Research Topics
Genomes and Genes
| Steven T DeKoskySummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Ginkgo biloba for prevention of dementia: a randomized controlled trialSteven T DeKosky
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 300:2253-62. 2008..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortexPurnima P Desai
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurobiol Dis 20:574-82. 2005..Elevated apoD in AD brain may influence Abeta aggregation, or facilitate phagocytosis and transport of Abeta fibrils from plaques to cerebral vasculature...- The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosisElise A Weamer
Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
Int Psychogeriatr 21:78-85. 2009..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset... - Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Brain 131:1630-45. 2008..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden... - Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-BMeryl A Butters
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Alzheimer Dis Assoc Disord 22:261-8. 2008..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals... - Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2Oscar L Lopez
Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Arch Neurol 60:1394-9. 2003..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study... - Patterns of mild cognitive impairment after treatment of depression in the elderlyRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 17:308-16. 2009.... - Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008.... - Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Arch Neurol 66:646-51. 2009..To examine alpha7 nicotinic acetylcholine receptor (nAChR) binding and beta-amyloid (Abeta) peptide load in superior frontal cortex (SFC) across clinical and neuropathological stages of Alzheimer disease (AD)... - Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's diseaseM Ilyas Kamboh
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurobiol Aging 27:1435-9. 2006..012). These data suggest that the ACT gene may affect AAO and disease duration of AD... - Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysisBrian J Lopresti
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Nucl Med 46:1959-72. 2005..This work reports on simplified methods of analysis for human PIB imaging... - Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brainWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 25:10598-606. 2005.... - Neuropathologic correlates of late-onset major depressionRobert A Sweet
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2242-50. 2004..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed... - Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's diseaseNicolaas I Bohnen
Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
Neurosci Lett 380:127-32. 2005..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD... - Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserveAnn D Cohen
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 29:14770-8. 2009.... - Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's diseaseAyla Ozturk
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 624 Parran Hall, Pittsburgh, PA 15261, USA
Neurobiol Aging 27:1440-4. 2006..0082) effects among non-APOE*4 carriers. The three CHAT SNPs also showed a modest association with MMSE score. Our data suggest that genetic variation in the CHAT gene may be associated with AD risk and quantitative traits related to AD... - Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer diseaseClayton A Wiley
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Arch Neurol 66:60-7. 2009..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood... - No association of SORL1 SNPs with Alzheimer's diseaseRyan L Minster
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States
Neurosci Lett 440:190-2. 2008..Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort... - Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-BJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Cereb Blood Flow Metab 25:1528-47. 2005..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum... - Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphismPatricia A Wilkosz
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype... - Trajectories of cognitive decline in Alzheimer's diseasePatricia A Wilkosz
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Int Psychogeriatr 22:281-90. 2010..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects... - Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humansSteven T DeKosky
Department of Neurology, University of Pittsburgh, 3471 Fifth Ave, Suite 811, Pittsburgh, PA 15213, USA
Arch Neurol 64:541-4. 2007..Changes in soluble Abeta levels and their relationship to Abeta plaque formation following TBI are unknown... - No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's diseaseRyan L Minster
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurobiol Aging 29:1602-4. 2008..We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs... - Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progressionPurnima Desai
Department of Human Genetics, University of Pittsburgh, 624 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Neurosci Lett 379:229-34. 2005..The significant effect of the C270T polymorphism observed on MMSE scores among American Blacks needs to be further explored in a larger cohort... - Alzheimer's pathology in human temporal cortex surgically excised after severe brain injuryMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
Exp Neurol 190:192-203. 2004.... - Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's diseaseOscar L Lopez
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Neuropsychiatry Clin Neurosci 15:346-53. 2003..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages... - APOE is associated with age-of-onset, but not cognitive functioning, in late-life depressionMeryl A Butters
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 18:1075-81. 2003..We also predicted that APOE4 allele frequency would be increased among subjects with LLD... - Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairmentSteven T DeKosky
Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
Ann Neurol 53:81-90. 2003.... - Does Ginkgo biloba reduce the risk of cardiovascular events?Lewis H Kuller
Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
Circ Cardiovasc Qual Outcomes 3:41-7. 2010..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia... - The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementiaSteven T DeKosky
Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
Contemp Clin Trials 27:238-53. 2006..Studies such as these are necessary for this and a variety of other potential protective agents to evaluate their effectiveness in preventing or slowing the emergence of dementia in the elderly population... - Frequency and correlates of advance planning among cognitively impaired older adultsJennifer Hagerty Lingler
Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:643-9. 2008..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity... - The relation of white matter hyperintensities to cognitive performance in the normal old: education mattersRobert D Nebes
University of Pittsburgh Medical Center, Pennsylvania, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies... - X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology and Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Methods Enzymol 412:123-44. 2006.... - Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's diseaseAyla Ozturk
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Neurobiol Aging 26:1161-5. 2005..However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD... - Marital quality in the context of mild cognitive impairmentLinda Garand
University of Pittsburgh, Pittsburgh, PA, USA
West J Nurs Res 29:976-92. 2007..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships... - Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypesPatricia A Wilkosz
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 14:352-60. 2006..Further exploration of the relationship between depressive symptoms and psychosis in patients with AD is warranted... - Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's diseasePurnima Desai Sundar
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurobiol Aging 28:856-62. 2007..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD... - Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traitsAyla Ozturk
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Med Genet B Neuropsychiatr Genet 144:79-82. 2007..01) and disease duration (P = 0.006). Our data on a large number of AD cases and controls suggest that genetic variation in PLAU may affect the risk and AAO of AD... - Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigreesWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 27:6174-84. 2007..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms... - Ginkgo biloba for preventing cognitive decline in older adults: a randomized trialBeth E Snitz
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 302:2663-70. 2009..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning... - Mild cognitive impairment, amnestic type: an epidemiologic studyMary Ganguli
Division of Geriatrics and Neuropsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neurology 63:115-21. 2004..To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample... - No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's diseaseRyan L Minster
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
Neurobiol Aging 30:1890-1. 2009..We did not detect associations with AD for any variation... - Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, 341 Fifth Ave, Ste 811, Pittsburgh, PA 15213, USA
Arch Neurol 64:1312-7. 2007.... - No association between CALHM1 variation and risk of Alzheimer diseaseRyan L Minster
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Hum Mutat 30:E566-9. 2009..368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034)... 
Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissuesVladimir A Tyurin
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
Methods Mol Biol 610:353-74. 2010..This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates...- Pathways linking late-life depression to persistent cognitive impairment and dementiaMeryl A Butters
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
Dialogues Clin Neurosci 10:345-57. 2008.... - Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibitionOscar L Lopez
Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 53:83-7. 2005..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes... - Alzheimer disease and mortality: a 15-year epidemiological studyMary Ganguli
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 2593, USA
Arch Neurol 62:779-84. 2005..Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow-up of representative US cohorts... - Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapiesSteven T DeKosky
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurochem 90:998-1004. 2004..These results have implications for clinical treatment of TBI, demonstrating that moderate hypothermia suppresses NGF and the antioxidant response after TBI; the latter cannot be countered by exogenous NGF administration... - Anticipatory grief in new family caregivers of persons with mild cognitive impairment and dementiaLinda Garand
Health and Community Systems Department, 415 Victoria Building, University of Pittsburgh School of Nursing, 3500 Victoria Street, Pittsburgh, PA 15261, USA
Alzheimer Dis Assoc Disord 26:159-65. 2012..Given these findings, family caregivers of individuals with mild cognitive deficits or a new AD diagnosis may benefit from interventions specifically addressing anticipatory grief... - Association of CLU and PICALM variants with Alzheimer's diseaseM Ilyas Kamboh
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
Neurobiol Aging 33:518-21. 2012..Our data from an independent and large case-control sample suggest that these gene regions should be followed up by comprehensive resequencing to find functional variants... - Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controlsXiaoyan Wang
Department of Human Genetics, Graduate School of Public Health, 130 DeSoto Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurobiol Aging 23:377-82. 2002..In conclusion, ACT may play an important role in the AD pathogenesis and genetic variation in the ACT gene appears to have some effect on plasma ACT concentrations... - Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onsetElise A Eror
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:325-30. 2005..Subsyndromal psychosis might be useful for classifying AD+P families for genetic mapping studies. Prospective confirmation is required... - Detection and management of cognitive impairment in primary care: The Steel Valley Seniors SurveyMary Ganguli
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 52:1668-75. 2004..To identify characteristics of older primary care patients who were cognitively impaired and who underwent mental status testing by their physicians... - Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1Oscar L Lopez
Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Arch Neurol 60:1385-9. 2003..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study... - Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapyCharles F Reynolds
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:51-60. 2011..Cognitive impairment in late-life depression is a core feature of the illness... - Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition studyOscar L Lopez
Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
Arch Neurol 64:416-20. 2007..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study... - The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid componentWilliam E Klunk
Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 23:2086-92. 2003..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits... - Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition StudyOscar L Lopez
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neurology 79:1599-606. 2012..9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011... - A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Hippocampus 21:461-6. 2011..These results are consistent with a division of labor in the MTL and the dual process model... - Association studies of 22 candidate SNPs with late-onset Alzheimer's diseaseJessica A Figgins
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Med Genet B Neuropsychiatr Genet 150:520-6. 2009..Our data suggest that the association of the studied variants with LOAD risk, if it exists, is not statistically significant in our sample... - Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000Oscar L Lopez
Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Neuropsychiatry Clin Neurosci 15:67-73. 2003..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades... - Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology and the Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 25213, USA
Arch Neurol 62:425-30. 2005..It appears that this change relates to generalized cognitive abnormalities but not specifically to visuospatial function... - Evidence supporting a role for the calcium-sensing receptor in Alzheimer diseaseYvette P Conley
Department of Health Promotion and Development, University of Pittsburgh, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 150:703-9. 2009..These data support our hypothesis that the CASR has a role in AD susceptibility, particularly in individuals without an APOE4 allele... - Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12Erin Luedecking-Zimmer
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Hum Genet 111:443-51. 2002..Our data suggest that genetic variation in the OLR1 gene may modify the risk of AD in an APOE*4-dependent fashion... - Incidence and predictors of advance care planning among persons with cognitive impairmentLinda Garand
Department of Health and Community Systems, University of Pittsburgh, PA 15261, USA
Am J Geriatr Psychiatry 19:712-20. 2011..We sought to characterize advance care planning (ACP) rates over time in individuals who had no advance directives (living will or durable power of attorney) in place when they initially presented for a cognitive evaluation... - Development of a short form of the Severe Impairment BatteryJudith Saxton
Univ of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 13:999-1005. 2005..The authors sought to develop a short form of the Severe Impairment Battery (SIB)... - Maintaining adherence and retention in dementia prevention trialsSteven T DeKosky
Alzheimer Disease Research Center, Department of Neurology, University of Pittsburgh, Pttsburgh, Pennsylvania 15213, USA
Neurology 67:S14-6. 2006..In this section methods by which compliance and adherence can be optimized are discussed. Research on the effectiveness of these and other evolving methods will be of help in assuring success of such large scale studies in the future... - Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohortAnne B Newman
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Am Geriatr Soc 53:1101-7. 2005..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)... - Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic studyNicolaas I Bohnen
Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Neurol 60:1745-8. 2003..1%), except for regionally selective involvement of the lateral temporal cortex (-15%; P<.001). CONCLUSION: Reduced cortical AChE activity is more characteristic of patients with PDem than of patients with mild AD... - Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementiaEllen M Whyte
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 10:321-7. 2002..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment... - Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's diseaseXiaoyan Wang
Department of Human Genetics, Graduate School of Public Health, 130 DeSoto Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
Hum Genet 110:356-65. 2002.... - Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-AmericansPurnima P Desai
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Med Genet B Neuropsychiatr Genet 116:98-101. 2003..14; P = 0.13). Our data suggest that the risk of AD among African-Americans may be modified by genetic variation in APOD. Larger population-based or case-control studies are needed to confirm the role of APOD genetic variation in AD... - Functional transitions and active life expectancy associated with Alzheimer diseaseHiroko H Dodge
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
Arch Neurol 60:253-9. 2003.... - Pathology and pathways of Alzheimer's disease with an update on new developments in treatmentSteven T DeKosky
Department of Neurology, Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Am Geriatr Soc 51:S314-20. 2003.... - Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletionCaroline Hope
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neurobiol Dis 14:504-12. 2003..These observations suggest a possible functional basis by which the A2M deletion may influence multifactorial AD pathogenesis... - Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's diseaseRobert A Sweet
Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
J Geriatr Psychiatry Neurol 15:24-30. 2002..The findings support the hypothesis that these two genetic determinants of AD risk do not contribute to the risk of development of psychotic symptoms in AD... - Statin therapy in the treatment of Alzheimer disease: what is the rationale?Steven T DeKosky
Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania 15213 2582, USA
Am J Med 118:48-53. 2005..Two randomized double-blind statin trials in patients with AD to assess the potential for statins to slow disease progression are currently under way. If successful, statin AD primary prevention trials may be developed... - Lack of association of two chromosome 10q24 SNPs with Alzheimer's diseaseRyan L Minster
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neurosci Lett 408:170-2. 2006..We examined the association of these two SNPs with LOAD risk in a large Caucasian American cohort comprising about 2000 cases and controls. Neither SNP revealed significant association with LOAD risk or age-at-onset... - Caregivers as subjects of clinical drug trials: a review of human subjects protection practices in published studies of Alzheimer's disease pharmacotherapiesJennifer Hagerty Lingler
Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
IRB 28:11-8. 2006 - Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, BSTWR S 521, Pittsburgh, PA 15261, USA
J Histochem Cytochem 56:1065-73. 2008..The relationship between elevated intracellular 5-LOX and hallmark AD pathological lesions provides further evidence that neuroinflammatory pathways contribute to the pathogenesis of AD... - Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memoryDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
Neuropsychologia 46:1965-78. 2008..As familiarity is thought to be spared in normal aging, its measurement may provide a relatively specific marker for the early pathological changes of Alzheimer's disease...