. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  39. pmc No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 29:1602-4. 2008
    ..We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs...
  40. ncbi Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    Steven T DeKosky
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Ann Neurol 53:81-90. 2003
    ....
  41. ncbi Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  42. ncbi Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression
    Purnima Desai
    Department of Human Genetics, University of Pittsburgh, 624 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Neurosci Lett 379:229-34. 2005
    ..The significant effect of the C270T polymorphism observed on MMSE scores among American Blacks needs to be further explored in a larger cohort...
  43. ncbi APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  44. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  45. pmc Amyloid imaging in dementias with atypical presentation
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:389-98. 2012
    ..We explored the potential value of amyloid imaging in patients with atypical presentations of dementia...
  46. pmc Marital quality in the context of mild cognitive impairment
    Linda Garand
    University of Pittsburgh, Pittsburgh, PA, USA
    West J Nurs Res 29:976-92. 2007
    ..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships...
  47. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  48. pmc Frequency and correlates of advance planning among cognitively impaired older adults
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:643-9. 2008
    ..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity...
  49. pmc Does Ginkgo biloba reduce the risk of cardiovascular events?
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
    Circ Cardiovasc Qual Outcomes 3:41-7. 2010
    ..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia...
  50. ncbi Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Neurobiol Aging 26:1161-5. 2005
    ..However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD...
  51. ncbi X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology and Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Methods Enzymol 412:123-44. 2006
    ....
  52. ncbi Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:352-60. 2006
    ..Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases...
  53. pmc Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
    Acta Neuropathol 123:433-47. 2012
    ..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal...
  54. doi Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 610:353-74. 2010
    ..This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates...
  55. ncbi Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 341 Fifth Ave, Ste 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:1312-7. 2007
    ....
  56. pmc No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurobiol Aging 30:1890-1. 2009
    ..We did not detect associations with AD for any variation...
  57. ncbi Mild cognitive impairment, amnestic type: an epidemiologic study
    Mary Ganguli
    Division of Geriatrics and Neuropsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 63:115-21. 2004
    ..To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample...
  58. ncbi Alzheimer disease and mortality: a 15-year epidemiological study
    Mary Ganguli
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 2593, USA
    Arch Neurol 62:779-84. 2005
    ..Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow-up of representative US cohorts...
  59. ncbi Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease
    Purnima Desai Sundar
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 28:856-62. 2007
    ..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD...
  60. ncbi Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 144:79-82. 2007
    ..01) and disease duration (P = 0.006). Our data on a large number of AD cases and controls suggest that genetic variation in PLAU may affect the risk and AAO of AD...
  61. ncbi Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan...
  62. ncbi Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Alzheimers Dis 5:39-48. 2003
    ..Moreover, the present findings suggest that the short-term memory loss observed in MCI is not caused by cholinergic deficits; it more likely relates to disrupted entorhinal-hippocampal connectivity...
  63. pmc No association between CALHM1 variation and risk of Alzheimer disease
    Ryan L Minster
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Mutat 30:E566-9. 2009
    ..368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034)...
  64. ncbi Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  65. pmc Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors
    Kyle B Womack
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
    Arch Neurol 68:329-37. 2011
    ....
  66. ncbi Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset
    Elise A Eror
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:325-30. 2005
    ..One prediction of this model would be that AD+P subjects would have evidence of increased degrees of subsyndromal psychosis before AD onset...
  67. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  68. ncbi Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease
    Robert A Sweet
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:24-30. 2002
    ..The findings support the hypothesis that these two genetic determinants of AD risk do not contribute to the risk of development of psychotic symptoms in AD...
  69. ncbi Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  70. ncbi Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
    Purnima Desai
    Department of Human Genetics, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15216, USA
    Neurosci Lett 328:9-12. 2002
    ..Our data indicate that the Intron 2 polymorphism of CYP46 does not affect the risk of AD in our sample...
  71. ncbi Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury
    Mary E Kerr
    University of Pittsburgh, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA, USA
    Crit Care Med 31:2371-9. 2003
    ....
  72. ncbi Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 51:145-55. 2002
    ..The upregulation in frontal cortex and hippocampal ChAT activity could be an important factor in preventing the transition of MCI subjects to AD...
  73. ncbi 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:13244-56. 2003
    ..These effects of 22R-hydroxycholesterol may provide a novel strategy to decrease amyloid beta secretion and consequently reduce the amyloid burden in the brain...
  74. pmc Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment
    Linda Garand
    The University of Pittsburgh School of Nursing, Health and Community Systems Department, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:512-22. 2005
    ..We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI...
  75. ncbi Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort
    Anne B Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 53:1101-7. 2005
    ..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)...
  76. ncbi Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  77. ncbi Functional transitions and active life expectancy associated with Alzheimer disease
    Hiroko H Dodge
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Arch Neurol 60:253-9. 2003
    ....
  78. ncbi Blood pressure and cognitive impairment in India and the United States: a cross-national epidemiological study
    Rajesh Pandav
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Arch Neurol 60:1123-8. 2003
    ..To evaluate the relationship between blood pressure (BP) and cognitive impairment in elderly populations in India and the United States in a cross-national epidemiological study...
  79. ncbi Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey
    Mary Ganguli
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:1668-75. 2004
    ..To identify characteristics of older primary care patients who were cognitively impaired and who underwent mental status testing by their physicians...
  80. ncbi Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies
    Chester A Mathis
    Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Neurol 62:196-200. 2005
    ....
  81. ncbi Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  82. pmc Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, BSTWR S 521, Pittsburgh, PA 15261, USA
    J Histochem Cytochem 56:1065-73. 2008
    ..The relationship between elevated intracellular 5-LOX and hallmark AD pathological lesions provides further evidence that neuroinflammatory pathways contribute to the pathogenesis of AD...
  83. ncbi Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  84. ncbi Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  85. ncbi Use of herbal medicine and other dietary supplements in community-dwelling older people: Baseline data from the ginkgo evaluation of memory study
    Richard L Nahin
    National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 54:1725-35. 2006
    ..To analyze baseline data from the Ginkgo Evaluation of Memory (GEM) study, in which information was collected on the use of all dietary supplements...
  86. ncbi Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:481-4. 2004
    ..Our study suggests that hnRNP B1-associated post-transcriptional regulations are preserved in the inferior temporal cortex of Alzheimer's disease...
  87. ncbi Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease
    Elliott J Mufson
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 2242 W Harrison Street, Chicago, IL 60612, USA
    Arch Neurol 60:1143-8. 2003
    ..The status of nerve growth factor (NGF) levels during the prodromal phase of Alzheimer disease (AD), characterized by mild cognitive impairment (MCI), remains unknown...
  88. ncbi Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 64:1771-6. 2007
    ..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression...
  89. ncbi Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
    Bruno Dubois
    INSERM U610, Hopital de la Salpetriere, Paris, France
    Lancet Neurol 6:734-46. 2007
    ..Validation studies in existing and prospective cohorts are needed to advance these criteria and optimise their sensitivity, specificity, and accuracy...
  90. pmc Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse
    Sylvia E Perez
    Department of Neurological Sciences, Alla V and Solomon Jesmer Chair in Aging, Rush University Medical Center, 1735 W Harrison Street, Suite 300, Chicago, IL 60612, USA
    Neurobiol Dis 28:3-15. 2007
    ....
  91. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  92. ncbi Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, NE, Seattle, WA 98115, USA
    J Gerontol A Biol Sci Med Sci 62:1244-51. 2007
    ..Recent evidence suggests that physical decline and slower gait may be associated with early signs of dementia, but more information on healthy older adults is needed...
  93. ncbi Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory Study experience
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
    Contemp Clin Trials 27:541-53. 2006
    ..Information on the experience of the GEM Study recruitment may be helpful to other clinical trials attempting to randomize older adults into prevention trials...

Research Grants2

  1. GINKGO BILOBA PREVENTION TRIAL IN OLDER INDIVIDUALS
    Steven DeKosky; Fiscal Year: 2007
    ..abstract_text> ..