Onofre T DeJesus

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint 6-fluoroDOPA metabolism in rat striatum: time course of extracellular metabolites
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Brain Res 877:31-6. 2000
  2. ncbi request reprint Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School Madison, Wisconsin 53706, USA
    Synapse 39:58-63. 2001
  3. ncbi request reprint Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys
    Onofre T DeJesus
    Medical Physics Department, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Synapse 44:246-51. 2002
  4. doi request reprint Sensory processing disorder in a primate model: evidence from a longitudinal study of prenatal alcohol and prenatal stress effects
    Mary L Schneider
    University of Wisconsin Madison, Department of Kinesiology, 2175 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Child Dev 79:100-13. 2008
  5. ncbi request reprint Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys
    Mary L Schneider
    Department of Kinesiology, The Harlow Center for Biological Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Alcohol Clin Exp Res 29:1685-97. 2005
  6. pmc Fetal dopamine receptor characteristics assessed in utero
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Cereb Blood Flow Metab 30:1437-40. 2010
  7. pmc Fetal dose estimates for (18)F-fluoro-L-thymidine using a pregnant monkey model
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:288-92. 2010
  8. pmc A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Veterans Hospital, Madison, Wisconsin, USA
    Mov Disord 26:2032-8. 2011
  9. ncbi request reprint Sensory processing disorders in a nonhuman primate model: evidence for occupational therapy practice
    Mary L Schneider
    Department of Kinesiology, Occupational Therapy Program, University of Wisconsin Madison, 2175 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Am J Occup Ther 61:247-53. 2007
  10. pmc Assessment of fetal brain uptake of paraquat in utero using in vivo PET/CT imaging
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Toxicol Sci 122:551-6. 2011

Detail Information

Publications23

  1. ncbi request reprint 6-fluoroDOPA metabolism in rat striatum: time course of extracellular metabolites
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Brain Res 877:31-6. 2000
    ..These metabolic steps and their role in tracer kinetics are, thus, important factors to consider in ascribing physiologic significance to PET-derived measures...
  2. ncbi request reprint Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School Madison, Wisconsin 53706, USA
    Synapse 39:58-63. 2001
    ..Furthermore, comparison of results of this study with previous studies support the notion that the effect of aging in the dopamine system is different from that of MPTP-induced parkinsonism...
  3. ncbi request reprint Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys
    Onofre T DeJesus
    Medical Physics Department, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Synapse 44:246-51. 2002
    ..Results also showed diminished responsivity of AAAD to TBZ challenge in aged monkey brain...
  4. doi request reprint Sensory processing disorder in a primate model: evidence from a longitudinal study of prenatal alcohol and prenatal stress effects
    Mary L Schneider
    University of Wisconsin Madison, Department of Kinesiology, 2175 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Child Dev 79:100-13. 2008
    ..Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress...
  5. ncbi request reprint Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys
    Mary L Schneider
    Department of Kinesiology, The Harlow Center for Biological Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Alcohol Clin Exp Res 29:1685-97. 2005
    ..In this study, we manipulated the timing of moderate-level alcohol exposure and compared the risk of adverse effects on striatal dopamine (DA) system function in rhesus monkeys...
  6. pmc Fetal dopamine receptor characteristics assessed in utero
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Cereb Blood Flow Metab 30:1437-40. 2010
    ..The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met...
  7. pmc Fetal dose estimates for (18)F-fluoro-L-thymidine using a pregnant monkey model
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:288-92. 2010
    ..This study was undertaken to estimate-on the basis of biodistribution data obtained by PET/CT in pregnant rhesus monkeys-radiation absorbed dose to a human fetus administered (18)F-FLT...
  8. pmc A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Veterans Hospital, Madison, Wisconsin, USA
    Mov Disord 26:2032-8. 2011
    ..These results also imply that L-aromatic amino acid decarboxylase activity is a major determinant of clinical status...
  9. ncbi request reprint Sensory processing disorders in a nonhuman primate model: evidence for occupational therapy practice
    Mary L Schneider
    Department of Kinesiology, Occupational Therapy Program, University of Wisconsin Madison, 2175 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Am J Occup Ther 61:247-53. 2007
    ..Aversive responsiveness was associated with up-regulated striatal dopamine receptor binding measured with positron emission tomography...
  10. pmc Assessment of fetal brain uptake of paraquat in utero using in vivo PET/CT imaging
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Toxicol Sci 122:551-6. 2011
    ....
  11. ncbi request reprint PET Measurement of rCBF in the presence of a neurochemical tracer
    Alexander K Converse
    Keck Laboratory for Functional Brain Imaging, University of Wisconsin, T 121 Waisman Center, 1500 N Highland Avenue, Madison, WI 53705, USA
    J Neurosci Methods 132:199-208. 2004
    ..Comparing consecutive 6 min scans, reproducibility of relative rCBF and striatal [18F]fallypride concentration were 9 and 8%, respectively...
  12. pmc A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Memorial Veterans Hospital, Madison, WI 53792, USA
    Brain Imaging Behav 5:203-11. 2011
    ..These findings provide evidence that regional loss of nigrostriatal inputs to frontostriatal networks affects specific aspects of motor function...
  13. pmc Paraquat is excluded by the blood brain barrier in rhesus macaque: An in vivo pet study
    Rachel M Bartlett
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1005 Wisconsin Institutes of Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Brain Res 1259:74-9. 2009
    ..This acute exposure study found that paraquat is excluded from the brain by the blood brain barrier and thus does not readily support the causative role of paraquat exposure in idiopathic Parkinson's disease...
  14. ncbi request reprint Time profile of cerebral [18F]6-fluoro-L-DOPA metabolites in nonhuman primate: implications for the kinetics of therapeutic L-DOPA
    Christopher J Endres
    Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53706, USA
    Front Biosci 9:505-12. 2004
    ..These findings extend and confirm previous observations of FDOPA metabolites. The implications for the interpretation of FDOPA PET, particularly in terms of the availability of dopamine synthesized from therapeutic L-DOPA, are discussed...
  15. ncbi request reprint Localization of trapping of 6-[(18)F]fluoro-L-m-tyrosine, an aromatic L-amino acid decarboxylase tracer for PET
    W D Brown
    Department of Radiology, University of Wisconsin Madison, USA
    Synapse 34:111-23. 1999
    ..This may be especially important in diseases or experimental states in which dopaminergic neurons are selectively reduced, and may allow for the study of nondopaminergic neuronal systems in vivo with this tracer...
  16. ncbi request reprint Aromatic L-amino acid decarboxylase turnover in vivo in rhesus macaque striatum: a microPET study
    O T DeJesus
    Medical Physics, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Brain Res 1054:55-60. 2005
    ..These findings show that normal movement and behavior do not depend on complete recovery of AAAD function but likely on pre-synaptic and post-synaptic compensatory mechanisms...
  17. ncbi request reprint Aromatic L-amino acid decarboxylase (AAAD) activity in rhesus macaque striatum after MAO-B inhibition by Ro 16-6491
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Synapse 56:54-6. 2005
  18. ncbi request reprint Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study
    Miguel A Avila-Rodriguez
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    Nucl Med Biol 34:585-90. 2007
    ..However, only resins labeled with (86)Y and (89)Zr proved to have the in vivo stability required for clinical applications...
  19. ncbi request reprint Aromatic L-amino acid decarboxylase (AAAD) inhibitors as carcinoid tumor-imaging agents: synthesis of 18F-labeled alpha-fluoromethyl-6-fluoro-m-tyrosine (FM-6-FmT)
    D Murali
    Department of Medical Physics, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Appl Radiat Isot 59:237-43. 2003
    ..Since FM-6-FmT lacks the catechol moiety, it is expected to be better than FMDOPA since it is not a substrate for catechol-O-methyltransferase...
  20. pmc Production of 34m Cl and 38 Cl via the (d,α) reaction on 36 Ar and nat Ar gas at 8.4 MeV
    Jonathan W Engle
    University of Wisconsin, Department of Medical Physics, 1111 Highland Avenue, Madison, WI 53705, USA
    Appl Radiat Isot 69:75-9. 2011
    ..Production yields, cyclotron target development, cryo-recovery of enriched gases, and nucleophilic chemistry of a model compound are described...
  21. ncbi request reprint The impact of prenatal stress, fetal alcohol exposure, or both on development: perspectives from a primate model
    Mary L Schneider
    Department of Kinesiology, 2175 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Psychoneuroendocrinology 27:285-98. 2002
    ..Fetal alcohol exposed monkeys also showed increased HPA axis activity in response to stressful conditions. Finally, altered patterns of alcohol consumption during adolescence were associated with prenatal stress...
  22. ncbi request reprint Synthesis of [64Cu]Cu-NOTA-Bn-GE11 for PET imaging of EGFR-rich tumors
    Onofre T DeJesus
    School of Medicine and Public Health, University of Wisconsin Madison, B1316 Wisconsin Institutes for Medical Research WIMR, Madison, WI 53705, USA
    Curr Radiopharm 5:15-8. 2012
    ..To enable the exploration of this possibility, positron emitting [64Cu]Cu-NOTA-Bn-GE11 was prepared for further evaluation as PET EGFR imaging agent...
  23. ncbi request reprint Prenatal stress, moderate fetal alcohol, and dopamine system function in rhesus monkeys
    A D Roberts
    Department of Psychology, University of Wisconsin Madison, Madison, WI 53706, USA
    Neurotoxicol Teratol 26:169-78. 2004
    ..The latter supports a hypothesis linking striatal function to behavioral inhibitory control...