Research Topics
Genomes and Genes | Scott M DehmSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Androgen receptor gene rearrangements: new perspectives on prostate cancer progressionLucas J Brand
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
Curr Drug Targets 14:441-9. 2013..We further suggest that genomic events leading to ARV expression could act as novel biomarkers of disease progression that may guide the optimal use of current and next-generation AR-targeted therapy...
Alternatively spliced androgen receptor variantsScott M Dehm
Department of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Endocr Relat Cancer 18:R183-96. 2011..In this review, we will summarize the various alternatively spliced AR variants that have been discovered, with a focus on their role and origin in the pathologic conditions of AIS and PCa...- Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistanceScott M Dehm
Department of Urology and Biochemistry, Mayo Clinical College of Medicine, Rochester, Minnesota, USA
Cancer Res 68:5469-77. 2008..Together, our data describe a simple and effective mechanism by which PCa cells can synthesize a constitutively active AR and thus circumvent androgen ablation... - Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancerHannelore V Heemers
Department of Urology Research Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
Cancer Res 67:10592-9. 2007..These results suggest a novel indirect mechanism of androgen action on FHL2 expression and provide evidence that SRF is an important determinant of AR action in prostate cancer cells... - Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell linesYingming Li
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Cancer Res 73:483-9. 2013.... - p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6Jose D Debes
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 65:5965-73. 2005.... - Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosisKristin A Raclaw
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Prostate 68:1696-706. 2008..In the current study, we examined the androgenic regulation of FLIP and its contribution to protecting prostate cancer cells from death receptor-mediated apoptosis... - Ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cellsScott M Dehm
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 281:27882-93. 2006..Our data thus demonstrate that the AR can inappropriately activate transcription in ADI PCa cells via mechanisms that are resistant to castration and AR antagonism, the two modes of androgen ablation used to treat advanced PCa... - Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion independent prostate cancer cellsScott M Dehm
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 67:10067-77. 2007..These data show that ligand-dependent and ligand-independent AR activation rely on fundamentally distinct mechanisms, and define WxxLF as the major transactivation motif within the AR TAU5 domain... - Molecular regulation of androgen action in prostate cancerScott M Dehm
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Cell Biochem 99:333-44. 2006..We will also summarize several recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer... - Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signalSiu Chiu Chan
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 287:19736-49. 2012..Together, our data demonstrate that diverse truncated AR species with varying efficiencies of nuclear localization can contribute to castration-resistant PCa pathology by driving persistent ligand-independent AR transcriptional activity... - Androgen receptor structural and functional elements: role and regulation in prostate cancerScott M Dehm
Departments of Urology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
Mol Endocrinol 21:2855-63. 2007..A comprehensive understanding of the role and functional relationships between these AR domains could lead to the development of novel AR-directed therapies for prostate cancer... - Regulation of androgen receptor signaling in prostate cancerScott M Dehm
Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
Expert Rev Anticancer Ther 5:63-74. 2005..How these mechanisms of androgen receptor activation could be targeted in this advanced stage of the disease is also discussed... - Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progressionYingming Li
Department of Electrical and Computer Engineering, Masonic Cancer Center, University of Minnesota, Twin Cities, Minnesota 55455, USA
Cancer Res 71:2108-17. 2011..Together, these data provide the first report of AR intragenic rearrangements in CRPCa and an association with pathologic expression of truncated AR isoforms in a cell-based model of PCa progression... - The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoterDanielle J P Ellis
Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, SK, Canada
Gene 379:68-78. 2006..These results provide new insights into the complexity of Sp3 mediated transcription which appears to be highly dependent on the isoform bound, SUMOylation status and the promoter context... - Regulation of alternative SRC promoter usage in HepG2 hepatocellular carcinoma cellsScott M Dehm
Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Canada
Gene 337:141-50. 2004..This approach identified a HepG2-specific DH site that displayed activating potential towards the SRC1alpha promoter. These results thus provide important insight to the mechanism of SRC transcriptional activation in liver cancer cells... - SRC proximal and core promoter elements dictate TAF1 dependence and transcriptional repression by histone deacetylase inhibitorsScott M Dehm
Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
Mol Cell Biol 24:2296-307. 2004....