James V DeGregori

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Impaired DNA replication within progenitor cell pools promotes leukemogenesis
    Ganna Bilousova
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    PLoS Biol 3:e401. 2005
  2. ncbi Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene
    Michael Roshon
    Department of Microbiology and Immunology, Room AA4210 MCN, Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232 2363, USA
    BMC Genomics 4:2. 2003
  3. ncbi The genetics of the E2F family of transcription factors: shared functions and unique roles
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado, Health Sciences Center, Denver, CO 80262, USA
    Biochim Biophys Acta 1602:131-50. 2002
  4. ncbi Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell Biol 26:1165-9. 2006
  5. ncbi Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Curr Mol Med 6:739-48. 2006
  6. ncbi Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection
    Christopher C Porter
    Rick Wilson Center for Cancer and Blood Disorders, The Children s Hospital, Aurora, CO, USA
    Blood 112:4466-74. 2008

Research Grants

  1. PREDOCTORAL TRAINING IN MOLECULAR BIOLOGY
    James DeGregori; Fiscal Year: 2007
  2. Poor competition in hematopoietic stem/ progenitor pools favors tumorigenesis
    James DeGregori; Fiscal Year: 2007
  3. Regulation of the Lymphocytic cell cycle by E2F
    James DeGregori; Fiscal Year: 2007
  4. Noncell autonomous control of Beta islet cells
    James DeGregori; Fiscal Year: 2004
  5. SPECIFIC ROLES FOR E2F FAMILY MEMBERS
    James DeGregori; Fiscal Year: 2002
  6. Poor competition in hematopoietic stem/progenitor pools favors tumorigenesis
    James DeGregori; Fiscal Year: 2009

Collaborators

  • Christopher C Porter
  • Ganna Bilousova
  • Michael Roshon
  • Andriy Marusyk
  • Robert D Cardiff
  • H Earl Ruley

Detail Information

Publications6

  1. ncbi Impaired DNA replication within progenitor cell pools promotes leukemogenesis
    Ganna Bilousova
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    PLoS Biol 3:e401. 2005
    ....
  2. ncbi Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene
    Michael Roshon
    Department of Microbiology and Immunology, Room AA4210 MCN, Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232 2363, USA
    BMC Genomics 4:2. 2003
    ..The mutation was selected for analysis because it occurred in a highly expressed gene and yet did not produce obvious phenotypes following germline transmission...
  3. ncbi The genetics of the E2F family of transcription factors: shared functions and unique roles
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado, Health Sciences Center, Denver, CO 80262, USA
    Biochim Biophys Acta 1602:131-50. 2002
  4. ncbi Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell Biol 26:1165-9. 2006
  5. ncbi Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis
    James DeGregori
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Curr Mol Med 6:739-48. 2006
    ....
  6. ncbi Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection
    Christopher C Porter
    Rick Wilson Center for Cancer and Blood Disorders, The Children s Hospital, Aurora, CO, USA
    Blood 112:4466-74. 2008
    ..These findings indicate that iPAR/6TG can be used for in vivo hematopoietic progenitor cell selection...

Research Grants18

  1. PREDOCTORAL TRAINING IN MOLECULAR BIOLOGY
    James DeGregori; Fiscal Year: 2007
    ..This increase will enable us to continue to grow and to reach our full potential as a training program. ..
  2. Poor competition in hematopoietic stem/ progenitor pools favors tumorigenesis
    James DeGregori; Fiscal Year: 2007
    ..These studies should define novel factors governing tumorigenesis, and will create unique model systems that could suggest further epidemiological studies in humans. ..
  3. Regulation of the Lymphocytic cell cycle by E2F
    James DeGregori; Fiscal Year: 2007
    ..Understanding the cellular functions of E2F1/2 and their target genes should facilitate a better understanding of organismal roles for these E2Fs at a more mechanistic level. ..
  4. Noncell autonomous control of Beta islet cells
    James DeGregori; Fiscal Year: 2004
    ..2) Further characterization of non-cell autonomous control of beta islet maintenance using islet transplantation. 3) Analysis of beta islet mass and function in mutant mice with defined hematopoietic defects. ..
  5. SPECIFIC ROLES FOR E2F FAMILY MEMBERS
    James DeGregori; Fiscal Year: 2002
    ....
  6. Poor competition in hematopoietic stem/progenitor pools favors tumorigenesis
    James DeGregori; Fiscal Year: 2009
    ..These studies should define novel factors governing tumorigenesis, and will create unique model systems that could suggest further epidemiological studies in humans. ..